Fred De Clerck

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi request reprint In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis
    Fred De Clerck
    Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Clin Ther 26:1261-73. 2004
  2. ncbi request reprint Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors
    J Ignacio Andrés
    Janssen Cilag, Basic Research Centre, Jarama s n, 45007, Toledo, Spain
    Bioorg Med Chem Lett 12:653-8. 2002
  3. ncbi request reprint In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity
    Fred De Clerck
    Center of Excellence for Cardiovascular Safety Research, Janssen Research Foundation, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Fundam Clin Pharmacol 16:125-40. 2002
  4. ncbi request reprint Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations
    Hua Rong Lu
    Center of Excellence for Cardiovascular Safety Research, Johnson and Johnson Pharmaceutical Research and Development, a division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Eur J Pharmacol 452:183-92. 2002
  5. pmc Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Respir Res 7:58. 2006
  6. ncbi request reprint In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine)
    Paul A J Janssen
    Center for Molecular Design, Janssen Pharmaceutica, B 2350 Vosselaar, Belgium
    J Med Chem 48:1901-9. 2005
  7. ncbi request reprint Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs
    Jean Pierre Valentin
    Safety Assessment UK, AstraZeneca, Mereside Alderley Park, Macclessfield, Cheshire, England, UK
    J Pharmacol Toxicol Methods 49:171-81. 2004
  8. ncbi request reprint Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Lab Invest 84:29-40. 2004
  9. ncbi request reprint Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 476:151-7. 2003
  10. ncbi request reprint Detection of proarrhythmia in the female rabbit heart: blinded validation
    Luc M Hondeghem
    Department of Pharmacology, K U Leuven, Leuven, Belgium
    J Cardiovasc Electrophysiol 14:287-94. 2003

Collaborators

  • Hua Rong Lu
  • Marielle Eerdekens
  • Javier Fernandez
  • Jean Van Wauwe
  • L M Hondeghem
  • Rudi Pauwels
  • Peter Hoffmann
  • John Camm
  • Jan Heeres
  • Robert Ten Broeke
  • Gert Folkerts
  • Thea Leusink-Muis
  • Frans P Nijkamp
  • Paul A J Janssen
  • Ingrid Van Ark
  • Jean Pierre Valentin
  • Matteo Villain
  • J Edwin Blalock
  • Joris Kloek
  • J Ignacio Andrés
  • Rini de Crom
  • Rien van Haperen
  • Vivienne Verweij
  • Art D Clark
  • Paul J Lewi
  • Don Ludovici
  • Ann Lampo
  • Hilde Bohets
  • Luc Koymans
  • Mike Kukla
  • Jerome Guillemont
  • Marc de Jonge
  • Peter Williams
  • Paul Stoffels
  • Kalyan Das
  • Marie Pierre de Béthune
  • Eddy Arnold
  • Koen Andries
  • Maarten Vinkers
  • Bart Medaer
  • Stephen H Hughes
  • Elisabeth Pasquier
  • Frits Daeyaert
  • Fons De Knaep
  • Yulia Volovik Frenkel
  • Rogier Hilberdink
  • Tim G Hammond
  • Edwin van den Worm
  • Marcel C Brandhorst
  • Frans Nijkamp
  • Anton Megens
  • Gaston Diels
  • Paul Stoppie
  • Danielle Peeters
  • Pedro Martinez
  • Nanne Bloksma
  • Gustaaf Boeckx
  • Adolfo Díaz
  • Eddy J Freyne
  • Didier de Chaffoy
  • Laura Iturrino
  • Jose M Alonso
  • Encarna Matesanz
  • Davy Petit
  • Marijke Somers
  • Marina Cools
  • Frederik Deroose

Detail Information

Publications12

  1. ncbi request reprint In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis
    Fred De Clerck
    Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Clin Ther 26:1261-73. 2004
    ..Thrombotic events have been reported with the use of antipsychotic compounds, although the incidence, predisposing factors, and biological mechanisms associated with these events in psychiatric patients are subject to debate...
  2. ncbi request reprint Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors
    J Ignacio Andrés
    Janssen Cilag, Basic Research Centre, Jarama s n, 45007, Toledo, Spain
    Bioorg Med Chem Lett 12:653-8. 2002
    ..Several compounds proved to be potent PDE4 inhibitors and some 2-cyanoiminoimidazoles showed less pronounced gastro-intestinal side effects than reference compounds but maintained anti-inflammatory activity after topical administration...
  3. ncbi request reprint In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity
    Fred De Clerck
    Center of Excellence for Cardiovascular Safety Research, Janssen Research Foundation, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Fundam Clin Pharmacol 16:125-40. 2002
    ..Appropriate tests in experimental animals play a key role in this process...
  4. ncbi request reprint Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations
    Hua Rong Lu
    Center of Excellence for Cardiovascular Safety Research, Johnson and Johnson Pharmaceutical Research and Development, a division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Eur J Pharmacol 452:183-92. 2002
    ....
  5. pmc Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Respir Res 7:58. 2006
    ..The exact role of the endothelial NOS (eNOS) isoform in asthma is still unknown. We hypothezised that a delicate regulation in the production of NO and its bioactive forms by eNOS might be the key to the pathogenesis of asthma...
  6. ncbi request reprint In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine)
    Paul A J Janssen
    Center for Molecular Design, Janssen Pharmaceutica, B 2350 Vosselaar, Belgium
    J Med Chem 48:1901-9. 2005
    ..The discovery of R278474 was the result of a coordinated multidisciplinary effort involving medicinal chemists, virologists, crystallographers, molecular modelers, toxicologists, analytical chemists, pharmacists, and many others...
  7. ncbi request reprint Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs
    Jean Pierre Valentin
    Safety Assessment UK, AstraZeneca, Mereside Alderley Park, Macclessfield, Cheshire, England, UK
    J Pharmacol Toxicol Methods 49:171-81. 2004
    ..In combination with other in vitro and in vivo repolarization assays and with pharmacokinetic data in man, it is a valuable tool to establish an integrated cardiovascular risk assessment of pharmaceutical compounds...
  8. ncbi request reprint Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Lab Invest 84:29-40. 2004
    ..These results may contribute to new therapeutic strategies against oxidative stress in airway diseases...
  9. ncbi request reprint Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 476:151-7. 2003
    ..Specific modulation of calmodulin activity might therefore be a potential new target for the treatment of allergic asthma...
  10. ncbi request reprint Detection of proarrhythmia in the female rabbit heart: blinded validation
    Luc M Hondeghem
    Department of Pharmacology, K U Leuven, Leuven, Belgium
    J Cardiovasc Electrophysiol 14:287-94. 2003
    ..Reliable detection of drug-induced proarrhythmia, especially the potential for polymorphic ventricular tachycardia, is of great importance in the development of new compounds that are safe for the heart and was evaluated in a blinded study...
  11. ncbi request reprint Differential responsiveness of proximal and distal parts of isolated guinea pig trachea
    Joris Kloek
    Department of Pharmacology and Pathophysiology, Faculty of Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 442:289-94. 2002
    ..In conclusion, the higher intrinsic contractility of proximal tracheal segments is counteracted by serosal cyclo-oxygenase products...
  12. ncbi request reprint Short patent lives jeopardize drug and patient safety
    Luc M Hondeghem
    Department of Pharmacology, Catholic University of Leuven, Belgium
    J Cardiovasc Pharmacol 50:353-7. 2007
    ..Therefore, we suggest that the potential benefits of patent life prolongation should be considered, under certain conditions for the sake of patient safety...