Research Topics
Species | ROLLIE CLEMSummaryAffiliation: Kansas State University Country: USA Publications
Research Grants
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Detail Information
Publications
Analysis and functional annotation of expressed sequence tags from the fall armyworm Spodoptera frugiperdaYouping Deng
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
BMC Genomics 7:264. 2006..This study reports the results of an expressed sequence tag (EST) sequencing project in cells from the lepidopteran insect S. frugiperda, the fall armyworm...
Baculoviruses and apoptosis: the good, the bad, and the uglyR J Clem
Division of Biology, Kansas State University, Manhattan 66506, USA
Cell Death Differ 8:137-43. 2001..In this review, I discuss a number of interesting recent developments in the areas of apoptotic regulation by baculoviruses and the effects of apoptosis on baculovirus replication and pathogenesis...- Baculoviruses and apoptosis: a diversity of genes and responsesRollie J Clem
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
Curr Drug Targets 8:1069-74. 2007..This review highlights the range of apoptotic responses observed between different baculoviruses and different lepidopteran insects, and the diverse baculovirus genes that have evolved to regulate apoptosis... - The role of apoptosis in defense against baculovirus infection in insectsR J Clem
Division of Biology, Kansas State University, 232 Ackert Hall, Manhattan, KS 66506, USA
Curr Top Microbiol Immunol 289:113-29. 2005..Apoptosis is especially effective when it is combined with other innate antiviral defenses, which are largely unexplored in insects to date... - Mechanism of Dronc activation in Drosophila cellsIsrael Muro
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Ackert Hall, Kansas State University, Manhattan 66506, USA
J Cell Sci 117:5035-41. 2004..These results provide the first details of the mechanisms regulating initiator caspase activation in an invertebrate organism... 
Baculovirus infection induces a DNA damage response that is required for efficient viral replicationNing Huang
Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506, USA
J Virol 85:12547-56. 2011....- Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cellsIsrael Muro
Division of Biology, Kansas State University, Manhattan, Kansas, 66506, USA
J Biol Chem 280:18683-8. 2005..These results expand our knowledge of the events that occur in the Drosophila apoptosome prior to and after receiving an apoptotic signal... - The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONCIsrael Muro
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
J Biol Chem 277:49644-50. 2002.... - Sequence requirements for Hid binding and apoptosis regulation in the baculovirus inhibitor of apoptosis Op-IAP. Hid binds Op-IAP in a manner similar to Smac binding of XIAPCasey W Wright
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
J Biol Chem 277:2454-62. 2002.... - Silencing of the baculovirus Op-iap3 gene by RNA interference reveals that it is required for prevention of apoptosis during Orgyia pseudotsugata M nucleopolyhedrovirus infection of Ld652Y cellsJohn C Means
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
J Virol 77:4481-8. 2003..These results show for the first time that Op-IAP3 is necessary to prevent apoptosis during OpMNPV infection. In addition, our results demonstrate that the RNAi technique can be an effective tool for studying baculovirus gene function... - The baculovirus anti-apoptotic protein Op-IAP does not inhibit Drosophila caspases or apoptosis in Drosophila S2 cells and instead sensitizes S2 cells to virus-induced apoptosisCasey W Wright
Molecular, Cellular and Developmental Biology Program, Division of Biology, Kansas State University, 232 Ackert Hall, Manhattan, KS 66506, USA
Virology 335:61-71. 2005..The observation that Op-IAP cannot inhibit these insect caspases suggests that it functions by a mechanism that does not involve direct caspase inhibition... - Ubiquitin protein ligase activity of the anti-apoptotic baculovirus protein Op-IAP3Melissa C Green
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
Virus Res 105:89-96. 2004..Thus, we conclude that Op-IAP3 is a functional E3 ubiquitin ligase, and the ability to ubiquitinate pro-apoptotic cellular proteins such as HID may play an important role in the anti-apoptotic function of Op-IAP3... - Identification and functional characterization of AMVp33, a novel homolog of the baculovirus caspase inhibitor p35 found in Amsacta moorei entomopoxvirusJohn C Means
Molecular, Cellular and Developmental Biology Program, Division of Biology, Kansas State University, 232 Ackert Hall, Manhattan, KS 66506, USA
Virology 358:436-47. 2007..Thus, AMVp33 encodes a caspase inhibitor similar to baculovirus P35 with a preference for effector caspases. This is the first report of a p35 homolog from any viral or cellular genome outside of the baculovirus family... - Mutation of juxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and alters interaction with other proteins at the cell surfaceCaroline Delandre
Molecular, Cellular and Developmental Biology Program, Kansas State University, Manhattan, KS 66506, USA
Exp Cell Res 315:1953-63. 2009.... - Caspase inhibitor P35 is required for the production of robust baculovirus virions in Trichoplusia ni TN-368 cellsBart Bryant
Molecular, Cellular and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
J Gen Virol 90:654-61. 2009..These results suggest that caspases can directly or indirectly damage baculovirus virions, and reveal a novel aspect of the role of apoptosis in antiviral defence... - Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cellsHua Wang
Molecular, Cellular, and Developmental Biology Program, Arthropod Genomics Center, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
J Gen Virol 89:2651-61. 2008..This study is the first to test directly whether inducing or inhibiting apoptosis affects arbovirus replication in mosquito cells... - Insect defenses against virus infection: the role of apoptosisThomas E Clarke
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
Int Rev Immunol 22:401-24. 2003..Recent work has characterized the apoptotic response during infection of the host insect, and the results directly demonstrate the power of apoptosis as an antiviral response... - Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanismsSoon Ji Yoo
Division of Biology, MC156 29, California Institute of Technology, Pasadena, CA 91125, USA
Nat Cell Biol 4:416-24. 2002..Because loss of DIAP1 is sufficient to promote caspase activation, these mechanisms should promote apoptosis... - A caspase-like decoy molecule enhances the activity of a paralogous caspase in the yellow fever mosquito, Aedes aegyptiBart Bryant
Molecular, Cellular, and Developmental Biology Program, Kansas State University, Manhattan, KS 66506, USA
Insect Biochem Mol Biol 40:516-23. 2010..The discovery of potential caspase-like decoy molecules in several insect species opens new avenues for investigating caspase regulation in insects, particularly in disease vectors such as mosquitoes... - Improving baculovirus resistance to UV inactivation: increased virulence resulting from expression of a DNA repair enzymeDustin T Petrik
Division of Biology, 232 Ackert Hall, Kansas State University, Manhattan, KS 66506, USA
J Invertebr Pathol 82:50-6. 2003..frugiperda and not in T. ni larvae... - Lack of involvement of haemocytes in the establishment and spread of infection in Spodoptera frugiperda larvae infected with the baculovirus Autographa californica M nucleopolyhedrovirus by intrahaemocoelic injectionThomas E Clarke
Molecular, Cellular and Developmental Biology Program, Division of Biology, 232 Ackert Hall, Kansas State University, Manhattan, KS 66506, USA
J Gen Virol 83:1565-72. 2002..frugiperda, haemocytes do not appear to have a primary role in AcMNPV pathogenesis. This relative lack of infection of haemocytes may in part explain why S. frugiperda larvae are more resistant to AcMNPV infection than T. ni larvae...
Research Grants
- INTERACTIONS BETWEEN PATHOGENS AND ARTHROPOD MIDGUT EPITHELIAL CELLSROLLIE CLEM; Fiscal Year: 2002..The proposed project thus addresses two key aspects of pathogen-arthropod host interactions that are fundamental to the pathogen survival and transmission. ..
- FUNCTIONAL ANALYSIS OF ANTIAPOPTOTIC IAP PROTEINSROLLIE CLEM; Fiscal Year: 2002....
- Apoptosis as an anti-viral response in mosquito midgutROLLIE CLEM; Fiscal Year: 2007....