Yun Zhou

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Relative equilibrium plot improves graphical analysis and allows bias correction of standardized uptake value ratio in quantitative 11C-PiB PET studies
    Yun Zhou
    Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21287 0807, USA
    J Nucl Med 53:622-8. 2012
  2. pmc Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 36:298-312. 2007
  3. pmc A consistent and efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Neuroimage 44:661-70. 2009
  4. ncbi request reprint Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model
    Yun Zhou
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuroimage 18:975-89. 2003
  5. ncbi request reprint An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC room 3245, Baltimore, MD 21287, USA
    Neuroimage 33:550-63. 2006
  6. pmc Multi-graphical analysis of dynamic PET
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 49:2947-57. 2010
  7. pmc Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 107:1236-47. 2008
  8. ncbi request reprint Sex differences in striatal dopamine release in healthy adults
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 59:966-74. 2006
  9. pmc Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    Neuropsychopharmacology 33:1239-51. 2008
  10. ncbi request reprint VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease
    Ming Kai Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 105:78-90. 2008

Detail Information

Publications41

  1. pmc Relative equilibrium plot improves graphical analysis and allows bias correction of standardized uptake value ratio in quantitative 11C-PiB PET studies
    Yun Zhou
    Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21287 0807, USA
    J Nucl Med 53:622-8. 2012
    ..The objective of this study was to use a recently developed relative equilibrium-based graphical (RE) plot method to improve and simplify the 2 commonly used methods for quantification of (11)C-Pittsburgh compound B ((11)C-PiB) PET...
  2. pmc Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 36:298-312. 2007
    ..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies...
  3. pmc A consistent and efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Neuroimage 44:661-70. 2009
    ..In conclusion, the new plot is a consistent and computationally efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies...
  4. ncbi request reprint Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model
    Yun Zhou
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuroimage 18:975-89. 2003
    ..We conclude that the new linear equations yield a reliable, computationally efficient, and robust LRSC algorithm to generate parametric images of ligand-receptor dynamic PET studies...
  5. ncbi request reprint An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC room 3245, Baltimore, MD 21287, USA
    Neuroimage 33:550-63. 2006
    ..Violations of this assumption may result in unreliable estimation of the amphetamine-induced percent change in the binding potential (DeltaBP%)...
  6. pmc Multi-graphical analysis of dynamic PET
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 49:2947-57. 2010
    ..In conclusion, the bi-graphical analysis method using the RE-GP plots was a reliable, robust and computationally efficient kinetic modeling approach to improve the quantification of dynamic PET...
  7. pmc Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 107:1236-47. 2008
    ..These findings provide compelling evidence that the effects of Mn on DA synapses in the striatum are mediated by inhibition of DA neurotransmission and are responsible for the motor deficits documented in these animals...
  8. ncbi request reprint Sex differences in striatal dopamine release in healthy adults
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 59:966-74. 2006
    ..Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human studies have yet to substantiate these findings...
  9. pmc Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    Neuropsychopharmacology 33:1239-51. 2008
    ..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD...
  10. ncbi request reprint VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease
    Ming Kai Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 105:78-90. 2008
    ..Genetic or environmental factors that decrease VMAT2 function may be important determinants of PD...
  11. ncbi request reprint Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 32:2310-20. 2007
    ..The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans...
  12. ncbi request reprint Striatal dopamine release and family history of alcoholism
    Cynthia A Munro
    Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 30:1143-51. 2006
    ....
  13. ncbi request reprint Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006
    ..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine...
  14. ncbi request reprint Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Neurol 202:381-90. 2006
    ....
  15. pmc Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques
    Ira Driscoll
    National Institute on Aging, Baltimore, MD, USA
    Acta Neuropathol 124:823-31. 2012
    ..The strong associations of PiB retention with region-matched, quantitative analyses of Aβ in postmortem tissue offer support for the validity of (11)C-PiB-PET imaging as a method for evaluation of plaque burden in vivo...
  16. pmc Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals
    Ira Driscoll
    NIH Biomedical Research Center, 251 Bayview Blvd, Suite 100, Baltimore, MD 21224, USA
    Neurobiol Aging 32:2123-30. 2011
    ..Consistent with a threshold model of disease, our findings suggest that Aβ load does not seem to affect brain volume changes in individuals without dementia...
  17. pmc Positron emission tomography experience with 2-[¹⁸F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[¹⁸F]FA) in the living human brain of smokers with paranoid schizophrenia
    James Robert Brasic
    Division of Nuclear Medicine, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0807, USA
    Synapse 66:352-68. 2012
    ..0105) (StataCorp, 2003), which was likely due to occupancy of nAChRs by inhaled nicotine in smokers. Further research is needed to rule out the effects of confounding variables...
  18. pmc Longitudinal patterns of β-amyloid deposition in nondemented older adults
    Jitka Sojkova
    Laboratory of Behavioral Neuroscience, National Institutes of Health Biomedical Research Center, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:644-9. 2011
    ..High levels of β-amyloid (Aβ) characterize Alzheimer disease...
  19. pmc In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    J Nucl Med 51:913-20. 2010
    ..Here we present the results of a clinical trial with (E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45 or florbetapir [corrected] F 18)...
  20. pmc Direct 4D parametric imaging for linearized models of reversibly binding PET tracers using generalized AB-EM reconstruction
    Arman Rahmim
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Phys Med Biol 57:733-55. 2012
    ....
  21. pmc Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers
    James Robert Brasic
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Synapse 63:339-58. 2009
    ..We conclude that 5-[(123)I]IA is a safe, well-tolerated, and effective pharmacologic agent for human subjects to estimate high-affinity alpha4/beta2 nAChRs in the living human brain...
  22. ncbi request reprint Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 30:821-32. 2005
    ..The results are consistent with those of preclinical studies, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans...
  23. ncbi request reprint Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 159:1329-36. 2002
    ..The objective of this study was to test the hypothesis that presynaptic dopamine release from the striatum is abnormal in adults with Tourette's syndrome...
  24. ncbi request reprint Improved parametric image generation using spatial-temporal analysis of dynamic PET studies
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neuroimage 15:697-707. 2002
    ..NLRRSC provided a reliable estimate of glucose metabolite uptake rate with a comparable image quality compared to Patlak analysis. In conclusion, NLRRSC is a reliable and robust parametric imaging algorithm for dynamic PET studies...
  25. doi request reprint Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Caroline Street, Room 3245, Johns Hopkins Outpatient Center, Baltimore, MD 21287 0807, USA
    Neuroimage 75:282-90. 2013
    ....
  26. pmc Long-term exposure to oral methylphenidate or dl-amphetamine mixture in peri-adolescent rhesus monkeys: effects on physiology, behavior, and dopamine system development
    Paul L Soto
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 37:2566-79. 2012
    ..Thus, methylphenidate and amphetamine at therapeutic blood/plasma levels during peri-adolescence in non-human primates have little effect on physiological or behavioral/cognitive development...
  27. pmc In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults
    Jitka Sojkova
    National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:232-40. 2011
    ..In demented older adults, in vivo amyloid imaging shows agreement with diagnostic neuropathologic assessment of β-amyloid (Aβ). However, the extent of agreement in nondemented older adults remains unclear...
  28. ncbi request reprint 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase)
    Martin G Pomper
    Division of Neuroradiology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2182, USA
    Mol Imaging 1:96-101. 2002
    ..For PET, distribution volumes (DVs) were 1.38 then 0.87 pre- and postblocker (PMPA). Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery...
  29. pmc Correlation of the vesicular acetylcholine transporter densities in the striata to the clinical abilities of women with Rett syndrome
    James Robert Brasic
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Maryland 21287 0807, USA
    Synapse 66:471-82. 2012
    ..I]IBVM is a promising tool to characterize the pathophysiological mechanisms of RTT and other neurodevelopmental disabilities...
  30. pmc Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals
    Madhav Thambisetty
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Alzheimers Dis 22:1099-109. 2010
    ..Our strategy combining proteomics with in vivo brain amyloid imaging holds promise for the discovery of biologically relevant peripheral markers in those at risk for AD...
  31. pmc Gene set enrichment analysis made simple
    Rafael A Irizarry
    Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    Stat Methods Med Res 18:565-75. 2009
    ..In this article we compare the performance of a simple alternative to GSEA. We find that this simple solution clearly outperforms GSEA. We demonstrate this with eight different microarray datasets...
  32. ncbi request reprint Accelerating the optimization of requantization codebook for vector quantization
    Yun Zhou
    Signals and Information Processing, Lanzhou Uriversity, Lanzhou 730000, China
    IEEE Trans Image Process 16:1281-8. 2007
    ..All these features pave the way toward real-time variable-rate data compression and transmission over heterogeneous networks. Simulation results support the theory and the advantages of our method...
  33. ncbi request reprint Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, MD 21205, USA
    Neuroimage 36:153-66. 2007
    ..No associations were observed between impulsivity or stress and cortisol responses to AMPH. The findings are consistent with notions that blunted DA responses represent an endophenotype for substance use disorders...
  34. ncbi request reprint Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Nucl Med 44:109-16. 2003
    ..18)F-Desmethoxyfallypride ((18)F-DMFP) is a benzamide tracer with the advantage of an (18)F label. We optimized the synthesis and evaluated (18)F-DMFP in PET studies on healthy human volunteers...
  35. ncbi request reprint Parametric mapping of binding in human brain of D2 receptor ligands of different affinities
    Thomas Siessmeier
    Department of Nuclear Medicine, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Nucl Med 46:964-72. 2005
    ..However, the in vivo kinetics of these compounds and the quantification approaches for parametric mapping of their specific bindings have not been systematically compared...
  36. ncbi request reprint Fluorescence imaging for real-time monitoring of high-intensity focused ultrasound cardiac ablation
    Cheri X Deng
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    Ann Biomed Eng 33:1352-9. 2005
    ....
  37. ncbi request reprint Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models
    Yun Zhou
    Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People s Republic of China
    J Nat Prod 70:652-5. 2007
    ..Compounds 4, 5, and 6 showed antidepressant activity when tested on forced swimming and tail suspension in mice, respectively...
  38. ncbi request reprint EUS spectrum analysis for in vivo characterization of pancreatic and lymph node tissue: a pilot study
    Ronald E Kumon
    Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106 5066, USA
    Gastrointest Endosc 66:1096-106. 2007
    ..By using information otherwise discarded by conventional EUS systems, quantitative spectral analysis of the raw radiofrequency (RF) signals underlying EUS images enables tissue to be characterized more objectively...
  39. ncbi request reprint [The clinical manifestations and assessment of post stroke dysphagia]
    Jing Zhang
    Department of Neurology, Tiantan Hospital, Capital University of Medical Science, Beijing 100050, China
    Zhonghua Nei Ke Za Zhi 45:379-81. 2006
    ..To find the relationship between the clinical manifestations of dysphagia resulting from stroke and dysfunction of swallowing organs. It is helpful to understand the mechanism of dysphagia so as to guide its diagnosis and therapy...
  40. ncbi request reprint Up-regulation of IL-10 expression in dendritic cells is involved in Trichosanthin-induced immunosuppression
    Xiaorong Zhou
    Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Immunol Lett 110:74-81. 2007
    ..These data suggest that Tk acts on the function of DCs to change the ratio of IL-10 to IL-12 production and, thus, predominantly inhibits Th1 responses...
  41. doi request reprint Trade-offs between constitutive and induced resistance in wild crucifers shown by a natural, but not an artificial, elicitor
    Peng Jun Zhang
    Institute of Insect Sciences, Zhejiang University, 268 Kaixuan Road, 310029 Hangzhou, China
    Oecologia 157:83-92. 2008
    ....