Genomes and Genes
Jonathan G Zaroff
Affiliation: Kaiser Permanente
- Cardiovascular predictors of long-term outcomes after non-traumatic subarachnoid hemorrhageJonathan G Zaroff
Kaiser Northern California Division of Research, San Francisco, CA, USA
Neurocrit Care 17:374-81. 2012..The second aim was to quantify the effects of cardiac injury on the outcome rates...
- Independent associations between electrocardiographic abnormalities and outcomes in patients with aneurysmal subarachnoid hemorrhage: findings from the intraoperative hypothermia aneurysm surgery trialLandis A Coghlan
University of California, Los Angeles, California, USA
Stroke 40:412-8. 2009..The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes...
- Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAHLandis A Fisher
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 5:180-5. 2006..075). CONCLUSION: In the acute period after SAH, hypernatremia is associated with adverse cardiac outcomes and death. SAH patients with hypernatremia should be monitored for evidence of cardiac dysfunction...
- Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatmentAchal S Achrol
Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
Neurosurgery 61:731-9; discussion 740. 2007..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes...
- Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformationsBahar Mikhak
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
Cerebrovasc Dis 31:338-45. 2011..We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH...
- Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhageJonathan G Zaroff
Department of Medicine, University of California, San Francisco, USA
Stroke 37:1680-5. 2006..We hypothesized that adrenoceptor polymorphisms resulting in greater catecholamine sensitivity would be associated with an increased risk of cardiac injury...
- Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhageSirisha Yarlagadda
Department of Medicine, University of California San Francisco, San Francisco, CA 94143-0124, USA
Neurocrit Care 5:102-7. 2006..Though these effects may be explained by a reduction in cerebral perfusion pressure or other mechanisms, further research is required to determine whether or not they are causal in nature...
- Predictors of left ventricular regional wall motion abnormalities after subarachnoid hemorrhageAvinash Kothavale
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 4:199-205. 2006..34 per 10 bpm increase, p = 0.024) were predictive of RWMA. CONCLUSIONS: RWMA were frequent after SAH. High-grade SAH, an elevation in cTi levels, a history of prior stimulant drug use, and tachycardia are independent predictors of RWMA...
- Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhageNerissa U Ko
Department of Neurology, University of California, San Francisco, USA
Stroke 39:1103-8. 2008..Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients...
- Acute neurocardiogenic injury after subarachnoid hemorrhageNader M Banki
Division of Cardiology, Department of Radiology, UCSF Medical Center, San Francisco, California, USA
Circulation 112:3314-9. 2005..These findings may be explained by excessive release of norepinephrine from myocardial sympathetic nerves, which could damage both myocytes and nerve terminals...
- Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformationHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Cerebrovasc Dis 27:176-82. 2009..The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients...
- Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined populationRodney A Gabriel
UCSF Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Room 3C 38, San Francisco, CA 94110, USA
Stroke 41:21-6. 2010....
- Elevated BNP is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhagePam R Taub
Department of Medicine, Cardiology Division, University of California, San Diego, CA 94114, USA
Neurocrit Care 15:13-8. 2011..We sought to determine whether elevated levels of BNP are independently associated with radiographic cerebral infarction after SAH...
- Plasma B-type natriuretic peptide levels are associated with early cardiac dysfunction after subarachnoid hemorrhagePoyee P Tung
Division of Cardiology, University of California, San Francisco, CA, USA
Stroke 36:1567-9. 2005..The aim of this study was to prospectively quantify the relationship between BNP levels and cardiac outcomes after SAH...
- Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformationsLudmila Pawlikowska
The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
Neurosurgery 58:838-43; discussion 838-43. 2006..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention...
- Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulationWhittemore G Tingley
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:8461-6. 2007..Our stem cell-based screen may provide a means of identifying other genes that control heart rhythm...
- Perioperative hypothermia (33 degrees C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery TrialHoang P Nguyen
Department of Medicine, Kaiser San Francisco Medical Center, San Francisco, California, USA
Anesthesiology 113:327-42. 2010..By increasing the activity of sympathetic nervous system, perioperative hypothermia also has the potential to increase cardiac injury and dysfunction associated with subarachnoid hemorrhage...
- Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul StudyGregory M Marcus
Electrophysiology Section, Division of Cardiology, University of California, San Francisco, CA 94143 1354, USA
Am Heart J 155:303-9. 2008..We therefore examined several biomarkers of inflammation and ultimately genotyped IL-6 polymorphisms in patients with AF in a cohort of subjects with known CAD...
- Surgical candidacy and selection biases in nonemergent left main stenting: implications for observational studiesEdward J McNulty
Division of Cardiology, Kaiser Permanente Medical Center, San Francisco, California 94115, USA
JACC Cardiovasc Interv 4:1020-7. 2011....
- Donor cardiac troponin I levels do not predict recipient survival after cardiac transplantationKiran K Khush
Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, San Francisco, California, USA
J Heart Lung Transplant 26:1048-53. 2007..This study was performed to determine whether donor cardiac cTnI levels exceeding 1.0 microg/liter are associated with adverse recipient outcomes...
- Neurocardiogenic injury in neurovascular disordersAlexander Kopelnik
Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Crit Care Clin 22:733-52; abstract ix-x. 2006..For patients who develop brain death, cardiac evaluation under optimal conditions may help increase the organ donor pool...
- Cardiac injury after subarachnoid hemorrhage is independent of the type of aneurysm therapyJacob C Miss
Department of Medicine, University of California, San Francisco, California 94143-0124, USA
Neurosurgery 55:1244-50; discussion 1250-1. 2004..CONCLUSION: Surgical and endovascular aneurysm therapies were associated with similar risks of cardiac injury and dysfunction after SAH. The presence of neurocardiogenic injury should not affect aneurysm treatment decisions...
- Neurogenic stunned myocardiumHoang Nguyen
Cardiology Department, Kaiser San Francisco Medical Center, San Francisco, CA 94115, USA
Curr Neurol Neurosci Rep 9:486-91. 2009..These are reversible abnormalities, and although management should include careful cardiac monitoring, treatments should generally focus on the underlying neurologic process to maximize neurologic recovery...
- Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformationsAchal S Achrol
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
Stroke 37:231-4. 2006....
- Electrocardiographic repolarization abnormalities in subarachnoid hemorrhageClaire E Sommargren
Department of Physiological Nursing, University of California, San Francisco, USA
J Electrocardiol 35:257-62. 2002..Prolonged QTc interval after SAH is significantly related to myocardial injury, but unrelated to mortality, and there is no association between ST-T wave abnormalities and either myocardial injury or mortality...