James C Lanter

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi request reprint Structure-activity relationships of N-acyl pyrroloquinolone PDE-5 inhibitors
    James C Lanter
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development LLC, 1000 Route 202 S, P O Box 300, Raritan, New Jersey 08869, USA
    J Med Chem 47:656-62. 2004
  2. ncbi request reprint beta-Alkylthio indolyl carbinols: potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development L L C, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:2545-8. 2007
  3. ncbi request reprint Asymmetric aza-Mannich reactions of sulfinimines: scope and application to the total synthesis of a bromopyrrole alkaloid
    James C Lanter
    Department of Medicinal Chemisty, Johnson and Johnson Pharmaceutical Research and Development, 1000 Route 202S, Raritan, New Jersey 08869, USA
    Org Lett 7:5905-7. 2005
  4. ncbi request reprint A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development L L C, 1000 Route 202 S, Raritan, NJ 08869, USA
    Bioorg Med Chem Lett 16:5646-9. 2006
  5. ncbi request reprint The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development L L C, 666 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:123-6. 2007
  6. ncbi request reprint 2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists
    Raymond A Ng
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Drug Discovery, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:955-8. 2007
  7. ncbi request reprint Synthesis of potent and tissue-selective androgen receptor modulators (SARMs): 2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold
    Raymond A Ng
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Drug Discovery, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:1784-7. 2007
  8. ncbi request reprint Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction
    Weiqin Jiang
    Johnson and Johnson Pharmaceutical Research and Development L L C, 1000 Route 202 South, P O Box 300, Raritan, New Jersey 08869, USA
    J Med Chem 46:441-4. 2003
  9. ncbi request reprint Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives
    Raymond A Ng
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Drug Discovery, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:784-8. 2007
  10. ncbi request reprint Silicon-directed oxa-Pictet-Spengler cyclization and an unusual dimerization of 2-trimethylsilanyl tryptophols
    Xuqing Zhang
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, New Jersey 08869, USA
    Org Lett 7:2043-6. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Structure-activity relationships of N-acyl pyrroloquinolone PDE-5 inhibitors
    James C Lanter
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development LLC, 1000 Route 202 S, P O Box 300, Raritan, New Jersey 08869, USA
    J Med Chem 47:656-62. 2004
    ..This compound also displayed in vivo efficacy in an anesthetized canine model of erection when dosed intravenously...
  2. ncbi request reprint beta-Alkylthio indolyl carbinols: potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development L L C, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:2545-8. 2007
    ..Through these efforts we identified a compound with potent oral in vivo efficacy in both immature and mature rat prostate weight reduction models and in a murine xenograft prostate cancer model...
  3. ncbi request reprint Asymmetric aza-Mannich reactions of sulfinimines: scope and application to the total synthesis of a bromopyrrole alkaloid
    James C Lanter
    Department of Medicinal Chemisty, Johnson and Johnson Pharmaceutical Research and Development, 1000 Route 202S, Raritan, New Jersey 08869, USA
    Org Lett 7:5905-7. 2005
    ..Application of this methodology to the total synthesis of a natural product is reported...
  4. ncbi request reprint A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development L L C, 1000 Route 202 S, Raritan, NJ 08869, USA
    Bioorg Med Chem Lett 16:5646-9. 2006
    ..Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain...
  5. ncbi request reprint The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development L L C, 666 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:123-6. 2007
    ..Through the use of this paradigm, we were able to identify compounds that exhibited in vivo potency equal to that of the marketed antiandrogen Casodex when orally administered...
  6. ncbi request reprint 2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists
    Raymond A Ng
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Drug Discovery, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:955-8. 2007
    ..SAR studies led to the discovery of 4-bromo-benzyl benzimidazole 17 as a more potent androgen receptor antagonist in the rat prostate (ID(50)=0.13mg/day), compared with bicalutamide (ID(50)=0.23mg/day)...
  7. ncbi request reprint Synthesis of potent and tissue-selective androgen receptor modulators (SARMs): 2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold
    Raymond A Ng
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Drug Discovery, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:1784-7. 2007
    ..03-0.11 mg/day). True SARMs showing both prostate antagonism and levator ani agonism were revealed...
  8. ncbi request reprint Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction
    Weiqin Jiang
    Johnson and Johnson Pharmaceutical Research and Development L L C, 1000 Route 202 South, P O Box 300, Raritan, New Jersey 08869, USA
    J Med Chem 46:441-4. 2003
    ..Incorporation of solublizing groups resulted in bioavailable analogues. Selected compounds showed in vivo efficacy in anesthetized dog model for penile erection...
  9. ncbi request reprint Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives
    Raymond A Ng
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Drug Discovery, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:784-8. 2007
    ..During screening of 2-alkyl benzimidazoles, it was found that a trifluoromethyl group greatly enhances antagonist activity in the prostate. Benzimidazole 1 is a potent AR antagonist in the rat prostate (ID50 = 0.15 mg/day)...
  10. ncbi request reprint Silicon-directed oxa-Pictet-Spengler cyclization and an unusual dimerization of 2-trimethylsilanyl tryptophols
    Xuqing Zhang
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, New Jersey 08869, USA
    Org Lett 7:2043-6. 2005
    ..An unusual reaction led to the dimeric products 7 when some of 5 was treated with acetone using BF(3) as the catalyst...
  11. doi request reprint Recent advances in the development of selective androgen receptor modulators
    Xuqing Zhang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Drug Discovery, Rm 42 3502, Welsh and McKean Roads, Spring House, PA 19477, USA
    Expert Opin Ther Pat 19:1239-58. 2009
    ..A new class of molecules targeting androgen receptors called selective androgen receptor modulators is being developed, analogous to the clinically successful and at present marketed selective estrogen receptor modulators...
  12. doi request reprint Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA
    Chem Commun (Camb) 46:1347-9. 2010
    ....
  13. doi request reprint The discovery of novel cyclohexylamide CCR2 antagonists
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, PA 19002, USA
    Bioorg Med Chem Lett 21:7496-501. 2011
    ..While having some in vitro hERG activity, this molecule was clean in an in vivo model of QT prolongation. In addition, it showed excellent efficacy when dosed orally in a transgenic murine model of acute inflammation...