P Bonaventure

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi request reprint Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Eur J Pharmacol 513:181-92. 2005
  2. ncbi request reprint Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 321:690-8. 2007
  3. ncbi request reprint Histamine H3 receptor antagonists: from target identification to drug leads
    P Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Biochem Pharmacol 73:1084-96. 2007
  4. ncbi request reprint Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 302:240-8. 2002
  5. ncbi request reprint Nuclei and subnuclei gene expression profiling in mammalian brain
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA
    Brain Res 943:38-47. 2002
  6. ncbi request reprint Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 308:1130-7. 2004
  7. ncbi request reprint Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors
    P Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, San Diego, CA 92121, USA
    Neuroscience 124:901-11. 2004
  8. ncbi request reprint Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)
    S Masure
    Department of Applied Molecular Biology, Janssen Research Foundation, Beerse, Belgium
    Eur J Biochem 251:622-30. 1998
  9. ncbi request reprint Co-localization of 5-HT1B- and 5-HT1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphé nucleus: a double labeling in situ hybridization histochemistry study
    P Bonaventure
    Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Neurosci Lett 254:113-6. 1998
  10. ncbi request reprint Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization
    P Bonaventure
    Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Mol Pharmacol 56:54-67. 1999

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Eur J Pharmacol 513:181-92. 2005
    ..The availability of the full sequence and pharmacology of the canine 5-HT2A and canine 5-HT2B receptors provides useful information for the interpretation of previous and future pharmacological studies of 5-HT2A/2B ligands in dog...
  2. ncbi request reprint Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 321:690-8. 2007
    ..Overall, these results indicate that selective blockade of 5-HT7 receptors may enhance the antidepressant efficacy of citalopram and may provide a novel therapy to alleviate sleep disturbances associated with depression...
  3. ncbi request reprint Histamine H3 receptor antagonists: from target identification to drug leads
    P Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Biochem Pharmacol 73:1084-96. 2007
    ..Therefore, H(3) antagonists are promising clinical candidates for the treatment of excessive day time sleepiness and/or cognitive disorders...
  4. ncbi request reprint Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 302:240-8. 2002
    ..Also, the lower affinity ligand [(3)H]8-OH-DPAT is a much better tracer for autoradiographic studies at the 5-HT(7) receptor binding sites...
  5. ncbi request reprint Nuclei and subnuclei gene expression profiling in mammalian brain
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA
    Brain Res 943:38-47. 2002
    ..This study demonstrates the importance, feasibility and utility of cellular brain nuclei profiling...
  6. ncbi request reprint Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor
    Pascal Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 308:1130-7. 2004
    ..Hence, JNJ-5207787 is a potent and selective pharmacological tool available to establish the potential role of central and peripheral Y(2) receptors in vivo...
  7. ncbi request reprint Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors
    P Bonaventure
    Johnson and Johnson Pharmaceutical Research and Development, L L C, San Diego, CA 92121, USA
    Neuroscience 124:901-11. 2004
    ..The mapping revealed binding sites consistent with the mRNA distribution with the highest densities found in anterior thalamic nuclei...
  8. ncbi request reprint Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)
    S Masure
    Department of Applied Molecular Biology, Janssen Research Foundation, Beerse, Belgium
    Eur J Biochem 251:622-30. 1998
    ..Using a GFRalpha-3-specific [35S]cRNA[gammaS] probe, in situ hybridization histochemistry experiments confirmed the expression in the cerebellum...
  9. ncbi request reprint Co-localization of 5-HT1B- and 5-HT1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphé nucleus: a double labeling in situ hybridization histochemistry study
    P Bonaventure
    Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Neurosci Lett 254:113-6. 1998
    ..The present study demonstrates that 5-HT1B- and 5-HT1D receptor mRNA is co-localized in serotonergic cell bodies of the guinea pig dorsal raphé nucleus...
  10. ncbi request reprint Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization
    P Bonaventure
    Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Mol Pharmacol 56:54-67. 1999
    ..However, modulation of [3H]5-HT release could not be shown. Furthermore, behavioral effects were not clearly observed, which may be due to a lack of appropriate tools...
  11. ncbi request reprint Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand
    P Bonaventure
    Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Receptors Channels 5:225-30. 1997
    ..The present data indicate that [3H]alniditan is a suitable radioligand for measuring 5-HT1B/1D receptor in the human brain and that the 5-HT1B binding sites are predominant in the presently investigated regions of the human brain...
  12. ncbi request reprint Mapping of serotonin 5-HT(4) receptor mRNA and ligand binding sites in the post-mortem human brain
    P Bonaventure
    Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium
    Synapse 36:35-46. 2000
    ..These data indicate that in the substantia nigra 5-HT(4) receptors are more strongly coupled to their signal transduction pathway than in other brain regions...
  13. doi request reprint Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity
    Ruggero Galici
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Behav Pharmacol 19:153-9. 2008
    ..Collectively, these results indicate that blockade of 5-HT7 receptors partially modulates glutamatergic and dopaminergic function and could be clinically useful for the treatment of positive symptoms of schizophrenia...
  14. doi request reprint 2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists
    Brock T Shireman
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:2103-8. 2008
    ..Optimal placement of a basic nitrogen relative to the pyrimidine and the presence of a 4-fluorophenyl group in the pyrimidine 4-position was found to have a profound effect on affinity and selectivity...
  15. ncbi request reprint Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors
    Kiev S Ly
    Johnson and Johnson Pharmaceutical Research and Development L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:39-43. 2008
    ..The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H3 ligands and serotonin reuptake inhibitors...
  16. doi request reprint In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor
    Leah Aluisio
    Department of Neuroscience, Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Eur J Pharmacol 587:141-6. 2008
    ..3 mg/kg, i.p.). These results demonstrate that JNJ-7925476 is a triple reuptake inhibitor with in-vivo efficacy in biochemical and behavioral models of depression...
  17. ncbi request reprint Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors
    Michael A Letavic
    Johnson and Johnson Pharmaceutical Research and Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 17:4799-803. 2007
    ..The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described...
  18. ncbi request reprint R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization
    Chester Kuei
    Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, California 92121, USA
    J Biol Chem 282:25425-35. 2007
    ..Thus, R3(BDelta23-27)R/I5 should prove a useful tool for the further delineation of the functions of the relaxin-3/GPCR135 system...
  19. ncbi request reprint Genomic and functional conservation of sedative-hypnotic targets in the zebrafish
    Corinne Renier
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Pharmacogenet Genomics 17:237-53. 2007
    ..We investigated the effects of sedative hypnotics commonly used in humans on zebrafish locomotor activity and identified the corresponding genomic and receptor binding targets...
  20. ncbi request reprint Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor
    Ann J Barbier
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Eur J Pharmacol 576:43-54. 2007
    ..9 h and a C(max) of 260 ng/ml after 10 mg/kg p.o. In summary, JNJ-28583867 is a combined histamine H(3) receptor antagonist-SERT inhibitor with in vivo efficacy in biochemical and behavioral models of depression and wakefulness...
  21. ncbi request reprint Novel non-peptidic neuropeptide Y Y2 receptor antagonists
    Jill A Jablonowski
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 14:1239-42. 2004
    ..The SAR studies around the piperidinyl, the indolinyl, and the cinnamyl moieties are discussed...
  22. ncbi request reprint 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Pharmacol 487:125-32. 2004
    ..3 mg/kg 8-OH-DPAT. Thus, both 5-HT(7) and 5-HT(1A) receptors are involved in a complex manner in thermoregulation, with the 5-HT(7) receptor being more important at lower, possibly more physiological, concentrations...
  23. ncbi request reprint Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species
    Jingcai Chen
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 312:83-95. 2005
    ..Boels and Schaller recently reported bradykinin as a ligand for GPCR142 (also known as GPR100). In this report, we demonstrate that bradykinin activates neither GPCR135 nor GPCR142, whereas relaxin-3 does...
  24. ncbi request reprint Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development, L L C, San Diego, CA 92121, USA
    Mol Pharmacol 67:231-40. 2005
    ....
  25. ncbi request reprint INSL5 is a high affinity specific agonist for GPCR142 (GPR100)
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development, San Diego, California 92121, USA
    J Biol Chem 280:292-300. 2005
    ..The high affinity interaction between INSL5 and GPCR142 coupled with their co-evolution and partially overlapping tissue expression patterns strongly suggest that INSL5 is an endogenous ligand for GPCR142...
  26. ncbi request reprint Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing
    Steven W Sutton
    Neuroscience Group, Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Neuroendocrinology 80:298-307. 2004
    ....
  27. ncbi request reprint Recent progress in relaxin-3-related research
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA 92121
    Ann N Y Acad Sci 1041:47-60. 2005
    ..Autoradiographic distribution of GPCR135 binding sites using [125I]R3/I5 in rat brain shows that GPCR135 receptor is most prominent in areas known for the processing of sensory signals...
  28. ncbi request reprint G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135
    Steven W Sutton
    Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA 92121, USA
    Neuroendocrinology 82:139-50. 2005
    ..GPCR135 mRNA and GPCR135 receptor binding sites are most prominent in the mouse amygdala and hypothalamus. These data suggest that relaxin-3/GPCR135 is the receptor ligand pair with physiological relevance in mouse brain...
  29. ncbi request reprint Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors
    Michael A Letavic
    Johnson and Johnson Pharmaceutical Research and Development L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 17:1047-51. 2007
    ..The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed...
  30. doi request reprint Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135)
    Jessica Zhu
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Eur J Pharmacol 590:43-52. 2008
    ..These results suggest that the N-terminus and EL2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation...