Lorraine A Everett

Summary

Affiliation: Kansas State University
Country: USA

Publications

  1. pmc SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice
    Xiangming Li
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, USA
    PLoS Genet 9:e1003641. 2013
  2. pmc NOS inhibition enhances myogenic tone by increasing rho-kinase mediated Ca2+ sensitivity in the male but not the female gerbil spiral modiolar artery
    Katrin Reimann
    Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 8:e53655. 2013
  3. pmc Endolymphatic Na⁺ and K⁺ concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin
    Xiangming Li
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 8:e65977. 2013
  4. doi request reprint The role of pendrin in the development of the murine inner ear
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
    Cell Physiol Biochem 28:527-34. 2011
  5. pmc Calcium sparks in the intact gerbil spiral modiolar artery
    Gayathri Krishnamoorthy
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
    BMC Physiol 11:15. 2011
  6. pmc Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
    Am J Physiol Renal Physiol 292:F1345-53. 2007
  7. ncbi request reprint Neurogenic regulation of cochlear blood flow occurs along the basilar artery, the anterior inferior cerebellar artery and at branch points of the spiral modiolar artery
    Philine Wangemann
    Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, Manhattan, 66506, USA
    Hear Res 209:91-6. 2005
  8. pmc Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
    Am J Physiol Renal Physiol 297:F1435-47. 2009
  9. ncbi request reprint Cochlear blood flow regulation
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
    Adv Otorhinolaryngol 59:51-7. 2002
  10. ncbi request reprint Adrenergic and muscarinic control of cochlear endolymph production
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
    Adv Otorhinolaryngol 59:42-50. 2002

Research Grants

  1. Cellular regulation of cochlear blood flow
    A PHILINE WANGEMANN; Fiscal Year: 2007
  2. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
  3. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2006
  4. CORE--CONFOCAL MICROFLUOROMETRY AND MICROSCOPY
    A PHILINE WANGEMANN; Fiscal Year: 2002
  5. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2003
  6. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2001
  7. Cellular regulation of cochlear blood flow
    A PHILINE WANGEMANN; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. pmc SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice
    Xiangming Li
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, USA
    PLoS Genet 9:e1003641. 2013
    ....
  2. pmc NOS inhibition enhances myogenic tone by increasing rho-kinase mediated Ca2+ sensitivity in the male but not the female gerbil spiral modiolar artery
    Katrin Reimann
    Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 8:e53655. 2013
    ..The larger role of NO-dependent mechanisms in male SMAs predicts greater restrictions on cochlear blood flow under conditions of impaired endothelial cell function...
  3. pmc Endolymphatic Na⁺ and K⁺ concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin
    Xiangming Li
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 8:e65977. 2013
    ..The data suggest that the endolymphatic enlargement caused by a loss of Slc26a4 is a consequence of disrupted Na(+) transport...
  4. doi request reprint The role of pendrin in the development of the murine inner ear
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
    Cell Physiol Biochem 28:527-34. 2011
    ..This review summarizes studies in mouse models that have focused on delineating the role of pendrin in the physiology of the inner ear and the pathobiology that leads to hearing loss...
  5. pmc Calcium sparks in the intact gerbil spiral modiolar artery
    Gayathri Krishnamoorthy
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
    BMC Physiol 11:15. 2011
    ..The goal of the present study was to determine the presence and properties of calcium sparks in the intact gerbil spiral modiolar artery...
  6. pmc Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas 66506, USA
    Am J Physiol Renal Physiol 292:F1345-53. 2007
    ..Degeneration of the hair cells closes a window of opportunity to restore the normal development of hearing in Slc26a4(-/-) mice and possibly human patients suffering from Pendred syndrome...
  7. ncbi request reprint Neurogenic regulation of cochlear blood flow occurs along the basilar artery, the anterior inferior cerebellar artery and at branch points of the spiral modiolar artery
    Philine Wangemann
    Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, Manhattan, 66506, USA
    Hear Res 209:91-6. 2005
    ....
  8. pmc Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
    Am J Physiol Renal Physiol 297:F1435-47. 2009
    ....
  9. ncbi request reprint Cochlear blood flow regulation
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
    Adv Otorhinolaryngol 59:51-7. 2002
    ....
  10. ncbi request reprint Adrenergic and muscarinic control of cochlear endolymph production
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
    Adv Otorhinolaryngol 59:42-50. 2002
    ..Recent observations suggest that the rate of K+ secretion in strial marginal cells is stimulated by beta1-adrenergic receptors and inhibited by M3 and/or M4 muscarinic receptors...
  11. ncbi request reprint K(+) cycling and its regulation in the cochlea and the vestibular labyrinth
    Philine Wangemann
    Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, Manhattan, Kans 66506, USA
    Audiol Neurootol 7:199-205. 2002
    ..This review details recent advances in the understanding of K(+) transport and its regulation in the cochlea and the vestibular labyrinth...
  12. ncbi request reprint K+ cycling and the endocochlear potential
    Philine Wangemann
    Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, 1600 Denison Avenue, Manhattan 66506, USA
    Hear Res 165:1-9. 2002
    ..The importance of K+ cycling is underscored by the fact that mutations of KCNQ1, KCNE1, KCNQ4, GJB2, GJB3 and GJB6 lead to deafness in humans and that null mutations of KCNQ1, KCNE1, KCNJ10 and SLC12A2 lead to deafness in mouse models...
  13. pmc Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels
    Kazuhiro Nakaya
    Cellular Biophysics Laboratory, Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
    Am J Physiol Renal Physiol 292:F1314-21. 2007
    ....
  14. pmc Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model
    Sairam V Jabba
    Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
    BMC Med 4:37. 2006
    ..Here we determine the time course of hyperpigmentation and marginal cell disorganization, and test the hypothesis that inflammation contributes to this tissue degeneration...
  15. pmc Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, USA
    BMC Med 2:30. 2004
    ..We investigated the relationship between pendrin and deafness using mice that have (Slc26a4+/+) or lack a complete Slc26a4 gene (Slc26a4-/-)...
  16. ncbi request reprint Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model
    Ruchira Singh
    Department of Anatomy and Physiology, Kansas State University, 205 Coles Hall, Manhattan, KS 66506, USA
    Am J Physiol Renal Physiol 294:F139-48. 2008
    ..These data demonstrate that free radical stress provides a link between loss of pendrin and loss of Kcnj10 in Slc26a4(-/-) mice and possibly in human patients suffering from Pendred syndrome...
  17. pmc Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth
    Daisuke Yamauchi
    Cellular Biophysics Laboratory, Dept, Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
    BMC Physiol 10:1. 2010
    ..We recently reported the expression of mRNA for a Ca2+-absorptive transport system in primary cultures of semicircular canal duct (SCCD) epithelium...
  18. ncbi request reprint KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential
    Daniel C Marcus
    Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
    Am J Physiol Cell Physiol 282:C403-7. 2002
    ..KCNJ10 is also a limiting pathway for K(+) secretion...
  19. ncbi request reprint Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide
    Elias Q Scherer
    Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
    Stroke 33:2965-71. 2002
    ....
  20. pmc Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin
    Hyoung Mi Kim
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 6:e17949. 2011
    ....
  21. pmc Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression
    Hyoung Mi Kim
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 5:e14041. 2010
    ..Failure of fluid absorption in the endolymphatic sac due to lack of Slc26a4 expression appears to initiate cochlear enlargement in mice, and possibly humans, lacking functional Slc26a4 expression...
  22. ncbi request reprint ETA receptors in the gerbil spiral modiolar artery
    Elias Q Scherer
    Anatomy and Physiology Department, Kansas State University, Manhattan 66506, USA
    Adv Otorhinolaryngol 59:58-65. 2002
    ..The data suggest that the signal transduction pathway of the ET(A) receptor involves phospholipase C, IP3 receptors and release of Ca2+ from thapsigargin-sensitive Ca2+ stores...
  23. pmc Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential
    Philine Wangemann
    Anatomy and Physiology Department, 205 Coles Hall, Kansas State University, Manhattan, 66506, USA
    J Physiol 576:11-21. 2006
    ..It covers cochlear fluid composition, the generation of the endocochlear potential, K(+) secretion and cycling and its regulation, the role of gap junctions, mechanisms of acid-base homeostasis, and Ca(2+) transport...
  24. ncbi request reprint Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channel
    Satyanarayana R Pondugula
    Kansas State Univ, Dept of Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506 5802, USA
    Am J Physiol Renal Physiol 286:F1127-35. 2004
    ..The results provide for the first time an understanding of the therapeutic benefit of glucocorticoids in the treatment of Meniere's disease, a condition that is associated with increased luminal fluid volume...
  25. pmc Microarray-based comparison of three amplification methods for nanogram amounts of total RNA
    Ruchira Singh
    Dept of Anatomy and Physiology, College of Veterinary Medicine, Kansas State Univ, 1600 Denison Ave, Coles Hall 205, Manhattan, KS 66506, USA
    Am J Physiol Cell Physiol 288:C1179-89. 2005
    ..3 ng of total RNA. In addition, RS and pRS were faster and simpler to use than the T7-based methods and resulted in the generation of cDNA, which is more stable than cRNA...
  26. pmc Gender differences in myogenic regulation along the vascular tree of the gerbil cochlea
    Katrin Reimann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, United States of America
    PLoS ONE 6:e25659. 2011
    ..Male spiral modiolar arteries responded more to L-NNA than female spiral modiolar arteries, suggesting that NO-dependent mechanisms play a bigger role in the myogenic regulation of male than female gerbil cochlear vessels...

Research Grants19

  1. Cellular regulation of cochlear blood flow
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ....
  2. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ..first, middle) The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  3. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2006
    ..abstract_text> ..
  4. CORE--CONFOCAL MICROFLUOROMETRY AND MICROSCOPY
    A PHILINE WANGEMANN; Fiscal Year: 2002
    ..This instrumentation in conjunction with the provided expertise, training and mentoring will enable COBRE investigators to establish themselves through advancing their research on epithelia in health and disease. ..
  5. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2003
    ..abstract_text> ..
  6. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2001
    ..These methods are well-established in this laboratory and represent powerful techniques for addressing the proposed hypotheses. ..
  7. Cellular regulation of cochlear blood flow
    A PHILINE WANGEMANN; Fiscal Year: 2010
    ....