Ning Qin

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit
    Ning Qin
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477 0776, USA
    Mol Pharmacol 62:485-96. 2002
  2. ncbi Attenuated cold sensitivity in TRPM8 null mice
    Raymond W Colburn
    Analgesics Team, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, PA 19477 0776, USA
    Neuron 54:379-86. 2007
  3. ncbi Inhibition of the rat brain sodium channel Nav1.2 after prolonged exposure to gabapentin
    Yi Liu
    Analgesics Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477 0776, USA
    Epilepsy Res 70:263-8. 2006
  4. doi A novel series of pyrazolylpiperidine N-type calcium channel blockers
    Nalin L Subasinghe
    Janssen Research and Development, L L C, Welsh and McKean Roads, Spring House, PA 19477, USA
    Bioorg Med Chem Lett 22:4080-3. 2012
  5. ncbi Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine
    Yi Liu
    Analgesics Research Team, Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477 0776, USA
    Eur J Pharmacol 530:23-32. 2006
  6. doi TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons
    Ning Qin
    Analgesics Team, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477 0776, USA
    J Neurosci 28:6231-8. 2008
  7. doi An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists
    Michael F A Finley
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania, USA
    Assay Drug Dev Technol 8:685-94. 2010
  8. doi Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists
    Daniel J Parks
    Janssen Research and Development, Spring House, Pennsylvania 19477 0776, United States
    J Med Chem 54:233-47. 2011
  9. ncbi A nonadherent cell-based HTS assay for N-type calcium channel using calcium 3 dye
    Mary Lou Lubin
    Johnson and Johnson PRD, Spring House, PA 19477, USA
    Assay Drug Dev Technol 4:689-94. 2006
  10. ncbi Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit
    Ning Qin
    Department of Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA
    Eur J Biochem 270:4762-70. 2003

Collaborators

Detail Information

Publications17

  1. ncbi Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit
    Ning Qin
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477 0776, USA
    Mol Pharmacol 62:485-96. 2002
    ..Whether the alpha(2)delta-4 subunit plays a distinct physiological role in select endocrine tissues remains to be demonstrated...
  2. ncbi Attenuated cold sensitivity in TRPM8 null mice
    Raymond W Colburn
    Analgesics Team, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, PA 19477 0776, USA
    Neuron 54:379-86. 2007
    ..These results suggest that TRPM8 may play an important role in certain types of cold-induced pain in humans...
  3. ncbi Inhibition of the rat brain sodium channel Nav1.2 after prolonged exposure to gabapentin
    Yi Liu
    Analgesics Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477 0776, USA
    Epilepsy Res 70:263-8. 2006
    ..These effects provide a mechanistic basis for the inhibition of Na(+)-dependent repetitive firing upon prolonged exposure to gabapentin and may contribute to its anticonvulsant activity...
  4. doi A novel series of pyrazolylpiperidine N-type calcium channel blockers
    Nalin L Subasinghe
    Janssen Research and Development, L L C, Welsh and McKean Roads, Spring House, PA 19477, USA
    Bioorg Med Chem Lett 22:4080-3. 2012
    ..In vivo efficacy in rat models of inflammatory and neuropathic pain was demonstrated by a representative compound from this series...
  5. ncbi Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine
    Yi Liu
    Analgesics Research Team, Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477 0776, USA
    Eur J Pharmacol 530:23-32. 2006
    ..6 mM at -100 mV). These results constitute the first study of cTRPM8 and support the idea that cTRPM8 functions as a transducer of cold stimuli in vivo...
  6. doi TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons
    Ning Qin
    Analgesics Team, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477 0776, USA
    J Neurosci 28:6231-8. 2008
    ..Together, these data suggest not only that TRPV2 may comprise a mechanism whereby cannabidiol exerts its clinically beneficial effects in vivo, but also that TRPV2 may constitute a viable, new drug target...
  7. doi An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists
    Michael F A Finley
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania, USA
    Assay Drug Dev Technol 8:685-94. 2010
    ..This integrated approach provides a more comprehensive evaluation of small-molecule N-type inhibitors that may lead to improved therapeutic pharmacology...
  8. doi Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists
    Daniel J Parks
    Janssen Research and Development, Spring House, Pennsylvania 19477 0776, United States
    J Med Chem 54:233-47. 2011
    ..Taken together, the present results suggest that the in vivo antagonism of TRPM8 constitutes a viable new strategy for treating a variety of disorders associated with cold hypersensitivity, including certain types of neuropathic pain...
  9. ncbi A nonadherent cell-based HTS assay for N-type calcium channel using calcium 3 dye
    Mary Lou Lubin
    Johnson and Johnson PRD, Spring House, PA 19477, USA
    Assay Drug Dev Technol 4:689-94. 2006
    ..6), and minimal handling of the cells. Thus, this assay can be used to reliably and efficiently screen large compound libraries in the search for small molecule N-type calcium channel blockers...
  10. ncbi Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit
    Ning Qin
    Department of Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA
    Eur J Biochem 270:4762-70. 2003
    ..2, without significantly changing voltage dependent kinetics and steady-state properties, thus distinguishing it from the human beta1 and rat beta1A subunits...
  11. ncbi Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence
    Michael P Neeper
    Analgesics Team, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, Pennsylvania 19477 0776, USA
    J Biol Chem 282:15894-902. 2007
    ....
  12. doi Development and validation of a secondary screening assay for TRPM8 antagonists using QPatch HT
    Edward J Beck
    Analgesics Drug Discovery, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development L L C, Welsh and McKean Roads, P O Box 776, Spring House, PA 19477 0776, USA
    Assay Drug Dev Technol 8:63-72. 2010
    ..Our results validate the use of QPatch HT for secondary screening of TRPM8 antagonists and, along with other recent studies, illustrate its utility as an important tool for ion channel drug discovery...
  13. ncbi Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention
    Ning Qin
    Analgesics, Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, P O Box 776, Welsh and McKean Roads, Spring House, PA 19477 0776, USA
    J Pharmacol Exp Ther 315:1298-305. 2005
    ..Accordingly, we conclude that intron 1-retained human COX-1 is not likely to be the therapeutic target of acetaminophen or a candidate of COX-3...
  14. doi TRPM8 in health and disease: cold sensing and beyond
    Yi Liu
    Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA 92121, USA
    Adv Exp Med Biol 704:185-208. 2011
    ....
  15. doi Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists
    Bin Zhu
    Janssen Research and Development, L L C, Welsh and McKean Roads, Spring House, PA 19477, USA
    Bioorg Med Chem Lett 23:2234-7. 2013
    ..TRPM8 antagonists of the type described here may be useful in treating pain conditions wherein cold hypersensitivity is a dominant feature...
  16. doi Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies
    Michael H Parker
    Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477 0776, USA
    J Med Chem 52:7528-36. 2009
    ..Mechanistically, 4a inhibited voltage-gated Na(+) channels and N-type Ca(2+) channels but was not effective as a K(+) channel opener. The pharmacokinetics and metabolic properties of 4a are discussed...
  17. ncbi Ca2+-sensitive regulation of E-type Ca2+ channel activity depends on an arginine-rich region in the cytosolic II-III loop
    Jérôme Leroy
    Institute of Neurophysiology, Institute of Vegetative Physiology, University of Cologne, Robert Koch Strasse 39, D 50931 Köln, Germany
    Eur J Neurosci 18:841-55. 2003
    ..As a positive feedback-regulation of channel activity this novel activation mechanism might determine specific biological functions of E-type Ca2+ channels...