Anne Comi

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. doi request reprint Presentation, diagnosis, pathophysiology, and treatment of the neurological features of Sturge-Weber syndrome
    Anne M Comi
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Departments of Neurology and Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurologist 17:179-84. 2011
  2. ncbi request reprint Central hypothyroidism and Sturge-Weber syndrome
    Anne M Comi
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Pediatr Neurol 39:58-62. 2008
  3. doi request reprint Update on Sturge-Weber syndrome: diagnosis, treatment, quantitative measures, and controversies
    Anne M Comi
    Neurology and Developmental Medicine, Kennedy Krieger Institute, Department of Neurology and Pediatrics, Johns Hopkins School of Medicine Baltimore, MD 21205, USA
    Lymphat Res Biol 5:257-64. 2007
  4. doi request reprint Neural stem cells reduce brain injury after unilateral carotid ligation
    Anne M Comi
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Pediatr Neurol 38:86-92. 2008
  5. ncbi request reprint Sturge-Weber syndrome and epilepsy: an argument for aggressive seizure management in these patients
    Anne M Comi
    Department of Neurology, Kennedy Krieger Institute and Johns Hopkins Medicine, Baltimore, MD, USA
    Expert Rev Neurother 7:951-6. 2007
  6. ncbi request reprint Advances in Sturge-Weber syndrome
    Anne M Comi
    Neurology and Pediatrics, Kennedy Krieger Institute and Johns Hopkins Medicine, 707 N Broadway, Baltimore, MD 21205, USA
    Curr Opin Neurol 19:124-8. 2006
  7. ncbi request reprint Immature mouse unilateral carotid ligation model of stroke
    Anne M Comi
    Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University, Baltomore, MD 21205, USA
    J Child Neurol 20:980-3. 2005
  8. ncbi request reprint Sturge-Weber syndrome associated with other abnormalities: a medical record and literature review
    Anne M Comi
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Neurol 62:1924-7. 2005
  9. ncbi request reprint Strain variability, injury distribution, and seizure onset in a mouse model of stroke in the immature brain
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dev Neurosci 27:127-33. 2005
  10. pmc Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia
    Beatrix S Traa
    Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Pediatr Res 64:81-5. 2008

Collaborators

Detail Information

Publications35

  1. doi request reprint Presentation, diagnosis, pathophysiology, and treatment of the neurological features of Sturge-Weber syndrome
    Anne M Comi
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Departments of Neurology and Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurologist 17:179-84. 2011
    ..Some of these clinical features have only recently been described...
  2. ncbi request reprint Central hypothyroidism and Sturge-Weber syndrome
    Anne M Comi
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Pediatr Neurol 39:58-62. 2008
    ..Therefore, it is important that patients with Sturge-Weber syndrome undergo routine thyroid-function testing, especially in the face of any clinical manifestations...
  3. doi request reprint Update on Sturge-Weber syndrome: diagnosis, treatment, quantitative measures, and controversies
    Anne M Comi
    Neurology and Developmental Medicine, Kennedy Krieger Institute, Department of Neurology and Pediatrics, Johns Hopkins School of Medicine Baltimore, MD 21205, USA
    Lymphat Res Biol 5:257-64. 2007
    ....
  4. doi request reprint Neural stem cells reduce brain injury after unilateral carotid ligation
    Anne M Comi
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Pediatr Neurol 38:86-92. 2008
    ..Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern...
  5. ncbi request reprint Sturge-Weber syndrome and epilepsy: an argument for aggressive seizure management in these patients
    Anne M Comi
    Department of Neurology, Kennedy Krieger Institute and Johns Hopkins Medicine, Baltimore, MD, USA
    Expert Rev Neurother 7:951-6. 2007
    ..Continued efforts are needed to develop a multicentered network for SWS clinical trials. Future research should be focused on this goal and on studies to improve our understanding of the cause(s) and molecular neuropathology of SWS...
  6. ncbi request reprint Advances in Sturge-Weber syndrome
    Anne M Comi
    Neurology and Pediatrics, Kennedy Krieger Institute and Johns Hopkins Medicine, 707 N Broadway, Baltimore, MD 21205, USA
    Curr Opin Neurol 19:124-8. 2006
    ..Recent neuroimaging, clinical and molecular neuropathologic studies have provided new insights into the neurologic aspects of Sturge-Weber syndrome and are summarized here...
  7. ncbi request reprint Immature mouse unilateral carotid ligation model of stroke
    Anne M Comi
    Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University, Baltomore, MD 21205, USA
    J Child Neurol 20:980-3. 2005
    ..In addition, more work is needed to delineate the long-term consequences of the insult in this new model...
  8. ncbi request reprint Sturge-Weber syndrome associated with other abnormalities: a medical record and literature review
    Anne M Comi
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Neurol 62:1924-7. 2005
    ..To develop hypotheses regarding the relationship between Sturge-Weber syndrome (SWS) and other abnormalities in a subset of patients...
  9. ncbi request reprint Strain variability, injury distribution, and seizure onset in a mouse model of stroke in the immature brain
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dev Neurosci 27:127-33. 2005
    ....
  10. pmc Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia
    Beatrix S Traa
    Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Pediatr Res 64:81-5. 2008
    ..When analyzed by animal sex, the data suggest that gabapentin may more effectively reduce acute seizures and injury in male pups vs. female pups...
  11. ncbi request reprint A new model of stroke and ischemic seizures in the immature mouse
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Pediatr Neurol 31:254-7. 2004
    ..This new model should be useful for examining the pathogenesis of stroke in the immature brain and the potential contribution of seizures to final outcome...
  12. pmc Impact of age and strain on ischemic brain injury and seizures after carotid ligation in immature mice
    Anne M Comi
    Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
    Int J Dev Neurosci 27:271-7. 2009
    ..We also found that the age at which ligation is performed and genetic strain have a strong influence on the severity of injury...
  13. pmc Use of quantitative EEG in infants with port-wine birthmark to assess for Sturge-Weber brain involvement
    Joshua B Ewen
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Clin Neurophysiol 120:1433-40. 2009
    ..The current study looks at the ability of qEEG to differentiate between infants with radiographically demonstrated SWS and those without...
  14. doi request reprint Neuropsychological features and risk factors in children with Sturge-Weber syndrome: four case reports
    T Andrew Zabel
    Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21231, USA
    Clin Neuropsychol 24:841-59. 2010
    ..We discuss the need for broad-based assessment in this medical population, as various impairment combinations (e.g., perceptual, language, executive) create unique presentations as well as the need for individualized intervention...
  15. ncbi request reprint Comorbidity of epilepsy and headache in patients with Sturge-Weber syndrome
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Child Neurol 20:678-82. 2005
    ..Correlations of family history with both age at symptom onset and behavior problems suggest that genetic substrate could be one factor determining the variable neurologic manifestations seen in Sturge-Weber syndrome...
  16. ncbi request reprint Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome
    Joshua B Ewen
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:115-7. 2007
    ..In such cases, treatment with a broad-spectrum antiepileptic may be advantageous...
  17. ncbi request reprint Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndrome
    Laura A Hatfield
    Department of Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Epilepsia 48:191-5. 2007
    ..SWS results in ischemic brain injury, seizures, and neurologic deficits. We hypothesized that a decrease in quantitative EEG (qEEG) power, on the affected side, correlates with clinical severity in subjects with SWS...
  18. doi request reprint Behavioral and psychiatric features of Sturge-Weber syndrome
    Elizabeth Turin
    Kennedy Krieger Institute, Department of Psychiatry, Baltimore, MD 21205, USA
    J Nerv Ment Dis 198:905-13. 2010
    ..Problems with mood, attention, sleep, learning, and substance use were common. Disruptive behavior disorders and their association with medical conditions should be further investigated...
  19. doi request reprint Hemiparesis is a clinical correlate of general adaptive dysfunction in children and adolescents with Sturge-Weber syndrome
    Jennifer Reesman
    Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    J Child Neurol 24:701-8. 2009
    ..Information obtained during neurological examination of children and adolescents with Sturge-Weber syndrome particularly hemiparetic status is useful for identifying children who may need additional intervention...
  20. ncbi request reprint Dextromethorphan protects male but not female mice with brain ischemia
    Anne M Comi
    Departments of aNeurology and Developmental Medicine bNeuroscience, Kennedy Krieger Research Institute Departments of cNeurology dPediatrics eNeuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neuroreport 17:1319-22. 2006
    ..These results suggest that dextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent...
  21. ncbi request reprint Quantitative analysis of cerebral cortical atrophy and correlation with clinical severity in unilateral Sturge-Weber syndrome
    Thomas M Kelley
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21297 1000, USA
    J Child Neurol 20:867-70. 2005
    ..This method offers the advantages of relative simplicity, objectivity, and wide applicability to films from outside institutions, as would be encountered in clinical practice...
  22. doi request reprint An infantile-onset, severe, yet sporadic seizure pattern is common in Sturge-Weber syndrome
    Eric H Kossoff
    The Johns Hopkins Hospital, Baltimore, MD 21287 1000, USA
    Epilepsia 50:2154-7. 2009
    ..This seizure pattern appears to be common with SWS and leads to difficult treatment decisions, especially in regard to the timing of potential surgical resection...
  23. pmc Chronic brain injury and behavioral impairments in a mouse model of term neonatal strokes
    Shilpa D Kadam
    Department of Neurology and Developmental Medicine, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
    Behav Brain Res 197:77-83. 2009
    ..Overall, our results demonstrate that ischemia induced by our neonatal stroke model produces behavioral deficits that are consistent with the brain injury...
  24. ncbi request reprint Encephalofacial angiomatosis sparing the occipital lobe and without facial nevus: on the spectrum of Sturge-Weber syndrome variants?
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Child Neurol 18:35-8. 2003
    ..This diagnosis should be considered in any child presenting with seizures or complicated migraines and intracranial calcifications...
  25. pmc Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury
    Lavinia Alberi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 41:S64-71. 2010
    ..The purpose of this study was to understand whether Notch-2 is induced after neonatal stroke and to investigate its functional relevance...
  26. ncbi request reprint Pathophysiology of Sturge-Weber syndrome
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Child Neurol 18:509-16. 2003
    ..Neurologic deterioration in Sturge-Weber syndrome is likely secondary to impaired blood flow to the brain and is worsened by the presence of seizures. Insights from related areas are discussed, and future research studies are suggested...
  27. ncbi request reprint Transcranial Doppler ultrasound in children with Sturge-Weber syndrome
    Lori C Jordan
    Department of Neurology, The Johns Hopkins University School of Medicine, USA
    J Child Neurol 23:137-43. 2008
    ..Further study of Transcranial Doppler in children with Sturge-Weber syndrome is indicated...
  28. ncbi request reprint Early characteristics of Sturge-Weber syndrome shown by perfusion MR imaging and proton MR spectroscopic imaging
    Doris D M Lin
    Department of Radiology and Radiologic Science Johns Hopkins University School of Medicine, Baltimore, MD, USA
    AJNR Am J Neuroradiol 24:1912-5. 2003
    ..The perfusion and subtle metabolic abnormalities are comparable with the extent of the overlying leptomeningeal enhancement, illustrating the early pathophysiological manifestation of this disease...
  29. pmc Physiatric findings in individuals with Sturge-Weber syndrome
    Stacy J Suskauer
    Kennedy Krieger Institute, Baltimore, Maryland, USA
    Am J Phys Med Rehabil 89:323-30. 2010
    ....
  30. ncbi request reprint Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Pediatr Res 53:762-9. 2003
    ..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS...
  31. doi request reprint Effect of a single application of pulsed dye laser treatment of port-wine birthmarks on intraocular pressure
    Susan Y Quan
    Departments of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arch Dermatol 146:1015-8. 2010
    ..Pressures before and after laser treatment were measured to determine pressure difference in 15 patients receiving laser treatment...
  32. ncbi request reprint Self-reported treatment patterns in patients with Sturge-Weber syndrome and migraines
    Eric H Kossoff
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Child Neurol 22:720-6. 2007
    ..The small sample size precludes any safety analysis, however, and future prospective trials of both treatment options are needed...
  33. ncbi request reprint Dynamic MR perfusion and proton MR spectroscopic imaging in Sturge-Weber syndrome: correlation with neurological symptoms
    Doris D M Lin
    Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 24:274-81. 2006
    ..To investigate physiological alterations in Sturge-Weber syndrome (SWS) using MR perfusion imaging (PWI) and proton spectroscopic imaging (MRSI), and their association with neurological status...
  34. ncbi request reprint Sturge-Weber syndrome: altered blood vessel fibronectin expression and morphology
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Child Neurol 20:572-7. 2005
    ..Altered blood vessel fibronectin expression in Sturge-Weber syndrome could contribute to abnormal vascular structure and function in this disorder...

Research Grants4

  1. Ischemic Injury and Neuroprotection in the Immature Brain
    Anne Comi; Fiscal Year: 2007
    ..This work will provide important insights into the brain injury and regenerative response after stroke in this new immature mouse model and will test neuroprotective interventions with relevance to this population. ..
  2. Anticonvulsants, ischemic seizures and regeneration in the immature brain
    Anne Comi; Fiscal Year: 2009
    ..The studies will also inform our understanding of processes important to new cell birth and cognitive outcome in the immature brain after neonatal stroke. ..
  3. Anticonvulsants, ischemic seizures and regeneration in the immature brain
    Anne M Comi; Fiscal Year: 2010
    ..The studies will also inform our understanding of processes important to new cell birth and cognitive outcome in the immature brain after neonatal stroke. ..