M R D'Andrea

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi request reprint Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease
    M R Dandrea
    The R W Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, PA, 19477, USA
    Biotech Histochem 76:97-106. 2001
  2. ncbi request reprint MAP-2 immunolabeling can distinguish diffuse from dense-core amyloid plaques in brains with Alzheimer's disease
    M R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, Pennsylvania 19477, USA
    Biotech Histochem 77:95-103. 2002
  3. ncbi request reprint Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues
    M R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, PA 19477, USA
    Neurosci Lett 306:137-40. 2001
  4. ncbi request reprint Lipofuscin and Abeta42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains
    Michael R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, PA 19477, USA
    Neurosci Lett 323:45-9. 2002
  5. ncbi request reprint Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
    M R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    Histopathology 38:120-34. 2001
  6. ncbi request reprint beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
    H Y Wang
    R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477 0776, USA
    J Biol Chem 275:5626-32. 2000
  7. ncbi request reprint Altered vascular injury responses in mice deficient in protease-activated receptor-1
    W M Cheung
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
    Arterioscler Thromb Vasc Biol 19:3014-24. 1999
  8. ncbi request reprint Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats
    P Andrade-Gordon
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477 0776, USA
    J Pharmacol Exp Ther 298:34-42. 2001
  9. ncbi request reprint Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery
    B P Damiano
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    Thromb Haemost 81:808-14. 1999
  10. pmc Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues
    M R D'Andrea
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    Am J Pathol 158:2031-41. 2001

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease
    M R Dandrea
    The R W Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, PA, 19477, USA
    Biotech Histochem 76:97-106. 2001
    ..Furthermore, the shape of the amyloid plaques may be altered subsequently from its typical spherical to an aspherical shape by the inflammatory cells...
  2. ncbi request reprint MAP-2 immunolabeling can distinguish diffuse from dense-core amyloid plaques in brains with Alzheimer's disease
    M R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, Pennsylvania 19477, USA
    Biotech Histochem 77:95-103. 2002
    ..Furthermore, this biochemical distinction indicates that dense-core and diffuse plaques are formed by different mechanisms...
  3. ncbi request reprint Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues
    M R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, PA 19477, USA
    Neurosci Lett 306:137-40. 2001
    ..These PD-associated alterations in MAP-2 morphology and distribution suggest that impaired neuronal transport may contribute to the progression of neuronal loss in the brains of PD patients...
  4. ncbi request reprint Lipofuscin and Abeta42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains
    Michael R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, PA 19477, USA
    Neurosci Lett 323:45-9. 2002
    ..Our results show separate and distinct localization patterns of Abeta42 and lipofuscin in neurons and amyloid plaques...
  5. ncbi request reprint Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
    M R D'Andrea
    The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    Histopathology 38:120-34. 2001
    ..We have investigated the possibility of a link between these two apparently conflicting observations...
  6. ncbi request reprint beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
    H Y Wang
    R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477 0776, USA
    J Biol Chem 275:5626-32. 2000
    ....
  7. ncbi request reprint Altered vascular injury responses in mice deficient in protease-activated receptor-1
    W M Cheung
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
    Arterioscler Thromb Vasc Biol 19:3014-24. 1999
    ..These data suggest that PAR-1(-/-) may play a role in vascular injury responses in this mouse model via possible effects on extracellular matrix regulation...
  8. ncbi request reprint Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats
    P Andrade-Gordon
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477 0776, USA
    J Pharmacol Exp Ther 298:34-42. 2001
    ..From these results, it is evident that a PAR-1 antagonist is not especially effective for treating platelet-dependent thrombosis; however, it could well be beneficial for treating restenosis attendant to arterial injury...
  9. ncbi request reprint Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery
    B P Damiano
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    Thromb Haemost 81:808-14. 1999
    ..Possible functional consequences of this receptor upregulation and its role in the response to vascular injury remain to be determined...
  10. pmc Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues
    M R D'Andrea
    Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    Am J Pathol 158:2031-41. 2001
    ..PAR-1 and PAR-2 in the cells forming the tumor microenvironment suggest that these receptors mediate the signaling of secreted thrombin and trypsin in the processes of cellular metastasis...
  11. doi request reprint Simultaneous PCNA and TUNEL labeling for testicular toxicity evaluation suggests that detection of apoptosis may be more sensitive than proliferation
    M R D'Andrea
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania, USA
    Biotech Histochem 85:195-204. 2010
    ....
  12. doi request reprint Morphologically distinct types of amyloid plaques point the way to a better understanding of Alzheimer's disease pathogenesis
    M R D'Andrea
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA
    Biotech Histochem 85:133-47. 2010
    ....
  13. ncbi request reprint Increased expression of serine palmitoyltransferase (SPT) in balloon-injured rat carotid artery
    D J Uhlinger
    R W Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA
    Thromb Haemost 86:1320-6. 2001
    ..The possible functional consequences of this enzyme upregulation and its role in the response to vascular injury are suggested but remain to be determined...
  14. doi request reprint PCNA indexing as a preclinical immunohistochemical biomarker for testicular toxicity
    M R D'Andrea
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania, USA
    Biotech Histochem 83:211-20. 2008
    ..The assay has potential utility as an in vivo biomarker for detecting early testicular toxicity of experimental compounds in preclinical development as well as for refining follow-up compounds with reduced testicular toxicity...
  15. ncbi request reprint Collagenase predigestion on paraffin sections enhances collagen immunohistochemical detection without distorting tissue morphology
    M R D'Andrea
    Johnson and Johnson Pharmaceutical Research and Development, Drug, Discovery, Spring House, PA 19477, USA
    Biotech Histochem 79:55-64. 2004
    ..This new use of collagenase for immunohistochemistry promotes increased collagen immunolabeling, is easy to use, is versatile, and allows preservation of tissue structure that provides maximal and accurate histological information...
  16. doi request reprint Cleaved secretory leucocyte protease inhibitor as a biomarker of chymase activity in allergic airway disease
    S M Belkowski
    Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA
    Clin Exp Allergy 39:1179-86. 2009
    ..Previously, we demonstrated that chymase is able to cleave SLPI and that the cleaved portion, cSLPI, is a biomarker of chymase activity...
  17. ncbi request reprint Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues
    M R D'Andrea
    Drug Discovery Research, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
    J Histochem Cytochem 46:157-64. 1998
    ..A role for PAR-2 in the skin was further supported by its immunolocalization in the epidermis. PAR-2C antibody exemplifies an important tool to address the physiological role(s) of PAR-2...