ROLLIE CLEM

Summary

Affiliation: Kansas State University
Country: USA

Publications

  1. pmc Analysis and functional annotation of expressed sequence tags from the fall armyworm Spodoptera frugiperda
    Youping Deng
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
    BMC Genomics 7:264. 2006
  2. ncbi request reprint Baculoviruses and apoptosis: a diversity of genes and responses
    Rollie J Clem
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Curr Drug Targets 8:1069-74. 2007
  3. ncbi request reprint The role of apoptosis in defense against baculovirus infection in insects
    R J Clem
    Division of Biology, Kansas State University, 232 Ackert Hall, Manhattan, KS 66506, USA
    Curr Top Microbiol Immunol 289:113-29. 2005
  4. ncbi request reprint Mechanism of Dronc activation in Drosophila cells
    Israel Muro
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Ackert Hall, Kansas State University, Manhattan 66506, USA
    J Cell Sci 117:5035-41. 2004
  5. ncbi request reprint Baculoviruses and apoptosis: the good, the bad, and the ugly
    R J Clem
    Division of Biology, Kansas State University, Manhattan 66506, USA
    Cell Death Differ 8:137-43. 2001
  6. pmc Baculovirus infection induces a DNA damage response that is required for efficient viral replication
    Ning Huang
    Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506, USA
    J Virol 85:12547-56. 2011
  7. ncbi request reprint Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells
    Israel Muro
    Division of Biology, Kansas State University, Manhattan, Kansas, 66506, USA
    J Biol Chem 280:18683-8. 2005
  8. ncbi request reprint The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
    Israel Muro
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 277:49644-50. 2002
  9. ncbi request reprint Sequence requirements for Hid binding and apoptosis regulation in the baculovirus inhibitor of apoptosis Op-IAP. Hid binds Op-IAP in a manner similar to Smac binding of XIAP
    Casey W Wright
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 277:2454-62. 2002
  10. ncbi request reprint Ubiquitin protein ligase activity of the anti-apoptotic baculovirus protein Op-IAP3
    Melissa C Green
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Virus Res 105:89-96. 2004

Collaborators

Detail Information

Publications22

  1. pmc Analysis and functional annotation of expressed sequence tags from the fall armyworm Spodoptera frugiperda
    Youping Deng
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
    BMC Genomics 7:264. 2006
    ..This study reports the results of an expressed sequence tag (EST) sequencing project in cells from the lepidopteran insect S. frugiperda, the fall armyworm...
  2. ncbi request reprint Baculoviruses and apoptosis: a diversity of genes and responses
    Rollie J Clem
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Curr Drug Targets 8:1069-74. 2007
    ..This review highlights the range of apoptotic responses observed between different baculoviruses and different lepidopteran insects, and the diverse baculovirus genes that have evolved to regulate apoptosis...
  3. ncbi request reprint The role of apoptosis in defense against baculovirus infection in insects
    R J Clem
    Division of Biology, Kansas State University, 232 Ackert Hall, Manhattan, KS 66506, USA
    Curr Top Microbiol Immunol 289:113-29. 2005
    ..Apoptosis is especially effective when it is combined with other innate antiviral defenses, which are largely unexplored in insects to date...
  4. ncbi request reprint Mechanism of Dronc activation in Drosophila cells
    Israel Muro
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Ackert Hall, Kansas State University, Manhattan 66506, USA
    J Cell Sci 117:5035-41. 2004
    ..These results provide the first details of the mechanisms regulating initiator caspase activation in an invertebrate organism...
  5. ncbi request reprint Baculoviruses and apoptosis: the good, the bad, and the ugly
    R J Clem
    Division of Biology, Kansas State University, Manhattan 66506, USA
    Cell Death Differ 8:137-43. 2001
    ..In this review, I discuss a number of interesting recent developments in the areas of apoptotic regulation by baculoviruses and the effects of apoptosis on baculovirus replication and pathogenesis...
  6. pmc Baculovirus infection induces a DNA damage response that is required for efficient viral replication
    Ning Huang
    Division of Biology, Ackert Hall, Kansas State University, Manhattan, KS 66506, USA
    J Virol 85:12547-56. 2011
    ....
  7. ncbi request reprint Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells
    Israel Muro
    Division of Biology, Kansas State University, Manhattan, Kansas, 66506, USA
    J Biol Chem 280:18683-8. 2005
    ..These results expand our knowledge of the events that occur in the Drosophila apoptosome prior to and after receiving an apoptotic signal...
  8. ncbi request reprint The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
    Israel Muro
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 277:49644-50. 2002
    ....
  9. ncbi request reprint Sequence requirements for Hid binding and apoptosis regulation in the baculovirus inhibitor of apoptosis Op-IAP. Hid binds Op-IAP in a manner similar to Smac binding of XIAP
    Casey W Wright
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 277:2454-62. 2002
    ....
  10. ncbi request reprint Ubiquitin protein ligase activity of the anti-apoptotic baculovirus protein Op-IAP3
    Melissa C Green
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Virus Res 105:89-96. 2004
    ..Thus, we conclude that Op-IAP3 is a functional E3 ubiquitin ligase, and the ability to ubiquitinate pro-apoptotic cellular proteins such as HID may play an important role in the anti-apoptotic function of Op-IAP3...
  11. pmc Silencing of the baculovirus Op-iap3 gene by RNA interference reveals that it is required for prevention of apoptosis during Orgyia pseudotsugata M nucleopolyhedrovirus infection of Ld652Y cells
    John C Means
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
    J Virol 77:4481-8. 2003
    ..These results show for the first time that Op-IAP3 is necessary to prevent apoptosis during OpMNPV infection. In addition, our results demonstrate that the RNAi technique can be an effective tool for studying baculovirus gene function...
  12. ncbi request reprint The baculovirus anti-apoptotic protein Op-IAP does not inhibit Drosophila caspases or apoptosis in Drosophila S2 cells and instead sensitizes S2 cells to virus-induced apoptosis
    Casey W Wright
    Molecular, Cellular and Developmental Biology Program, Division of Biology, Kansas State University, 232 Ackert Hall, Manhattan, KS 66506, USA
    Virology 335:61-71. 2005
    ..The observation that Op-IAP cannot inhibit these insect caspases suggests that it functions by a mechanism that does not involve direct caspase inhibition...
  13. pmc Mutation of juxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and alters interaction with other proteins at the cell surface
    Caroline Delandre
    Molecular, Cellular and Developmental Biology Program, Kansas State University, Manhattan, KS 66506, USA
    Exp Cell Res 315:1953-63. 2009
    ....
  14. pmc Caspase inhibitor P35 is required for the production of robust baculovirus virions in Trichoplusia ni TN-368 cells
    Bart Bryant
    Molecular, Cellular and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Gen Virol 90:654-61. 2009
    ..These results suggest that caspases can directly or indirectly damage baculovirus virions, and reveal a novel aspect of the role of apoptosis in antiviral defence...
  15. pmc Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells
    Hua Wang
    Molecular, Cellular, and Developmental Biology Program, Arthropod Genomics Center, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Gen Virol 89:2651-61. 2008
    ..This study is the first to test directly whether inducing or inhibiting apoptosis affects arbovirus replication in mosquito cells...
  16. ncbi request reprint Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
    Soon Ji Yoo
    Division of Biology, MC156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Cell Biol 4:416-24. 2002
    ..Because loss of DIAP1 is sufficient to promote caspase activation, these mechanisms should promote apoptosis...
  17. pmc Identification and functional characterization of AMVp33, a novel homolog of the baculovirus caspase inhibitor p35 found in Amsacta moorei entomopoxvirus
    John C Means
    Molecular, Cellular and Developmental Biology Program, Division of Biology, Kansas State University, 232 Ackert Hall, Manhattan, KS 66506, USA
    Virology 358:436-47. 2007
    ..Thus, AMVp33 encodes a caspase inhibitor similar to baculovirus P35 with a preference for effector caspases. This is the first report of a p35 homolog from any viral or cellular genome outside of the baculovirus family...
  18. ncbi request reprint Insect defenses against virus infection: the role of apoptosis
    Thomas E Clarke
    Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Int Rev Immunol 22:401-24. 2003
    ..Recent work has characterized the apoptotic response during infection of the host insect, and the results directly demonstrate the power of apoptosis as an antiviral response...
  19. pmc A caspase-like decoy molecule enhances the activity of a paralogous caspase in the yellow fever mosquito, Aedes aegypti
    Bart Bryant
    Molecular, Cellular, and Developmental Biology Program, Kansas State University, Manhattan, KS 66506, USA
    Insect Biochem Mol Biol 40:516-23. 2010
    ..The discovery of potential caspase-like decoy molecules in several insect species opens new avenues for investigating caspase regulation in insects, particularly in disease vectors such as mosquitoes...
  20. ncbi request reprint Lack of involvement of haemocytes in the establishment and spread of infection in Spodoptera frugiperda larvae infected with the baculovirus Autographa californica M nucleopolyhedrovirus by intrahaemocoelic injection
    Thomas E Clarke
    Molecular, Cellular and Developmental Biology Program, Division of Biology, 232 Ackert Hall, Kansas State University, Manhattan, KS 66506, USA
    J Gen Virol 83:1565-72. 2002
    ..frugiperda, haemocytes do not appear to have a primary role in AcMNPV pathogenesis. This relative lack of infection of haemocytes may in part explain why S. frugiperda larvae are more resistant to AcMNPV infection than T. ni larvae...
  21. ncbi request reprint Improving baculovirus resistance to UV inactivation: increased virulence resulting from expression of a DNA repair enzyme
    Dustin T Petrik
    Division of Biology, 232 Ackert Hall, Kansas State University, Manhattan, KS 66506, USA
    J Invertebr Pathol 82:50-6. 2003
    ..frugiperda and not in T. ni larvae...

Research Grants4

  1. INTERACTIONS BETWEEN PATHOGENS AND ARTHROPOD MIDGUT EPITHELIAL CELLS
    ROLLIE CLEM; Fiscal Year: 2002
    ..The proposed project thus addresses two key aspects of pathogen-arthropod host interactions that are fundamental to the pathogen survival and transmission. ..
  2. FUNCTIONAL ANALYSIS OF ANTIAPOPTOTIC IAP PROTEINS
    ROLLIE CLEM; Fiscal Year: 2002
    ....
  3. Apoptosis as an anti-viral response in mosquito midgut
    ROLLIE CLEM; Fiscal Year: 2007
    ....