Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Vlaminck J, Lagatie O, Verheyen A, Dana D, Van Dorst B, Mekonnen Z, et al
. Patent infections with soil-transmitted helminths and Schistosoma mansoni are not associated with increased prevalence of antibodies to the Onchocerca volvulus peptide epitopes OvMP-1 and OvMP-23. Parasit Vectors. 2019;12:63 pubmed publisher
..This study demonstrates that a patent infection with either soil-transmitted helminths or S. mansoni does not lead to increased antibody recognition of both OvMP-1 and OvMP23. ..
Lagatie O, Tritsmans L, Stuyver L. The miRNA world of polyomaviruses. Virol J. 2013;10:268 pubmed publisher
..We also give an overview of the current understanding on how host miRNAs may function in controlling polyomavirus replication, immune evasion and pathogenesis. ..
Lagatie O, Van Loy T, Tritsmans L, Stuyver L. Antibodies reacting with JCPyV_VP2 _167-15mer as a novel serological marker for JC polyomavirus infection. Virol J. 2014;11:174 pubmed publisher
..No correlation could be observed with JCPyV VP1 antibody levels, or urinary viral load. This work indicates that specific antibodies against JCPyV_VP2_167-15mer might be considered as a novel serological marker for infection with JCPyV. ..
Lagatie O, Njumbe Ediage E, Batsa Debrah L, Diels L, Nolten C, Vinken P, et al
. Evaluation of the diagnostic potential of urinary N-Acetyltyramine-O,?-glucuronide (NATOG) as diagnostic biomarker for Onchocerca volvulus infection. Parasit Vectors. 2016;9:302 pubmed publisher
..05). Results of the present study indicate the limited potential of NATOG as a diagnostic biomarker for O. volvulus infection in amicrofilaridermic individuals. ..
Lagatie O, Njumbe Ediage E, Pikkemaat J, Djuardi Y, Stuyver L. 2-methyl butyramide, a previously identified urine biomarker for Ascaris lumbricoides, is not present in infected Indonesian individuals. Parasit Vectors. 2017;10:629 pubmed publisher
..Urine samples used in this study were collected as part of a clinical trial with trial number ISRCTN75636394 (12 November 2013). ..
Lagatie O, Van Loy T, Tritsmans L, Stuyver L. Viral miRNAs in plasma and urine divulge JC polyomavirus infection. Virol J. 2014;11:158 pubmed publisher
..Also, our data indicate higher infection rates than would be expected from serology alone. ..
Lagatie O, Merino M, Batsa Debrah L, Debrah A, Stuyver L. An isothermal DNA amplification method for detection of Onchocerca volvulus infection in skin biopsies. Parasit Vectors. 2016;9:624 pubmed
..2% and a specificity of 99.2%. We have developed a sensitive and specific loop-mediated amplification method for detection of O. volvulus DNA in skin biopsies that is capable of providing results within 30 min. ..
Lagatie O, Batsa Debrah L, Debrah A, Stuyver L. Plasma-derived parasitic microRNAs have insufficient concentrations to be used as diagnostic biomarker for detection of Onchocerca volvulus infection or treatment monitoring using LNA-based RT-qPCR. Parasitol Res. 2017;116:1013-1022 pubmed publisher
..Our data indicate that parasitic miRNAs are not present in circulation at a sufficiently high level to be used as biomarker for O. volvulus infection or treatment monitoring using LNA-based RT-qPCR analysis. ..