Research Topics
| Bruce FiremanSummaryAffiliation: Kaiser Permanente Country: USA Publications
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Detail Information
Publications
Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysisHenry Shinefield
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
N Engl J Med 346:491-6. 2002..The capsular polysaccharides are essential for the pathogenesis of and immunity to S. aureus infection and are targets for vaccines...
Influenza vaccination and mortality: differentiating vaccine effects from biasBruce Fireman
Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
Am J Epidemiol 170:650-6. 2009....
Can disease management reduce health care costs by improving quality?Bruce Fireman
Permanente Medical Group of Northern California, Oakland, CA, USA
Health Aff (Millwood) 23:63-75. 2004..We conclude that the rationale for DM programs, like the rationale for any medical treatments, should rest on their effectiveness and value...
Impact of the pneumococcal conjugate vaccine on otitis mediaBruce Fireman
Kaiser Permanente Division of Research and the Kaiser Permanente Vaccine Studies Center, Oakland, CA 94612, USA
Pediatr Infect Dis J 22:10-6. 2003..The heptavalent pneumococcal conjugate vaccine (PCV) is recommended for infants to protect against invasive disease, but its impact on otitis might also have public health importance...
A protocol for active surveillance of acute myocardial infarction in association with the use of a new antidiabetic pharmaceutical agentBruce Fireman
Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
Pharmacoepidemiol Drug Saf 21:282-90. 2012..To describe a protocol for active surveillance of acute myocardial infarction (AMI) in users of a recently approved oral antidiabetic medication, saxagliptin, and to provide the rationale for decisions made in drafting the protocol...
Early experiences with e-health services (1999-2002): promise, reality, and implicationsVicki Fung
Kaiser Permanente Medical Care Program, Division of Research, Oakland, California 94612, USA
Med Care 44:491-6. 2006..Subjects with greater clinical need and better ties to the health system were more likely to use both types of e-health services...
Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccineSteven Black
Division of Pediatric Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA
Pediatr Infect Dis J 26:771-7. 2007....
Medicare beneficiaries' knowledge of Part D prescription drug program benefits and responses to drug costsJohn Hsu
Center for Health Policy Studies and the Division of Research, Kaiser Permanente Medical Care Program, 2000 Broadway, Third Floor, Oakland, California 94612, USA
JAMA 299:1929-36. 2008..Medicare Part D drug benefits include substantial cost sharing...
Postlicensure surveillance for pneumococcal invasive disease after use of heptavalent pneumococcal conjugate vaccine in Northern California Kaiser PermanenteSteven Black
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Pediatr Infect Dis J 23:485-9. 2004..Secondary objectives included determination of the risk of pneumococcal infections in unvaccinated older children and adults in the same population and the impact of vaccine introduction on patterns of antimicrobial resistance...
Meaningful variation in performance: what does variation in quality tell us about improving quality?Joseph V Selby
Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612, USA
Med Care 48:133-9. 2010..However, the absolute amount of variation, expressed in clinically meaningful units, is less frequently reported. Moreover, changes in variance components have not been studied as quality improves...
Unintended consequences of caps on Medicare drug benefitsJohn Hsu
Division of Research, Kaiser Permanente, Oakland, Calif 94612, USA
N Engl J Med 354:2349-59. 2006..Little information exists about the consequences of limits on prescription-drug benefits for Medicare beneficiaries...
Cost-sharing for emergency care and unfavorable clinical events: findings from the safety and financial ramifications of ED copayments studyJohn Hsu
Kaiser Permanente-Division of Research, 2000 Broadway, 3rd Floor, Oakland, CA 94612, USA
Health Serv Res 41:1801-20. 2006..CONCLUSIONS: Relatively modest levels of patient cost-sharing for ED care decreased ED visit rates without increasing the rate of unfavorable clinical events...
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizuresNicola P Klein
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Pediatrics 126:e1-8. 2010..Now with data on twice as many vaccine recipients, our goal was to reexamine seizure risk after MMRV vaccine...
Impact of the use of heptavalent pneumococcal conjugate vaccine on disease epidemiology in children and adultsSteven Black
Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza, 16th Floor, Oakland, CA 94612, USA
Vaccine 24:S2-79-80. 2006..There was no evidence of any concomittant increase in pneumococcal disease caused by non-vaccine serotypes. High-level resistance of pneumococci to penicillin fell from a peak of 15% in year 2000 to 5% in the first half of 2003...
Care-seeking behavior in response to emergency department copaymentsMary Reed
Division of Research, Kaiser Permanente Medical Care Program, Oakland, California 94612, USA
Med Care 43:810-6. 2005..CONCLUSIONS: When faced with an ED copayment, patients in the health system most commonly shifted toward seeking care from other available alternatives, and rarely avoid medical care altogether...
Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumoniaSteven B Black
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Pediatr Infect Dis J 21:810-5. 2002..To determine the effectiveness of the Wyeth heptavalent pneumococcal conjugate vaccine against clinical and radiograph-confirmed pneumonia in children...
Catastrophizing, depression and pain-related disabilityBruce A Arnow
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
Gen Hosp Psychiatry 33:150-6. 2011..The objective of the study was to examine catastrophizing, depression and their interactive effects in predicting disability in patients with chronic pain...
Evaluation of immunization rates and safety among children with inborn errors of metabolismNicola P Klein
Kaiser Permanente Vaccine Study Center, 1 Kaiser Plaza, 16th Floor, Oakland, CA 94612, USA
Pediatrics 127:e1139-46. 2011..Children with inherited metabolic disorders are a potential high-risk group for vaccine-preventable diseases, yet information regarding immunization rates and vaccine safety within this population is limited...
Rates of autoimmune diseases in Kaiser Permanente for use in vaccine adverse event safety studiesNicola P Klein
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Vaccine 28:1062-8. 2010..These background incidence rates should prove useful for future observational vaccine safety studies and will help guide evaluation of potential vaccine AID events following introduction of new vaccines...
Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism studyLisa A Croen
Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
Biol Psychiatry 64:583-8. 2008..Immune dysfunction has been associated with autism, yet whether maternal immune status during pregnancy plays a causal role remains to be clarified...
Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than 5 years of age for prevention of pneumonia: updated analysis using World Health Organization standardized interpretation of chest radiographsJohn Hansen
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Pediatr Infect Dis J 25:779-81. 2006..We reevaluated radiographs from the Kaiser Permanente Pneumococcal Efficacy trial using this method...
Meaningful variation in performance: a systematic literature reviewVicki Fung
Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA, USA
Med Care 48:140-8. 2010..Recommendations for directing quality improvement initiatives at particular levels (eg, patients, physicians, provider groups) have been made on the basis of empirical components of variance analyses of performance...
Treatment intensification and risk factor control: toward more clinically relevant quality measuresJoseph V Selby
Division of Research, Kaiser Permanente Medical Care Program, Oakland, California 94612, USA
Med Care 47:395-402. 2009..Intensification of pharmacotherapy in persons with poorly controlled chronic conditions has been proposed as a clinically meaningful process measure of quality...
Safety of Zostavax™--a cohort study in a managed care organizationRoger Baxter
Kaiser Permanente Vaccine Study Center, Oakland, CA, USA
Vaccine 30:6636-41. 2012....
Outpatient electronic health records and the clinical care and outcomes of patients with diabetes mellitusMary Reed
Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
Ann Intern Med 157:482-9. 2012..Physicians can receive federal payments for meaningful use of complete certified electronic health records (EHRs). Evidence is limited on how EHR use affects clinical care and outcomes...
Patterns of infliximab use among Crohn's disease patients in a community settingAlice R Pressman
Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
Inflamm Bowel Dis 14:1265-72. 2008..We sought to understand predictors of initiation and discontinuation of infliximab in the community-based setting of Kaiser Permanente, Northern California, which provides integrated care to its members...
Distributing $800 billion: an early assessment of Medicare Part D risk adjustmentJohn Hsu
Center for Health Policy Studies and Division of Research, Kaiser Permanente Medical Care Program, Oakland, California, USA
Health Aff (Millwood) 28:215-25. 2009..Combining RxHCCs with individual-level information on prior-year drug use greatly improves performance and decreases incentives for plans to select against bad risks...
Comorbid depression, chronic pain, and disability in primary careBruce A Arnow
Department of Psychiatry and Behavioral Sciences, University School of Medicine, Stanford, CA, USA
Psychosom Med 68:262-8. 2006....
Waning protection after fifth dose of acellular pertussis vaccine in childrenNicola P Klein
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
N Engl J Med 367:1012-9. 2012..In the United States, children receive five doses of diphtheria, tetanus, and acellular pertussis (DTaP) vaccine before 7 years of age. The duration of protection after five doses of DTaP is unknown...
Measles-containing vaccines and febrile seizures in children age 4 to 6 yearsNicola P Klein
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Pediatrics 129:809-14. 2012..Among 1- to 2-year-olds, the risk of febrile seizures 7 to 10 days after MMRV is double that after separate MMR + V. Whether MMRV or MMR + V affects risk for febrile seizure risk among 4- to 6-year-olds has not been reported...
Immunization and Bell's palsy in children: a case-centered analysisAli Rowhani-Rahbar
Kaiser Permanente Vaccine Study Center, Oakland, California, USA
Am J Epidemiol 175:878-85. 2012..Similarly, no association was found between vaccines and BP during the periods 1-14 and 29-56 days following immunization. Results of this study suggest that there is no association between immunization and BP in children...
Efficacy, immunogenicity and safety of heptavalent pneumococcal conjugate vaccine in low birth weight and preterm infantsHenry Shinefield
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Pediatr Infect Dis J 21:182-6. 2002..To determine the efficacy, immunogenicity and safety of the heptavalent CRM197 pneumococcal conjugate vaccine (PCV) in low birth weight (LBW) and preterm (PT) infants against invasive pneumococcal disease caused by vaccine types...
Evidence of bias in studies of influenza vaccine effectiveness in elderly patientsRoger Baxter
Vaccine Study Center, Kaiser Permanente, Oakland, California 94612, USA
J Infect Dis 201:186-9. 2010..We conclude that bias is inherent in studies of influenza vaccination and death among elderly patients...
Cost-sharing: patient knowledge and effects on seeking emergency department careJohn Hsu
Division of Research, Kaiser Foundation Research Institute, Oakland, CA 94612, USA
Med Care 42:290-6. 2004..The use of cost-sharing to control healthcare expenditures is increasing, but there is scant information about patients' knowledge of cost-sharing or its influence on behavior...
Improving treatment intensification to reduce cardiovascular disease risk: a cluster randomized trialJoe V Selby
Patient Centered Outcomes Research Institute, Washington, DC, USA
BMC Health Serv Res 12:183. 2012..The purpose of this study is to evaluate provision of new information to non-physician outreach teams on need for treatment intensification in patients with increased CVD risk...
Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) StudyLisa A Croen
Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
Autism Res 1:130-7. 2008....
Trends in use of antidepressants, lithium, and anticonvulsants in Kaiser Permanente-insured youths, 1994-2003Enid M Hunkeler
Kaiser Permanente, Division of Research, Oakland, California 94612, USA
J Child Adolesc Psychopharmacol 15:26-37. 2005..Although the safety and efficacy of antidepressants in youths needs to be more firmly established, these findings may reflect progress in the diagnosis and treatment of mental illness...
Hazardous drinkers and drug users in HMO primary care: prevalence, medical conditions, and costsJennifer R Mertens
Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612, USA
Alcohol Clin Exp Res 29:989-98. 2005..However, little is known about the larger population of "hazardous" drinkers (those whose consumption increases their "risk of physical and psychological harm") and drug users...
Biologically plausible and evidence-based risk intervals in immunization safety researchAli Rowhani-Rahbar
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, United States
Vaccine 31:271-7. 2012..In addition, we review methodologic issues related to the determination of risk intervals for consideration in future studies of immunization safety...
A web-delivered care management and patient self-management program for recurrent depression: a randomized trialEnid M Hunkeler
Division of Research, The Permanente Medical Group, Inc, 2000 Broadway, Second Floor, Oakland, CA 94612, USA
Psychiatr Serv 63:1063-71. 2012..001), and more confidence in managing depression (p=.006). CONCLUSIONS Internet-delivered care management can help improve outcomes of patients treated for recurrent or chronic depression...
Dynamic marginal structural modeling to evaluate the comparative effectiveness of more or less aggressive treatment intensification strategies in adults with type 2 diabetesRomain Neugebauer
Division of Research, Kaiser Permanente Northern California, CA, USA
Pharmacoepidemiol Drug Saf 21:99-113. 2012....
Glycemic status and risk of prostate cancerJeanne A Darbinian
Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
Cancer Epidemiol Biomarkers Prev 17:628-35. 2008..To examine the risk of prostate cancer and glucose tolerance in a large, racially diverse cohort...
Time trends in therapies and outcomes for adult inflammatory bowel disease, Northern California, 1998-2005Lisa J Herrinton
Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
Gastroenterology 137:502-11. 2009..The management of inflammatory bowel disease (IBD) has become increasingly complicated, and it is unknown whether poor outcomes (prolonged steroid use, hospitalizations, and surgery) have declined in the general population...
Predicted quality-adjusted life years as a composite measure of the clinical value of diabetes risk factor controlJulie Schmittdiel
Kaiser Permanente Northern California Division of Research, Oakland, California 94612, USA
Med Care 45:315-21. 2007..These quality indicators often are examined separately and weighted equally in performance measurement, potentially discarding important information...
Lack of association between receipt of conjugate haemophilus influenzae type B vaccine (HbOC) in infancy and risk of type 1 (juvenile onset) diabetes: long term follow-up of the HbOC efficacy trial cohortSteven B Black
Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
Pediatr Infect Dis J 21:568-9. 2002..These children are now 10 to 12 years of age. We found no evidence that vaccination with Hib conjugate vaccine in infancy is associated with risk of diabetes later in life...
Validation of an algorithm for categorizing the severity of hospital emergency department visitsDustin W Ballard
Emergency Department, Kaiser Permanente San Rafael, San Rafael, CA 94903, USA
Med Care 48:58-63. 2010..The New York University Emergency Department (NYU ED) visit severity algorithm attempts to classify visits to the ED based on diagnosis, but it has not been formally validated...
Treatment decisions about lumbar herniated disk in a shared decision-making programPaul H Barrett
Clinical Research Unit, Kaiser Permanente of Colorado, 10350 E Dakota Ave, Denver, CO 80231 1314, USA
Jt Comm J Qual Improv 28:211-9. 2002..One such example is laminectomy for lumbar herniated disk (HD). An observational study was undertaken to evaluate the impact of an HD videodisk program on patient satisfaction, decision making, and treatment preferences...
Use of e-Health services between 1999 and 2002: a growing digital divideJohn Hsu
Kaiser Permanente Medical Care Program, Oakland, CA 94612, USA
J Am Med Inform Assoc 12:164-71. 2005..To evaluate the patterns of e-Health use over a four-year period and the characteristics of users...
A role for genetics in the immune response to the varicella vaccineNicola P Klein
Kaiser Permanente Vaccine Study Center and Division of Research, Oakland, CA 94612, USA
Pediatr Infect Dis J 26:300-5. 2007..A wide range in antibody titers has been found after immunization with the varicella vaccine, although the basis for these differences has not been described...
Psychiatric symptoms, impaired function, and medical care costs in an HMO settingEnid M Hunkeler
Kaiser Permanente Northern California Division of Research, Oakland, CA, USA
Gen Hosp Psychiatry 25:178-84. 2003..We conclude that depressed mood, persistent anxiety, and related impaired function are associated with substantial increases in the use and cost of general medical care...
Primary health care teams. Opportunities and challenges in evaluation of service delivery innovationsDouglas W Roblin
Kaiser Permanente, Atlanta, USA
J Ambul Care Manage 26:22-35; discussion 36-8. 2003..The article concludes with recommendations for evaluation of natural experiments in primary care redesign...
Maternal and paternal age and risk of autism spectrum disordersLisa A Croen
Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612, USA
Arch Pediatr Adolesc Med 161:334-40. 2007..To explore the association between maternal and paternal age and risk of autism spectrum disorders (ASDs) in offspring...
Patient choice. A randomized controlled trial of provider selectionJohn Hsu
Kaiser Permanente Division of Research JH, TS, BF, JS, Oakland, Calif, USA
J Gen Intern Med 18:319-25. 2003..To evaluate the impact of an intervention designed to help patients choose a new primary care provider (PCP) compared with the usual method of assigning patients to a new PCP...
Pneumococcal conjugate vaccine in childrenRobert L Davis
N Engl J Med 350:84-5; author reply 84-5. 2004
The prevalence, burden, and treatment of urinary incontinence among women in a managed care planKraig S Kinchen
Outcomes Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Womens Health (Larchmt) 16:415-22. 2007..We used survey and utilization data to determine the prevalence, burden, and treatment use for incontinence among women at Kaiser Permanente in Northern California...
Suicide risk in bipolar disorder during treatment with lithium and divalproexFrederick K Goodwin
Department of Psychiatry, George Washington University Medical Center, Washington, DC 20037, USA
JAMA 290:1467-73. 2003....
Risk of suicide attempt and suicide death in patients treated for bipolar disorderGregory E Simon
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
Bipolar Disord 9:526-30. 2007..To evaluate demographic and clinical predictors of suicide attempt and suicide death in a population-based sample of people treated for bipolar disorder (BD)...
Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimateX Henry Hu
Outcomes Research and Management, Merck and Co, Inc, West Point, PA 19486, USA
J Clin Psychiatry 65:959-65. 2004..Selective serotonin reuptake inhibitors (SSRIs) are widely used as the first-line treatment for depression. Information regarding their side effects is mostly based on controlled clinical trials...
