Amy Bastian

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. pmc Active force perception depends on cerebellar function
    Nasir H Bhanpuri
    Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Neurophysiol 107:1612-20. 2012
  2. ncbi request reprint Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson's disease
    Amy J Bastian
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Mov Disord 18:1008-17. 2003
  3. ncbi request reprint Learning to predict the future: the cerebellum adapts feedforward movement control
    Amy J Bastian
    Kennedy Krieger Institute, The Johns Hopkins School of Medicine, North Broadway, G04 Baltimore, MD 21205, USA
    Curr Opin Neurobiol 16:645-9. 2006
  4. pmc Moving, sensing and learning with cerebellar damage
    Amy J Bastian
    Kennedy Krieger Institute, Department of Neuroscience, The Johns Hopkins School of Medicine, United States
    Curr Opin Neurobiol 21:596-601. 2011
  5. pmc Natural error patterns enable transfer of motor learning to novel contexts
    Gelsy Torres-Oviedo
    Kennedy Krieger Institute, Motion Analysis Laboratory, 707 N Broadway, Baltimore, MD 21205, USA
    J Neurophysiol 107:346-56. 2012
  6. ncbi request reprint Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease
    Amy J Bastian
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Mov Disord 18:1000-7. 2003
  7. ncbi request reprint Cerebellar limb ataxia: abnormal control of self-generated and external forces
    Amy J Bastian
    Department of Neurology, Johns Hopkins Medical School, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 978:16-27. 2002
  8. ncbi request reprint Sensory prediction errors drive cerebellum-dependent adaptation of reaching
    Ya weng Tseng
    Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Neurophysiol 98:54-62. 2007
  9. pmc Acquisition of internal models of motor tasks in children with autism
    Jennifer C Gidley Larson
    Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Brain 131:2894-903. 2008
  10. pmc Reach adaptation: what determines whether we learn an internal model of the tool or adapt the model of our arm?
    Joann Kluzik
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurophysiol 100:1455-64. 2008

Collaborators

Detail Information

Publications45

  1. pmc Active force perception depends on cerebellar function
    Nasir H Bhanpuri
    Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Neurophysiol 107:1612-20. 2012
    ..Our results are consistent with the hypothesis that the cerebellum is vital to sensory prediction of self-generated movement and suggest a general role for the cerebellum in multiple forms of active perception...
  2. ncbi request reprint Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson's disease
    Amy J Bastian
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Mov Disord 18:1008-17. 2003
    ....
  3. ncbi request reprint Learning to predict the future: the cerebellum adapts feedforward movement control
    Amy J Bastian
    Kennedy Krieger Institute, The Johns Hopkins School of Medicine, North Broadway, G04 Baltimore, MD 21205, USA
    Curr Opin Neurobiol 16:645-9. 2006
    ..Prediction mechanisms must be learned and maintained through comparisons between predicted and observed outcomes. New results show that not all such error information is equivalent in driving cerebellar learning...
  4. pmc Moving, sensing and learning with cerebellar damage
    Amy J Bastian
    Kennedy Krieger Institute, Department of Neuroscience, The Johns Hopkins School of Medicine, United States
    Curr Opin Neurobiol 21:596-601. 2011
    ..This review covers these and other recent advances, focusing on how cerebellar damage affects human abilities ranging from sensory perception to movement control and motor learning...
  5. pmc Natural error patterns enable transfer of motor learning to novel contexts
    Gelsy Torres-Oviedo
    Kennedy Krieger Institute, Motion Analysis Laboratory, 707 N Broadway, Baltimore, MD 21205, USA
    J Neurophysiol 107:346-56. 2012
    ..This result helps explain how transfer of motor learning is controlled, and it offers an important strategy for clinical rehabilitation, where transfer of motor learning to other contexts is essential...
  6. ncbi request reprint Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease
    Amy J Bastian
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Mov Disord 18:1000-7. 2003
    ..Our findings also suggest that maximal improvement of walking requires bilateral rather than unilateral STN stimulation...
  7. ncbi request reprint Cerebellar limb ataxia: abnormal control of self-generated and external forces
    Amy J Bastian
    Department of Neurology, Johns Hopkins Medical School, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 978:16-27. 2002
    ..Given these findings, we think that the cerebellum is important in anticipating and adjusting for the mechanical demands of movement though trial-and-error practice...
  8. ncbi request reprint Sensory prediction errors drive cerebellum-dependent adaptation of reaching
    Ya weng Tseng
    Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Neurophysiol 98:54-62. 2007
    ..Therefore adaptation to visuomotor perturbations depends on the cerebellum and is driven by the mismatch between predicted and actual sensory outcome of motor commands...
  9. pmc Acquisition of internal models of motor tasks in children with autism
    Jennifer C Gidley Larson
    Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Brain 131:2894-903. 2008
    ..Furthermore, the findings may have therapeutic implications, highlighting a reliable mechanism by which children with autism can most effectively alter their behaviour...
  10. pmc Reach adaptation: what determines whether we learn an internal model of the tool or adapt the model of our arm?
    Joann Kluzik
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurophysiol 100:1455-64. 2008
    ..Gradual changes in the tool's dynamics increased the extent to which the nervous system recalibrated the model of the subject's own arm...
  11. pmc Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback control
    Julia T Choi
    The Kennedy Krieger Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Brain 132:722-33. 2009
    ..These results suggest that the cerebrum is involved in adaptation of the timing, but not spatial, elements of limb movements...
  12. pmc Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways
    Alexander H Hoon
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Dev Med Child Neurol 51:697-704. 2009
    ..We investigated the relationship between DTI-observed thalamocortical (posterior thalamic radiation) injury, motor (corticospinal tract) injury, and sensorimotor function...
  13. pmc Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord
    Kathleen M Zackowski
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Brain 132:1200-9. 2009
    ..30, P < 0.001). These results help to understand the anatomic basis of sensorimotor disability in multiple sclerosis and have implications for testing the effects of neuroprotective and reparative interventions...
  14. pmc Split-belt treadmill adaptation shows different functional networks for fast and slow human walking
    Erin V L Vasudevan
    Motion Analysis Laboratory, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
    J Neurophysiol 103:183-91. 2010
    ..Taken together, our results suggest that there are some neural networks for controlling locomotion that are recruited specifically for fast versus slow walking in humans, similar to recent findings in other vertebrates...
  15. ncbi request reprint Children with autism adapt normally during a catching task requiring the cerebellum
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Neurocase 10:60-4. 2004
    ..Results showed no differences in adaptation rates or after-effects for HFA subjects versus controls. The findings indicate normal motor adaptation in HFA, suggesting normal or compensated cerebellar function for this task...
  16. ncbi request reprint Cerebellar damage produces context-dependent deficits in control of leg dynamics during obstacle avoidance
    Susanne M Morton
    Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Brain Res 156:149-63. 2004
    ....
  17. ncbi request reprint Prism adaptation during walking generalizes to reaching and requires the cerebellum
    Susanne M Morton
    Kennedy Krieger Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurophysiol 92:2497-509. 2004
    ..In contrast, prism adaptation during isolated movements of the limbs is probably recalibrated by effector-specific mechanisms. The cerebellum is an essential component in the network for both types of prism adaptation...
  18. pmc Virtual lesion of angular gyrus disrupts the relationship between visuoproprioceptive weighting and realignment
    HANNAH BLOCK
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cogn Neurosci 25:636-48. 2013
    ....
  19. ncbi request reprint Can spasticity and dystonia be independently measured in cerebral palsy?
    Laurie M Gordon
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Pediatr Neurol 35:375-81. 2006
    ..Use of quantitative measures should improve selection and evaluation of treatments for childhood motor disorders...
  20. ncbi request reprint Cerebellar contributions to locomotor adaptations during splitbelt treadmill walking
    Susanne M Morton
    Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:9107-16. 2006
    ..We postulate that reactive adjustments may instead be predominantly controlled by lower neural centers, such as the spinal cord or brainstem...
  21. doi request reprint Where is your arm? Variations in proprioception across space and tasks
    Christina T Fuentes
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Neurophysiol 103:164-71. 2010
    ....
  22. pmc Children with autism show specific handwriting impairments
    Christina T Fuentes
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 73:1532-7. 2009
    ..As a result, the specific aspects of handwriting in which individuals with autism demonstrate difficulty remain unknown...
  23. ncbi request reprint Adaptation reveals independent control networks for human walking
    Julia T Choi
    The Kennedy Krieger Institute, 707 North Broadway, Baltimore, Maryland 21205, USA
    Nat Neurosci 10:1055-62. 2007
    ..Such training could provide a new therapeutic approach for correcting various walking asymmetries...
  24. ncbi request reprint 'Motor cognition' - what is it and is the cerebellum involved?
    Christina T Fuentes
    Kennedy Krieger Institute, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cerebellum 6:232-6. 2007
    ..The data for a cerebellar role in understanding the meaning of movement are mixed, although anatomical findings suggest that it probably has some influence that bears further study...
  25. pmc Understanding sensorimotor adaptation and learning for rehabilitation
    Amy J Bastian
    Kennedy Krieger Institute, Department of Neuroscience, Neurology, and Physical Medicine and Rehabilitation, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Neurol 21:628-33. 2008
    ..Understanding the behavioral mechanisms of sensorimotor adaptation and learning is essential for designing rational rehabilitation interventions...
  26. pmc A cerebellar deficit in sensorimotor prediction explains movement timing variability
    Jin Bo
    Kennedy Krieger Institute, 401 Washtenaw Ave, Ann Arbor, MI 48109 2214, USA
    J Neurophysiol 100:2825-32. 2008
    ..One interpretation of these combined results is that the cerebellum is indeed functioning as an internal model and is needed to make appropriate predictions for movement initiation and termination...
  27. pmc Modulating locomotor adaptation with cerebellar stimulation
    Gowri Jayaram
    Kennedy Krieger Institute, Baltimore, MD, USA
    J Neurophysiol 107:2950-7. 2012
    ..It may be that spatial and temporal control mechanisms are accessible through different neural circuits. Our results suggest that tDCS could be used as a tool to modulate locomotor training in neurological patients with gait impairments...
  28. pmc Perceptual reasoning predicts handwriting impairments in adolescents with autism
    Christina T Fuentes
    Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 75:1825-9. 2010
    ..It is not known whether the same handwriting impairments persist into adolescence and whether they remain linked to motor deficits...
  29. doi request reprint Multidigit movement synergies of the human hand in an unconstrained haptic exploration task
    Pramodsingh H Thakur
    Department of Neuroscience, Zanvyl Krieger Mind Brain Institute and Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 28:1271-81. 2008
    ..Our results demonstrate that the synergies reported here generalize across tasks, and suggest that they represent basic building blocks underlying natural human hand motions...
  30. ncbi request reprint Cerebellar control of balance and locomotion
    Susanne M Morton
    Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroscientist 10:247-59. 2004
    ..The purpose of this review is to examine mechanisms of cerebellar control of balance and locomotion, emphasizing studies of humans and other animals. Implications for rehabilitation are also considered...
  31. pmc Sensory reweighting in targeted reaching: effects of conscious effort, error history, and target salience
    Hannah J Block
    Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA
    J Neurophysiol 103:206-17. 2010
    ..We also found that experimental weights can be predicted by minimizing the variance of visual and proprioceptive estimates, supporting the idea that minimum variance integration is an important principle of sensorimotor processing...
  32. ncbi request reprint Sensorimotor function and axonal integrity in adrenomyeloneuropathy
    Kathleen M Zackowski
    Kennedy Krieger Institute, The Johns Hopkins University Baltimore, MD 21205, USA
    Arch Neurol 63:74-80. 2006
    ..Gait abnormalities and sensorimotor disturbances are principal defects in adrenomyeloneuropathy (AMN). However, to our knowledge, their association with overall impairment and neuroanatomical changes has not been defined...
  33. pmc Sensory weighting and realignment: independent compensatory processes
    Hannah J Block
    Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurophysiol 106:59-70. 2011
    ....
  34. ncbi request reprint Mechanisms of cerebellar gait ataxia
    Susanne M Morton
    Departments of Physical Therapy and Rehabilitation Science and Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
    Cerebellum 6:79-86. 2007
    ..The purpose of this review is to examine mechanisms of cerebellar control of locomotion, emphasizing studies of humans and other animals. Implications for rehabilitation are also considered...
  35. ncbi request reprint Role of the cerebellum in the control and adaptation of gait in health and disease
    W Thomas Thach
    Departments of Anatomy and Neurobiology, Program in Physical Therapy, Neurology and Neurological Surgery, Irene Walter Johnson Rehabilitation Research Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Prog Brain Res 143:353-66. 2004
    ..These issues have become increasingly important in rehabilitation research and practice...
  36. ncbi request reprint Relative contributions of balance and voluntary leg-coordination deficits to cerebellar gait ataxia
    Susanne M Morton
    Interdisciplinary Program in Movement Science, Program in Physical Therapy, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurophysiol 89:1844-56. 2003
    ..Our findings are consistent with animal literature, which has suggested that cerebellar control of balance and gait are interrelated, and dissociable from cerebellar control of voluntary, visually guided limb movements...
  37. ncbi request reprint Cerebellar damage impairs automaticity of a recently practiced movement
    Catherine E Lang
    Program in Physical Therapy, Washington University School of Medicine, St Louis, MO 63108, USA
    J Neurophysiol 87:1336-47. 2002
    ..Overall, our findings suggest that the cerebellum may be important for shifting movement performance from an attentionally demanding (unpracticed) state to a more automatic (practiced) state...
  38. ncbi request reprint Interaction of levodopa and cues on voluntary reaching in Parkinson's disease
    Valerie E Kelly
    Program in Physical Therapy, Washington University School of Medicine, St Louis, Missouri, USA
    Mov Disord 17:38-44. 2002
    ..cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated...
  39. ncbi request reprint Antiparkinson medications improve agonist activation but not antagonist inhibition during sequential reaching movements
    Valerie E Kelly
    Department of Rehabilitation Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Mov Disord 20:694-704. 2005
    ..Instead, antagonist activity was also increased, resulting in minimal improvements in muscle modulation during sequential reaching movements...
  40. ncbi request reprint Interlimb coordination during locomotion: what can be adapted and stored?
    Darcy S Reisman
    Department of Physical Therapy, University of Delaware, Newark, USA
    J Neurophysiol 94:2403-15. 2005
    ..The differences in intra- versus interlimb control may be related to the varying complexity of the parameters, task demands, and/or the level of neural control necessary for their adaptation...
  41. ncbi request reprint Deficits in grasp versus reach during acute hemiparesis
    Catherine E Lang
    Program in Physical Therapy, Washington University, 4444 Forest Park Blvd, Campus Box 8502, St Louis, MO, USA
    Exp Brain Res 166:126-36. 2005
    ....
  42. pmc Locomotor adaptation on a split-belt treadmill can improve walking symmetry post-stroke
    Darcy S Reisman
    Department of Physical Therapy, University of Delaware, 322 McKinly Laboratory, Newark, DE 19716, USA
    Brain 130:1861-72. 2007
    ..This raises the possibility that asymmetric walking patterns post-stroke could be remediated utilizing the split-belt treadmill as a long-term rehabilitation strategy...
  43. pmc Temporal variability in continuous versus discontinuous drawing for children with Developmental Coordination Disorder
    Jin Bo
    Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA
    Neurosci Lett 431:215-20. 2008
    ..This work raises a critical issue with respect to the functional heterogeneity of this population and emphasizes the importance of an individualized analysis in this movement disorder...
  44. ncbi request reprint Relationships between sensorimotor impairments and reaching deficits in acute hemiparesis
    Joanne M Wagner
    Program in Physical Therapy, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurorehabil Neural Repair 20:406-16. 2006
    ....
  45. pmc Continuous and discontinuous drawing: high temporal variability exists only in discontinuous circling in young children
    Jin Bo
    Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Mot Behav 40:391-9. 2008
    ..The authors argue that both explicit timing and dynamic complexity of limb control may be determinants of temporal consistency and may thus play an important role in the development of drawing and writing skills in children...

Research Grants14

  1. MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIA
    Amy J Bastian; Fiscal Year: 2010
    ..We will also study the effects of a rehabilitation program designed to improve balance and walking. ..
  2. Human Locomotor Plasticity in Health and Disease
    Amy Bastian; Fiscal Year: 2009
    ..We will do this using a new type of treadmill that has two belts so that the legs can be independently controlled at different speeds. ..
  3. MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIA
    Amy Bastian; Fiscal Year: 2009
    ..We will also study the effects of a rehabilitation program designed to improve balance and walking. ..
  4. Human Locomotor Plasticity in Health and Disease
    Amy Bastian; Fiscal Year: 2007
    ..We will do this using a new type of treadmill that has two belts so that the legs can be independently controlled at different speeds. ..
  5. MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIA
    Amy Bastian; Fiscal Year: 2007
    ..We will also study the effects of a rehabilitation program designed to improve balance and walking. ..
  6. MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIA
    Amy Bastian; Fiscal Year: 2005
    ..abstract_text> ..
  7. Human Locomotor Plasticity in Health and Disease
    Amy J Bastian; Fiscal Year: 2010
    ..In this grant, we will work to understand how split-belt treadmill training can help people learn to improve their walking patterns. ..