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The oxidation of methionine-54 of epoetinum alfa does not affect molecular structure or stability, but does decrease biological activitySteven R LaBrenz
Pharmaceutical Technology, Global Biologics Supply Chain, LLC, 200 Great Valley Parkway, Malvern, PA 19355, USA
PDA J Pharm Sci Technol 62:211-23. 2008..Oxidation can affect potency, but only at levels significantly in excess of those seen in EPREX...
