Research Topics
| STEWART MOSTOFSKYSummaryAffiliation: Kennedy Krieger Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Developmental dyspraxia is not limited to imitation in children with autism spectrum disordersStewart H Mostofsky
Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 N Broadway, Baltimore, MD 21205, USA
J Int Neuropsychol Soc 12:314-26. 2006..e., learning) of sensory representations of movement and/or the motor sequence programs necessary to execute them...- Judgment of duration in individuals with ataxia-telangiectasiaS H Mostofsky
Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Dev Neuropsychol 17:63-74. 2000..01). Children and adolescents with AT show deficits in judgment of duration but not of pitch, suggesting that the cerebellum may be critical for judgment of explicit time intervals at all ages... - Response inhibition and response selection: two sides of the same coinStewart H Mostofsky
Kennedy Krieger Institute, Baltimore, MD 21205, USA
J Cogn Neurosci 20:751-61. 2008..Recruitment of additional prefrontal and posterior cortical circuits, necessary to guide response selection, varies depending on the cognitive and behavioral demands of the task... - Increased motor cortex white matter volume predicts motor impairment in autismStewart H Mostofsky
Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
Brain 130:2117-22. 2007.... - Decreased connectivity and cerebellar activity in autism during motor task performanceStewart H Mostofsky
Kennedy Krieger Institute, Baltimore, MD 21205, USA
Brain 132:2413-25. 2009..The findings might explain impairments in motor development in autism, as well as abnormal and delayed acquisition of gestures important for socialization and communication... - Atypical motor and sensory cortex activation in attention-deficit/hyperactivity disorder: a functional magnetic resonance imaging study of simple sequential finger tappingStewart H Mostofsky
Kennedy Krieger Institute, Baltimore, MD 21205, USA
Biol Psychiatry 59:48-56. 2006..Functional magnetic resonance imaging (fMRI) was used to determine whether differences in brain activation during sequential finger tapping are present in children with ADHD compared with typically developing control subjects... - Children with autism adapt normally during a catching task requiring the cerebellumStewart H Mostofsky
Kennedy Krieger Institute, Baltimore, MD 21205, USA
Neurocase 10:60-4. 2004..Results showed no differences in adaptation rates or after-effects for HFA subjects versus controls. The findings indicate normal motor adaptation in HFA, suggesting normal or compensated cerebellar function for this task... - Overflow movements predict impaired response inhibition in children with ADHDStewart H Mostofsky
Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Percept Mot Skills 97:1315-31. 2003.... - Oculomotor abnormalities in boys with tourette syndrome with and without ADHDS H Mostofsky
Kennedy Krieger Institute and the Department of Neurology at the Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
J Am Acad Child Adolesc Psychiatry 40:1464-72. 2001..To assess saccadic eye movements in boys with Tourette syndrome (TS) with and without attention-deficit hyperactivity disorder (ADHD), comparing performance with that of an age-matched group of male controls... - Evidence for a deficit in procedural learning in children and adolescents with autism: implications for cerebellar contributionS H Mostofsky
Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
J Int Neuropsychol Soc 6:752-9. 2000..The data suggest that deficits in procedural learning may contribute to the cognitive and behavioral phenotype of autism; these deficits may be secondary to abnormalities in cerebellar-frontal circuitry... - fMRI evidence that the neural basis of response inhibition is task-dependentStewart H Mostofsky
Developmental Cognitive Neurology, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
Brain Res Cogn Brain Res 17:419-30. 2003.... - Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: differences in activation associated with response inhibition but not habitual motor responseStacy J Suskauer
Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
J Cogn Neurosci 20:478-93. 2008.... - Corpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD)Melanie A McNally
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Child Neurol 25:453-62. 2010..Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control... - Functional brain correlates of response time variability in childrenDaniel J Simmonds
Kennedy Krieger Institute, Baltimore, MD 21205, USA
Neuropsychologia 45:2147-57. 2007.... - MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndromeWendy R Kates
Division of Psychiatric Neuroimaging, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychiatry Res 116:63-81. 2002.... - Effects of gender and age on motor exam in typically developing childrenJennifer C Gidley Larson
Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore 21231, USA
Dev Neuropsychol 32:543-62. 2007..Motor development appears to follow a different developmental course in girls than in boys; separate gender and age norms should be used in clinical assessment of motor function in children... - Evidence for impairments in using static line drawings of eye gaze cues to orient visual-spatial attention in children with high functioning autismMelissa C Goldberg
Kennedy Krieger Institute, 707 North Broadway, Room 232, Baltimore, MD, 21205, USA
J Autism Dev Disord 38:1405-13. 2008..The results suggest that children with HFA show impairments in utilizing static line drawings of gaze cues to orient visual-spatial attention... - Moderate variability in stimulus presentation improves motor response controlEricka L Wodka
Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21231, USA
J Clin Exp Neuropsychol 31:483-8. 2009..More deliberate and controlled responding observed with increasing jitter may have important treatment implications for disorders (e.g., attention-deficit/hyperactivity disorder, ADHD), associated with impaired response control... - Abnormal cerebral cortex structure in children with ADHDSasha M Wolosin
Kennedy Krieger Institute, 707 North Broadway, Baltimore, Maryland 21205, USA
Hum Brain Mapp 30:175-84. 2009.... - Acquisition of internal models of motor tasks in children with autismJennifer C Gidley Larson
Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Brain 131:2894-903. 2008..Furthermore, the findings may have therapeutic implications, highlighting a reliable mechanism by which children with autism can most effectively alter their behaviour... - Representation of internal models of action in the autistic brainCourtney C Haswell
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 12:970-2. 2009.... - Motor and perceptual timing deficits among survivors of childhood leukemiaE Mark Mahone
Department of Neuropsychology, Kennedy Krieger Institute, 1750 E Fairmount Avenue, Baltimore, MD 21231, USA
J Pediatr Psychol 32:918-25. 2007..There is growing evidence of cerebellar-frontal system change in children treated for leukemia with chemotherapy alone (Lesnik et al., 1998)... - Process examination of executive function in ADHD: sex and subtype effectsEricka L Wodka
Department of Neuropsychology, Kennedy Krieger Institute, 1750 E Fairmount Avenue, Baltimore, MD 21231, USA
Clin Neuropsychol 22:826-41. 2008..Overall, children with ADHD did not differ from TD on most optional measures from the D-KEFS. When sex and ADHD subtype were considered, children with the subtype of ADHD less common for sex were at greater risk for poorer performance... - Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependentDaniel J Simmonds
Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
Neuropsychologia 46:224-32. 2008.... - Motor persistence and inhibition in autism and ADHDE Mark Mahone
Kennedy Krieger Institute and Johns Hopkins University School of Medicine, 1750 East Fairmount Avenue, Baltimore, MD 21231, USA
J Int Neuropsychol Soc 12:622-31. 2006..The findings highlight the utility of brief assessments of motor control in delineating the unique neurobehavioral phenotypes of ADHD and HFA... - Oculomotor anomalies in attention-deficit/hyperactivity disorder: evidence for deficits in response preparation and inhibitionE Mark Mahone
Kennedy Krieger Institute, Baltimore, MD 21231, USA
J Am Acad Child Adolesc Psychiatry 48:749-56. 2009..To examine patterns of executive and oculomotor control in a group of both boys and girls with attention-deficit/hyperactivity disorder (ADHD)... - Associations of postural knowledge and basic motor skill with dyspraxia in autism: implication for abnormalities in distributed connectivity and motor learningLauren R Dowell
Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Neuropsychology 23:563-70. 2009..Distributed abnormality across parietal, premotor, and motor circuitry, as well as anomalous connectivity, may be implicated... - Increased intra-individual reaction time variability in attention-deficit/hyperactivity disorder across response inhibition tasks with different cognitive demandsRebecca G Vaurio
Kennedy Krieger Institute, Department of Neuropsychology, Baltimore, MD 21211, USA
Neuropsychologia 47:2389-96. 2009..FFT analyses reveal that the periodicity of intermittent lapses of attention in ADHD varies with task demand. The findings provide further support for intra-individual variability as a candidate intermediate endophenotype of ADHD... - Manual MRI parcellation of the frontal lobeMarin E Ranta
Laboratory for Neurocognitive Imaging and Research, Kennedy Krieger Institute, Baltimore, MD 21211, USA
Psychiatry Res 172:147-54. 2009..These findings support the method as a reliable and valid technique for parcellating the frontal lobe into functionally relevant sub-regions... - Interstimulus jitter facilitates response control in children with ADHDMatthew Ryan
Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, Maryland, USA
J Int Neuropsychol Soc 16:388-93. 2010..This bottom-up approach may be mediated by increases in vigilance through noradrenergic circuits that facilitate maintenance of frontal circuits critical to response control... - Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorderStewart H Mostofsky
Department of Neurology, Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205, USA
Biol Psychiatry 52:785-94. 2002..More than one subdivision of the frontal lobes appears to be reduced in volume, suggesting that the clinical picture of ADHD encompasses dysfunctions attributable to anomalous development of both premotor and prefrontal cortices... - Perceptual reasoning predicts handwriting impairments in adolescents with autismChristina T Fuentes
Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurology 75:1825-9. 2010..It is not known whether the same handwriting impairments persist into adolescence and whether they remain linked to motor deficits... - Children with autism show specific handwriting impairmentsChristina T Fuentes
Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurology 73:1532-7. 2009..As a result, the specific aspects of handwriting in which individuals with autism demonstrate difficulty remain unknown... - Specificity of cerebellar vermian abnormalities in autism: a quantitative magnetic resonance imaging studyWalter E Kaufmann
Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Child Neurol 18:463-70. 2003..The latter results are consistent with MRI studies showing lobules VI-VII hyperplasia in a subset of subjects with idiopathic autism and cerebral and hippocampal enlargements in fragile X syndrome... - Two-stage decompositions for the analysis of functional connectivity for fMRI with application to Alzheimer's disease riskBrian S Caffo
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Neuroimage 51:1140-9. 2010..The relevant brain network loads primarily on the temporal lobe and overlaps significantly with the olfactory areas and temporal poles... - Impaired habituation in children with attention deficit hyperactivity disorderEva M Jansiewicz
Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cogn Behav Neurol 17:1-8. 2004..The findings provide evidence of frontal dysfunction in attention deficit hyperactivity disorder and suggest that impaired habituation contributes to off-task behavior in children with the disorder... - Quantifying excessive mirror overflow in children with attention-deficit/hyperactivity disorderL K Macneil
Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neurology 76:622-8. 2011..The goal of this study was to develop and implement methods for quantifying excessive mirror overflow movements in children with ADHD... - Toward a narrower, more pragmatic view of developmental dyspraxiaKyle J Steinman
Division of Child Neurology, Department of Neurology, University of California San Francisco, San Francisco, California 94117, USA
J Child Neurol 25:71-81. 2010.... - Stimulant dosage and age, race, and insurance type in a sample of children with attention-deficit/hyperactivity disorderPaul H Lipkin
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
J Child Adolesc Psychopharmacol 15:240-8. 2005..The aim of this study was to examine the association of age, race, insurance, and other factors with the prescription of stimulant medications... - Duration judgments in children with ADHD suggest deficient utilization of temporal information rather than general impairment in timingKrestin J Radonovich
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, USA
Child Neuropsychol 10:162-72. 2004.... - Speeded processing of grammar and tool knowledge in Tourette's syndromeMatthew Walenski
Brain and Language Lab, Department of Neuroscience, Georgetown University, Washington, DC 20057 1464, USA
Neuropsychologia 45:2447-60. 2007..The frontal/basal-ganglia abnormalities may thus lead not only to tics, but also to a wider range of rapid behaviors, including the cognitive processing of rule-governed forms in language and other types of procedural knowledge... - Motor signs distinguish children with high functioning autism and Asperger's syndrome from controlsEva M Jansiewicz
Georgia State University, Atlanta, GA, USA
J Autism Dev Disord 36:613-21. 2006..Regression analyses revealed that a model including four PANESS variables offered a high level of discrimination in distinguishing boys with high-functioning autism from controls... - Evidence that response inhibition is a primary deficit in ADHDEricka L Wodka
Drexel University, Philadelphia, PA, USA
J Clin Exp Neuropsychol 29:345-56. 2007..Although increasing working memory demand appears to impede response inhibition, this effect is similar in ADHD and typically developing children... - Prediction of ADHD in boys and girls using the D-KEFSEricka L Wodka
Kennedy Krieger Institute, MD, United States
Arch Clin Neuropsychol 23:283-93. 2008..In this carefully screened sample of children with ADHD, few significant differences were found between groups suggesting limited sensitivity or specificity of the D-KEFS for classifying children with ADHD...
Research Grants
- CORTICAL & SUBCORTICAL BRAIN MECHANISMS UNDERLYING ADHDSTEWART MOSTOFSKY; Fiscal Year: 2002..Research will be conducted in a multidisciplinary environment enhanced by the addition of the F M. Kirby Center for Functional Brain Imaging. ..
- Neurologic Basis of the Inhibitory Deficits in ADHDSTEWART MOSTOFSKY; Fiscal Year: 2007..abstract_text> ..
- Neurology of Deficient Response Inhibition in ADHDSTEWART MOSTOFSKY; Fiscal Year: 2007....
- Motor Skill Learning in AutismSTEWART MOSTOFSKY; Fiscal Year: 2009..abstract_text> ..
- Anomalous Motor Physiology In ADHDSTEWART MOSTOFSKY; Fiscal Year: 2009..The data from these studies will yield critical insights into the neurobiological basis of ADHD and will also set the stage for future development of more effective therapies for this population. ..
- Neurology of Deficient Response Control in ADHDStewart H Mostofsky; Fiscal Year: 2010..This work may help to improve diagnosis and treatment of ADHD. ..
- Anomalous Motor Physiology In ADHDStewart H Mostofsky; Fiscal Year: 2010..The data from these studies will yield critical insights into the neurobiological basis of ADHD and will also set the stage for future development of more effective therapies for this population. ..
- Neurology of Deficient Response Control in ADHDSTEWART MOSTOFSKY; Fiscal Year: 2009..This work may help to improve diagnosis and treatment of ADHD. ..
- Motor Skill Learning in AutismStewart H Mostofsky; Fiscal Year: 2010....