Research Topics
| Denis MedeirosSummaryAffiliation: Kansas State University Country: USA Publications
Research Grants
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Detail Information
Publications
Ontogeny of enhanced decorin levels and distribution within myocardium of failing heartsDenis M Medeiros
Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, KS 66506 1407, USA
Connect Tissue Res 43:32-43. 2002..The enhanced expression and greater distribution of decorin may be linked to extracellular matrix remodeling which occurs with the development of heart failure...- Bone morphology, strength and density are compromised in iron-deficient rats and exacerbated by calcium restrictionDenis M Medeiros
Department of Human Nutrition, Kansas State University, Manhattan 66505, USA
J Nutr 132:3135-41. 2002..These data suggest that a commonly deficient trace element in American diets, iron, has a negative impact upon bone health, and this impact is exacerbated by a calcium-restricted diet... - Role of copper in mitochondrial biogenesis via interaction with ATP synthase and cytochrome c oxidaseDenis M Medeiros
Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, Kansas 66506, USA
J Bioenerg Biomembr 34:389-95. 2002..The limited data available suggest that copper, either indirectly or directly, alters ATP synthase function... 
Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1alpha transcript and protein as a cause for mitochondrial biogenesis in copper deficiencyDenis M Medeiros
Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
J Nutr Biochem 20:823-30. 2009..5-fold, was observed. It would appear that increased mitochondrial biogenesis known to occur in copper deficiency hearts is caused by an increased expression in the master regulator of mitochondrial biogenesis, PGC-1alpha...- Assessing mitochondria biogenesisDenis M Medeiros
Department of Human Nutrition, 213 Justin Hall, Kansas State University, Manhattan, KS 66506, USA
Methods 46:288-94. 2008..These techniques are described in isolation and in the context of transgenic and dietary animal models that have been used as tools to study the regulation of mitochondria biogenesis and its role in disease pathology... - Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weightDenis M Medeiros
Department of Human Nutrition, 213 Justin Hall, Kansas State University, Manhattan, KS 66506, USA
J Nutr 134:3061-7. 2004.... - Iron restriction negatively affects bone in female rats and mineralization of hFOB osteoblast cellsMardi Parelman
Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
Exp Biol Med (Maywood) 231:378-86. 2006..Impaired mineralization with iron depletion appears to be a possible mechanism for the observed bone abnormalities... - Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1Darcey Klaahsen
Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
J Nutr Biochem 18:719-26. 2007..The results of this study merit the further investigation of the role of reactive oxidative species with regard to Nfkappab1 in the copper deficient rat heart... - KNACK Online: an evidence-based Web site developed to address adolescent obesityTandalayo Kidd
Department of Human Nutrition, Kansas State University, Manhattan, Kansas 66506-1407, USA
J Nutr Educ Behav 40:189-90. 2008 - Mitochondrial membrane potential is reduced in copper-deficient C2C12 cells in the absence of apoptosisXiulian Chen
Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
Biol Trace Elem Res 106:51-64. 2005..Cells with decreased mitochondrial membrane potential were not destined to apoptosis as a result of copper deficiency... - Impaired cardiac mitochondrial membrane potential and respiration in copper-deficient ratsXiulian Chen
Department of Human Nutrition, Kansas State University, Manhattan, Kansas 66506, USA
J Bioenerg Biomembr 34:397-406. 2002..We conclude that cardiac mitochondrial respiration is compromised in copper-deficient rats, and may be related to an altered ATP synthase complex and/or a decreased mitochondrial membrane potential... 
Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetesLing Tang
Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
Exp Biol Med (Maywood) 236:1051-63. 2011..Taken together, dietary wolfberry on retinal protection in diabetic mice is, at least partially, due to zeaxanthin and/or lutein...- Plasma phenylalanine concentrations are associated with hepatic iron content in a murine model for phenylketonuriaSareen S Gropper
Department of Nutrition and Food Science, 328 Spidle Hall, Auburn University, Auburn, AL 36849, USA
Mol Genet Metab 82:76-82. 2004..No animal group effects or protein level effects were found for fecal copper, iron, or zinc contents. We conclude that hyperphenylalaninemia alters the metabolism of iron, copper, and zinc in PKU mice... - Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathwayJennifer G Duncan
Center for Cardiovascular Research, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Circulation 115:909-17. 2007..We hypothesized that regulatory events involved in the control of mitochondrial function are activated in the prediabetic, insulin-resistant stage... - PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosisTeresa C Leone
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA
PLoS Biol 3:e101. 2005..Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/-) mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life... - Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent mannerLaurie K Russell
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Circ Res 94:525-33. 2004....
Research Grants
- Kansas Bridges to the FutureDenis Medeiros; Fiscal Year: 2007..The overall goal is to increase the number of Kansas minority students pursuing PhDs or MD-PhDs in the biomedical field. ..