John J Laterra

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. pmc Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity
    Peng Sun
    Hugo W, Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
    BMC Cancer 14:401. 2014
  2. pmc Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5
    Yang Li
    Hugo W, Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
    BMC Cancer 8:325. 2008
  3. ncbi request reprint Scatter factor/hepatocyte growth factor expression enhances human glioblastoma tumorigenicity and growth
    J Laterra
    Department of Neurology, The Johns Hopkins University School of Medicine, The Kennedy Krieger Research Institute, Baltimore, Maryland 21205, USA
    Biochem Biophys Res Commun 235:743-7. 1997
  4. pmc Suramin and radiotherapy in newly diagnosed glioblastoma: phase 2 NABTT CNS Consortium study
    John J Laterra
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Neuro Oncol 6:15-20. 2004

Collaborators

  • Eliot M Rosen
  • Peng Sun
  • Shuli Xia
  • Yang Li
  • Xiaohai Shi
  • Bachchu Lal
  • Kil Sung Yang
  • Paul A Watkins
  • Xing Fan
  • C Rory Goodwin

Detail Information

Publications4

  1. pmc Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity
    Peng Sun
    Hugo W, Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
    BMC Cancer 14:401. 2014
    ..This study investigates the role of ACSVL3 in the maintenance of glioblastoma multiforme (GBM) stem cell self-renewal and the capacity of GBM stem cells to initiate tumor xenograft formation...
  2. pmc Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5
    Yang Li
    Hugo W, Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
    BMC Cancer 8:325. 2008
    ..Dependent on cell context and the involvement of specific downstream effectors, both pro- and anti-apoptotic effects of HGF have been reported...
  3. ncbi request reprint Scatter factor/hepatocyte growth factor expression enhances human glioblastoma tumorigenicity and growth
    J Laterra
    Department of Neurology, The Johns Hopkins University School of Medicine, The Kennedy Krieger Research Institute, Baltimore, Maryland 21205, USA
    Biochem Biophys Res Commun 235:743-7. 1997
    ..These results are the first to show that SF/HGF expression by human glioblastoma cells enhances their growth dysregulation in vitro and malignancy in vivo...
  4. pmc Suramin and radiotherapy in newly diagnosed glioblastoma: phase 2 NABTT CNS Consortium study
    John J Laterra
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Neuro Oncol 6:15-20. 2004
    ..However, overall survival is not significantly improved when compared with the New Approaches to Brain Tumor Therapy GBM database or other comparable patient populations...

Research Grants33

  1. THERAPEUTIC ANGIOGENESIS FOR ISCHEMIC DISEASES OF BRAIN
    John Laterra; Fiscal Year: 2002
    ..These experiments will establish the feasibility of therapeutic angiogenesis for treating ischemic brain injury and will establish treatment strategies relevant to future clinical applications. ..
  2. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2007
    ..The successful completion of the proposed experiments will reveal novel mechanisms of growth factor-stimulated glioma malignancy and new therapeutic targets for clinical development. ..
  3. Neutralizing Anti-HGF mAbs and CNS Malignancy
    John Laterra; Fiscal Year: 2007
    ..Histological, biochemical, and genetic markers for predicting tumor sensitivity and assessing anti-tumor responses to HGF inhibition will also be determined. Results will impact on how HGF inhibitors are used in brain tumor patients. ..
  4. Neutralizing Anti-HGF mAbs and CNS Malignancy
    John J Laterra; Fiscal Year: 2010
    ..Histological, biochemical, and genetic markers for predicting tumor sensitivity and assessing anti-tumor responses to HGF inhibition will also be determined. Results will impact on how HGF inhibitors are used in brain tumor patients. ..
  5. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2003
    ..The successful completion of the proposed experiments will reveal novel mechanisms of growth factor-stimulated glioma maligancy and new therapeutic targets for clinical development. ..
  6. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2005
    ..The successful completion of the proposed experiments will reveal novel mechanisms of growth factor-stimulated glioma malignancy and new therapeutic targets for clinical development. ..
  7. Mechanisms of Chemo/Radioresistance in Human Gliomas
    John Laterra; Fiscal Year: 2005
    ..These studies will determine mechanisms of human glioma chemo-and radio resistance identify new approaches to enhancing brain tumor cytotoxic therapy. ..
  8. Mechanisms of Chemo/Radioresistance in Human Gliomas
    John Laterra; Fiscal Year: 2006
    ..These studies will determine mechanisms of human glioma chemo-and radio resistance identify new approaches to enhancing brain tumor cytotoxic therapy. ..
  9. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2006
    ..The successful completion of the proposed experiments will reveal novel mechanisms of growth factor-stimulated glioma malignancy and new therapeutic targets for clinical development. ..
  10. Mechanisms of Chemo/Radioresistance in Human Gliomas
    John Laterra; Fiscal Year: 2007
    ..These studies will determine mechanisms of human glioma chemo-and radio resistance identify new approaches to enhancing brain tumor cytotoxic therapy. ..
  11. Neutralizing Anti-HGF mAbs and CNS Malignancy
    John Laterra; Fiscal Year: 2009
    ..Histological, biochemical, and genetic markers for predicting tumor sensitivity and assessing anti-tumor responses to HGF inhibition will also be determined. Results will impact on how HGF inhibitors are used in brain tumor patients. ..
  12. Mechanisms of Chemo/Radioresistance in Human Gliomas
    John Laterra; Fiscal Year: 2009
    ..This research plan will identify molecular/biochemical approaches for overcoming glioma cell resistance to cytotoxic agents and test their therapeutic applicability in vivo. ..
  13. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2004
    ..The successful completion of the proposed experiments will reveal novel mechanisms of growth factor-stimulated glioma malignancy and new therapeutic targets for clinical development. ..
  14. Mechanisms of Chemo/Radioresistance in Human Gliomas
    John Laterra; Fiscal Year: 2004
    ..These studies will determine mechanisms of human glioma chemo-and radio resistance identify new approaches to enhancing brain tumor cytotoxic therapy. ..
  15. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2003
    ..The successful completion of the proposed experiments will reveal novel mechanisms of growth factor-stimulated glioma malignancy and new therapeutic targets for clinical development. ..
  16. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 1999
    ..These studies will produce new information on mechanisms of glioblastoma malignancy and BBB dysfunction and will establish the feasibility of altering SF/HGF:c-met signaling within gliomas for therapeutic intervention. ..
  17. THERAPEUTIC ANGIOGENESIS FOR ISCHEMIC DISEASES OF BRAIN
    John Laterra; Fiscal Year: 1999
    ..These experiments will establish the feasibility of therapeutic angiogenesis for treating ischemic brain injury and will establish treatment strategies relevant to future clinical applications. ..
  18. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2000
    ..These studies will produce new information on mechanisms of glioblastoma malignancy and BBB dysfunction and will establish the feasibility of altering SF/HGF:c-met signaling within gliomas for therapeutic intervention. ..
  19. THERAPEUTIC ANGIOGENESIS FOR ISCHEMIC DISEASES OF BRAIN
    John Laterra; Fiscal Year: 2000
    ..These experiments will establish the feasibility of therapeutic angiogenesis for treating ischemic brain injury and will establish treatment strategies relevant to future clinical applications. ..
  20. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2000
    ..These studies will produce new information on mechanisms of glioblastoma malignancy and BBB dysfunction and will establish the feasibility of altering SF/HGF:c-met signaling within gliomas for therapeutic intervention. ..
  21. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2000
    ..These studies will produce new information on mechanisms of glioblastoma malignancy and BBB dysfunction and will establish the feasibility of altering SF/HGF:c-met signaling within gliomas for therapeutic intervention. ..
  22. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2001
    ..These studies will produce new information on mechanisms of glioblastoma malignancy and BBB dysfunction and will establish the feasibility of altering SF/HGF:c-met signaling within gliomas for therapeutic intervention. ..
  23. THERAPEUTIC ANGIOGENESIS FOR ISCHEMIC DISEASES OF BRAIN
    John Laterra; Fiscal Year: 2001
    ..These experiments will establish the feasibility of therapeutic angiogenesis for treating ischemic brain injury and will establish treatment strategies relevant to future clinical applications. ..
  24. BIOCHEMISTRY OF BRAIN TUMOR MICROVESSEL DEVELOPMENT
    John Laterra; Fiscal Year: 2002
    ..These studies will produce new information on mechanisms of glioblastoma malignancy and BBB dysfunction and will establish the feasibility of altering SF/HGF:c-met signaling within gliomas for therapeutic intervention. ..
  25. Mechanisms of Chemo/Radioresistance in Human Gliomas
    John Laterra; Fiscal Year: 2003
    ..These studies will determine mechanisms of human glioma chemo-and radio resistance identify new approaches to enhancing brain tumor cytotoxic therapy. ..
  26. Mechanisms of Chemo/Radioresistance in Human Gliomas
    Eliot M Rosen; Fiscal Year: 2010
    ..This research plan will identify molecular/biochemical approaches for overcoming glioma cell resistance to cytotoxic agents and test their therapeutic applicability in vivo. ..