Research Topics
| ROY ZIEGELSTEINSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Patients with depression are less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarctionR C Ziegelstein
Department of Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224 2780, USA
Arch Intern Med 160:1818-23. 2000..This study was performed to determine whether depression affects adherence to recommendations intended to reduce the risk of cardiac events after an MI...
Near-syncope after exerciseRoy C Ziegelstein
Department of Medicine, Division of Cardiology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
JAMA 292:1221-6. 2004..The patient discussed in this case highlights the importance of the clinical history in the evaluation of this condition, since the diagnosis was revealed as the patient's story was described and eventually acted out...
Acute emotional stress and cardiac arrhythmiasRoy C Ziegelstein
Department of Medicine, Johns Hopkins University School of Medicine and Division of Cardiology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224 2780, USA
JAMA 298:324-9. 2007....
Selective serotonin reuptake inhibitor use by patients with acute coronary syndromesRoy C Ziegelstein
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224 2780, USA
Am J Med 120:525-30. 2007..Selective serotonin reuptake inhibitors inhibit platelet activation and may, therefore, affect outcomes in patients with acute coronary syndromes...
Can doctors and nurses recognize depression in patients hospitalized with an acute myocardial infarction in the absence of formal screening?Roy C Ziegelstein
Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
Psychosom Med 67:393-7. 2005....
"The mirror" and "the village": a new method for teaching practice-based learning and improvement and systems-based practiceRoy C Ziegelstein
Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Acad Med 79:83-8. 2004..Methods for introducing these concepts are needed if PBLI and SBP are to be incorporated into education and practice...
"Rocking the match": applying and getting into residencyRoy C Ziegelstein
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Natl Med Assoc 99:994-9. 2007..Hopefully, students can use the information in this manuscript as a recipe for "rocking the match."..
Depression and coronary artery disease: is there a platelet link?Roy C Ziegelstein
Department of Medicine, B 1 North, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, Baltimore, MD 21224 2780, USA
Mayo Clin Proc 82:1366-8. 2007
Platelet function in patients with major depressionR C Ziegelstein
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224 2780, USA
Intern Med J 39:38-43. 2009..e. the selective serotonin re-uptake inhibitors) to increased risk of bleeding...
Routine screening for depression in patients with coronary heart disease never mindRoy C Ziegelstein
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Coll Cardiol 54:886-90. 2009..We call for the AHA to reassess their recommendations in light of this systematic review and considering the potential impact of their document on clinical practice...
Depression in patients recovering from a myocardial infarctionR C Ziegelstein
Department of Medicine, Division of Cardiology, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, Baltimore, MD 21224 2780, USA
JAMA 286:1621-7. 2001..Treatment of depression itself should be individualized until safety and efficacy are determined for antidepressant therapy in patients who recently have had an MI...
The seventh competencyColleen Christmas
Department of Medicine, School of Medicine, Johns Hopkins University, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Teach Learn Med 21:159-62. 2009..Despite this, residency training programs do not commonly address this in their curricula, and competence in the identification and disclosure of adverse events and medical error is typically not assessed...
Depressive symptoms, physical inactivity and risk of cardiovascular mortality in older adults: the Cardiovascular Health StudySithu Win
Johns Hopkins University School of Medicine, Department of Medicine, B 1 North, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224 2780, USA
Heart 97:500-5. 2011..Depression is associated with physical inactivity, and low levels of physical activity have been shown in some cohorts to be a partial mediator of the relationship between depression and cardiovascular events and mortality...
Revolutionizing the doctor's black bag. A step to revitalizing primary care in medicineDavid B Hellmann
Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Pharos Alpha Omega Alpha Honor Med Soc 68:22-6. 2005
The rate at which residents learn to use hand-held echocardiography at the bedsideDavid B Hellmann
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Med 118:1010-8. 2005....
Systems survivor: voting unsafe patient care practices off the islandColleen Christmas
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Teach Learn Med 19:200-1. 2007
Depression following acute myocardial infarction: a prospective relationship with ongoing health and functionJames A Fauerbach
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychosomatics 46:355-61. 2005....
Phospholipase D regulates calcium oscillation frequency and nuclear factor-kappaB activity in histamine- stimulated human endothelial cellsQinghua Hu
Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224 2780, USA
Biochem Biophys Res Commun 292:325-32. 2002..This study shows that activation of PLD by histamine regulates [Ca(2+)](i) oscillation frequency and NF-kappaB activity in HAEC...
Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injuryJeffrey M Dodd-o
Department of Anesthesia and Critical Care, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 9106, USA
Am J Physiol Heart Circ Physiol 287:H927-36. 2004..05). NADPH oxidase-derived ROS contribute to the severe hypoxemia but not to the increased cytokine generation and pulmonary vascular protein permeability, which occur following CPB...
52 precepts that medical trainees and physicians should consider regularlyScott M Wright
Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Am J Med 118:435-8. 2005..The list of precepts may also be useful to medical educators who wish to successfully mold the physicians of tomorrow...
Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2+ oscillations in human aortic endothelial cells stimulated by histamineQinghua Hu
Department of Medicine, Division of Cardiology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Biol Chem 277:32546-51. 2002..NADPH oxidase-derived ROS are critical to the generation of [Ca(2+)](i) oscillations in HAEC during histamine stimulation, perhaps by increasing the sensitivity of the endoplasmic reticulum to Ins-1,4,5-P(3)...
Hypoxia/reoxygenation stimulates Ca2+-dependent ICAM-1 mRNA expression in human aortic endothelial cellsRoy C Ziegelstein
Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
Biochem Biophys Res Commun 322:68-73. 2004..Characterizing the signaling pathways involved in H/R-induced adhesion molecule expression may result in a better understanding of the vascular biology of normal aging and the pathobiology of atherosclerosis...
Writing more informative letters of referenceScott M Wright
Department of Medicine, John Hopkins Bayview Medical Ccenter, Baltimore, MD 21224, USA
J Gen Intern Med 19:588-93. 2004..This report offers suggestions that should help physicians write more informative letters of reference...
Quality of life in physical health domains predicts adherence among myocardial infarction patients even after adjusting for depressive symptomsJoshua Fogel
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
J Psychosom Res 56:75-82. 2004..To prospectively study the relationship of quality of life (QOL) to adherence among myocardial infarction (MI) patients and also to determine if either QOL or depressive symptoms (DEP) has a primary role in predicting adherence...
Effect of depression on late (8 years) mortality after myocardial infarctionKapil Parakh
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
Am J Cardiol 101:602-6. 2008..24, p = 0.27). In conclusion, depression after MI was associated with increased short-term mortality, but its relation with mortality over time appeared to wane, at least in a group of older patients who had multiple co-morbidities...
The isolated polycystin-1 COOH-terminal can activate or block polycystin-1 signalingUma Basavanna
Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Biochem Biophys Res Commun 359:367-72. 2007..Our data raise the possibility that the cytoplasmic carboxyl terminus, either through cleavage products or intramolecular interactions, might feed back to modulate the activity of parent or intact polycystin-1...
Performance characteristics of depression screening instruments in survivors of acute myocardial infarction: review of the evidenceBrett D Thombs
Johns Hopkins University Evidence Based Practice Center, the Dept of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychosomatics 48:185-94. 2007....
Clopidogrel: the good, the bad, and the uglyGrant Chow
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224-2780, USA
Am J Cardiovasc Drugs 7:169-71. 2007
Hand-carried ultrasound performed by hospitalists: does it improve the cardiac physical examination?L David Martin
Department of Medicine, The Johns Hopkins University, School of Medicine and the Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
Am J Med 122:35-41. 2009..The purpose of this study was to determine whether hand-carried ultrasound can add to the accuracy of hospitalists' cardiac physical examinations...
Hospitalist performance of cardiac hand-carried ultrasound after focused trainingL David Martin
Department of Medicine, Johns Hopkins University, School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Am J Med 120:1000-4. 2007..Because the training that noncardiologists require to perform cardiac hand-carried ultrasound has not been defined, we studied how well hospitalists perform hand-carried echocardiography after limited training...
Expression of a functional extracellular calcium-sensing receptor in human aortic endothelial cellsRoy C Ziegelstein
Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Division of Cardiology, Baltimore, MD 21224 2780, USA
Biochem Biophys Res Commun 342:153-63. 2006..Expression of alternatively spliced variants of the CaR may result in the absence of a functional response to other known CaR agonists in HAEC...
Heterologous expression of polycystin-1 inhibits endoplasmic reticulum calcium leak in stably transfected MDCK cellsKimberly H Weber
Department of Nephrology, John Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Physiol Renal Physiol 294:F1279-86. 2008..We conclude that disruption of ER luminal calcium homeostasis may contribute to the cyst phenotype in autosomal dominant polycystic kidney disease...
Prevalence of depression in survivors of acute myocardial infarctionBrett D Thombs
Johns Hopkins University Evidence-Based Practice Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gen Intern Med 21:30-8. 2006..CONCLUSIONS: Depression is common and persistent in AMI survivors. Prevalence varies depending on assessment method, likely reflecting treatment of somatic symptoms...
Platelet function in patients with depressionKapil Parakh
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224 2780, USA
South Med J 101:612-7. 2008..Larger, carefully designed, adequately powered studies with standardized methods of assessing platelet function are needed to address this issue...
Cultural sensitivity in screening adults for a history of childhood abuse: evidence from a community sampleBrett D Thombs
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gen Intern Med 22:368-73. 2007..A number of practice guidelines and recommendations call for the assessment of childhood abuse history among adult medical patients. The cultural sensitivity of screening questions, however, has not been examined...
Self-assessed physical health predicts 10-year mortality after myocardial infarctionKapil Parakh
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
J Cardiopulm Rehabil Prev 30:35-9. 2010..The objective of the present study was to ascertain the relationship between self-assessed physical health at the time of the MI and long-term mortality...
Depression in patients with heart disease: the case for more trialsStanley S Liu
Johns Hopkins Bayview Medical Center, Department of Medicine, B 1 North, 4940 Eastern Avenue, Baltimore, MD 21224 2780, USA
Future Cardiol 6:547-56. 2010....
Long-term significance of Killip class and left ventricular systolic dysfunctionKapil Parakh
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224 2780, USA
Am J Med 121:1015-8. 2008..The long-term prognostic significance of Killip class and left ventricular systolic dysfunction, however, is unknown...
Effect of rate of administration on subjective and physiological effects of intravenous cocaine in humansRichard A Nelson
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Drug Alcohol Depend 82:19-24. 2006..These findings provide support for the rate hypothesis as it applies to both subjective and cardiovascular effects of IV cocaine administration in humans...
An evaluation of screening questions for childhood abuse in 2 community samples: implications for clinical practiceBrett D Thombs
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Intern Med 166:2020-6. 2006....
Differential effects of pulsatile versus steady flow on coronary endothelial membrane potentialWei-Ping Qiu
Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Am J Physiol Heart Circ Physiol 285:H341-6. 2003..This supports studies showing greater potency of pulsatile flow for triggering KCa-dependent vasorelaxation...
The association of depression with adherence to antihypertensive medications: a systematic reviewChete M Eze-Nliam
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Hypertens 28:1785-95. 2010..To examine the strength and consistency of the evidence on the relationship between depression and adherence to antihypertensive medications...
Prognostic significance of cardiac troponin I levels in hospitalized patients presenting with supraventricular tachycardiaGrant V Chow
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 2780, USA
Medicine (Baltimore) 89:141-8. 2010..Further study is needed to determine the mechanisms of SVT-related cTnI elevation and its association with elevated cardiovascular risk...
The significance of depression in older patients after myocardial infarctionJeanine Romanelli
Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
J Am Geriatr Soc 50:817-22. 2002..Efforts to improve adherence to post-MI treatment guidelines and to enhance patient compliance may improve prognosis in this high-risk group...
Usefulness of persistent symptoms of depression to predict physical health status 12 months after an acute coronary syndromeBrett D Thombs
Department of Psychiatry, Sir Mortimer B Davis Jewish General Hospital and McGill University, Montreal, Quebec, Canada
Am J Cardiol 101:15-9. 2008..060), whereas patients with transient depressive symptoms were not at increased risk. In conclusion, these results underscore the importance of assessing depression at the time of ACS and on an ongoing basis...
Depression screening and patient outcomes in cardiovascular care: a systematic reviewBrett D Thombs
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
JAMA 300:2161-71. 2008..Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear...
Mortality and adherence to pharmacotherapy after acute myocardial infarctionKapil Parakh
JAMA 297:1877; author reply 1878. 2007
Depression and adherence to antihypertensive therapyChete M Eze-Nliam
Am J Hypertens 21:724-5; author reply 726. 2008
Probit structural equation regression model: general depressive symptoms predicted post-myocardial infarction mortality after controlling for somatic symptoms of depressionBrett D Thombs
Department of Psychiatry, Sir Mortimer B Davis Jewish General Hospital and McGill University, 4333 Cote Ste Catherine Road, Montreal, Quebec H3T 1E4, Canada
J Clin Epidemiol 61:832-9. 2008..The objective of this study was to assess the relationship between depressive symptoms and 12-month post-AMI mortality after removing potential bias from somatic symptoms of depression...
Capillary leak syndrome in children with C4A-deficiency undergoing cardiac surgery with cardiopulmonary bypass: a double-blind, randomised controlled studyShihai Zhang
Department of Anaesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Lancet 366:556-62. 2005....
The effect of a primary care practice-based depression intervention on mortality in older adultsBrett D Thombs
Ann Intern Med 148:244-5; author reply 245. 2008
The brain and the heart: the twain meetRoy C Ziegelstein
Eur Heart J 26:2607-8. 2005
Clopidogrel in patients with acute coronary syndromes: learning from clinical practiceRoy C Ziegelstein
Arch Intern Med 166:2292-3; author reply 2293. 2006
Just a spoonful of sugarRoy C Ziegelstein
J Am Coll Cardiol 48:2223-4. 2006
A brief two-item screener for detecting a history of physical or sexual abuse in childhoodBrett D Thombs
Department of Psychiatry, Sir Mortimer B Davis Jewish General Hospital and McGill University, Montreal, Quebec, Canada H3T 1E4
Gen Hosp Psychiatry 29:8-13. 2007..The objective of this study was to assess the accuracy of a two-item screener for physical or sexual abuse in childhood...
The brain and the heart: independent or interactive?Roy C Ziegelstein
J Am Coll Cardiol 49:1824; author reply 1824-5. 2007
Treatment of depression in patients with coronary artery diseaseRoy C Ziegelstein
JAMA 297:1878-9; author reply 1880. 2007
Do symptom dimensions of depression following myocardial infarction relate differently to physical health indicators and cardiac prognosis?Brett D Thombs
Am J Psychiatry 163:1295-6; author reply 1296. 2006
Low-density lipoprotein cholesterol and post-myocardial infarction depressionRoy C Ziegelstein
Am J Cardiol 91:1532. 2003
Throw the window out the doorBrett D Thombs
J Am Coll Cardiol 50:1519-20; author reply 1520. 2007
Retrospective screening of patients for age of initial diagnosis of coronary artery disease: shouldn't we just ask?Brett D Thombs
J Cardiovasc Nurs 23:79-81; author reply 81-3. 2008
Wake up and smell the caffeineRoy C Ziegelstein
Am J Cardiol 94:981-2. 2004
Research Grants
- AGONIST-AND OXIDANT-STIMULATED SIGNALING MECHANISMSROY ZIEGELSTEIN; Fiscal Year: 2004..The proposed studies could lead to novel methods of regulating proinflammatory gene expression by specifically targeting upstream signaling mechanisms in the endothelium. ..
