STEWART MOSTOFSKY

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. ncbi request reprint Developmental dyspraxia is not limited to imitation in children with autism spectrum disorders
    Stewart H Mostofsky
    Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 N Broadway, Baltimore, MD 21205, USA
    J Int Neuropsychol Soc 12:314-26. 2006
  2. ncbi request reprint Judgment of duration in individuals with ataxia-telangiectasia
    S H Mostofsky
    Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Dev Neuropsychol 17:63-74. 2000
  3. pmc Decreased connectivity and cerebellar activity in autism during motor task performance
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Brain 132:2413-25. 2009
  4. ncbi request reprint Atypical motor and sensory cortex activation in attention-deficit/hyperactivity disorder: a functional magnetic resonance imaging study of simple sequential finger tapping
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Biol Psychiatry 59:48-56. 2006
  5. ncbi request reprint Children with autism adapt normally during a catching task requiring the cerebellum
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Neurocase 10:60-4. 2004
  6. doi request reprint Response inhibition and response selection: two sides of the same coin
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Cogn Neurosci 20:751-61. 2008
  7. ncbi request reprint Overflow movements predict impaired response inhibition in children with ADHD
    Stewart H Mostofsky
    Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Percept Mot Skills 97:1315-31. 2003
  8. ncbi request reprint Increased motor cortex white matter volume predicts motor impairment in autism
    Stewart H Mostofsky
    Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
    Brain 130:2117-22. 2007
  9. ncbi request reprint Evidence for a deficit in procedural learning in children and adolescents with autism: implications for cerebellar contribution
    S H Mostofsky
    Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Int Neuropsychol Soc 6:752-9. 2000
  10. ncbi request reprint fMRI evidence that the neural basis of response inhibition is task-dependent
    Stewart H Mostofsky
    Developmental Cognitive Neurology, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Brain Res Cogn Brain Res 17:419-30. 2003

Research Grants

  1. CORTICAL & SUBCORTICAL BRAIN MECHANISMS UNDERLYING ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2002
  2. Neurologic Basis of the Inhibitory Deficits in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2007
  3. Neurology of Deficient Response Inhibition in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2007
  4. Motor Skill Learning in Autism
    STEWART MOSTOFSKY; Fiscal Year: 2009
  5. Anomalous Motor Physiology In ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2009
  6. Neurology of Deficient Response Control in ADHD
    Stewart H Mostofsky; Fiscal Year: 2010
  7. Anomalous Motor Physiology In ADHD
    Stewart H Mostofsky; Fiscal Year: 2010
  8. Neurology of Deficient Response Control in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2009
  9. Motor Skill Learning in Autism
    STEWART MOSTOFSKY; Fiscal Year: 2007
  10. Motor Skill Learning in Autism
    STEWART MOSTOFSKY; Fiscal Year: 2006

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Developmental dyspraxia is not limited to imitation in children with autism spectrum disorders
    Stewart H Mostofsky
    Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 N Broadway, Baltimore, MD 21205, USA
    J Int Neuropsychol Soc 12:314-26. 2006
    ..e., learning) of sensory representations of movement and/or the motor sequence programs necessary to execute them...
  2. ncbi request reprint Judgment of duration in individuals with ataxia-telangiectasia
    S H Mostofsky
    Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Dev Neuropsychol 17:63-74. 2000
    ..01). Children and adolescents with AT show deficits in judgment of duration but not of pitch, suggesting that the cerebellum may be critical for judgment of explicit time intervals at all ages...
  3. pmc Decreased connectivity and cerebellar activity in autism during motor task performance
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Brain 132:2413-25. 2009
    ..The findings might explain impairments in motor development in autism, as well as abnormal and delayed acquisition of gestures important for socialization and communication...
  4. ncbi request reprint Atypical motor and sensory cortex activation in attention-deficit/hyperactivity disorder: a functional magnetic resonance imaging study of simple sequential finger tapping
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Biol Psychiatry 59:48-56. 2006
    ..Functional magnetic resonance imaging (fMRI) was used to determine whether differences in brain activation during sequential finger tapping are present in children with ADHD compared with typically developing control subjects...
  5. ncbi request reprint Children with autism adapt normally during a catching task requiring the cerebellum
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Neurocase 10:60-4. 2004
    ..Results showed no differences in adaptation rates or after-effects for HFA subjects versus controls. The findings indicate normal motor adaptation in HFA, suggesting normal or compensated cerebellar function for this task...
  6. doi request reprint Response inhibition and response selection: two sides of the same coin
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Cogn Neurosci 20:751-61. 2008
    ..Recruitment of additional prefrontal and posterior cortical circuits, necessary to guide response selection, varies depending on the cognitive and behavioral demands of the task...
  7. ncbi request reprint Overflow movements predict impaired response inhibition in children with ADHD
    Stewart H Mostofsky
    Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Percept Mot Skills 97:1315-31. 2003
    ....
  8. ncbi request reprint Increased motor cortex white matter volume predicts motor impairment in autism
    Stewart H Mostofsky
    Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
    Brain 130:2117-22. 2007
    ....
  9. ncbi request reprint Evidence for a deficit in procedural learning in children and adolescents with autism: implications for cerebellar contribution
    S H Mostofsky
    Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Int Neuropsychol Soc 6:752-9. 2000
    ..The data suggest that deficits in procedural learning may contribute to the cognitive and behavioral phenotype of autism; these deficits may be secondary to abnormalities in cerebellar-frontal circuitry...
  10. ncbi request reprint fMRI evidence that the neural basis of response inhibition is task-dependent
    Stewart H Mostofsky
    Developmental Cognitive Neurology, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Brain Res Cogn Brain Res 17:419-30. 2003
    ....
  11. ncbi request reprint Oculomotor abnormalities in boys with tourette syndrome with and without ADHD
    S H Mostofsky
    Kennedy Krieger Institute and the Department of Neurology at the Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Am Acad Child Adolesc Psychiatry 40:1464-72. 2001
    ..To assess saccadic eye movements in boys with Tourette syndrome (TS) with and without attention-deficit hyperactivity disorder (ADHD), comparing performance with that of an age-matched group of male controls...
  12. pmc Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: differences in activation associated with response inhibition but not habitual motor response
    Stacy J Suskauer
    Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    J Cogn Neurosci 20:478-93. 2008
    ....
  13. pmc Corpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD)
    Melanie A McNally
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Child Neurol 25:453-62. 2010
    ..Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control...
  14. ncbi request reprint Functional brain correlates of response time variability in children
    Daniel J Simmonds
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Neuropsychologia 45:2147-57. 2007
    ....
  15. ncbi request reprint MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome
    Wendy R Kates
    Division of Psychiatric Neuroimaging, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychiatry Res 116:63-81. 2002
    ....
  16. pmc Effects of gender and age on motor exam in typically developing children
    Jennifer C Gidley Larson
    Department of Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore 21231, USA
    Dev Neuropsychol 32:543-62. 2007
    ..Motor development appears to follow a different developmental course in girls than in boys; separate gender and age norms should be used in clinical assessment of motor function in children...
  17. pmc Moderate variability in stimulus presentation improves motor response control
    Ericka L Wodka
    Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21231, USA
    J Clin Exp Neuropsychol 31:483-8. 2009
    ..More deliberate and controlled responding observed with increasing jitter may have important treatment implications for disorders (e.g., attention-deficit/hyperactivity disorder, ADHD), associated with impaired response control...
  18. pmc Evidence for impairments in using static line drawings of eye gaze cues to orient visual-spatial attention in children with high functioning autism
    Melissa C Goldberg
    Kennedy Krieger Institute, 707 North Broadway, Room 232, Baltimore, MD, 21205, USA
    J Autism Dev Disord 38:1405-13. 2008
    ..The results suggest that children with HFA show impairments in utilizing static line drawings of gaze cues to orient visual-spatial attention...
  19. pmc Abnormal cerebral cortex structure in children with ADHD
    Sasha M Wolosin
    Kennedy Krieger Institute, 707 North Broadway, Baltimore, Maryland 21205, USA
    Hum Brain Mapp 30:175-84. 2009
    ....
  20. pmc Process examination of executive function in ADHD: sex and subtype effects
    Ericka L Wodka
    Department of Neuropsychology, Kennedy Krieger Institute, 1750 E Fairmount Avenue, Baltimore, MD 21231, USA
    Clin Neuropsychol 22:826-41. 2008
    ..Overall, children with ADHD did not differ from TD on most optional measures from the D-KEFS. When sex and ADHD subtype were considered, children with the subtype of ADHD less common for sex were at greater risk for poorer performance...
  21. ncbi request reprint Motor and perceptual timing deficits among survivors of childhood leukemia
    E Mark Mahone
    Department of Neuropsychology, Kennedy Krieger Institute, 1750 E Fairmount Avenue, Baltimore, MD 21231, USA
    J Pediatr Psychol 32:918-25. 2007
    ..There is growing evidence of cerebellar-frontal system change in children treated for leukemia with chemotherapy alone (Lesnik et al., 1998)...
  22. pmc Associations of postural knowledge and basic motor skill with dyspraxia in autism: implication for abnormalities in distributed connectivity and motor learning
    Lauren R Dowell
    Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Neuropsychology 23:563-70. 2009
    ..Distributed abnormality across parietal, premotor, and motor circuitry, as well as anomalous connectivity, may be implicated...
  23. pmc Representation of internal models of action in the autistic brain
    Courtney C Haswell
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 12:970-2. 2009
    ....
  24. doi request reprint Increased intra-individual reaction time variability in attention-deficit/hyperactivity disorder across response inhibition tasks with different cognitive demands
    Rebecca G Vaurio
    Kennedy Krieger Institute, Department of Neuropsychology, Baltimore, MD 21211, USA
    Neuropsychologia 47:2389-96. 2009
    ..FFT analyses reveal that the periodicity of intermittent lapses of attention in ADHD varies with task demand. The findings provide further support for intra-individual variability as a candidate intermediate endophenotype of ADHD...
  25. ncbi request reprint Motor persistence and inhibition in autism and ADHD
    E Mark Mahone
    Kennedy Krieger Institute and Johns Hopkins University School of Medicine, 1750 East Fairmount Avenue, Baltimore, MD 21231, USA
    J Int Neuropsychol Soc 12:622-31. 2006
    ..The findings highlight the utility of brief assessments of motor control in delineating the unique neurobehavioral phenotypes of ADHD and HFA...
  26. pmc Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent
    Daniel J Simmonds
    Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Neuropsychologia 46:224-32. 2008
    ....
  27. pmc Oculomotor anomalies in attention-deficit/hyperactivity disorder: evidence for deficits in response preparation and inhibition
    E Mark Mahone
    Kennedy Krieger Institute, Baltimore, MD 21231, USA
    J Am Acad Child Adolesc Psychiatry 48:749-56. 2009
    ..To examine patterns of executive and oculomotor control in a group of both boys and girls with attention-deficit/hyperactivity disorder (ADHD)...
  28. pmc Acquisition of internal models of motor tasks in children with autism
    Jennifer C Gidley Larson
    Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Brain 131:2894-903. 2008
    ..Furthermore, the findings may have therapeutic implications, highlighting a reliable mechanism by which children with autism can most effectively alter their behaviour...
  29. pmc Manual MRI parcellation of the frontal lobe
    Marin E Ranta
    Laboratory for Neurocognitive Imaging and Research, Kennedy Krieger Institute, Baltimore, MD 21211, USA
    Psychiatry Res 172:147-54. 2009
    ..These findings support the method as a reliable and valid technique for parcellating the frontal lobe into functionally relevant sub-regions...
  30. pmc Interstimulus jitter facilitates response control in children with ADHD
    Matthew Ryan
    Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 16:388-93. 2010
    ..This bottom-up approach may be mediated by increases in vigilance through noradrenergic circuits that facilitate maintenance of frontal circuits critical to response control...
  31. ncbi request reprint Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder
    Stewart H Mostofsky
    Department of Neurology, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
    Biol Psychiatry 52:785-94. 2002
    ..g., prefrontal cortex). We present an investigation of cerebral volumes in ADHD using a Talairach-based approach that uses cortical landmarks to define functionally relevant regions...
  32. pmc Analysis of group ICA-based connectivity measures from fMRI: application to Alzheimer's disease
    Shanshan Li
    Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA
    PLoS ONE 7:e49340. 2012
    ..We found empirical evidence of alternative ICA-based metrics of connectivity when comparing subjects evidencing mild cognitive impairment relative to carefully matched controls...
  33. pmc Perceptual reasoning predicts handwriting impairments in adolescents with autism
    Christina T Fuentes
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 75:1825-9. 2010
    ..It is not known whether the same handwriting impairments persist into adolescence and whether they remain linked to motor deficits...
  34. pmc Children with autism show specific handwriting impairments
    Christina T Fuentes
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 73:1532-7. 2009
    ..As a result, the specific aspects of handwriting in which individuals with autism demonstrate difficulty remain unknown...
  35. ncbi request reprint Impaired habituation in children with attention deficit hyperactivity disorder
    Eva M Jansiewicz
    Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cogn Behav Neurol 17:1-8. 2004
    ..To investigate whether children with attention deficit hyperactivity disorder show impaired habituation to peripheral stimuli...
  36. pmc Two-stage decompositions for the analysis of functional connectivity for fMRI with application to Alzheimer's disease risk
    Brian S Caffo
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Neuroimage 51:1140-9. 2010
    ..The relevant brain network loads primarily on the temporal lobe and overlaps significantly with the olfactory areas and temporal poles...
  37. ncbi request reprint Specificity of cerebellar vermian abnormalities in autism: a quantitative magnetic resonance imaging study
    Walter E Kaufmann
    Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Child Neurol 18:463-70. 2003
    ..The latter results are consistent with MRI studies showing lobules VI-VII hyperplasia in a subset of subjects with idiopathic autism and cerebral and hippocampal enlargements in fragile X syndrome...
  38. pmc Quantifying excessive mirror overflow in children with attention-deficit/hyperactivity disorder
    L K Macneil
    Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neurology 76:622-8. 2011
    ..The goal of this study was to develop and implement methods for quantifying excessive mirror overflow movements in children with ADHD...
  39. pmc Toward a narrower, more pragmatic view of developmental dyspraxia
    Kyle J Steinman
    Division of Child Neurology, Department of Neurology, University of California San Francisco, San Francisco, California 94117, USA
    J Child Neurol 25:71-81. 2010
    ....
  40. ncbi request reprint Stimulant dosage and age, race, and insurance type in a sample of children with attention-deficit/hyperactivity disorder
    Paul H Lipkin
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    J Child Adolesc Psychopharmacol 15:240-8. 2005
    ..The aim of this study was to examine the association of age, race, insurance, and other factors with the prescription of stimulant medications...
  41. pmc Speeded processing of grammar and tool knowledge in Tourette's syndrome
    Matthew Walenski
    Brain and Language Lab, Department of Neuroscience, Georgetown University, Washington, DC 20057 1464, USA
    Neuropsychologia 45:2447-60. 2007
    ..The frontal/basal-ganglia abnormalities may thus lead not only to tics, but also to a wider range of rapid behaviors, including the cognitive processing of rule-governed forms in language and other types of procedural knowledge...
  42. ncbi request reprint Duration judgments in children with ADHD suggest deficient utilization of temporal information rather than general impairment in timing
    Krestin J Radonovich
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, USA
    Child Neuropsychol 10:162-72. 2004
    ....
  43. ncbi request reprint Motor signs distinguish children with high functioning autism and Asperger's syndrome from controls
    Eva M Jansiewicz
    Georgia State University, Atlanta, GA, USA
    J Autism Dev Disord 36:613-21. 2006
    ..Regression analyses revealed that a model including four PANESS variables offered a high level of discrimination in distinguishing boys with high-functioning autism from controls...
  44. ncbi request reprint Evidence that response inhibition is a primary deficit in ADHD
    Ericka L Wodka
    Drexel University, Philadelphia, PA, USA
    J Clin Exp Neuropsychol 29:345-56. 2007
    ..Although increasing working memory demand appears to impede response inhibition, this effect is similar in ADHD and typically developing children...
  45. pmc Prediction of ADHD in boys and girls using the D-KEFS
    Ericka L Wodka
    Kennedy Krieger Institute, MD, United States
    Arch Clin Neuropsychol 23:283-93. 2008
    ..In this carefully screened sample of children with ADHD, few significant differences were found between groups suggesting limited sensitivity or specificity of the D-KEFS for classifying children with ADHD...

Research Grants18

  1. CORTICAL & SUBCORTICAL BRAIN MECHANISMS UNDERLYING ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2002
    ..Research will be conducted in a multidisciplinary environment enhanced by the addition of the F M. Kirby Center for Functional Brain Imaging. ..
  2. Neurologic Basis of the Inhibitory Deficits in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2007
    ..abstract_text> ..
  3. Neurology of Deficient Response Inhibition in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2007
    ....
  4. Motor Skill Learning in Autism
    STEWART MOSTOFSKY; Fiscal Year: 2009
    ..abstract_text> ..
  5. Anomalous Motor Physiology In ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2009
    ..The data from these studies will yield critical insights into the neurobiological basis of ADHD and will also set the stage for future development of more effective therapies for this population. ..
  6. Neurology of Deficient Response Control in ADHD
    Stewart H Mostofsky; Fiscal Year: 2010
    ..This work may help to improve diagnosis and treatment of ADHD. ..
  7. Anomalous Motor Physiology In ADHD
    Stewart H Mostofsky; Fiscal Year: 2010
    ..The data from these studies will yield critical insights into the neurobiological basis of ADHD and will also set the stage for future development of more effective therapies for this population. ..
  8. Neurology of Deficient Response Control in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2009
    ..This work may help to improve diagnosis and treatment of ADHD. ..
  9. Motor Skill Learning in Autism
    STEWART MOSTOFSKY; Fiscal Year: 2007
    ..abstract_text> ..
  10. Motor Skill Learning in Autism
    STEWART MOSTOFSKY; Fiscal Year: 2006
    ..abstract_text> ..
  11. Neurology of Deficient Response Inhibition in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2006
    ....
  12. Motor Skill Learning in Autism
    STEWART MOSTOFSKY; Fiscal Year: 2005
    ..abstract_text> ..
  13. Neurology of Deficient Response Inhibition in ADHD
    STEWART MOSTOFSKY; Fiscal Year: 2005
    ....
  14. Motor Skill Learning in Autism
    Stewart H Mostofsky; Fiscal Year: 2010
    ....