Michael D Southall

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes
    Michael D Southall
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 304:217-22. 2003
  2. ncbi The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines
    Tao Li
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:16614-21. 2003
  3. ncbi Identification of platelet-activating factor acetylhydrolase II in human skin
    Mariangela Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, U S A
    J Invest Dermatol 119:913-9. 2002
  4. ncbi Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma
    Steven D Billings
    Departments of Pathology and Laboratory Medicine and Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 163:2451-8. 2003
  5. ncbi Epidermal peroxisome proliferator-activated receptor gamma as a target for ultraviolet B radiation
    Qiwei Zhang
    Department of Dermatology, Indiana University School of Medicine, Indinapolis, Indiana 46202, USA
    J Biol Chem 280:73-9. 2005
  6. ncbi The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway
    Silvio A Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Pharmacol Exp Ther 300:1026-35. 2002
  7. ncbi Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage
    Gopal K Marathe
    Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 280:35448-57. 2005
  8. ncbi Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signaling
    Runa Sur
    Preclinical Pharmacology, Johnson and Johnson Skin Research Center, CPPW, a Unit of Johnson and Johnson Consumer Companies Inc, Skillman, New Jersey 08558, USA
    J Invest Dermatol 128:1116-22. 2008
  9. ncbi Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway
    Runa Sur
    Preclinical Pharmacology, Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson and Johnson Consumer Companies, Inc, Skillman, New Jersey 08558, USA
    J Invest Dermatol 128:336-44. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes
    Michael D Southall
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 304:217-22. 2003
    ..Our results suggest that VR1 expression in keratinocytes may have a role in the inflammation that occurs secondary to epidermal damage or insult, and thus may function as a sensor for noxious cutaneous stimulation...
  2. ncbi The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines
    Tao Li
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:16614-21. 2003
    ..These studies provide evidence for a novel pathway whereby the epidermal PAF-R can augment chemotherapy-induced apoptotic effects through an NF-kappaB-dependent process...
  3. ncbi Identification of platelet-activating factor acetylhydrolase II in human skin
    Mariangela Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, U S A
    J Invest Dermatol 119:913-9. 2002
    ....
  4. ncbi Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma
    Steven D Billings
    Departments of Pathology and Laboratory Medicine and Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 163:2451-8. 2003
    ..The HaCaT-NIE cells formed thin tumors resembling conventional SCC. The HaCaT-AR cells formed rapidly growing tumors with AR expression similar to KA. HaCaT-AR cells may represent a new system for the further evaluation of KA...
  5. ncbi Epidermal peroxisome proliferator-activated receptor gamma as a target for ultraviolet B radiation
    Qiwei Zhang
    Department of Dermatology, Indiana University School of Medicine, Indinapolis, Indiana 46202, USA
    J Biol Chem 280:73-9. 2005
    ..These studies demonstrated that epithelial cells contain a functional PPAR gamma system, and this system is a target for UVB through the production of novel oxidatively modified endogenous phospholipids...
  6. ncbi The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway
    Silvio A Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Pharmacol Exp Ther 300:1026-35. 2002
    ..In summary, these studies provide a mechanism whereby the PAF-R can exert proliferative effects through the activation of the EGF-R...
  7. ncbi Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage
    Gopal K Marathe
    Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 280:35448-57. 2005
    ..PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses...
  8. ncbi Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signaling
    Runa Sur
    Preclinical Pharmacology, Johnson and Johnson Skin Research Center, CPPW, a Unit of Johnson and Johnson Consumer Companies Inc, Skillman, New Jersey 08558, USA
    J Invest Dermatol 128:1116-22. 2008
    ..Thus, Hsp27 plays a protective role in regulating inflammatory responses in skin...
  9. ncbi Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway
    Runa Sur
    Preclinical Pharmacology, Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson and Johnson Consumer Companies, Inc, Skillman, New Jersey 08558, USA
    J Invest Dermatol 128:336-44. 2008
    ..Biochemical analysis of tissue biopsies revealed increase in PGE2 levels in sertaconazole-treated mice. Thus, activation of the p38-COX-2-PGE2 pathway by agents such as sertaconazole provides anti-inflammatory therapeutic benefits...