Denis Medeiros

Summary

Affiliation: Kansas State University
Country: USA

Publications

  1. ncbi request reprint Ontogeny of enhanced decorin levels and distribution within myocardium of failing hearts
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, KS 66506 1407, USA
    Connect Tissue Res 43:32-43. 2002
  2. ncbi request reprint Bone morphology, strength and density are compromised in iron-deficient rats and exacerbated by calcium restriction
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, Manhattan 66505, USA
    J Nutr 132:3135-41. 2002
  3. ncbi request reprint Role of copper in mitochondrial biogenesis via interaction with ATP synthase and cytochrome c oxidase
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, Kansas 66506, USA
    J Bioenerg Biomembr 34:389-95. 2002
  4. doi request reprint Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1alpha transcript and protein as a cause for mitochondrial biogenesis in copper deficiency
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 20:823-30. 2009
  5. doi request reprint Assessing mitochondria biogenesis
    Denis M Medeiros
    Department of Human Nutrition, 213 Justin Hall, Kansas State University, Manhattan, KS 66506, USA
    Methods 46:288-94. 2008
  6. ncbi request reprint Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight
    Denis M Medeiros
    Department of Human Nutrition, 213 Justin Hall, Kansas State University, Manhattan, KS 66506, USA
    J Nutr 134:3061-7. 2004
  7. ncbi request reprint Iron restriction negatively affects bone in female rats and mineralization of hFOB osteoblast cells
    Mardi Parelman
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    Exp Biol Med (Maywood) 231:378-86. 2006
  8. ncbi request reprint Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1
    Darcey Klaahsen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 18:719-26. 2007
  9. doi request reprint KNACK Online: an evidence-based Web site developed to address adolescent obesity
    Tandalayo Kidd
    Department of Human Nutrition, Kansas State University, Manhattan, Kansas 66506 1407, USA
    J Nutr Educ Behav 40:189-90. 2008
  10. ncbi request reprint Mitochondrial membrane potential is reduced in copper-deficient C2C12 cells in the absence of apoptosis
    Xiulian Chen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    Biol Trace Elem Res 106:51-64. 2005

Research Grants

  1. Kansas Bridges to the Future
    Denis Medeiros; Fiscal Year: 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Ontogeny of enhanced decorin levels and distribution within myocardium of failing hearts
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, KS 66506 1407, USA
    Connect Tissue Res 43:32-43. 2002
    ..The enhanced expression and greater distribution of decorin may be linked to extracellular matrix remodeling which occurs with the development of heart failure...
  2. ncbi request reprint Bone morphology, strength and density are compromised in iron-deficient rats and exacerbated by calcium restriction
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, Manhattan 66505, USA
    J Nutr 132:3135-41. 2002
    ..These data suggest that a commonly deficient trace element in American diets, iron, has a negative impact upon bone health, and this impact is exacerbated by a calcium-restricted diet...
  3. ncbi request reprint Role of copper in mitochondrial biogenesis via interaction with ATP synthase and cytochrome c oxidase
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, Kansas 66506, USA
    J Bioenerg Biomembr 34:389-95. 2002
    ..The limited data available suggest that copper, either indirectly or directly, alters ATP synthase function...
  4. doi request reprint Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1alpha transcript and protein as a cause for mitochondrial biogenesis in copper deficiency
    Denis M Medeiros
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 20:823-30. 2009
    ..5-fold, was observed. It would appear that increased mitochondrial biogenesis known to occur in copper deficiency hearts is caused by an increased expression in the master regulator of mitochondrial biogenesis, PGC-1alpha...
  5. doi request reprint Assessing mitochondria biogenesis
    Denis M Medeiros
    Department of Human Nutrition, 213 Justin Hall, Kansas State University, Manhattan, KS 66506, USA
    Methods 46:288-94. 2008
    ..These techniques are described in isolation and in the context of transgenic and dietary animal models that have been used as tools to study the regulation of mitochondria biogenesis and its role in disease pathology...
  6. ncbi request reprint Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight
    Denis M Medeiros
    Department of Human Nutrition, 213 Justin Hall, Kansas State University, Manhattan, KS 66506, USA
    J Nutr 134:3061-7. 2004
    ....
  7. ncbi request reprint Iron restriction negatively affects bone in female rats and mineralization of hFOB osteoblast cells
    Mardi Parelman
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    Exp Biol Med (Maywood) 231:378-86. 2006
    ..Impaired mineralization with iron depletion appears to be a possible mechanism for the observed bone abnormalities...
  8. ncbi request reprint Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1
    Darcey Klaahsen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 18:719-26. 2007
    ..The results of this study merit the further investigation of the role of reactive oxidative species with regard to Nfkappab1 in the copper deficient rat heart...
  9. doi request reprint KNACK Online: an evidence-based Web site developed to address adolescent obesity
    Tandalayo Kidd
    Department of Human Nutrition, Kansas State University, Manhattan, Kansas 66506 1407, USA
    J Nutr Educ Behav 40:189-90. 2008
  10. ncbi request reprint Mitochondrial membrane potential is reduced in copper-deficient C2C12 cells in the absence of apoptosis
    Xiulian Chen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    Biol Trace Elem Res 106:51-64. 2005
    ..Cells with decreased mitochondrial membrane potential were not destined to apoptosis as a result of copper deficiency...
  11. ncbi request reprint Impaired cardiac mitochondrial membrane potential and respiration in copper-deficient rats
    Xiulian Chen
    Department of Human Nutrition, Kansas State University, Manhattan, Kansas 66506, USA
    J Bioenerg Biomembr 34:397-406. 2002
    ..We conclude that cardiac mitochondrial respiration is compromised in copper-deficient rats, and may be related to an altered ATP synthase complex and/or a decreased mitochondrial membrane potential...
  12. pmc Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes
    Ling Tang
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    Exp Biol Med (Maywood) 236:1051-63. 2011
    ..Taken together, dietary wolfberry on retinal protection in diabetic mice is, at least partially, due to zeaxanthin and/or lutein...
  13. ncbi request reprint Plasma phenylalanine concentrations are associated with hepatic iron content in a murine model for phenylketonuria
    Sareen S Gropper
    Department of Nutrition and Food Science, 328 Spidle Hall, Auburn University, Auburn, AL 36849, USA
    Mol Genet Metab 82:76-82. 2004
    ..No animal group effects or protein level effects were found for fecal copper, iron, or zinc contents. We conclude that hyperphenylalaninemia alters the metabolism of iron, copper, and zinc in PKU mice...
  14. ncbi request reprint Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway
    Jennifer G Duncan
    Center for Cardiovascular Research, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 115:909-17. 2007
    ..We hypothesized that regulatory events involved in the control of mitochondrial function are activated in the prediabetic, insulin-resistant stage...
  15. pmc PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
    Teresa C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 3:e101. 2005
    ..Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/-) mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life...
  16. ncbi request reprint Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    Laurie K Russell
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 94:525-33. 2004
    ....

Research Grants2

  1. Kansas Bridges to the Future
    Denis Medeiros; Fiscal Year: 2007
    ..The overall goal is to increase the number of Kansas minority students pursuing PhDs or MD-PhDs in the biomedical field. ..