Research Topics
Genomes and Genes | Philine WangemannSummaryAffiliation: Kansas State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potentialPhiline Wangemann
Anatomy and Physiology Department, 205 Coles Hall, Kansas State University, Manhattan, 66506, USA
J Physiol 576:11-21. 2006..It covers cochlear fluid composition, the generation of the endocochlear potential, K(+) secretion and cycling and its regulation, the role of gap junctions, mechanisms of acid-base homeostasis, and Ca(2+) transport...
Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse modelPhiline Wangemann
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, USA
BMC Med 2:30. 2004..We investigated the relationship between pendrin and deafness using mice that have (Slc26a4+/+) or lack a complete Slc26a4 gene (Slc26a4-/-)...- Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse modelPhiline Wangemann
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
Am J Physiol Renal Physiol 292:F1345-53. 2007..Degeneration of the hair cells closes a window of opportunity to restore the normal development of hearing in Slc26a4(-/-) mice and possibly human patients suffering from Pendred syndrome... - Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expressionPhiline Wangemann
Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
Am J Physiol Renal Physiol 297:F1435-47. 2009.... - Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinthDaisuke Yamauchi
Cellular Biophysics Laboratory, Dept, Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
BMC Physiol 10:1. 2010..We recently reported the expression of mRNA for a Ca2+-absorptive transport system in primary cultures of semicircular canal duct (SCCD) epithelium... - Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channelsKazuhiro Nakaya
Cellular Biophysics Laboratory, Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
Am J Physiol Renal Physiol 292:F1314-21. 2007.... 
Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse modelRuchira Singh
Department of Anatomy and Physiology, Kansas State University, 205 Coles Hall, Manhattan, KS 66506, USA
Am J Physiol Renal Physiol 294:F139-48. 2008..These data demonstrate that free radical stress provides a link between loss of pendrin and loss of Kcnj10 in Slc26a4(-/-) mice and possibly in human patients suffering from Pendred syndrome...- Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse modelSairam V Jabba
Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
BMC Med 4:37. 2006..Here we determine the time course of hyperpigmentation and marginal cell disorganization, and test the hypothesis that inflammation contributes to this tissue degeneration... - Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrinHyoung Mi Kim
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
PLoS ONE 6:e17949. 2011.... - Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expressionHyoung Mi Kim
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
PLoS ONE 5:e14041. 2010..Failure of fluid absorption in the endolymphatic sac due to lack of Slc26a4 expression appears to initiate cochlear enlargement in mice, and possibly humans, lacking functional Slc26a4 expression... - Calcium sparks in the intact gerbil spiral modiolar arteryGayathri Krishnamoorthy
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
BMC Physiol 11:15. 2011..The goal of the present study was to determine the presence and properties of calcium sparks in the intact gerbil spiral modiolar artery... - Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related PeptideElias Q Scherer
Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
Stroke 33:2965-71. 2002.... - KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potentialDaniel C Marcus
Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
Am J Physiol Cell Physiol 282:C403-7. 2002..KCNJ10 is also a limiting pathway for K(+) secretion... - Neurogenic regulation of cochlear blood flow occurs along the basilar artery, the anterior inferior cerebellar artery and at branch points of the spiral modiolar arteryPhiline Wangemann
Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, Manhattan, 66506, USA
Hear Res 209:91-6. 2005.... - Adrenergic and muscarinic control of cochlear endolymph productionPhiline Wangemann
Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
Adv Otorhinolaryngol 59:42-50. 2002..Recent observations suggest that the rate of K+ secretion in strial marginal cells is stimulated by beta1-adrenergic receptors and inhibited by M3 and/or M4 muscarinic receptors... - K+ cycling and the endocochlear potentialPhiline Wangemann
Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, 1600 Denison Avenue, Manhattan 66506, USA
Hear Res 165:1-9. 2002..The importance of K+ cycling is underscored by the fact that mutations of KCNQ1, KCNE1, KCNQ4, GJB2, GJB3 and GJB6 lead to deafness in humans and that null mutations of KCNQ1, KCNE1, KCNJ10 and SLC12A2 lead to deafness in mouse models... - Gender differences in myogenic regulation along the vascular tree of the gerbil cochleaKatrin Reimann
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
PLoS ONE 6:e25659. 2011..Male spiral modiolar arteries responded more to L-NNA than female spiral modiolar arteries, suggesting that NO-dependent mechanisms play a bigger role in the myogenic regulation of male than female gerbil cochlear vessels... - Cochlear blood flow regulationPhiline Wangemann
Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
Adv Otorhinolaryngol 59:51-7. 2002.... - K(+) cycling and its regulation in the cochlea and the vestibular labyrinthPhiline Wangemann
Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, Manhattan, Kans 66506, USA
Audiol Neurootol 7:199-205. 2002..This review details recent advances in the understanding of K(+) transport and its regulation in the cochlea and the vestibular labyrinth... - NOS Inhibition Enhances Myogenic Tone by Increasing Rho-Kinase Mediated Ca(2+) Sensitivity in the Male but Not the Female Gerbil Spiral Modiolar ArteryKatrin Reimann
Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America Universitätsklinik für Hals, Nasen und Ohrenheilkunde, Eberhard Karls Universitat, Tubingen, Germany
PLoS ONE 8:e53655. 2013..The larger role of NO-dependent mechanisms in male SMAs predicts greater restrictions on cochlear blood flow under conditions of impaired endothelial cell function... - ETA receptors in the gerbil spiral modiolar arteryElias Q Scherer
Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
Adv Otorhinolaryngol 59:58-65. 2002..The data suggest that the signal transduction pathway of the ET(A) receptor involves phospholipase C, IP3 receptors and release of Ca2+ from thapsigargin-sensitive Ca2+ stores... - Microarray-based comparison of three amplification methods for nanogram amounts of total RNARuchira Singh
Dept. of Anatomy and Physiology, College of Veterinary Medicine, Kansas State Univ, 1600 Denison Ave, Coles Hall 205, Manhattan, KS 66506, USA
Am J Physiol Cell Physiol 288:C1179-89. 2005..3 ng of total RNA. In addition, RS and pRS were faster and simpler to use than the T7-based methods and resulted in the generation of cDNA, which is more stable than cRNA... 
The role of pendrin in the development of the murine inner earPhiline Wangemann
Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
Cell Physiol Biochem 28:527-34. 2011..This review summarizes studies in mouse models that have focused on delineating the role of pendrin in the physiology of the inner ear and the pathobiology that leads to hearing loss...- Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channelSatyanarayana R Pondugula
Kansas State Univ, Dept. of Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506-5802, USA
Am J Physiol Renal Physiol 286:F1127-35. 2004..The results provide for the first time an understanding of the therapeutic benefit of glucocorticoids in the treatment of Meniere's disease, a condition that is associated with increased luminal fluid volume... - Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell deathMartine Cohen-Salmon
Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Curr Biol 12:1106-11. 2002..We conclude that prevention of cell death in the sensory epithelium is essential for any attempt to restore the auditory function in DFNB1 patients... - Functional significance of channels and transporters expressed in the inner ear and kidneyFlorian Lang
Department of Physiology, Eberhard Karls University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
Am J Physiol Cell Physiol 293:C1187-208. 2007..Thus, defects of channels and transporters expressed in the kidney and inner ear result in simultaneous dysfunctions of these seemingly unrelated organs...