Robert S Zeiger

..Accurate assessment of asthma control may help predict future asthma exacerbations...

..To determine whether montelukast is as effective as fluticasone in controlling mild persistent asthma as determined by rescue-free days...

..Fractional exhaled nitric oxide (FENO) is a marker of airway inflammation. Its role in assessing asthma burden in clinical practice needs more study...

..To describe the variability of the asthma phenotype in patients with mild persistent asthma enrolled in the Mild Asthma Montelukast versus Inhaled Corticosteroid (MIAMI) study...

..To determine whether step-up care recommended by national asthma guidelines improves asthma control in a large managed care organization...

..Medical costs and health care utilization associated with asthma and the variation by treatment are poorly understood...

..The Test for Respiratory and Asthma Control in Kids (TRACK) is the first validated questionnaire to assess respiratory and asthma control exclusively in young children...

..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...

..We compared daily therapy with intermittent therapy...

..Although there is much in common with these recommendations, differences exist. This review compares, contrasts, and reconciles them, presenting the evidence that has led to their statements...

..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...

..Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity...

..Asthma exacerbations are a common cause of critical illness in children...

..Clinical trials in children with moderate-to-severe persistent asthma are limited...

..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...

..The ratio of controller medication to total asthma medications has been related to asthma utilization outcomes, but its relationship to patient-centered outcomes has not been explored...

..However, determination of baseline features associated with ICS responsiveness may identify children most likely to benefit from ICS treatment...

..To validate a risk stratification scheme using computerized pharmacy data to predict emergency hospital utilization for persistent asthma...

..The effect on linear growth of daily long-term inhaled corticosteroid therapy in preschool-aged children with recurrent wheezing is controversial...

..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...

..Although nocturnal awakenings help categorize asthma severity and control, their clinical significance has not been thoroughly studied...

..Determination of the benefits and limitations of specific physiologic tests has not been well studied in long-term clinical pediatric trials...

..Asthma control has been defined clinically by using validated tools, but an asthma control scale using administrative data has not been reported...

..We compared three validated questionnaires reflecting asthma impairment in their ability to predict future exacerbations...

..To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued...

..Validated psychometric tools measuring quality of life, asthma control, and asthma severity have been developed, but their relationships with each other and with other important patient-centered outcomes have not been rigorously assessed...

..To provide additional validity data for the Asthma Control TestTM (ACT) using a different criterion measure, setting, and population...

..0001), COPD (p < 0.0001), absence of regular specialist care (p = 0.006), higher BMI (p = 0.01), gastroesophageal reflux (p = 0.02), not being Caucasian (p = 0.04), and low income (p = 0.04)...

..To describe the relationships between persistent asthma defined by administrative versus survey data and their stability over time...

..Prior studies suggest that allergist care improves asthma outcomes, but many of these studies have methodological shortcomings...

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..The Asthma Impact Survey (AIS-6) is a brief disease-specific quality-of-life instrument with limited published validation data...

..Asthma control has been hypothesized to be inversely related to asthma severity, directly related to effective management, and also related to other definable factors, but empiric data to support this construct are few...

..The fractional concentration of exhaled nitric oxide (FeNO) is a noninvasive marker for airway inflammation but requires further study in preschool-aged children to determine its clinical relevance...

..The effect of childhood asthma on lung growth is unclear...

..Rhinitis is a common health condition, but the extent of the burden in managed care organizations (MCOs) has not been well described...

..57-0.64); and lowest with the environment domain (r = 0.38-0.43). Asthma control tools reflect the symptoms and activity themes of asthma quality of life well, but reflect the environmental domain less well...

..The Asthma Impact Survey (AIS-6) is a new six question asthma outcome tool for which information on validity has not been published...

..Inherent asthma severity is difficult to assess clinically. The purpose of this study was to develop an Asthma Intensity Manifestations Score (AIMS) as a surrogate for asthma severity...

..To compare the relationship of surrogate markers of asthma control to subsequent asthma exacerbations...

..To identify an optimal cut-point score on the Mini-Asthma Quality of Life Questionnaire (mini-AQLQ) to predict subsequent asthma exacerbations, and to determine the additional risk conferred by a prior history of acute episodes...

..These data suggest that the limited intervention in our setting improved outcomes but that regular care manager follow-up thereafter did not add significantly to this intervention...

..In a prior study from our group, only 24% of patients reported making any recommended environmental changes...

..This study was designed to determine relationships of the Mini-Rhinitis Quality of Life Questionnaire (MiniRQLQ) and the Rhinitis Control Assessment Test (RCAT) to each other regarding content and predictive abilities...

..The Asthma Control Test (ACT) has been validated in a paper and pencil version but has not been validated for use by telephone...

..It is hoped that outreach to patients and providers based on these indicators will improve asthma outcomes in patients cared for in individual practices, as well as in large health plans...

..Risk stratification is used to identify patients with asthma at increased risk of experiencing morbidity and resource utilization. Validated psychometric tools are infrequently studied sources of data for this purpose...

..To examine the association between chorioamnionitis and childhood asthma based on gestational age at birth and race/ethnicity...

..Thus, we assessed the effects of multiple short courses of oral corticosteroids and long-term inhaled corticosteroids on bone mineral accretion over a period of years...

..The purpose of this study was to evaluate the relationship of the interval between routine physician visits to asthma outcomes in patients with moderate persistent asthma...

..Consistent with these findings, exclusive breast-feeding should be encouraged for at least 4 to 6 months in infants at both high and low risk of atopy and irrespective of a history of maternal asthma...

..A practical protocol that includes incremental dosing of influenza vaccine is presented to guide clinicians in influenza vaccination in this high-risk group...

..The divergence of exposure-response relationships by anti-inflammatory medication use is consistent with experimental data on inflammatory mechanisms of airborne pollutants and allergens...

..It is a noninvasive technique that could be used in decisional management of children with asthma...

..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...

..This survey include target group for dietary prevention and methods and diagnostic criteria of atopic dermatitis, asthma and food allergy for prevention studies...

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..In the absence of breast milk, formulas with documented reduced allergenicity for at least 4-6 months should be used...

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..Nonadherence with asthma therapy is common and may contribute to poor clinical outcomes...

..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...

..Persistently low levels of lung function are associated with subsequent symptoms in patients with asthma as children...

..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...

..Methods to document hypoallergenicity are discussed and evaluated in the preclinical and clinical steps...

..Are these very low, residual quantities hazardous to allergic consumers? How much of the offending food is too much? Very little quantitative information exists to allow any risk assessments to be conducted by the food industry...

..End of Abstract.) ..

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..To compare the effects of the two classes of anti-inflammatory medications, compared to bronchodilator medication and to each other, on physical and psychosocial development, and on quality of life...