Research Topics
| Amy BastianSummaryAffiliation: Kennedy Krieger Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Active force perception depends on cerebellar functionNasir H Bhanpuri
Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD, USA
J Neurophysiol 107:1612-20. 2012..Our results are consistent with the hypothesis that the cerebellum is vital to sensory prediction of self-generated movement and suggest a general role for the cerebellum in multiple forms of active perception...
Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson's diseaseAmy J Bastian
Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Mov Disord 18:1008-17. 2003....- Cerebellar limb ataxia: abnormal control of self-generated and external forcesAmy J Bastian
Department of Neurology, Johns Hopkins Medical School, Baltimore, Maryland 21205, USA
Ann N Y Acad Sci 978:16-27. 2002..Given these findings, we think that the cerebellum is important in anticipating and adjusting for the mechanical demands of movement though trial-and-error practice... - Natural error patterns enable transfer of motor learning to novel contextsGelsy Torres-Oviedo
Kennedy Krieger Institute, Motion Analysis Laboratory, 707 N Broadway, Baltimore, MD 21205, USA
J Neurophysiol 107:346-56. 2012..This result helps explain how transfer of motor learning is controlled, and it offers an important strategy for clinical rehabilitation, where transfer of motor learning to other contexts is essential... - Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's diseaseAmy J Bastian
Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Mov Disord 18:1000-7. 2003..Our findings also suggest that maximal improvement of walking requires bilateral rather than unilateral STN stimulation... - Learning to predict the future: the cerebellum adapts feedforward movement controlAmy J Bastian
Kennedy Krieger Institute, The Johns Hopkins School of Medicine, North Broadway, G04 Baltimore, MD 21205, USA
Curr Opin Neurobiol 16:645-9. 2006..Prediction mechanisms must be learned and maintained through comparisons between predicted and observed outcomes. New results show that not all such error information is equivalent in driving cerebellar learning... - Moving, sensing and learning with cerebellar damageAmy J Bastian
Kennedy Krieger Institute, Department of Neuroscience, The Johns Hopkins School of Medicine, United States
Curr Opin Neurobiol 21:596-601. 2011..This review covers these and other recent advances, focusing on how cerebellar damage affects human abilities ranging from sensory perception to movement control and motor learning... - Sensory prediction errors drive cerebellum-dependent adaptation of reachingYa weng Tseng
Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
J Neurophysiol 98:54-62. 2007..Therefore adaptation to visuomotor perturbations depends on the cerebellum and is driven by the mismatch between predicted and actual sensory outcome of motor commands... - Acquisition of internal models of motor tasks in children with autismJennifer C Gidley Larson
Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Brain 131:2894-903. 2008..Furthermore, the findings may have therapeutic implications, highlighting a reliable mechanism by which children with autism can most effectively alter their behaviour... - Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback controlJulia T Choi
The Kennedy Krieger Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Brain 132:722-33. 2009..These results suggest that the cerebrum is involved in adaptation of the timing, but not spatial, elements of limb movements... - Reach adaptation: what determines whether we learn an internal model of the tool or adapt the model of our arm?Joann Kluzik
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Neurophysiol 100:1455-64. 2008..Gradual changes in the tool's dynamics increased the extent to which the nervous system recalibrated the model of the subject's own arm... - Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathwaysAlexander H Hoon
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Dev Med Child Neurol 51:697-704. 2009..We investigated the relationship between DTI-observed thalamocortical (posterior thalamic radiation) injury, motor (corticospinal tract) injury, and sensorimotor function... - Children with autism adapt normally during a catching task requiring the cerebellumStewart H Mostofsky
Kennedy Krieger Institute, Baltimore, MD 21205, USA
Neurocase 10:60-4. 2004..Results showed no differences in adaptation rates or after-effects for HFA subjects versus controls. The findings indicate normal motor adaptation in HFA, suggesting normal or compensated cerebellar function for this task... - Split-belt treadmill adaptation shows different functional networks for fast and slow human walkingErin V L Vasudevan
Motion Analysis Laboratory, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
J Neurophysiol 103:183-91. 2010..Taken together, our results suggest that there are some neural networks for controlling locomotion that are recruited specifically for fast versus slow walking in humans, similar to recent findings in other vertebrates... - Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cordKathleen M Zackowski
Department of Physical Medicine and Rehabilitation, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
Brain 132:1200-9. 2009..30, P < 0.001). These results help to understand the anatomic basis of sensorimotor disability in multiple sclerosis and have implications for testing the effects of neuroprotective and reparative interventions... - Prism adaptation during walking generalizes to reaching and requires the cerebellumSusanne M Morton
Kennedy Krieger Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurophysiol 92:2497-509. 2004..In contrast, prism adaptation during isolated movements of the limbs is probably recalibrated by effector-specific mechanisms. The cerebellum is an essential component in the network for both types of prism adaptation... - Cerebellar damage produces context-dependent deficits in control of leg dynamics during obstacle avoidanceSusanne M Morton
Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Brain Res 156:149-63. 2004.... - Adaptation reveals independent control networks for human walkingJulia T Choi
The Kennedy Krieger Institute, 707 North Broadway, Baltimore, Maryland 21205, USA
Nat Neurosci 10:1055-62. 2007..Such training could provide a new therapeutic approach for correcting various walking asymmetries... - Can spasticity and dystonia be independently measured in cerebral palsy?Laurie M Gordon
Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Pediatr Neurol 35:375-81. 2006..Use of quantitative measures should improve selection and evaluation of treatments for childhood motor disorders... - Children with autism show specific handwriting impairmentsChristina T Fuentes
Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurology 73:1532-7. 2009..As a result, the specific aspects of handwriting in which individuals with autism demonstrate difficulty remain unknown... - Cerebellar contributions to locomotor adaptations during splitbelt treadmill walkingSusanne M Morton
Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 26:9107-16. 2006..We postulate that reactive adjustments may instead be predominantly controlled by lower neural centers, such as the spinal cord or brainstem... 
Where is your arm? Variations in proprioception across space and tasksChristina T Fuentes
Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
J Neurophysiol 103:164-71. 2010....- Understanding sensorimotor adaptation and learning for rehabilitationAmy J Bastian
Kennedy Krieger Institute, Department of Neuroscience, Neurology, and Physical Medicine and Rehabilitation, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Curr Opin Neurol 21:628-33. 2008..Understanding the behavioral mechanisms of sensorimotor adaptation and learning is essential for designing rational rehabilitation interventions... - A cerebellar deficit in sensorimotor prediction explains movement timing variabilityJin Bo
Kennedy Krieger Institute, 401 Washtenaw Ave, Ann Arbor, MI 48109 2214, USA
J Neurophysiol 100:2825-32. 2008..One interpretation of these combined results is that the cerebellum is indeed functioning as an internal model and is needed to make appropriate predictions for movement initiation and termination... - 'Motor cognition' - what is it and is the cerebellum involved?Christina T Fuentes
Kennedy Krieger Institute, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cerebellum 6:232-6. 2007..The data for a cerebellar role in understanding the meaning of movement are mixed, although anatomical findings suggest that it probably has some influence that bears further study... - Modulating locomotor adaptation with cerebellar stimulationGowri Jayaram
Kennedy Krieger Institute, Baltimore, MD, USA
J Neurophysiol 107:2950-7. 2012..It may be that spatial and temporal control mechanisms are accessible through different neural circuits. Our results suggest that tDCS could be used as a tool to modulate locomotor training in neurological patients with gait impairments... - Multidigit movement synergies of the human hand in an unconstrained haptic exploration taskPramodsingh H Thakur
Department of Neuroscience, Zanvyl Krieger Mind Brain Institute and Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 28:1271-81. 2008..Our results demonstrate that the synergies reported here generalize across tasks, and suggest that they represent basic building blocks underlying natural human hand motions... - Cerebellar control of balance and locomotionSusanne M Morton
Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroscientist 10:247-59. 2004..The purpose of this review is to examine mechanisms of cerebellar control of balance and locomotion, emphasizing studies of humans and other animals. Implications for rehabilitation are also considered... - Sensory reweighting in targeted reaching: effects of conscious effort, error history, and target salienceHannah J Block
Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA
J Neurophysiol 103:206-17. 2010..We also found that experimental weights can be predicted by minimizing the variance of visual and proprioceptive estimates, supporting the idea that minimum variance integration is an important principle of sensorimotor processing... - Sensorimotor function and axonal integrity in adrenomyeloneuropathyKathleen M Zackowski
Kennedy Krieger Institute, The Johns Hopkins University; Baltimore, MD 21205, USA
Arch Neurol 63:74-80. 2006..Tract-specific magnetic resonance imaging metrics, such as fractional anisotropy (used herein to evaluate structure-function relationships), significantly reflect disease severity in AMN... - Perceptual reasoning predicts handwriting impairments in adolescents with autismChristina T Fuentes
Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurology 75:1825-9. 2010..It is not known whether the same handwriting impairments persist into adolescence and whether they remain linked to motor deficits... - Sensory weighting and realignment: independent compensatory processesHannah J Block
Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Neurophysiol 106:59-70. 2011.... - Mechanisms of cerebellar gait ataxiaSusanne M Morton
Departments of Physical Therapy and Rehabilitation Science and Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
Cerebellum 6:79-86. 2007..The purpose of this review is to examine mechanisms of cerebellar control of locomotion, emphasizing studies of humans and other animals. Implications for rehabilitation are also considered... - Deficits in grasp versus reach during acute hemiparesisCatherine E Lang
Program in Physical Therapy, Washington University, 4444 Forest Park Blvd, Campus Box 8502, St Louis, MO, USA
Exp Brain Res 166:126-36. 2005.... - Cerebellar damage impairs automaticity of a recently practiced movementCatherine E Lang
Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63108, USA
J Neurophysiol 87:1336-47. 2002..Overall, our findings suggest that the cerebellum may be important for shifting movement performance from an attentionally demanding (unpracticed) state to a more automatic (practiced) state... - Relative contributions of balance and voluntary leg-coordination deficits to cerebellar gait ataxiaSusanne M Morton
Interdisciplinary Program in Movement Science, Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri 63108, USA
J Neurophysiol 89:1844-56. 2003..Our findings are consistent with animal literature, which has suggested that cerebellar control of balance and gait are interrelated, and dissociable from cerebellar control of voluntary, visually guided limb movements... - Role of the cerebellum in the control and adaptation of gait in health and diseaseW Thomas Thach
Departments of Anatomy and Neurobiology, Program in Physical Therapy, Neurology and Neurological Surgery, Irene Walter Johnson Rehabilitation Research Institute, Washington University School of Medicine, St Louis, MO 63110, USA
Prog Brain Res 143:353-66. 2004..These issues have become increasingly important in rehabilitation research and practice... - Interaction of levodopa and cues on voluntary reaching in Parkinson's diseaseValerie E Kelly
Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, USA
Mov Disord 17:38-44. 2002..cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated... - Locomotor adaptation on a split-belt treadmill can improve walking symmetry post-strokeDarcy S Reisman
Department of Physical Therapy, University of Delaware, 322 McKinly Laboratory, Newark, DE 19716, USA
Brain 130:1861-72. 2007..This raises the possibility that asymmetric walking patterns post-stroke could be remediated utilizing the split-belt treadmill as a long-term rehabilitation strategy... - Antiparkinson medications improve agonist activation but not antagonist inhibition during sequential reaching movementsValerie E Kelly
Department of Rehabilitation Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Mov Disord 20:694-704. 2005..Instead, antagonist activity was also increased, resulting in minimal improvements in muscle modulation during sequential reaching movements... - Interlimb coordination during locomotion: what can be adapted and stored?Darcy S Reisman
Department of Physical Therapy, University of Delaware, Newark, USA
J Neurophysiol 94:2403-15. 2005..The differences in intra- versus interlimb control may be related to the varying complexity of the parameters, task demands, and/or the level of neural control necessary for their adaptation... - Temporal variability in continuous versus discontinuous drawing for children with Developmental Coordination DisorderJin Bo
Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA
Neurosci Lett 431:215-20. 2008..This work raises a critical issue with respect to the functional heterogeneity of this population and emphasizes the importance of an individualized analysis in this movement disorder... - Relationships between sensorimotor impairments and reaching deficits in acute hemiparesisJoanne M Wagner
Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63108, USA
Neurorehabil Neural Repair 20:406-16. 2006..CONCLUSIONS: The authors' data show that deficits in strength appear to be the most influential sensorimotor impairment associated with limited reaching performance in subjects with acute hemiparesis... - Continuous and discontinuous drawing: high temporal variability exists only in discontinuous circling in young childrenJin Bo
Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA
J Mot Behav 40:391-9. 2008..The authors argue that both explicit timing and dynamic complexity of limb control may be determinants of temporal consistency and may thus play an important role in the development of drawing and writing skills in children...
Research Grants
- MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIAAmy J Bastian; Fiscal Year: 2010..We will also study the effects of a rehabilitation program designed to improve balance and walking. ..
- Human Locomotor Plasticity in Health and DiseaseAmy Bastian; Fiscal Year: 2009..We will do this using a new type of treadmill that has two belts so that the legs can be independently controlled at different speeds. ..
- MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIAAmy Bastian; Fiscal Year: 2009..We will also study the effects of a rehabilitation program designed to improve balance and walking. ..
- Human Locomotor Plasticity in Health and DiseaseAmy Bastian; Fiscal Year: 2007..We will do this using a new type of treadmill that has two belts so that the legs can be independently controlled at different speeds. ..
- MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIAAmy Bastian; Fiscal Year: 2007..We will also study the effects of a rehabilitation program designed to improve balance and walking. ..
- MECHANISMS AND REHABILITATION OF CEREBELLAR ATAXIAAmy Bastian; Fiscal Year: 2005..abstract_text> ..
- Human Locomotor Plasticity in Health and DiseaseAmy J Bastian; Fiscal Year: 2010..In this grant, we will work to understand how split-belt treadmill training can help people learn to improve their walking patterns. ..