Alexey Teplyakov

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi Crystal structure of the bacterial YhcH protein indicates a role in sialic acid catabolism
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland, USA
    J Bacteriol 187:5520-7. 2005
  2. ncbi Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Bacteriol 186:7134-40. 2004
  3. ncbi Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    J Bacteriol 185:4031-7. 2003
  4. ncbi Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Struct Funct Genomics 4:1-9. 2003
  5. ncbi Crystal structure of the Escherichia coli Tas protein, an NADP(H)-dependent aldo-keto reductase
    Galina Obmolova
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    Proteins 53:323-5. 2003
  6. ncbi Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 103:16218-23. 2006
  7. ncbi Crystal structure of the YffB protein from Pseudomonas aeruginosa suggests a glutathione-dependent thiol reductase function
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    BMC Struct Biol 4:5. 2004
  8. ncbi Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
    Jane E Ladner
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    BMC Struct Biol 3:7. 2003
  9. ncbi Crystal structure of the Escherichia coli YcdX protein reveals a trinuclear zinc active site
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    Proteins 51:315-8. 2003
  10. ncbi Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics
    Gary L Gilliland
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Curr Drug Targets Infect Disord 2:339-53. 2002

Detail Information

Publications21

  1. ncbi Crystal structure of the bacterial YhcH protein indicates a role in sialic acid catabolism
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland, USA
    J Bacteriol 187:5520-7. 2005
    ..A comparison to other proteins with a similar fold and analysis of the genomic context suggested that YhcH may be a sugar isomerase involved in processing of exogenous sialic acid...
  2. ncbi Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Bacteriol 186:7134-40. 2004
    ....
  3. ncbi Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    J Bacteriol 185:4031-7. 2003
    ..Taken together with other experimental data and genomic analysis, these results suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translation factor...
  4. ncbi Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Struct Funct Genomics 4:1-9. 2003
    ..This structural motif is a characteristic feature of many RNA-binding proteins. The tetrameric structure observed in the crystal suggests a possibility of binding two stretches of double-stranded nucleic acid...
  5. ncbi Crystal structure of the Escherichia coli Tas protein, an NADP(H)-dependent aldo-keto reductase
    Galina Obmolova
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    Proteins 53:323-5. 2003
  6. ncbi Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 103:16218-23. 2006
    ....
  7. ncbi Crystal structure of the YffB protein from Pseudomonas aeruginosa suggests a glutathione-dependent thiol reductase function
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    BMC Struct Biol 4:5. 2004
    ..The crystal structure determination of YffB was undertaken as part of a structural genomics effort in order to assist with the functional assignment of the protein...
  8. ncbi Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
    Jane E Ladner
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    BMC Struct Biol 3:7. 2003
    ..The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function...
  9. ncbi Crystal structure of the Escherichia coli YcdX protein reveals a trinuclear zinc active site
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    Proteins 51:315-8. 2003
  10. ncbi Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics
    Gary L Gilliland
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Curr Drug Targets Infect Disord 2:339-53. 2002
    ..In addition to aiding in functional assignment, this effort is identifying a number of possible new targets for drug development...
  11. ncbi Crystal structure of the petal death protein from carnation flower
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biochemistry 44:16377-84. 2005
    ..Models of bound substrates and comparison with the closed conformation of isocitrate lyase and 2-methylisocitrate lyase revealed the structural basis for the broad substrate profile of PDP...
  12. ncbi Promoting crystallization of antibody-antigen complexes via microseed matrix screening
    Galina Obmolova
    Centocor R and D, 145 King of Prussia Road, Radnor, PA 19087, USA
    Acta Crystallogr D Biol Crystallogr 66:927-33. 2010
    ....
  13. ncbi Coevolution of antibody stability and Vκ CDR-L3 canonical structure
    Jinquan Luo
    Centocor Research and Development, Inc, Radnor, PA 19087, USA
    J Mol Biol 402:708-19. 2010
    ....
  14. ncbi Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab
    Jinquan Luo
    Centocor Research and Development, Inc, 145 King of Prussia Road, Radnor, PA 19087, USA
    J Mol Biol 402:797-812. 2010
    ..Collectively, these data describe unique observations about IL-12p35 and ustekinumab interactions with p40 that account for its dual binding and neutralization of IL-12 and IL-23...
  15. ncbi On the domain pairing in chimeric antibodies
    Alexey Teplyakov
    Centocor R and D, Inc, 145 King of Prussia Road, Radnor, PA 19087, USA
    Mol Immunol 47:2422-6. 2010
    ..Comparison to the structures of the all-human and all-mouse constant domains indicates a remarkable plasticity of the inter-chain interface that can tolerate residue relocations of up to 6A...
  16. ncbi Structure-based engineering of a monoclonal antibody for improved solubility
    Sheng Jiun Wu
    Biologics Research, Centocor R and D, 145 King of Prussia Radnor, PA 19087 4557, USA
    Protein Eng Des Sel 23:643-51. 2010
    ..All three engineering approaches led to improved solubility and adding an N-linked carbohydrate to the CDR was the most effective route for enhancing the solubility of CNTO607...
  17. ncbi Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088
    Alexey Teplyakov
    Centocor R and D Inc, 145 King of Prussia Road, Radnor, PA 19087, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:229-32. 2010
    ..This makes CNTO4088 a benchmark case for developing prediction methods and structure-modeling tools...
  18. ncbi Epitope mapping of anti-interleukin-13 neutralizing antibody CNTO607
    Alexey Teplyakov
    Centocor R and D, Inc, Radnor, PA 19087, USA
    J Mol Biol 389:115-23. 2009
    ..This study confirmed the primary role of electrostatic interactions for antigen recognition...
  19. ncbi His-tag binding by antibody C706 mimics β-amyloid recognition
    Alexey Teplyakov
    Centocor R and D, 145 King of Prussia Road, Radnor, PA 19087, USA
    J Mol Recognit 24:570-5. 2011
    ..All three antibodies recognize the same immunodominant B-cell epitope of Aβ. By similarity, residues Phe-Arg-His of Aβ would be a major portion of the C706 epitope...
  20. ncbi Crystal structure of the YjeE protein from Haemophilus influenzae: a putative Atpase involved in cell wall synthesis
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Proteins 48:220-6. 2002
    ..The distribution of conserved residues suggests that the protein may work as a "molecular switch" triggered by ATP hydrolysis. The phylogenetic pattern of YjeE suggests its involvement in cell wall biosynthesis...
  21. ncbi From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland, Rockville 20850, USA
    Nat Prod Rep 19:60-9. 2002
    ..coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes...