- Changes in brain corticotropin-releasing factor messenger RNA expression in aged Fischer 344 ratsJ W Kasckow
Cincinnati VAMC Psychiatry Service, 3200 Vine Street, Cincinnati, OH 45220, USA
Brain Res 822:228-30. 1999..These changes may contribute to impaired adaptations to stress, cognitive decline and other pathophysiological processes during aging...
- The effect of feeding on cerebrospinal fluid corticotropin-releasing hormone levels in humansJ W Kasckow
Cincinnati VAMC, Psychiatry Service, 3200 Vine St, Cincinnati, OH 45220, USA
Brain Res 904:218-24. 2001..Alternatively, our findings could also reflect changes in CRH levels associated with feeding in multiple brain areas and in the spinal cord with the net effect being in the negative direction...
- Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviorsJohn W Kasckow
Psychiatry Service 116A, Cincinnati VAMC, and Department of Psychiatry, School of Medicine, University of Cincinnati, OH 45267 0559, USA
Prog Neuropsychopharmacol Biol Psychiatry 28:291-5. 2004..The results suggest that the vanilloid agonists and antagonists may impact on behaviors involving anxiety and affect. However, it cannot be ruled that the findings could be due to nonspecific motor effect...
- In vitro regulation of corticotropin-releasing hormoneJ W Kasckow
Psychiatry Service 116A, Cincinnati VAMC, 3200 Vine Street, OH 45220, USA
Life Sci 73:769-81. 2003..Thus, much more investigative work in better understanding CRH regulation in vitro is needed...
- Corticotropin-releasing hormone (CRH) expression and protein kinase A mediated CRH receptor signalling in an immortalized hypothalamic cell lineJ Kasckow
Cincinnati VAMC, Psychiatry Service 116A, and School of Medicine, Department of Psychiatry, and Neurosciences Program, University of Cincinnati, OH 45267 0559, USA
J Neuroendocrinol 15:521-9. 2003..The characteristics of IVB cells, such as CRH and VP coexpression, GR expression and a biologically active CRH-R1-mediated signalling pathway, suggest that this neuronal cell line may serve as model of parvocellular CRH neurones...
- Functioning in middle aged and older patients with schizophrenia and depressive symptoms: relationship to psychopathologyJohn Kasckow
VA Pittsburgh Health Care System MIRECC and Behavioral Health Service 7180 Highland Dr, Pittsburgh, PA 15206, USA
Am J Geriatr Psychiatry 16:660-3. 2008..Depressive symptoms are common in middle aged and older patients with schizophrenia. The authors hypothesized that worse functioning in these patients would be associated with worse psychopathology...
- Health-related quality of well-being in chronically hospitalized patients with schizophrenia: comparison with matched outpatientsJ W Kasckow
VA Cincinnati Healthcare System and University of Cincinnati, 231 Bethesda Ave, Cincinnati, OH 45267 0559, USA
Psychiatry Res 103:69-78. 2001..These findings further support the use of the QWB in severely mentally ill populations; implications for improving health-related quality of life among older patients with schizophrenia are discussed...
- Circulating human corticotropin-releasing factor-binding protein levels following cortisol infusionsJ W Kasckow
Cincinnati VAMC and University of Cincinnati School of Medicine, Department of Psychiatry, OH 45267 0559, USA
Life Sci 69:133-42. 2001..The data obtained in this study indicate that CRF binding protein levels within the time course examined may slightly appear to be affected in the peripheral circulation in response to pronounced, sustained hypercortisolemia...
- Corticotropin-releasing hormone in depression and post-traumatic stress disorderJ W Kasckow
Cincinnati VAMC, Psychiatry Service, 3200 Vine Street, Cincinnati, OH 45220, USA
Peptides 22:845-51. 2001..Furthermore, the neuroendocrinology of PTSD appears to be unique, in that patients have hyperactive central CRH systems with underactivity of the pituitary-adrenal axis...
- Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell lineJ W Kasckow
Cincinnati VAMC, Psychiatry Service, OH 45220, USA
Life Sci 65:2709-14. 1999..This cell line thus confirms that nicotinic agonists stimulate amygdalar CRF and appears to be a useful model for studying molecular factors important in this interaction...
- Regulation of corticotropin-releasing factor-binding protein expression in amygdalar neuronal culturesJ W Kasckow
Cincinnati VAMC, Psychiatry Service, Cincinnati, OH 45220, USA
J Neuroendocrinol 11:959-66. 1999..05; n=3 for each). The results suggest that CRF-BP in the amygdala is stimulated by numerous pathways which may play a significant role in promoting behavioural changes...
- The use of novel antipsychotics in the older patient with neurodegenerative disorders in the long-term care settingJ W Kasckow
Cincinnati Veterans Administration Medical Center, Psychiatry Service, and Department of Psychiatry, University of Cincinnati School of Medicine, OH 45220, USA
J Am Med Dir Assoc 5:242-8. 2004..These studies do suggest that ziprasidone and aripiprazole are worth further study in the long-term care setting...
- Subsyndromal depressive symptoms in middle-aged and older persons with schizophreniaSidney Zisook
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
Am J Geriatr Psychiatry 15:1005-14. 2007....
- Does antidepressant treatment improve cognition in older people with schizophrenia or schizoaffective disorder and comorbid subsyndromal depression?Sharron E Dawes
Department of Psychiatry, UC San Diego, San Diego, CA, USA
Neuropsychobiology 65:168-72. 2012..While treatment of depression in major depressive disorder may partially ameliorate cognitive deficits, the cognitive effects of antidepressant medications in patients with schizophrenia or schizoaffective disorder and SSD are unknown...
- Treatment of subsyndromal depressive symptoms in middle-aged and older adults with schizophrenia: effect on functioningJohn Kasckow
VA Pittsburgh Health Care System MIRECC and Behavioral Health Service, 7180 Highland Dr, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 25:183-90. 2010..We hypothesized that treating this population with the SSRI citalopram would lead to improvements in social, mental and physical functioning as well as improvements in medication management and quality of life...
- Treatment of subsyndromal depressive symptoms in middle-age and older patients with schizophrenia: effect of age on responseJohn Kasckow
VA Pittsburgh Health Care System MIRECC and Behavioral Health Service, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 18:853-7. 2010..Also, older patients would exhibit more side effects with citalopram...
- Case-control study of the relationship of functioning to suicide in a community-based sample of individuals with schizophrenia in ChinaJohn Kasckow
VA Pittsburgh Health Care System MIRECC, Behavioral Health Service, 7180 Highland Dr, Pittsburgh, PA 15206, USA
Community Ment Health J 48:317-20. 2012..This study of individuals with DSM-IV schizophrenia who died by suicide in a non-western culture only partially supports findings from clinical studies in western cultures...
- Differences in treatment attitudes between depressed African-American and Caucasian veterans in primary careJohn Kasckow
Behavioral Health Division, Department of Veterans Affairs VA Pittsburgh Health Care System, Pittsburgh, PA 15206, USA
Psychiatr Serv 62:426-9. 2011....
- Managing suicide risk in patients with schizophreniaJohn Kasckow
MIRECC and Behavioral Health Service, VA Pittsburgh Health Care System, Pittsburgh, Pennsylvania 15206, USA
CNS Drugs 25:129-43. 2011..Further research is needed to more effectively personalize the treatment of suicidal thoughts and behaviours and the prevention of suicide in patients with schizophrenia...
- Case-control study of the relationship of depressive symptoms to suicide in a community-based sample of individuals with schizophrenia in ChinaJohn Kasckow
VA Pittsburgh Health Care System MIRECC and Behavioral Health Service, 7180 Highland Dr, Pittsburgh, PA 15206, USA
Schizophr Res 122:226-31. 2010..Suicide is the leading cause of premature death among people with schizophrenia. Most studies on suicide and schizophrenia report an associated depression history, but they are based on clinical samples from mostly western countries...
- Depressive symptom patterns in patients with chronic schizophrenia and subsyndromal depressionSidney Zisook
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Schizophr Res 86:226-33. 2006..The purpose of this study is to learn more about the occurrence, pattern of symptoms and associated features of subsyndromal depressive symptoms in patients with chronic schizophrenia or schizoaffective disorder...
- Racial preferences for participation in a depression prevention trial involving problem-solving therapyJohn Kasckow
Department of Behavioral Health, U S Department of Veterans Affairs Pittsburgh Health Care System, 7180 Highland Dr, Pittsburgh, PA 15206, USA
Psychiatr Serv 61:722-4. 2010..It also examined participants' problem-solving skills. Hypotheses stated that there would be no racial differences in consent rates and that social problem-solving coping skills would be lower among African Americans than Caucasians...
- CSF corticotropin-releasing factor in personality disorder: relationship with self-reported parental careRoyce J Lee
Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
Neuropsychopharmacology 31:2289-95. 2006..The cross-sectional design of the study, however, limits causal inferences...
- Preventing depression in later life: translation from concept to experimental design and implementationRoy Sriwattanakomen
Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:460-8. 2008..Special attention is given to the recruitment of African Americans because of well-documented inequalities in mental health services and depression treatment outcomes between races...
- Suicide among patients with schizophrenia: a consideration of risk and protective factorsLori P Montross
University of California San Diego, Department of Psychiatry, Division of Geriatric Psychiatry, San Diego, CA 92161, USA
Ann Clin Psychiatry 17:173-82. 2005..This review serves to expand on the literature pertaining to suicide risk factors by additionally outlining how protective factors may shield against suicide within this unique patient population...
- Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]Sulaiman Sheriff
Department of Surgery, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Peptides 23:87-96. 2002..These findings suggest that the NPY Y(1) receptor induces the expression of CRE containing target genes through the CaM kinase-CREB pathway, and inhibits CRE containing genes when cellular cAMP levels are elevated...
- Stability of neuroendocrine and behavioral responsiveness in aging Fischer 344/Brown-Norway hybrid ratsJohn W Kasckow
Psychiatry Service, Cincinnati Veterans Affairs Medical Center, Ohio 45220, USA
Endocrinology 146:3105-12. 2005..The lack of a correlation between HPA axis measures and emotional as well as fear conditioning-related behaviors indicates that corticosteroid dysfunction may not predict age-related behavioral deficits in this aging model...
- Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorderThomas D Geracioti
Veterans Affairs Medical Center, Research Service, Cincinnati, OH, USA
Psychoneuroendocrinology 33:416-24. 2008....
- Citalopram treatment of minor depression in elderly men: an open pilot studyJohn W Kasckow
Department of Psychiatry, University of Cincinnati College of Medicine, and the Cincinnati VAMC, Cincinnati, OH 45267-0559, USA
Am J Geriatr Psychiatry 10:344-7. 2002..Citalopram was well tolerated, and GDS, MADRS, and CGI-S scores decreased after 12 weeks. These findings indicate that citalopram is safe and effective in the treatment of late-life minor depression...
- Hypothalamic administration of cAMP agonist/PKA activator inhibits both schedule feeding and NPY-induced feeding in ratsSulaiman Sheriff
Department of Surgery, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, 45267, Cincinnati, OH, USA
Peptides 24:245-54. 2003..These findings suggest that the increase in cAMP level and PKA activity in DMH and VMH areas may trigger a satiety signal...
- Insight in schizophrenia: a review of etiological models and supporting researchKaterine Osatuke
Cincinnati VA Medical Center, Cincinnati, OH, USA
Compr Psychiatry 49:70-7. 2008
- Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorderDewleen G Baker
Psychiatry Service, San Diego VA Healthcare System, CA, USA
Am J Psychiatry 162:992-4. 2005..The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD...
- Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrationsRoyce Lee
Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Am J Psychiatry 162:995-7. 2005....