Jean Pierre Perchellet

Summary

Affiliation: Kansas State University
Country: USA

Publications

  1. ncbi request reprint Antitumor activity of novel octalactin A analogs in murine leukemia cells in vitro
    J P Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Manhattan 66506, USA
    Anticancer Res 18:97-106. 1998
  2. ncbi request reprint Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities
    Buna Wang
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan 66506 4901, USA
    Anticancer Drugs 14:503-14. 2003
  3. ncbi request reprint Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, U S A
    Anticancer Res 34:1643-55. 2014
  4. ncbi request reprint Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, USA
    Anticancer Res 32:4671-84. 2012
  5. ncbi request reprint Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Department of Chemistry, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, USA
    Anticancer Res 31:2083-93. 2011
  6. pmc Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, USA
    Int J Mol Med 24:633-43. 2009
  7. ncbi request reprint Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomol
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan 66506 4901, USA
    Anticancer Drugs 13:567-81. 2002
  8. ncbi request reprint Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines
    Duy H Hua
    Department of Chemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Org Chem 67:2907-12. 2002
  9. ncbi request reprint Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fa
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506 4901, USA
    Biochem Pharmacol 67:523-37. 2004
  10. ncbi request reprint Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, Kansas 66506 4901, USA
    J Med Chem 48:5955-65. 2005

Research Grants

  1. TRIPTYCENE ANALOGS--NOVEL BIFUNCTIONAL ANTICANCER DRUGS
    Jean Pierre Perchellet; Fiscal Year: 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Antitumor activity of novel octalactin A analogs in murine leukemia cells in vitro
    J P Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Manhattan 66506, USA
    Anticancer Res 18:97-106. 1998
    ....
  2. ncbi request reprint Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities
    Buna Wang
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan 66506 4901, USA
    Anticancer Drugs 14:503-14. 2003
    ..Because of their ability to target nucleoside transport and topoisomerase activities, synthetic TT bisquinones might represent a novel class of bifunctional drugs valuable to develop new means of polychemotherapy and circumvent MDR...
  3. ncbi request reprint Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, U S A
    Anticancer Res 34:1643-55. 2014
    ....
  4. ncbi request reprint Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, USA
    Anticancer Res 32:4671-84. 2012
    ....
  5. ncbi request reprint Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Department of Chemistry, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, USA
    Anticancer Res 31:2083-93. 2011
    ..Ten novel quinazoliniminium salts were synthesized and tested for their effectiveness against murine and human tumor cell proliferation in vitro...
  6. pmc Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins
    Jean Pierre H Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506 4901, USA
    Int J Mol Med 24:633-43. 2009
    ....
  7. ncbi request reprint Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomol
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan 66506 4901, USA
    Anticancer Drugs 13:567-81. 2002
    ....
  8. ncbi request reprint Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines
    Duy H Hua
    Department of Chemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Org Chem 67:2907-12. 2002
    ..IC(50) values of triptycene bisquinones for the inhibition of L1210 leukemia cell viability are in the 0.11-0.27 microM range and for the inhibition of Plasmodium falciparum 3D7 are in the 4.7-8.0 microM range...
  9. ncbi request reprint Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fa
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506 4901, USA
    Biochem Pharmacol 67:523-37. 2004
    ....
  10. ncbi request reprint Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, Kansas 66506 4901, USA
    J Med Chem 48:5955-65. 2005
    ..Thus, the I45DCs represent a useful scaffold for anticancer lead discovery that is both readily accessible and easily diversified...
  11. pmc Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities
    Duy H Hua
    Department of Chemistry, Kansas State University, Manhattan, KS 66506 3701, USA
    Bioorg Med Chem 16:5232-46. 2008
    ..Compounds 46 and a precursor, (3S( *),4R( *),5R( *),6R( *))-5-methoxy-4-[(E)-(1',5'-dimethylhexa-1',4'-dienyl)]-6-(tert-butyldimethylsilyloxy)-1-oxaspiro[2.5]octan-4-ol (28), may be explored for the development of anti-parasitic drugs...
  12. ncbi request reprint Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Kansas State University, Manhattan, KS 66506 4901, USA
    Int J Oncol 31:1231-41. 2007
    ....
  13. ncbi request reprint Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs
    Duy H Hua
    Department of Chemistry, Kansas State University, 111 Willard Hall, Manhattan, KS 66506 3701, USA
    Anticancer Agents Med Chem 6:303-18. 2006
    ..This review provides a summary of synthetic efforts and mechanistic endeavor...
  14. ncbi request reprint Total syntheses of (+)-chloropuupehenone and (+)-chloropuupehenol and their analogues and evaluation of their bioactivities
    Duy H Hua
    Department of Chemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Org Chem 69:6065-78. 2004
    ..The synthetic sequence also produced four biologically active naturally occurring drimanic sesquiterpenes, (+)-drimane-8alpha,11-diol (34), (-)-drimenol (38), (+)-albicanol (39), and (-)-albicanal (31) as intermediates...
  15. ncbi request reprint Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines
    Yang Wang
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506 4901, USA
    Cancer Lett 188:73-83. 2002
    ....
  16. ncbi request reprint Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506 4901, USA
    Anticancer Res 26:2791-804. 2006
    ....
  17. ncbi request reprint Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall Department of Chemistry, Kansas State University, Manhattan, KS 66506 4901, USA
    Anticancer Drugs 15:929-46. 2004
    ....
  18. ncbi request reprint Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones
    Yang Wang
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan, Kansas 66506 4901, USA
    Anticancer Drugs 16:953-67. 2005
    ....
  19. ncbi request reprint Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition
    Elisabeth M Perchellet
    Anti Cancer Drug Laboratory, Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506 4901, USA
    Anticancer Res 27:3259-71. 2007
    ..Because mitochondrial permeability transition (MPT) requires more than depolarization, antitumor TTs were tested for their ability to directly trigger specific markers of MPT in isolated mitochondria...
  20. ncbi request reprint Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria
    Yang Wang
    Anti Cancer Drug Laboratory, Division of Biology, Kansas State University, Manhattan, KS 66506 4901, USA
    Int J Oncol 28:161-72. 2006
    ....
  21. pmc Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis
    Neil Brown
    Department of Chemistry, University of Missouri Kansas City, 205 Spencer Chemical Laboratories, 5100 Rockhill Road, Kansas City, MO 64110, USA
    Bioorg Med Chem Lett 18:4876-9. 2008
    ..A cursory examination of the biological properties of the library validates the relevance and significance of these structures...
  22. pmc Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach
    Neil Brown
    Department of Chemistry, University of Missouri, 205 Spencer Chemical Laboratories, 5100 Rockhill Road, Kansas City, Missouri 64110, USA
    J Comb Chem 10:628-31. 2008

Research Grants5

  1. TRIPTYCENE ANALOGS--NOVEL BIFUNCTIONAL ANTICANCER DRUGS
    Jean Pierre Perchellet; Fiscal Year: 2004
    ..abstract_text> ..