Marc Mercken

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi request reprint Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis
    Paul M Mathews
    Nathan Kline Institute and New York University School of Medicine, Orangeburg, New York 10962, USA
    J Biol Chem 277:5299-307. 2002
  2. ncbi request reprint Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein
    Stefan Pype
    Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica, Turnhoutseweg, Beerse, Belgium
    J Neurochem 84:602-9. 2003
  3. ncbi request reprint Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease
    Kangning Liu
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acta Neuropathol 112:163-74. 2006
  4. ncbi request reprint Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors
    Mohammed El Mouedden
    Johnson and Johnson Pharma ceutical Research and Development, Division of Janssen Pharmaceutica NV, Beerse, Belgium
    Curr Pharm Des 12:671-6. 2006
  5. ncbi request reprint Comparison of two different methods for measurement of amyloid-β peptides in cerebrospinal fluid after BACE1 inhibition in a dog model
    Herman Borghys
    Janssen Research and Development, Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium
    J Alzheimers Dis 38:39-48. 2014
  6. doi request reprint Analogues of morphanthridine and the tear gas dibenz[b,f][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel
    Harrie J M Gijsen
    Medicinal Chemistry Department, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
    J Med Chem 53:7011-20. 2010
  7. ncbi request reprint P2X currents in peritoneal macrophages of wild type and P2X4 -/- mice
    Bert Brône
    Gobal Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B2340 Beerse, Belgium
    Immunol Lett 113:83-9. 2007
  8. ncbi request reprint Method for the determination of the levels of beta-amyloid peptide in the CSF sampled from freely moving rats
    Mohammed El Mouedden
    Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Pharmacol Toxicol Methods 52:229-33. 2005
  9. doi request reprint Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators
    François Bischoff
    Janssen Research and Development, Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium
    J Med Chem 55:9089-106. 2012
  10. doi request reprint A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators
    Herman Borghys
    Janssen Research and Development, Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium
    J Alzheimers Dis 28:809-22. 2012

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis
    Paul M Mathews
    Nathan Kline Institute and New York University School of Medicine, Orangeburg, New York 10962, USA
    J Biol Chem 277:5299-307. 2002
    ....
  2. ncbi request reprint Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein
    Stefan Pype
    Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica, Turnhoutseweg, Beerse, Belgium
    J Neurochem 84:602-9. 2003
    ....
  3. ncbi request reprint Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease
    Kangning Liu
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acta Neuropathol 112:163-74. 2006
    ..The detection of Abeta11-42 in young DS brain suggests an early role for this N-terminally truncated Abeta peptide in the pathogenesis of SPs in AD and DS...
  4. ncbi request reprint Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors
    Mohammed El Mouedden
    Johnson and Johnson Pharma ceutical Research and Development, Division of Janssen Pharmaceutica NV, Beerse, Belgium
    Curr Pharm Des 12:671-6. 2006
    ..We can conclude that our data establish the usefulness of the wild-type rat model for testing small-molecule inhibitors of Abeta production...
  5. ncbi request reprint Comparison of two different methods for measurement of amyloid-β peptides in cerebrospinal fluid after BACE1 inhibition in a dog model
    Herman Borghys
    Janssen Research and Development, Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium
    J Alzheimers Dis 38:39-48. 2014
    ..This increases variability in the concentration of Aβ peptide measured with UPLC-MS/MS, especially for Aβ1-42, potentially masking the compound effect on Aβ1-42 levels. ..
  6. doi request reprint Analogues of morphanthridine and the tear gas dibenz[b,f][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel
    Harrie J M Gijsen
    Medicinal Chemistry Department, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
    J Med Chem 53:7011-20. 2010
    ....
  7. ncbi request reprint P2X currents in peritoneal macrophages of wild type and P2X4 -/- mice
    Bert Brône
    Gobal Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B2340 Beerse, Belgium
    Immunol Lett 113:83-9. 2007
    ..We conclude that the P2X(4) and P2X(7) currents are functionally expressed in recruited peritoneal macrophages of WT mice and that the P2X(4)-like current is absent in P2X(4)(-/-) mice...
  8. ncbi request reprint Method for the determination of the levels of beta-amyloid peptide in the CSF sampled from freely moving rats
    Mohammed El Mouedden
    Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Pharmacol Toxicol Methods 52:229-33. 2005
    ..In the present study, a model was developed to determine the effect of secretase inhibition on beta-amyloid peptide (Abeta) levels in the cerebrospinal fluid (CSF) of freely moving adult rats...
  9. doi request reprint Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators
    François Bischoff
    Janssen Research and Development, Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium
    J Med Chem 55:9089-106. 2012
    ....
  10. doi request reprint A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators
    Herman Borghys
    Janssen Research and Development, Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium
    J Alzheimers Dis 28:809-22. 2012
    ..Based on our data, we can conclude that the dog is a very appropriate species to assess efficacy and safety of compounds which have an effect on AβPP processing such as GSMs, GSIs, and BACE-inhibitors...
  11. pmc Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
    W Haung Yu
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    J Cell Biol 171:87-98. 2005
    ..Our results, therefore, link beta-amyloidogenic and cell survival pathways through macroautophagy, which is activated and is abnormal in AD...
  12. ncbi request reprint Development of a specific ELISA for the quantitative study of amino-terminally truncated beta-amyloid peptides
    Mohammed El Mouedden
    Johnson and Johnson Pharmaceutical Research and Development, Division of Janssen Pharmaceutica N V, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Neurosci Methods 145:97-105. 2005
    ..The assay has the sensitivity, selectivity and dynamic range to allow specific, direct quantitation of truncated Abeta11 peptides in cell culture medium, cerebrospinal fluid and brain tissue extracts...
  13. ncbi request reprint Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo
    Mark Burns
    Center for Dementia Research, Nathan S Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 23:5645-9. 2003
    ..Our results show that aberrant cholesterol trafficking is associated with the potentiation of APP processing components in vivo, leading to an overall increase in Abeta levels...
  14. ncbi request reprint Extracellular amyloid formation and associated pathology in neural grafts
    Melanie Meyer-Luehmann
    Department of Neuropathology, Institute of Pathology, University of Basel, Schonbeinstrasse 40, CH 4003 Basel, Switzerland
    Nat Neurosci 6:370-7. 2003
    ..Our results indicate that diffusion of soluble Abeta in the extracellular space is involved in the spread of Abeta pathology, and that extracellular amyloid formation can lead to neurodegeneration...
  15. ncbi request reprint Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments
    Paul M Mathews
    Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Biol Chem 277:36415-24. 2002
    ....
  16. ncbi request reprint Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
    Anne M Cataldo
    Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurobiol Aging 25:1263-72. 2004
    ....
  17. ncbi request reprint Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo
    Rime Madani
    Institute of Anatomy, University of Zurich, Zurich, Switzerland
    J Neurosci Res 84:1871-8. 2006
    ....
  18. ncbi request reprint No endogenous A beta production in presenilin-deficient fibroblasts
    Omar Nyabi
    Nat Cell Biol 4:E164; author reply E165-6. 2002