JOSHUA ISRAEL BARZILAY

Summary

Affiliation: Kaiser Permanente
Country: USA

Publications

  1. ncbi request reprint Cardiovascular disease in older adults with glucose disorders: comparison of American Diabetes Association criteria for diabetes mellitus with WHO criteria
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, Tucker 30084, USA
    Lancet 354:622-5. 1999
  2. ncbi request reprint Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders: the Cardiovascular Health Study
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, and Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 24:1233-9. 2001
  3. ncbi request reprint The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    Am J Kidney Dis 44:25-34. 2004
  4. pmc The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes
    Joshua I Barzilay
    Corresponding author Joshua I Barzilay
    Diabetes Care 37:1083-91. 2014
  5. doi request reprint The glycemic effects of antihypertensive medications
    Joshua I Barzilay
    Kaiser Permanente of Georgia, 3650 Steve Reynolds Blvd, Atlanta, GA, 30096, USA
    Curr Hypertens Rep 16:410. 2014
  6. ncbi request reprint Albuminuria is associated with hip fracture risk in older adults: the cardiovascular health study
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, Atlanta, GA, USA
    Osteoporos Int 24:2993-3000. 2013
  7. pmc Albuminuria and rapid loss of GFR and risk of new hip and pelvic fractures
    Joshua I Barzilay
    Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin J Am Soc Nephrol 8:233-40. 2013
  8. pmc Intensive blood pressure treatment does not improve cardiovascular outcomes in centrally obese hypertensive individuals with diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Blood Pressure Trial
    Joshua I Barzilay
    Kaiser Permanente of Georgia, USA
    Diabetes Care 35:1401-5. 2012
  9. ncbi request reprint Coronary artery disease in diabetic patients with lower-extremity arterial disease: disease characteristics and survival. A report from the Coronary Artery Surgery Study (CASS) registry
    J I Barzilay
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 20:1381-7. 1997
  10. ncbi request reprint Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, 200 Crescent Center Parkway, Tucker, GA 30084, USA
    Arch Intern Med 167:635-41. 2007

Research Grants

Detail Information

Publications34

  1. ncbi request reprint Cardiovascular disease in older adults with glucose disorders: comparison of American Diabetes Association criteria for diabetes mellitus with WHO criteria
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, Tucker 30084, USA
    Lancet 354:622-5. 1999
    ..We aimed to assess the sensitivity of these criteria for the detection of cardiovascular disease, the main complication of diabetes mellitus in the elderly...
  2. ncbi request reprint Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders: the Cardiovascular Health Study
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, and Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 24:1233-9. 2001
    ..However, there is little information regarding the prevalence of subclinical CVD and its relation to clinical CVD in diabetes and in the glucose disorders that precede diabetes...
  3. ncbi request reprint The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    Am J Kidney Dis 44:25-34. 2004
    ..Microalbuminuria is a risk factor for coronary heart disease (CHD). It occurs most commonly in the settings of diabetes and hypertension. The mechanisms by which it increases CHD risk are uncertain...
  4. pmc The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes
    Joshua I Barzilay
    Corresponding author Joshua I Barzilay
    Diabetes Care 37:1083-91. 2014
    ..There was a paradoxical increase in serum pentosidine levels suggestive of an increase in oxidative stress or decreased clearance of pentosidine precursor. ..
  5. doi request reprint The glycemic effects of antihypertensive medications
    Joshua I Barzilay
    Kaiser Permanente of Georgia, 3650 Steve Reynolds Blvd, Atlanta, GA, 30096, USA
    Curr Hypertens Rep 16:410. 2014
    ..Importantly, we show that the diabetogenic effects of older antihypertensive medications do not translate into increased cardiovascular disease risk. ..
  6. ncbi request reprint Albuminuria is associated with hip fracture risk in older adults: the cardiovascular health study
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, Atlanta, GA, USA
    Osteoporos Int 24:2993-3000. 2013
    ..Here, we examine whether albuminuria, a marker of renal microvascular disease, is associated with the risk of hip fracture in older adults (age, 78 years). We find a small independent association in women but not in men...
  7. pmc Albuminuria and rapid loss of GFR and risk of new hip and pelvic fractures
    Joshua I Barzilay
    Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin J Am Soc Nephrol 8:233-40. 2013
    ..The microvascular circulation plays an important role in bone health. This study examines whether albuminuria, a marker of renal microvascular disease, is associated with incident hip and pelvic fractures...
  8. pmc Intensive blood pressure treatment does not improve cardiovascular outcomes in centrally obese hypertensive individuals with diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Blood Pressure Trial
    Joshua I Barzilay
    Kaiser Permanente of Georgia, USA
    Diabetes Care 35:1401-5. 2012
    ..Many such individuals are centrally obese. Here we evaluate whether the trial outcomes varied by the level of central obesity...
  9. ncbi request reprint Coronary artery disease in diabetic patients with lower-extremity arterial disease: disease characteristics and survival. A report from the Coronary Artery Surgery Study (CASS) registry
    J I Barzilay
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 20:1381-7. 1997
    ....
  10. ncbi request reprint Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, 200 Crescent Center Parkway, Tucker, GA 30084, USA
    Arch Intern Med 167:635-41. 2007
    ..Our research group has previously shown that the geriatric syndrome of frailty is associated with features of the metabolic syndrome (MetS) on cross-sectional analysis...
  11. ncbi request reprint Antihypertensive medications and risk of diabetes mellitus
    Joshua I Barzilay
    Kaiser Permanente of Georgia and the Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    Curr Opin Nephrol Hypertens 16:256-60. 2007
    ..We also examine the impact of the glucose-sparing effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on preventing cardiovascular disease...
  12. pmc Albuminuria and dementia in the elderly: a community study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    Am J Kidney Dis 52:216-26. 2008
    ..In this study, we examine whether cognitive status (normal cognition, mild cognitive impairment, and dementia) is associated with albuminuria, a microvascular disorder of the kidney...
  13. pmc Insulin resistance is associated with decreased quadriceps muscle strength in nondiabetic adults aged >or=70 years
    Joshua I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 32:736-8. 2009
    ..Lower-limb muscle strength is reduced in many people with diabetes. In this study, we examined whether quadriceps muscle strength is reduced in relation to insulin resistance in well-functioning ambulatory nondiabetic individuals...
  14. doi request reprint Albuminuria and decline in cognitive function: The ONTARGET/TRANSCEND studies
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Emory University School of Medicine, Atlanta, USA
    Arch Intern Med 171:142-50. 2011
    ..Gaining an understanding of the concomitant history of these 2 conditions may inform clinical practice and lead to novel prevention and treatment approaches...
  15. pmc Effects of telmisartan on glucose levels in people at high risk for cardiovascular disease but free from diabetes: the TRANSCEND study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Atlanta, GA, USA
    Diabetes Care 34:1902-7. 2011
    ..Less is known about the effects of angiotensin receptor blockers (ARBs) on reducing incident diabetes or leading to regression of impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) to normoglycemia...
  16. ncbi request reprint The association of markers of inflammation with weight change in older adults: the Cardiovascular Health Study
    J I Barzilay
    Kaiser Permanente of Georgia and the Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30084, USA
    Int J Obes (Lond) 30:1362-7. 2006
    ..In this study, we examined whether inflammation factors are elevated in individuals, age >or=65 years, who lost or gained >5% weight over a 3 year follow-up period compared to those with stable weight...
  17. ncbi request reprint Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study
    Joshua I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    J Clin Hypertens (Greenwich) 6:116-25. 2004
    ....
  18. ncbi request reprint The association of fasting glucose levels with congestive heart failure in diabetic adults > or =65 years: the Cardiovascular Health Study
    Joshua I Barzilay
    Kaiser Permanente of Georgia and the Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Am Coll Cardiol 43:2236-41. 2004
    ..The purpose of this study was to determine if fasting glucose levels are an independent risk factor for congestive heart failure (CHF) in elderly individuals with diabetes mellitus (DM) with or without coronary heart disease (CHD)...
  19. ncbi request reprint The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, and the Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia 30084, USA
    Diabetes 50:2384-9. 2001
    ..Understanding the role of inflammation in the pathogenesis of glucose disorders in this age-group may lead to better classification and treatment of glucose disorders among them...
  20. ncbi request reprint Baseline characteristics of the diabetic participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, Tucker 30084, USA
    Diabetes Care 24:654-8. 2001
    ..Here we describe the characteristics of a cohort of hypertensive adults with diabetes who are part of a large prospective blood pressure study. This study will help clarify the treatment of HTN in the setting of diabetes...
  21. ncbi request reprint Inflammation and its association with glucose disorders and cardiovascular disease
    Joshua Barzilay
    Department of Medicine, Kaiser Permanente of Georgia, Tucker, Georgia 30084, USA
    Treat Endocrinol 2:85-94. 2003
    ..These data provide a new paradigm for understanding how insulin resistance, diabetes, and cardiovascular disease are related to one another. This paradigm also has the potential for opening up new areas of research and treatment...
  22. ncbi request reprint Fasting and 2-hour postchallenge serum glucose measures and risk of incident cardiovascular events in the elderly: the Cardiovascular Health Study
    Nicholas L Smith
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    Arch Intern Med 162:209-16. 2002
    ..This study examined the relative predictive power of fasting and 2-hour glucose level on cardiovascular event risk...
  23. ncbi request reprint Glucose, blood pressure, and lipid control in older people with and without diabetes mellitus: the Cardiovascular Health Study
    Nicholas L Smith
    Department of Medicine, Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Seattle, WA 98101, USA
    J Am Geriatr Soc 50:416-23. 2002
    ....
  24. pmc Adiponectin and risk of coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine and Public Health, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Clin Endocrinol Metab 93:3357-64. 2008
    ..Despite established insulin-sensitizing and antiatherogenic preclinical effects, epidemiological investigations of adiponectin have yielded conflicting findings, and its relationship with coronary heart disease (CHD) remains uncertain...
  25. ncbi request reprint The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: the Cardiovascular Health Study
    Jie J Cao
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Atherosclerosis 187:372-7. 2006
    ..It is not known whether this association is due to the effect of MA on the development of subclinical atherosclerosis or whether MA destabilizes subclinical atherosclerosis, leading to clinical events...
  26. doi request reprint Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study
    Phyllis K Stein
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Am Geriatr Soc 56:315-21. 2008
    ..To explore the relationship between (1) insulin resistance and inflammation factors with (2) higher heart rate (HR) and lower heart rate variability (HRV) in normoglycemic older adults...
  27. ncbi request reprint The relationship of fasting serum radioimmune insulin levels to incident coronary heart disease in an insulin-treated diabetic cohort
    Richard A Kronmal
    Department of Biostatistics, University of Washington, Seattle, Washington 98115, USA
    J Clin Endocrinol Metab 89:2852-8. 2004
    ..These observational findings should be confirmed through larger prospective studies, given their implications for insulin therapy...
  28. ncbi request reprint Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHA
    Joshua I Barzilay
    Kaiser Permanente of Georgia, USA
    Arch Intern Med 166:2191-201. 2006
    ....
  29. pmc Mortality in pharmacologically treated older adults with diabetes: the Cardiovascular Health Study, 1989-2001
    Richard A Kronmal
    Collaborative Heath Studies Coordinating Center and Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    PLoS Med 3:e400. 2006
    ..It is uncertain, however, whether excess DM mortality continues beyond age 75 years, is related to type of hypoglycemic therapy, and whether women continue to be disproportionately affected by DM into older age...
  30. ncbi request reprint New-onset diabetes and risk of all-cause and cardiovascular mortality: the Cardiovascular Health Study
    Nicholas L Smith
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    Diabetes Care 29:2012-7. 2006
    ..We hypothesized that risk of all-cause and cardiovascular mortality would be similar among participants with and without new-onset diabetes in the first years of follow-up and rise over time for new-onset diabetes...
  31. ncbi request reprint Prescribing patterns for thiazide diuretics in a large health maintenance organization: relationship to participation as an ALLHAT clinical center
    Diana B Petitti
    Kaiser Permanente Southern California, 393 E Walnut Street, Pasadena, 91188, USA
    Contemp Clin Trials 27:397-403. 2006
    ..8% to 13.0% in the two regions without an ALLHAT clinical site (p > 0.05). Participation in a clinical hypertension study does not appear to accelerate adoption of study recommendations...
  32. ncbi request reprint Metabolic syndrome and cardiovascular disease in older people: The cardiovascular health study
    Ann Marie McNeill
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    J Am Geriatr Soc 54:1317-24. 2006
    ....
  33. ncbi request reprint Thyroid hormone use and the risk of hip fracture in women > or = 65 years: a case-control study
    Stephen K Van Den Eeden
    Division of Research, Kaiser Permanente, Northern California, Oakland, California 94612, USA
    J Womens Health (Larchmt) 12:27-31. 2003
    ..There is controversy about whether thyroid hormone therapy may lead to osteoporosis, and less is known about the clinically more important end point of whether its use increases fracture risk...
  34. ncbi request reprint Longitudinal association between depressive symptoms and incident type 2 diabetes mellitus in older adults: the cardiovascular health study
    Mercedes R Carnethon
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    Arch Intern Med 167:802-7. 2007
    ..Prospective studies indicate that a single self-report of high depressive symptoms is associated with an increased risk of developing type 2 diabetes mellitus...

Research Grants1

  1. Salsalate: A Diabetes Treatment for Carbonyl, Oxidative & Nitrosative Stress
    JOSHUA ISRAEL BARZILAY; Fiscal Year: 2010
    ..If effective, this treatment could reduce the risk of heart attacks and strokes that frequently occur in people with diabetes. ..