John W McDonald

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. ncbi request reprint Spinal cord injury: promising interventions and realistic goals
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Am J Phys Med Rehabil 82:S38-49. 2003
  2. ncbi request reprint Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapies
    Visar Belegu
    The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Room 518, Baltimore, MD 21205, USA
    Neurosurg Clin N Am 18:143-68, xi. 2007
  3. doi request reprint Neural stem cells reduce brain injury after unilateral carotid ligation
    Anne M Comi
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Pediatr Neurol 38:86-92. 2008
  4. doi request reprint The changing field of rehabilitation: optimizing spontaneous regeneration and functional recovery
    John W McDonald
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Handb Clin Neurol 109:317-36. 2012
  5. ncbi request reprint Demyelination and remyelination after spinal cord injury
    John W McDonald
    International Center for Spinal Cord Injury, Kennedy Krieger Institute and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurotrauma 23:345-59. 2006
  6. doi request reprint Electrical stimulation promotes the survival of oligodendrocytes in mixed cortical cultures
    Devin S Gary
    The International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21205, USA
    J Neurosci Res 90:72-83. 2012
  7. doi request reprint Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ
    James C Pendleton
    International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, USA
    Exp Neurol 247:113-21. 2013
  8. pmc Role of neuregulin-1/ErbB signaling in stem cell therapy for spinal cord injury-induced chronic neuropathic pain
    Feng Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Stem Cells 31:83-91. 2013
  9. doi request reprint Activity-based restorative therapies: concepts and applications in spinal cord injury-related neurorehabilitation
    Cristina L Sadowsky
    International Center for Spinal Cord Injury, Department of Physical Medicine and Rehabilitation, Kennedy Krieger Institute, Johns Hopkins School of Medicine, 707 North Broadway, Baltimore, MD 21205, USA
    Dev Disabil Res Rev 15:112-6. 2009
  10. doi request reprint Axon myelination and electrical stimulation in a microfluidic, compartmentalized cell culture platform
    In Hong Yang
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Neuromolecular Med 14:112-8. 2012

Research Grants

  1. MECHANISM OF OLIGODENDROCYTE DEATH IN SPINAL CORD INJURY
    John McDonald; Fiscal Year: 2002
  2. Role of Integrins in Cardiac Myocytes
    John McDonald; Fiscal Year: 2003
  3. ES CELL MYELINATION IN INJURED SPINAL CORD
    John McDonald; Fiscal Year: 2003

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Spinal cord injury: promising interventions and realistic goals
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Am J Phys Med Rehabil 82:S38-49. 2003
    ....
  2. ncbi request reprint Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapies
    Visar Belegu
    The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Room 518, Baltimore, MD 21205, USA
    Neurosurg Clin N Am 18:143-68, xi. 2007
    ....
  3. doi request reprint Neural stem cells reduce brain injury after unilateral carotid ligation
    Anne M Comi
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Pediatr Neurol 38:86-92. 2008
    ..Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern...
  4. doi request reprint The changing field of rehabilitation: optimizing spontaneous regeneration and functional recovery
    John W McDonald
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Handb Clin Neurol 109:317-36. 2012
    ..We stress that lifelong ABRT is required to optimize return of function and to allow patients to benefit from any "cures" that will be discovered...
  5. ncbi request reprint Demyelination and remyelination after spinal cord injury
    John W McDonald
    International Center for Spinal Cord Injury, Kennedy Krieger Institute and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurotrauma 23:345-59. 2006
    ..This review focuses on concepts that are important for developing strategies of repair. The brightest young scientists will be attracted into this exciting field by its near-term potential for human application...
  6. doi request reprint Electrical stimulation promotes the survival of oligodendrocytes in mixed cortical cultures
    Devin S Gary
    The International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21205, USA
    J Neurosci Res 90:72-83. 2012
    ..This report suggests that patterned neuronal activity could repress delayed progression of white matter injury and promote CNS repair in neurological conditions that involve white matter damage...
  7. doi request reprint Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ
    James C Pendleton
    International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, USA
    Exp Neurol 247:113-21. 2013
    ..The identification of PTPσ as a receptor for CSPGs, and the participation of ROCK downstream of CSPG exposure, reveal potential therapeutic targets to enhance white matter repair in the damaged CNS. ..
  8. pmc Role of neuregulin-1/ErbB signaling in stem cell therapy for spinal cord injury-induced chronic neuropathic pain
    Feng Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Stem Cells 31:83-91. 2013
    ....
  9. doi request reprint Activity-based restorative therapies: concepts and applications in spinal cord injury-related neurorehabilitation
    Cristina L Sadowsky
    International Center for Spinal Cord Injury, Department of Physical Medicine and Rehabilitation, Kennedy Krieger Institute, Johns Hopkins School of Medicine, 707 North Broadway, Baltimore, MD 21205, USA
    Dev Disabil Res Rev 15:112-6. 2009
    ..This article reviews basic and clinical science evidence pertaining to implementation of physical activity and exercise as a therapeutic tool in the management of chronic spinal cord-related neurological paralysis...
  10. doi request reprint Axon myelination and electrical stimulation in a microfluidic, compartmentalized cell culture platform
    In Hong Yang
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Neuromolecular Med 14:112-8. 2012
    ..This work describes the modification of a microfluidic, multi-chamber system so that electrical stimulation can be used to achieve increased levels of myelination while maintaining control of the cell culture microenvironment...
  11. pmc Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats
    Daniel Becker
    International Center, for Spinal Cord Injury, Hugo Moser Research Institute, Department of Neurology, Johns Hopkins School of Medicine and Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Exp Neurol 222:211-8. 2010
    ..In uninjured rats, FES had no effect on cell birth/survival. This report suggests that controlled electrical activation of the CNS may enhance spontaneous regeneration after neurological injuries...
  12. doi request reprint Approaches to repairing the damaged spinal cord: overview
    Daniel Becker
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Handb Clin Neurol 109:445-61. 2012
    ..The ultimate goal is to harness the body's own potential to replace lost central nervous system cells by activation of endogenous progenitor cell repair mechanisms...
  13. pmc Electrical stimulation of the medullary pyramid promotes proliferation and differentiation of oligodendrocyte progenitor cells in the corticospinal tract of the adult rat
    Qun Li
    International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, United States
    Neurosci Lett 479:128-33. 2010
    ..Selective pathway electrical stimulation could be used to promote remyelination and recovery of function in CNS injury and disease...
  14. ncbi request reprint Generating chimeric spinal cord: a novel model for transplantable oligodendrocyte progenitors derived from embryonic stem cells
    Sudhakar Vadivelu
    The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurg Focus 19:E3. 2005
    ..To identify and evaluate stem cell-derived oligodendrocytes obtained for cell transplantation therapies, the authors developed a novel model to examine single, adult oligodendrocytes in situ...
  15. ncbi request reprint Restoring function after spinal cord injury
    Daniel Becker
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Neurologist 9:1-15. 2003
    ..Today, however, an understanding of the underlying pathophysiological mechanisms, the development of neuroprotective interventions, and progress toward regenerative interventions are increasing hope for functional restoration...
  16. ncbi request reprint Repairing the damaged spinal cord: from stem cells to activity-based restoration therapies
    John W McDonald
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Neurosurg 51:207-27. 2004
  17. doi request reprint Use of a virtual reality physical ride-on sailing simulator as a rehabilitation tool for recreational sports and community reintegration: a pilot study
    Albert C Recio
    From The International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger Institute, Baltimore, Maryland ACR, DB, MM, JWM Department of Biomedical Engineering LPS, Department of Neurology DB, JWM, and Department of Physical Medicine and Rehabilitation ACR, JWM, Johns Hopkins University, School of Medicine, Baltimore, Maryland and Department of Pharmacology and Therapeutics, University of Melbourne, Australia NRS
    Am J Phys Med Rehabil 92:1104-9. 2013
    ..In addition, the subjects were able to participate in a sports activity with their respective family members and experienced a sense of optimism about their future...
  18. pmc Extensive neurological recovery from a complete spinal cord injury: a case report and hypothesis on the role of cortical plasticity
    Ann S Choe
    Department of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Inc Baltimore, MD, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore, MD, USA
    Front Hum Neurosci 7:290. 2013
    ..This multimodal MR imaging study also shows the potential of rs-fMRI to measure the extent of cortical plasticity. ..
  19. ncbi request reprint Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair
    Ephron S Rosenzweig
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Neurol 17:121-31. 2004
    ..We have also catalogued the treatments used in studies published between October 2002 and November 2003, with special attention given to studies in which treatments were delayed for at least 4 days after injury...
  20. doi request reprint Robust CNS regeneration after complete spinal cord transection using aligned poly-L-lactic acid microfibers
    Andres Hurtado
    International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
    Biomaterials 32:6068-79. 2011
    ..Our findings outline a form of regeneration within the central nervous system that holds important implications for regeneration biology...
  21. ncbi request reprint Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration
    Hongxin Dong
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, Restorative Treatment and Research Program, and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosci 23:8682-91. 2003
    ..On the basis of these data, we hypothesize that the Wallerian degeneration of white matter axons that follows SCI removes axonal support and induces apoptotic death in oligodendrocytes by triggering Bax expression...
  22. pmc High-voltage electrical stimulation for the management of stage III and IV pressure ulcers among adults with spinal cord injury: demonstration of its utility for recalcitrant wounds below the level of injury
    Albert C Recio
    Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
    J Spinal Cord Med 35:58-63. 2012
    ..This data is mainly based on evidence from animal studies and very few rigorously controlled studies conducted in humans...
  23. pmc Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 tesla
    Seth A Smith
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
    NMR Biomed 23:207-17. 2010
    ..These column-specific MR measurements are expected to enhance understanding of the intimate structure-function relationship in the cervical spinal cord and may be useful for the assessment of disease progression...
  24. pmc Lower extremity functional electrical stimulation cycling promotes physical and functional recovery in chronic spinal cord injury
    Cristina L Sadowsky
    The International Center for Spinal Cord Injury and the Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA and Department of Physical Medicine and Rehabilitation, Department of Neurology JWM, John Hopkins, Baltimore, MD USA
    J Spinal Cord Med 36:623-31. 2013
    ....
  25. ncbi request reprint Spinal-cord injury
    John W McDonald
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, and Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 359:417-25. 2002
    ..We also discuss new treatment options, including functional electric stimulation and part-weight-supported walking...
  26. ncbi request reprint Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination
    John W McDonald
    Center for the Study of Nervous System Injury, Spinal Cord Injury Restorative Treatment and Research Program, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Prog Brain Res 137:299-309. 2002
    ..The role of myelination and remyelination will be discussed in the context of regeneration strategies...
  27. ncbi request reprint Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brain
    Sudhakar Vadivelu
    Center for the Study of Nervous System Injury and the Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosurg 103:124-35. 2005
    ..Here, the authors examined whether embryonic stem cell (ESC)-derived progenitors can selectively generate both neural and endothelial cells after transplantation in the damaged CNS...
  28. ncbi request reprint Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury
    Terence M Myckatyn
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, MO 63108, USA
    Transpl Immunol 12:343-58. 2004
    ..The potential role of nerve transfers for reconstructing the injured spinal cord, particularly the cauda equina and lumbosacral plexus, are also described...
  29. ncbi request reprint Repair of the injured spinal cord and the potential of embryonic stem cell transplantation
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurotrauma 21:383-93. 2004
    ..These features of ES cells will produce a predictable and explosive growth in scientific tools that will translate into discoveries and rapid progress in neural repair...
  30. ncbi request reprint Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved?
    F Avraham Dilmanian
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Exp Hematol 35:69-77. 2007
    ..The repairs apparently involve the microvasculature and the glial system. We evaluate a hypothesis on the involvement of bystander effects in these repairs...
  31. ncbi request reprint Late recovery following spinal cord injury. Case report and review of the literature
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosurg 97:252-65. 2002
    ..The role of patterned neural activity in regeneration and recovery of function after SCI therefore appears a fruitful area for future investigation...
  32. ncbi request reprint Correction addendum to: Late recovery following spinal cord injury
    John W McDonald
    J Neurosurg 97:405-6. 2002
  33. pmc Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery
    Maurizio Corbetta
    Departments of Neurology, Radiology, Anatomy and Neurobiology, and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:17066-71. 2002
    ....
  34. ncbi request reprint AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes
    Elizabeth A Leuchtmann
    Center for the Study of Nervous System Injury, Washington University School of Medicine, Box 8518, St Louis, MO 63108, USA
    Neurobiol Dis 14:336-48. 2003
    ..We conclude that when mature oligodendrocytes die after exposure to kainate: (1) AMPA receptors are the most important mediators, (2) kainate receptors play a smaller role, and (3) death occurs predominantly by necrosis, not apoptosis...
  35. ncbi request reprint Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury
    Sara J Taylor
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    J Control Release 98:281-94. 2004
    ..In a preliminary in vivo study, fibrin gels containing the HBDS and NT-3 showed increased neural fiber density in spinal cord lesions versus unmodified fibrin at 9 days...
  36. ncbi request reprint Gap junctions and connexon hemichannels in human embryonic stem cells
    James E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Stem Cells 24:1654-67. 2006
    ..Human ES cells provide a unique system for the study of human connexin proteins and their potential functions in cellular differentiation and the maintenance of pluripotency...
  37. pmc Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury
    Sara J Taylor
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Control Release 113:226-35. 2006
    ..Thus, controlled delivery of NT-3 from fibrin scaffolds enhanced the initial regenerative response by increasing neuronal fiber sprouting and cell migration into the lesion, while functional motor recovery was not observed in this model...

Research Grants9

  1. MECHANISM OF OLIGODENDROCYTE DEATH IN SPINAL CORD INJURY
    John McDonald; Fiscal Year: 2002
    ..The ultimate goal of this project is to enhance functional recovery after SCI, by understanding and limiting oligodendrocyte death and demyelination. ..
  2. Role of Integrins in Cardiac Myocytes
    John McDonald; Fiscal Year: 2003
    ..These studies will provide new insights into myocyte signaling pathways and approaches applicable to pathologic alterations in the human myocardium. ..
  3. ES CELL MYELINATION IN INJURED SPINAL CORD
    John McDonald; Fiscal Year: 2003
    ..The long-term goal of this project is to develop the ES cell system as a research and therapeutic tool aimed at understanding the mechanisms of remyelination ..