Research Topics
| MICHAEL VAN DOREN JOHNSTONSummaryAffiliation: Kennedy Krieger Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Recent progress in the neurology of learning: memory molecules in the developing brainM V Johnston
Johns Hopkins University School of Medicine and Kennedy Krieger Institute, Baltimore, MD 21205, USA
J Dev Behav Pediatr 20:50-6. 1999..Genetic defects in those pathways appear to be responsible for several human retardation and learning disability syndromes, including Coffin-Lowry syndrome and neurofibromatosis...- Diffusion tensor imaging of white matter and developmental outcomeMichael V Johnston
Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Departments of Neurology, Pediatrics, and Physical Medicine and Rehabilitation, 707 N Broadway, Baltimore, MD 21205, USA
Pediatrics 122:656-7. 2008 
Plasticity and injury in the developing brainMichael V Johnston
Department of Neurology, Kennedy Krieger Institute and Johns Hopkins University, School of Medicine, 707 North Broadway, Baltimore, MD 21205, USA
Brain Dev 31:1-10. 2009..This new information about the molecular pathways involved in brain plasticity and injury are leading to insights that will provide better therapies for pediatric neurological disorders...- Education of a child neurologist: developmental neuroscience relevant to child neurologyMichael V Johnston
Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, MD, USA
Semin Pediatr Neurol 18:133-8. 2011..This knowledge is increasingly being translated into therapies for previously untreatable disorders... - Sex and the pathogenesis of cerebral palsyMichael V Johnston
Kennedy Krieger Institute and The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Dev Med Child Neurol 49:74-8. 2007..This information is relevant to understanding the pathogenesis of CP as well as to the design of future clinical trials of potential neuroprotective strategies... - Neurobiology of Rett syndromeMichael V Johnston
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Child Neurol 18:688-92. 2003..These findings are consistent with other evidence that Rett syndrome disrupts genetic programs that establish and refine synaptic connections... - Clinical disorders of brain plasticityMichael V Johnston
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 North Broadway, Baltimore, MD 21205, USA
Brain Dev 26:73-80. 2004.... - Cerebral palsyMichael V Johnston
Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Baltimore, MD 21205, USA
Neuromolecular Med 8:435-50. 2006..Clinical trials indicate that mild hypothermia reduces death or disability in term infants following asphyxia and basic research suggests that this approach might be combined with pharmacological strategies in the future... - Models of cerebral palsy: which ones are best?Michael V Johnston
Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Child Neurol 20:984-7. 2005 - Rett syndrome and neuronal developmentMichael V Johnston
Department of Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
J Child Neurol 20:759-63. 2005..Taken together, this information supports the hypothesis that Rett syndrome is a genetic disorder of synapse development, especially synapses that use glutamate and GABA as neurotransmitters... - Excitotoxicity in perinatal brain injuryMichael V Johnston
Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Baltimore, MD 21205, USA
Brain Pathol 15:234-40. 2005..Insight into the molecular pathways that mediate perinatal brain injuries could lead to therapeutic interventions... - Brain plasticity in paediatric neurologyMichael V Johnston
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Eur J Paediatr Neurol 7:105-13. 2003..Information about these 'plasticity pathways' is useful for understanding their pathophysiology and potential therapy... - MRI for neonatal encephalopathy in full-term infantsMichael V Johnston
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Lancet 361:713-4. 2003 - Possible mechanisms in infants for selective basal ganglia damage from asphyxia, kernicterus, or mitochondrial encephalopathiesM V Johnston
Division of Neurology and Developmental Medicine, Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Child Neurol 15:588-91. 2000..This hypothesis has implications for designing neuroprotective therapies and for treating associated chronic movement disorders... - Neurobiology of hypoxic-ischemic injury in the developing brainM V Johnston
Division of Neurology and Developmental Medicine and Neuroscience Laboratory, Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Pediatr Res 49:735-41. 2001..The cascade of biochemical and histopathologic events triggered by hypoxic ischemia can extend for days to weeks after the insult is triggered, creating the potential for therapeutic interventions... - Developmental disorders of activity dependent neuronal plasticityM V Johnston
Kennedy Krieger Institute and Johns Hopkins University School of Medicine, 707 North Broadway, Baltimore, Maryland 21205, USA
Indian J Pediatr 68:423-6. 2001..Disruption of neuronal plasticity is a mechanism that may underlie a diverse group of neurodevelopmental disorders... - Neurobiology of Rett syndrome: a genetic disorder of synapse developmentM V Johnston
Kennedy Krieger Institute and Johns Hopkins University, Baltimore, MD 21205, USA
Brain Dev 23:S206-13. 2001..We hypothesize that a major effect of mutations in the MeCP2 protein is to cause age-related disruption of synaptic proliferation and pruning in the first decade of life... - Excitotoxicity in neonatal hypoxiaM V Johnston
Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Ment Retard Dev Disabil Res Rev 7:229-34. 2001..Understanding the complex molecular networks triggered by an excitotoxic insult in the neonate provides insight into patterns of selective neuronal vulnerability and potential therapeutic strategies... - Mechanisms of hypoxic neurodegeneration in the developing brainMichael V Johnston
Department of Neurology and Pediatrics and Kenedy Kreger Research Institute, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuroscientist 8:212-20. 2002..Although these molecular changes enhance the developing brain's capacity for plasticity by helping to prune redundant synapses and neurons, they can become "Achilles heels" in the face of a brain energy crisis... - Injury and plasticity in the developing brainMichael V Johnston
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Neurol 184:S37-41. 2003 
Treatment advances in neonatal neuroprotection and neurointensive careMichael V Johnston
Hugo W Moser Research Institute, at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Lancet Neurol 10:372-82. 2011..The search is on to discover adjuvant treatments that can further enhance the effects of hypothermia...- Plasticity in the developing brain: implications for rehabilitationMichael V Johnston
Departments of Neurology, Pediatrics and Physical Medicine and Rehabilitation, Kennedy Krieger Institute and Johns Hopkins University School of Medicine, 707 North Broadway, Baltimore, MD 21205, USA
Dev Disabil Res Rev 15:94-101. 2009..Plasticity is also influenced by genetic factors such as mutations in brain-derived neuronal growth factor. Understanding brain plasticity provides a basis for developing better therapies to improve outcome from acquired brain injuries... - Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemiaBeatrix S Traa
Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Pediatr Res 64:81-5. 2008..When analyzed by animal sex, the data suggest that gabapentin may more effectively reduce acute seizures and injury in male pups vs. female pups... - Impact of age and strain on ischemic brain injury and seizures after carotid ligation in immature miceAnne M Comi
Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
Int J Dev Neurosci 27:271-7. 2009..We also found that the age at which ligation is performed and genetic strain have a strong influence on the severity of injury... - Strain variability, injury distribution, and seizure onset in a mouse model of stroke in the immature brainAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Dev Neurosci 27:127-33. 2005.... - A new model of stroke and ischemic seizures in the immature mouseAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
Pediatr Neurol 31:254-7. 2004..This new model should be useful for examining the pathogenesis of stroke in the immature brain and the potential contribution of seizures to final outcome... - Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stressYasushi Teshima
Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, MD 21205, USA
Stroke 34:1796-802. 2003..CONCLUSIONS: MitoK(ATP) channel openers inhibited apoptosis by preserving mitochondrial inner membrane potential. These beneficial effects may suggest a possible new target for neuroprotection... - Chronic brain injury and behavioral impairments in a mouse model of term neonatal strokesShilpa D Kadam
Department of Neurology and Developmental Medicine, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
Behav Brain Res 197:77-83. 2009..Overall, our results demonstrate that ischemia induced by our neonatal stroke model produces behavioral deficits that are consistent with the brain injury... - Dextromethorphan protects male but not female mice with brain ischemiaAnne M Comi
Departments of aNeurology and Developmental Medicine bNeuroscience, Kennedy Krieger Research Institute Departments of cNeurology dPediatrics eNeuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Neuroreport 17:1319-22. 2006..These results suggest that dextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent... - Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathwaysAlexander H Hoon
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Dev Med Child Neurol 51:697-704. 2009..We investigated the relationship between DTI-observed thalamocortical (posterior thalamic radiation) injury, motor (corticospinal tract) injury, and sensorimotor function... - Neonatal electrolytic lesions of the basal forebrain stunt plasticity in mouse barrel field cortexAkira Nishimura
Neuroscience Laboratory, The Kennedy Krieger Research Institute, 707 North Broadway, Baltimore, MD 21205, USA
Int J Dev Neurosci 20:481-9. 2002..Cortex 8 (1998) 63]. These results suggest that cholinergic inputs play a role in regulating plasticity as well as in the morphogenesis of mouse sensory-motor cortex... - Protective effect of erythropoietin in neonatal hypoxic ischemia in miceHiroko Matsushita
Kennedy Krieger Research and Johns Hopkins School of medicine, Baltimore, MD 21205, USA
Neuroreport 14:1757-61. 2003..To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice... - Neural stem cells reduce brain injury after unilateral carotid ligationAnne M Comi
Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Pediatr Neurol 38:86-92. 2008..Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern... - Clinical variability in Rett syndromeSakkubai Naidu
Department of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD 21205, USA
J Child Neurol 18:662-8. 2003.... - Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse modelMasahiro Tsuji
Kennedy Krieger Research Institute, Baltimore, MD 21205, USA
Exp Neurol 189:58-65. 2004..However, it is important to examine this drug carefully before clinical use in human infants, taking our data in the mouse model into consideration... - Immature mouse unilateral carotid ligation model of strokeAnne M Comi
Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University, Baltomore, MD 21205, USA
J Child Neurol 20:980-3. 2005..In addition, more work is needed to delineate the long-term consequences of the insult in this new model... - Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopyChristopher J Barreiro
Division of Cardiac Surgery, Kennedy-Krieger Research Institute, Baltimore, Maryland, USA
Ann Thorac Surg 81:1593-8. 2006..Magnetic resonance spectroscopy assessment of NAA:Cho ratios offers an early, noninvasive means of potentially evaluating neurologic injury and the effect of neuroprotective agents... - Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgeryJason A Williams
Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Kennedy-Krieger Institute, Baltimore, Maryland, USA
Ann Thorac Surg 81:2235-41; discussion 2241-2. 2006..This commonly used drug may offer a promising new approach to neuroprotection during cardiac surgery... - Alpha II-spectrin breakdown products serve as novel markers of brain injury severity in a canine model of hypothermic circulatory arrestEric S Weiss
Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Ann Thorac Surg 88:543-50. 2009..We measured cerebrospinal fluid alpha II-spectrin breakdown products (alphaII-SBDPs) in a canine model of hypothermic circulatory arrest (HCA) and cardiopulmonary bypass... - Hypoxic-ischemic encephalopathy in the term infantAli Fatemi
Kennedy Krieger Institute, Department of Neurology, Johns Hopkins Medical Institutions, 707 N Broadway, Baltimore, MD 21205, USA
Clin Perinatol 36:835-58, vii. 2009..Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets... - MeCP2 expression and function during brain development: implications for Rett syndrome's pathogenesis and clinical evolutionWalter E Kaufmann
Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA
Brain Dev 27:S77-S87. 2005..Two models are proposed for explaining general and regional neuronal abnormalities in RTT and the phenotypical outcome of MeCP2 dysfunction, respectively... - Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrestElaine E Tseng
Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Ann Thorac Surg 89:440-5. 2010..This study was undertaken to determine whether glutamate receptor antagonism reduces nitric oxide formation and neuronal apoptosis after hypothermic circulatory arrest... - Ischemic stroke in children with critical illness: a poor prognostic signLori C Jordan
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Pediatr Neurol 36:244-6. 2007..Mortality resulted primarily from the underlying illness. Prognosis after stroke is markedly worsened in children with premorbid critical illness... - Activity-dependent expression of Egr1 mRNA in somatosensory cortex of developing ratsRamesh C Patra
Kennedy Krieger Research Institute, Baltimore, Maryland 21205, USA
J Neurosci Res 78:235-44. 2004.... - Oral baclofen in cerebral palsy: possible seizure potentiation?Donna E Hansel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Pediatr Neurol 29:203-6. 2003..Further study of the effects of baclofen on seizures is warranted... - Hawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypassJeremiah G Allen
Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Ann Thorac Surg 89:1965-71. 2010..Canine genome sequencing allows profiling of genomic changes after HCA and CPB alone. We hypothesize that gene regulation will increase with increased severity of injury... - Brain glucose metabolism in Rett SyndromePatricia M Villemagne
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-0807, USA
Pediatr Neurol 27:117-22. 2002..This pattern differs from those described in Down syndrome, autism, and Alzheimer's disease... - Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemiaDavid J Caparrelli
Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Ann Thorac Surg 74:838-44; discussion 844-5. 2002..Overall, this study suggests that diazoxide may be useful in the prevention of neurologic injury after thoracic aneurysm surgery... - Aicardi syndrome mimicking intrauterine hydrocephalusDeivasumathy Muthugovindan
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Brain Dev 31:638-40. 2009..Aicardi syndrome most commonly comes to medical attention because of seizures later in infancy... - PARP-1 gene disruption in mice preferentially protects males from perinatal brain injuryHenrik Hagberg
Perinatal Center, Sahlgrenska University Hospital, Goteborg, Sweden
J Neurochem 90:1068-75. 2004..The results indicate that hypoxia-ischemia activates Poly(ADP-ribose) polymerase-1 in the neonatal brain and that the sex of the animal strongly influences its role in the pathogenesis of brain injury... - Gene expression profiling: a new tool for pediatric neurology?Michael V Johnston
Curr Opin Neurol 18:89-90. 2005 - Fresh ideas for treating developmental cognitive disordersMichael V Johnston
Curr Opin Neurol 19:115-8. 2006 - Invited article: Residency Review Committee for neurology: structure and functionRonald Kanner
Albert Einstein College of Medicine, New Hyde Park, NY, USA
Neurology 71:452-6. 2008 - Congenital heart disease and brain injuryMichael V Johnston
N Engl J Med 357:1971-3. 2007 - Global gene expression in the developing rat brain after hypoxic preconditioning: involvement of apoptotic mechanisms?Malin Gustavsson
Department of Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Pediatr Res 61:444-50. 2007.... - Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injuryJoanne E Natale
Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
Pediatr Crit Care Med 8:1-9. 2007.... - Vascular response to hypoxic preconditioning in the immature brainMalin Gustavsson
Perinatal Center, Department of Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
J Cereb Blood Flow Metab 27:928-38. 2007..In conclusion, hypoxic PC upregulates vascular genes, increases vascular density and attenuates the decrease of CBF during a subsequent HI, which could contribute to tolerance...
Research Grants
- NEUROTRANSMITTER INJURY MECHANISMS IN DEVELOPING BRAINMichael Johnston; Fiscal Year: 2005..These studies are important for developing practical ways to salvage brain tissue in infants and young children who have suffered hypoxic-ischemic injuries. ..
- RESEARCH TRAINING IN BRAIN INJURY REHABILITATIONMichael Johnston; Fiscal Year: 2007..A weekly series of seminars, rounds, lectures and didactic course work brings together trainees to learn core information about neurorehabilitation in children. ..
- NEUROTRANSMITTER INJURY MECHANISMS IN DEVELOPING BRAINMichael Johnston; Fiscal Year: 2007..Detailed information about the molecular pathways that mediate cell death from hypoxia-ischemia is critically important for developing and testing neuroprotective interventions. ..
- NEUROTRANSMITTER INJURY MECHANISMS IN DEVELOPING BRAINMichael Johnston; Fiscal Year: 2009..Detailed information about the molecular pathways that mediate cell death from hypoxia-ischemia is critically important for developing and testing neuroprotective interventions. ..
- NEUROTRANSMITTER INJURY MECHANISMS IN DEVELOPING BRAINMichael Johnston; Fiscal Year: 2001..The information gained from these experiments is very important for developing practical neuroprotective therapies for fetuses, infants and young children. ..
- NEUROTRANSMITTER INJURY MECHANISMS IN DEVELOPING BRAINMichael Johnston; Fiscal Year: 1993
- NEUROTRANSMITTER INJURY MECHANISMS IN DEVELOPING BRAINMICHAEL VAN DOREN JOHNSTON; Fiscal Year: 2010..Detailed information about the molecular pathways that mediate cell death from hypoxia-ischemia is critically important for developing and testing neuroprotective interventions. ..