J S Karliner

Summary

Country: USA

Publications

  1. ncbi request reprint Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes
    Conrad C Alano
    Neurology Service, Veterans Affairs Medical Center, 127 Neurology, San Francisco, CA 94121, USA
    J Neurosci Res 85:3378-85. 2007
  2. ncbi request reprint Lysophospholipids and the cardiovascular system
    Joel S Karliner
    VA Medical Center 111C, University of California, 4150 Clement St, San Francisco, CA 94121, USA
    Biochim Biophys Acta 1582:216-21. 2002
  3. ncbi request reprint MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury
    Zhu Qiu Jin
    Cardiology Section 111C 4150 Clement St, San Francisco, CA 94121, USA
    Am J Physiol Heart Circ Physiol 288:H2986-94. 2005
  4. ncbi request reprint The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes
    J S Karliner
    Cardiology Section, VA Medical Center, San Francisco, CA 94121, USA
    J Mol Cell Cardiol 33:1713-7. 2001
  5. ncbi request reprint Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase
    J S Karliner
    Cardiology Section, VA Medical Center, San Francisco, CA 94121, USA
    J Mol Cell Cardiol 32:1779-86. 2000
  6. ncbi request reprint Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts
    Zhu Qiu Jin
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 282:H1970-7. 2002
  7. ncbi request reprint Sphingosine kinase activation mediates ischemic preconditioning in murine heart
    Zhu Qiu Jin
    Cardiology Section, VA Medical Center and Department of Medicine, University of California, San Francisco, USA
    Circulation 110:1980-9. 2004
  8. ncbi request reprint Gelsolin binding and cellular presentation of lysophosphatidic acid
    E J Goetzl
    Departments of Medicine and Microbiology Immunology, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 275:14573-8. 2000
  9. ncbi request reprint Chronic hypoxia increases beta 1-adrenergic receptor mRNA and density but not signaling in neonatal rat cardiac myocytes
    H T Li
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Circulation 94:3303-10. 1996
  10. ncbi request reprint Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes
    Rong Tao
    Cardiology Section, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Cardiovasc Res 74:56-63. 2007

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes
    Conrad C Alano
    Neurology Service, Veterans Affairs Medical Center, 127 Neurology, San Francisco, CA 94121, USA
    J Neurosci Res 85:3378-85. 2007
    ..These results also suggest large differences in the mitochondrial and cytosolic compartmentalization of NAD(+) in these cell types...
  2. ncbi request reprint Lysophospholipids and the cardiovascular system
    Joel S Karliner
    VA Medical Center 111C, University of California, 4150 Clement St, San Francisco, CA 94121, USA
    Biochim Biophys Acta 1582:216-21. 2002
    ....
  3. ncbi request reprint MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury
    Zhu Qiu Jin
    Cardiology Section 111C 4150 Clement St, San Francisco, CA 94121, USA
    Am J Physiol Heart Circ Physiol 288:H2986-94. 2005
    ..In contrast, fresh preparations exhibit early MnSOD release into the cytosol after I/R that is prevented by IPC and cyclosporin A administration...
  4. ncbi request reprint The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes
    J S Karliner
    Cardiology Section, VA Medical Center, San Francisco, CA 94121, USA
    J Mol Cell Cardiol 33:1713-7. 2001
    ..Both endogenous and exogenously applied S1P are effective in preventing cell death induced by inhibition of sphingosine kinase...
  5. ncbi request reprint Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase
    J S Karliner
    Cardiology Section, VA Medical Center, San Francisco, CA 94121, USA
    J Mol Cell Cardiol 32:1779-86. 2000
    ..We conclude that this cellular model, which is relatively simple to prepare, can be used for in-vitro examination of cardiac protection induced by preconditioning agents, various transgenes, and potentially by targeted gene deletions...
  6. ncbi request reprint Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts
    Zhu Qiu Jin
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 282:H1970-7. 2002
    ..In contrast, extracellular S1P induces equivalent cardioprotection through PKC epsilon-independent signaling pathways...
  7. ncbi request reprint Sphingosine kinase activation mediates ischemic preconditioning in murine heart
    Zhu Qiu Jin
    Cardiology Section, VA Medical Center and Department of Medicine, University of California, San Francisco, USA
    Circulation 110:1980-9. 2004
    ..Because protein kinase C (PKC)epsilon activation is necessary for myocardial ischemic preconditioning (IPC) and PKC activators increase SK activity, we tested the hypothesis that SK may be a central mediator of IPC...
  8. ncbi request reprint Gelsolin binding and cellular presentation of lysophosphatidic acid
    E J Goetzl
    Departments of Medicine and Microbiology Immunology, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 275:14573-8. 2000
    ..Thus, delivery of LPA to RCMs is affinity-coupled to Edg receptors by gelsolin in a PIP2-regulated process...
  9. ncbi request reprint Chronic hypoxia increases beta 1-adrenergic receptor mRNA and density but not signaling in neonatal rat cardiac myocytes
    H T Li
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Circulation 94:3303-10. 1996
    ..However, there are no data regarding either regulation of beta-adrenergic receptors, particularly at the mRNA level, or adenylylcyclase activity in isolated cardiac myocytes exposed to chronic hypoxia...
  10. ncbi request reprint Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes
    Rong Tao
    Cardiology Section, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Cardiovasc Res 74:56-63. 2007
    ....
  11. ncbi request reprint Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts
    M O Gray
    San Francisco Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco 94121, USA
    Cardiovasc Res 40:352-63. 1998
    ..We sought to determine whether angiotensin II (Ang II) promotes hypertrophy of cardiac directly or via paracrine mechanisms mediated by cardiac fibroblasts...
  12. pmc High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate
    Rong Tao
    Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, USA
    Am J Physiol Heart Circ Physiol 298:H1022-8. 2010
    ....
  13. ncbi request reprint A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury
    Zhu Qiu Jin
    Cardiology Section, VA Medical Center and University of California, San Francisco, CA 94121, USA
    Cardiovasc Res 76:41-50. 2007
    ..SphK is involved in ischemic preconditioning (IPC). To date no studies in genetically altered animals have examined the role of SphK1 in myocardial ischemia/reperfusion (IR) injury and IPC...
  14. ncbi request reprint Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism
    Zhu Qiu Jin
    Cardiology Section, VA Medical Center and Department of Medicine, University of California, San Francisco, CA 94121, USA
    Cardiovasc Res 71:725-34. 2006
    ..Although DMS is an endogenous sphingolipid, its effect on cardiac function and cardioprotection at low concentration has not been studied...
  15. pmc Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization
    Rong Tao
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    J Cardiovasc Pharmacol 53:486-94. 2009
    ..Thus, exogenous S1P induces rapid and reversible S1P1-mediated ERK phosphorylation. S1P-induced adult mouse cardiomyocyte survival requires ERK activation mediated via an S1P1-Gi pathway...
  16. ncbi request reprint A rapid radioassay for sphingosine kinase
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Anal Biochem 337:136-42. 2005
    ..The utility of the assay is demonstrated by using it to conduct a complete bisubstrate kinetic analysis of rat heart SKase...
  17. ncbi request reprint Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury
    Bo Qing Zhu
    Cardiology Section, VA Medical Center, Department of Medicine, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Cardiovasc Pharmacol Ther 11:119-28. 2006
    ..Combination therapy further reduces infarct size. PQQ is superior to metoprolol in protecting mitochondria from ischemia/reperfusion oxidative damage...
  18. ncbi request reprint Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Biochem Mol Toxicol 21:273-9. 2007
    ..SK2 from rat liver and spleen was also not inhibited by DMS. L-Sphingosine and to a lesser extent dihydrosphingosine and phytosphingosine were effective inhibitors of both forms...
  19. pmc Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction
    Hui Zhong Zhou
    Cardiology Section, Department of Medicine, UCSF, VA Medical Center, 4150 Clement Street, 111C 5, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 358:189-95. 2007
    ..We conclude that MMP-2 functions not only as a proteolytic enzyme but also as a previously unrecognized active negative regulator of mitochondrial function during superimposed oxidative stress...
  20. ncbi request reprint Mechanisms of cardioprotection by lysophospholipids
    Joel S Karliner
    Cardiology Section, VA Medical Center, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94121, USA
    J Cell Biochem 92:1095-103. 2004
    ..If not, the substitution of agents such as the monosialoganglioside GM-1, which activates sphingosine kinase, or the development of alternative ligands for S1P receptors will be necessary...
  21. ncbi request reprint Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt
    Hui Zhong Zhou
    Cardiology Section, San Francisco Veterans Affairs Medical Center and Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Am J Physiol Heart Circ Physiol 283:H165-74. 2002
    ..We conclude that signaling pathways involving PKC-epsilon are critical for sustained EtOH-mediated cardioprotection and that Akt may be a downstream effector of resistance to myocardial reperfusion injury...
  22. ncbi request reprint Effect of anoxia/reperfusion on the reversible active/de-active transition of NADH-ubiquinone oxidoreductase (complex I) in rat heart
    Elena Maklashina
    Molecular Biology Division 151 S, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochim Biophys Acta 1556:6-12. 2002
    ..Abrupt alternation of anoxic and normoxic perfusion allows cycling between the two states of the enzyme. The possible role in the physiological regulation of complex I activity is discussed...
  23. pmc Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 297:H1429-35. 2009
    ..These studies reveal that S1P is an important mediator of both IPC and IPOST that is released along with adenosine during each cycle of IPC or IPOST...
  24. pmc Sphingosine kinase and sphingosine 1-phosphate in cardioprotection
    Joel S Karliner
    Cardiology Section, VA Medical Center, San Francisco, CA 94121, USA
    J Cardiovasc Pharmacol 53:189-97. 2009
    ..These observations have considerable relevance for future therapeutic approaches to acute and chronic myocardial injury...
  25. pmc Sphingosine kinase regulation and cardioprotection
    Joel S Karliner
    Cardiology Section 111C, VA Medical Center, San Francisco, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Cardiovasc Res 82:184-92. 2009
    ..Ischaemic postconditioning combined with sphingosine and S1P rescues the heart from prolonged ischaemia. These observations may have considerable relevance for future therapeutic approaches to acute and chronic myocardial injury...
  26. doi request reprint Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Biochem Mol Toxicol 22:113-8. 2008
    ....
  27. ncbi request reprint Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center San Francisco CA 94121, USA
    Med Sci Monit 12:BR318-24. 2006
    ..Sphingosine kinase (SKase) has been implicated in the protection of hearts from ischemia/reperfusion injury. This hypothesis was further examined...
  28. ncbi request reprint Mechanisms of lysolipid phosphate effects on cellular survival and proliferation
    E J Goetzl
    Department of Medicine, University of California, San Francisco 94143, USA
    Ann N Y Acad Sci 905:177-87. 2000
    ....
  29. pmc Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction
    Che Chung Yeh
    Cardiothoracic Surgery, 4150 Clement St, 112D, San Francisco, CA 94121, USA
    Am J Physiol Heart Circ Physiol 296:H1193-9. 2009
    ....
  30. pmc Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase
    Alexander B Kotlyar
    Molecular Biology Division, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    FEBS Lett 584:159-65. 2010
    ..In isolated mouse hearts, addition of the inhibitor results in a substantial reduction of myocardial infarct size caused by global ischemia/reperfusion injury...
  31. doi request reprint Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation
    Zhu Qiu Jin
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Cardiovasc Res 79:134-40. 2008
    ..Ischaemic postconditioning (POST) has been shown to protect hearts against ischaemia/reperfusion injury (IR). To date, no studies have examined the role of SphK1 in POST...
  32. ncbi request reprint Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion
    Bo Qing Zhu
    Cardiology Section, VA Medical Center, San Francisco, California 94121, USA
    Cardiovasc Drugs Ther 18:421-31. 2004
    ..We conclude that PQQ, which appears to act as a free radical scavenger in ischemic myocardium, is a highly effective cardioprotective agent...
  33. ncbi request reprint Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart
    Elena Maklashina
    Molecular Biology Division, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    FEBS Lett 556:64-8. 2004
    ..In addition, these studies show that complex II is fully active in the mitochondrion and not inhibited by OAA regardless of the oxygen concentration...
  34. pmc Vincristine attenuates doxorubicin cardiotoxicity
    Kanu Chatterjee
    Cardiology Division, University of California, 505 Parnassus Avenue, San Francisco, California 94122, USA
    Biochem Biophys Res Commun 373:555-60. 2008
    ..Vincristine also exhibited greater protection than the antioxidant MPG. These novel findings may have clinical implications for the prevention of doxorubicin cardiomyopathy...
  35. pmc Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia
    Donald A Vessey
    Liver Study Unit 151 K, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 375:425-9. 2008
    ..The data indicate that detrimental changes are accumulating during protracted ischemia but for up to 90min this damage is not irreversible and hearts can still recover with proper treatment...
  36. ncbi request reprint Off the shelf but not mass produced
    Joel S Karliner
    Cardiology Section 111C, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Chem Biol 12:614-5. 2005
    ..SEW2871 binds to and activates the S1P(1) receptor and initiates a survival signaling pathway similar to that of S1P...
  37. pmc Vincristine attenuates N-methyl-N'-nitro-N-nitrosoguanidine-induced poly-(ADP) ribose polymerase activity in cardiomyocytes
    Jianqing Zhang
    Cardiology Section, VA Medical Center, San Francisco, CA 94121, USA
    J Cardiovasc Pharmacol 55:219-26. 2010
    ..We conclude that VCR protects cardiomyocytes from MNNG toxicity by regulating PARP-1 activation, intracellular energy metabolism, and prosurvival signaling...
  38. ncbi request reprint Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes
    Markus H Graeler
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 278:27737-41. 2003
    ..Biochemical requisites for recovery of down-regulated S1P1 Rs thus differ from those for S1P induction of down-regulation...
  39. pmc Myocardial survival signaling in response to stem cell transplantation
    Hongzhe Li
    Division of Cardiothoracic Surgery, University of California, San Francisco, CA 94143, USA
    J Am Coll Surg 208:607-13. 2009
    ..We hypothesize that these benefits can be best understood first at the level of key intracellular signaling cascades in the host myocardium, which can be responsible for functional and structural preservation of the heart...
  40. ncbi request reprint Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia
    Jianqing Zhang
    Medical Service and Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA, USA
    Am J Physiol Heart Circ Physiol 293:H3150-8. 2007
    ..These observations highlight the importance of S1P(1) receptors on ventricular myocytes as mediators of inducible resistance against cellular injury during severe hypoxic stress...
  41. ncbi request reprint Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function
    Bo Qing Zhu
    Department of Medicine, Cardiology Research, VA Medical Center, University of California, San Francisco, 94143 0124, USA
    J Renin Angiotensin Aldosterone Syst 4:31-7. 2003
    ..The present study was undertaken to see if aspirin (ASA) antagonised the beneficial effects of captopril or losartan...
  42. ncbi request reprint Acute vincristine pretreatment protects adult mouse cardiac myocytes from oxidative stress
    Kanu Chatterjee
    Cardiology Division, University of California, San Francisco, USA
    J Mol Cell Cardiol 43:327-36. 2007
    ..As vincristine and doxorubicin are often used in conjunction to treat patients, it is possible that vincristine could be used to modify the cardiotoxicity of doxorubicin...
  43. ncbi request reprint Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response
    Rachid Kacimi
    Cardiology Research, Cardiology Section 111C5, VA Medical Center, San Francisco, CA 94121, USA
    J Mol Cell Cardiol 43:85-91. 2007
    ..We conclude that activation of endogenous SphK-1 serves a dual regulatory function: it is required for optimal cardiac fibroblast proliferation but is a negative modulator of proinflammatory responses during hypoxia...
  44. ncbi request reprint Altered gene expression during hypoxia and reoxygenation of the heart
    L Piacentini
    Cardiology Section, VA Medical Center, San Francisco, CA 94121, USA
    Pharmacol Ther 83:21-37. 1999
    ..When the cardiomyocyte is reoxygenated after hypoxia, there is a rapid increase in antioxidants, pro-inflammatory cytokines, and stress proteins...
  45. ncbi request reprint Ischemic preconditioning depends on age and gender
    S Turcato
    University of California, San Francisco, VA Medical Center, Cardiology Division 111C, 4150 Clement St, San Francisco, CA 94121, USA
    Basic Res Cardiol 101:235-43. 2006
    ..However, for hearts from females, preconditioning depends on age. Moreover, consistent with previous studies, hearts from females have greater inherent resistance to ischemic injury, possibly involving increased signaling via p-Akt...
  46. pmc A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers
    Marina R Bergman
    Cardiology Section, Department of Medicine, San Francisco Veterans Affairs Medical Center, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem J 369:485-96. 2003
    ..This report is the first demonstration that defined members of the Fos and Jun transcription-factor families specifically regulate this gene under conditions relevant to critical pathophysiological processes...
  47. ncbi request reprint Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction
    Marina R Bergman
    Department of Medicine, San Francisco Department of Veterans Affairs Medical Center University of California, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 292:H1847-60. 2007
    ..5 +/- 1.5 vs. MMP 4.7 +/- 2.0; P = 0.016). Expression of active MMP-2 is sufficient to induce severe ventricular remodeling and systolic dysfunction in the absence of superimposed injury...
  48. ncbi request reprint Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors
    Neil C Chi
    Cardiology Section, Medical Service, Veterans Affairs Medical Center, University of California, 4150 Clement St, San Francisco, CA 94121, USA
    Cardiovasc Res 61:437-47. 2004
    ..Emphasis is placed on new mechanisms of action that regulate HIF-1alpha, HSF, and heat shock proteins as key responses to hypoxia and ischemia, and possible approaches to therapy based on these data are discussed...
  49. ncbi request reprint Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility
    Guan Ying Wang
    Department of Radiology, University of California, San Francisco, USA
    Cardiovasc Res 69:688-96. 2006
    ..To directly assess the role of MMP-2 in the absence of superimposed injury, we generated cardiac-specific, constitutively active MMP-2 transgenic mice...
  50. pmc Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes
    Rong Tao
    Cardiology Section, San Francisco VA Medical Center and UCSF, San Francisco, CA, USA
    Biochem Biophys Res Commun 363:257-62. 2007
    ..Our results provide direct evidence that PQQ reduces oxidative stress, mitochondrial dysfunction, and cell death in isolated adult rat cardiomyocytes. These findings provide new insight into the mechanisms of PQQ action in the heart...
  51. pmc Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy
    Diana T McCloskey
    VA Medical Center, Cardiology Division 111C, University of California San Francisco, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Physiol Heart Circ Physiol 294:H205-12. 2008
    ....
  52. ncbi request reprint A novel strong competitive inhibitor of complex I
    Alexander B Kotlyar
    Molecular Biology Division 151 S, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    FEBS Lett 579:4861-6. 2005
    ....
  53. ncbi request reprint Second hand smoke stimulates tumor angiogenesis and growth
    Bo Qing Zhu
    Cardiology Research, VA Medical Center, University of California, San Francisco, CA 94143, USA
    Cancer Cell 4:191-6. 2003
    ..These studies reveal that SHS promotes tumor angiogenesis and growth. These effects of SHS are associated with increases in plasma VEGF and MCP-1 levels, and EPC, mediated in part by isoprenylation and nicotinic acetylcholine receptors...
  54. pmc Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease
    Rajeev Mahimkar
    Department of Medicine, SFVAMC University of California San Francisco, San Francisco, CA, USA
    Cardiovasc Pathol 18:253-61. 2009
    ..In myxomatous valves, interstitial cells express extracellular matrix-degrading enzymes and it has been postulated that matrix metalloproteinases (MMPs) contribute to these changes...
  55. ncbi request reprint Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator
    Lynne Turnbull
    Department of Radiology, University of California, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 290:H1103-9. 2006
    ..Furthermore, investigations of cardioprotection using the Tet system may be aberrantly influenced by sustained preconditioning induced by cardiac transgenesis with tTA...
  56. pmc Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I
    Vera G Grivennikova
    Department of Biochemistry, School of Biology, Moscow State University, Moscow 119992, Russian Federation
    Biochemistry 46:10971-8. 2007
    ..Possible models to explain the different titration patterns for the forward and reverse reactions are briefly discussed...
  57. ncbi request reprint Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse
    Xuping Bao
    Department of Medicine, University of California San Diego, USA
    Circulation 116:1024-31. 2007
    ..Epinephrine (EPI) is an important neurotransmitter and hormone. Its role in regulating cardiovascular function at rest and with stress is unclear, however...
  58. ncbi request reprint Symbols within words: have we neglected the AdeNOsine A2 receptor?
    Joel S Karliner
    Cardiovasc Res 65:763-5. 2005