G Capone

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. doi request reprint Adolescents and young adults with Down syndrome presenting to a medical clinic with depression: co-morbid obstructive sleep apnea
    George T Capone
    Department of Neurology and Developmental Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet A 161:2188-96. 2013
  2. doi request reprint Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic study
    George T Capone
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    J Dev Behav Pediatr 29:106-16. 2008
  3. ncbi request reprint Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome
    George Capone
    Down Syndrome Clinic DSC at Kennedy Krieger Institute, 707 N Broadway, Baltimore MD 21205, USA
    Am J Med Genet C Semin Med Genet 142:158-72. 2006
  4. ncbi request reprint Down syndrome and comorbid autism-spectrum disorder: characterization using the aberrant behavior checklist
    George T Capone
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Am J Med Genet A 134:373-80. 2005
  5. ncbi request reprint Regulation of the preprosomatostatin gene by cyclic-AMP in cerebrocortical neurons
    G Capone
    Division of Developmental Pediatrics, Johns Hopkins University School of Medicine, 625 North Wolfe Street, Baltimore, MD 21205, USA
    Brain Res Mol Brain Res 60:247-58. 1998
  6. ncbi request reprint Down syndrome: advances in molecular biology and the neurosciences
    G T Capone
    Department of Pediatrics, Johns Hopkins University School of Medicine, and Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Dev Behav Pediatr 22:40-59. 2001
  7. ncbi request reprint Evidence for increased mitochondrial superoxide production in Down syndrome
    George Capone
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Life Sci 70:2885-95. 2002
  8. ncbi request reprint Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors
    Walter E Kaufmann
    Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet A 129:225-34. 2004
  9. ncbi request reprint Autistic-spectrum disorders in Down syndrome: further delineation and distinction from other behavioral abnormalities
    John C Carter
    Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet B Neuropsychiatr Genet 144:87-94. 2007
  10. ncbi request reprint Specificity of cerebellar vermian abnormalities in autism: a quantitative magnetic resonance imaging study
    Walter E Kaufmann
    Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Child Neurol 18:463-70. 2003

Collaborators

Detail Information

Publications16

  1. doi request reprint Adolescents and young adults with Down syndrome presenting to a medical clinic with depression: co-morbid obstructive sleep apnea
    George T Capone
    Department of Neurology and Developmental Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet A 161:2188-96. 2013
    ..Recognition of this association maybe critical to understanding the pathogenesis and management of mood-related disorders, and functional decline in affected individuals...
  2. doi request reprint Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic study
    George T Capone
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    J Dev Behav Pediatr 29:106-16. 2008
    ..We hypothesized that hyperactivity and disruptive behaviors would improve in response to risperidone treatment consistent with previous studies of children with ASD...
  3. ncbi request reprint Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome
    George Capone
    Down Syndrome Clinic DSC at Kennedy Krieger Institute, 707 N Broadway, Baltimore MD 21205, USA
    Am J Med Genet C Semin Med Genet 142:158-72. 2006
    ..Improvement in physiologic regulation, emotional stability, and neurocognitive processing is one of the most elusive but fundamental goals of pharmacologic intervention in these disorders...
  4. ncbi request reprint Down syndrome and comorbid autism-spectrum disorder: characterization using the aberrant behavior checklist
    George T Capone
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Am J Med Genet A 134:373-80. 2005
    ..This study demonstrates the feasibility of using the ABC to characterize the neurobehavioral phenotype of a cohort of children with trisomy 21 and ASD for ongoing research purposes...
  5. ncbi request reprint Regulation of the preprosomatostatin gene by cyclic-AMP in cerebrocortical neurons
    G Capone
    Division of Developmental Pediatrics, Johns Hopkins University School of Medicine, 625 North Wolfe Street, Baltimore, MD 21205, USA
    Brain Res Mol Brain Res 60:247-58. 1998
    ....
  6. ncbi request reprint Down syndrome: advances in molecular biology and the neurosciences
    G T Capone
    Department of Pediatrics, Johns Hopkins University School of Medicine, and Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Dev Behav Pediatr 22:40-59. 2001
    ..To develop novel therapeutic strategies, the effects of gene dosage imbalance need to be understood within the framework of those critical biological events that regulate brain organization and function...
  7. ncbi request reprint Evidence for increased mitochondrial superoxide production in Down syndrome
    George Capone
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Life Sci 70:2885-95. 2002
    ..The role of the mitochondria in superoxide anion production and the mechanisms underlying its generation in DS deserves further study...
  8. ncbi request reprint Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors
    Walter E Kaufmann
    Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet A 129:225-34. 2004
    ..Altogether, our findings demonstrate that the diagnosis of ASD in FraX reflects, to a large extent, an impairment in social interaction that is expressed with variable severity in young males with FraX...
  9. ncbi request reprint Autistic-spectrum disorders in Down syndrome: further delineation and distinction from other behavioral abnormalities
    John C Carter
    Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet B Neuropsychiatr Genet 144:87-94. 2007
    ..Overall, our findings indicate that a diagnosis of DS + ASD represents a distinctive set of aberrant behaviors marked by characteristic odd/bizarre stereotypic behavior, anxiety, and social withdrawal...
  10. ncbi request reprint Specificity of cerebellar vermian abnormalities in autism: a quantitative magnetic resonance imaging study
    Walter E Kaufmann
    Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Child Neurol 18:463-70. 2003
    ..The latter results are consistent with MRI studies showing lobules VI-VII hyperplasia in a subset of subjects with idiopathic autism and cerebral and hippocampal enlargements in fragile X syndrome...
  11. ncbi request reprint Cerebral growth in Fragile X syndrome: review and comparison with Down syndrome
    Wendy R Kates
    aMRI Analysis Laboratory, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Microsc Res Tech 57:159-67. 2002
    ..These neuroimaging data are discussed in the context of FraX neurobiology and other developmental disorders...
  12. doi request reprint Neuroanatomic correlates of autism and stereotypy in children with Down syndrome
    John C Carter
    Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute, Baltimore, MD 21211, USA
    Neuroreport 19:653-6. 2008
    ..Cerebellar white matter volumes were positively correlated with severity of stereotypies, a distinctive feature of ASD in DS...
  13. pmc Obstructive sleep apnea in adults with Down syndrome
    Maria S Trois
    Department of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore MD, USA
    J Clin Sleep Med 5:317-23. 2009
    ..Although adults with DS have many predisposing factors for OSAS, this population has not been well studied. We hypothesized that OSAS is common in adults with DS, and that the severity of OSAS is worse in DS adults who are more obese...
  14. pmc New onset focal weakness in children with Down syndrome
    Gordon Worley
    Department of Pediatrics, Program in Neurodevelopmental Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Med Genet A 128:15-8. 2004
    ..The differential diagnosis of new onset focal weakness in DS is broad, with diseases reported involving all levels of the nervous system from brain to muscle. For some diagnoses, expeditious diagnosis may improve outcome...
  15. doi request reprint The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome
    Priya S Kishnani
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet A 149:1641-54. 2009
    ..Outcomes in post hoc analyses suggested efficacy in some, but not all subjects, consistent with phenotypic variability of DS. Additional studies are required to confirm potential benefits of donepezil in this population...
  16. ncbi request reprint The effects of piracetam on cognitive performance in a mouse model of Down's syndrome
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Physiol Behav 77:403-9. 2002
    ..The 300-mg/kg/day-piracetam dose was associated with a reversal of the nocturnal spontaneous hyperactivity in Ts65Dn. These data do not provide support for piracetam treatment for individuals with DS...