Zhen Zhang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer
    Zhen Zhang
    Department of Pathology, Biomarker Discovery Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 64:5882-90. 2004
  2. ncbi request reprint Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions
    Steven J Skates
    Massachusetts General Hospital, 50 Stanford St, Suite 560, Boston, MA 02114, USA
    J Clin Oncol 22:4059-66. 2004
  3. ncbi request reprint Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Clin Chem 51:102-12. 2005
  4. ncbi request reprint Classification of cancer types by measuring variants of host response proteins using SELDI serum assays
    Eric T Fung
    Ciphergen Biosystems, Fremont, CA 94555, USA
    Int J Cancer 115:783-9. 2005
  5. ncbi request reprint Using proteomic approaches to identify new biomarkers for detection and monitoring of ovarian cancer
    Fanbing Kong
    Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
    Gynecol Oncol 100:247-53. 2006
  6. pmc Genome-wide identification of significant aberrations in cancer genome
    Xiguo Yuan
    School of Computer Science and Technology, Xidian University, Xi an, P R China
    BMC Genomics 13:342. 2012
  7. pmc Knowledge-guided multi-scale independent component analysis for biomarker identification
    Li Chen
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:416. 2008
  8. pmc Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer
    Zhen Zhang
    Center for Biomarker Discovery, Department of Pathology, Johns Hopkins Medical Institutions, CRB II 3M04, 1550 Orleans Street, Baltimore, MD 21231, USA
    Gynecol Oncol 107:526-31. 2007
  9. ncbi request reprint Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay
    Jin Song
    Center for Biomarker Discovery, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Clin Chem 52:1045-53. 2006
  10. ncbi request reprint Serum markers in patients with resectable pancreatic adenocarcinoma: macrophage inhibitory cytokine 1 versus CA19-9
    Jens Koopmann
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Clin Cancer Res 12:442-6. 2006

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer
    Zhen Zhang
    Department of Pathology, Biomarker Discovery Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 64:5882-90. 2004
    ..These biomarkers demonstrated the potential to improve the detection of early stage ovarian cancer...
  2. ncbi request reprint Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions
    Steven J Skates
    Massachusetts General Hospital, 50 Stanford St, Suite 560, Boston, MA 02114, USA
    J Clin Oncol 22:4059-66. 2004
    ..For direct comparisons between marker panels, all sensitivity results correspond to a 98% fixed first-line specificity (referral rate 2%)...
  3. ncbi request reprint Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Clin Chem 51:102-12. 2005
    ..This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutional evaluation and validation of this approach for detection of prostate cancer...
  4. ncbi request reprint Classification of cancer types by measuring variants of host response proteins using SELDI serum assays
    Eric T Fung
    Ciphergen Biosystems, Fremont, CA 94555, USA
    Int J Cancer 115:783-9. 2005
    ....
  5. ncbi request reprint Using proteomic approaches to identify new biomarkers for detection and monitoring of ovarian cancer
    Fanbing Kong
    Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China
    Gynecol Oncol 100:247-53. 2006
    ..This study uses proteomic approaches to identify new biomarkers for detection and monitoring of ovarian cancer...
  6. pmc Genome-wide identification of significant aberrations in cancer genome
    Xiguo Yuan
    School of Computer Science and Technology, Xidian University, Xi an, P R China
    BMC Genomics 13:342. 2012
    ....
  7. pmc Knowledge-guided multi-scale independent component analysis for biomarker identification
    Li Chen
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:416. 2008
    ..In this paper, we develop a novel strategy, namely knowledge-guided multi-scale independent component analysis (ICA), to first infer regulatory signals and then identify biologically relevant biomarkers from microarray data...
  8. pmc Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer
    Zhen Zhang
    Center for Biomarker Discovery, Department of Pathology, Johns Hopkins Medical Institutions, CRB II 3M04, 1550 Orleans Street, Baltimore, MD 21231, USA
    Gynecol Oncol 107:526-31. 2007
    ..In this paper, an ANN model was evaluated for its performance in detecting early stage epithelial ovarian cancer using multiple serum markers...
  9. ncbi request reprint Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay
    Jin Song
    Center for Biomarker Discovery, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Clin Chem 52:1045-53. 2006
    ....
  10. ncbi request reprint Serum markers in patients with resectable pancreatic adenocarcinoma: macrophage inhibitory cytokine 1 versus CA19-9
    Jens Koopmann
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Clin Cancer Res 12:442-6. 2006
    ..More accurate serum markers of pancreatic cancer could improve the early detection and prognosis of this deadly disease. We compared the diagnostic utility of a panel of candidate serum markers of pancreatic cancer...
  11. pmc Suppression of annexin A11 in ovarian cancer: implications in chemoresistance
    Jin Song
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Neoplasia 11:605-14, 1 p following 614. 2009
    ..Collectively, annexin A11 is directly involved in cell proliferation and cisplatin resistance of ovarian cancer. Manipulation of annexin A11 and its associated genes may represent a novel therapeutic strategy in human ovarian cancers...
  12. ncbi request reprint Predicting prostate cancer biochemical recurrence using a panel of serum proteomic biomarkers
    C Nicole Rosenzweig
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 181:1407-14. 2009
    ..We hypothesized that biomarkers are present in preoperative serum, which may be used to predict the probability of biochemical recurrence following radical prostatectomy...
  13. ncbi request reprint Proteomic approaches to tumor marker discovery
    Alex J Rai
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 126:1518-26. 2002
    ..High-throughput proteomic profiling and bioinformatics tools allow for the rapid screening of a large number of potential biomarkers in serum, plasma, or other body fluids...
  14. ncbi request reprint Independent validation of candidate breast cancer serum biomarkers identified by mass spectrometry
    Jinong Li
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Clin Chem 51:2229-35. 2005
    ....
  15. ncbi request reprint Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: multi-institution correlation of spectra and identification of
    Alex J Rai
    Department of Pathology, Division of Clinical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7065, USA
    Proteomics 5:3467-74. 2005
    ..This approach could be exploited for population-based studies in all phases of the HUPO PPP...
  16. pmc Glycoproteomics for prostate cancer detection: changes in serum PSA glycosylation patterns
    Danni L Meany
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Proteome Res 8:613-9. 2009
    ..71) appeared to perform better than percent free PSA (AUC = 0.54) in its diagnostic gray zone between 10 and 20% in a subset of 21 subjects. A separate study of 16 additional subjects showed similar findings...
  17. ncbi request reprint Serum diagnosis of pancreatic adenocarcinoma using surface-enhanced laser desorption and ionization mass spectrometry
    Jens Koopmann
    Department of Pathology, Johns Hopkins Medical Institutions, 632 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Clin Cancer Res 10:860-8. 2004
    ..Fewer than 5% of patients survive >5 years after diagnosis, because most patients present with advanced disease. Early diagnosis may improve the prognosis of patients with pancreatic cancer...
  18. ncbi request reprint Detection of prostate cancer using serum proteomics pattern in a histologically confirmed population
    Jinong Li
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 171:1782-7. 2004
    ..We retrospectively identified a panel of serum proteins that can discriminate between men with prostate cancer (clinically organ confined) and men with benign prostate disease...
  19. ncbi request reprint Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer
    Hsueh Wei Chang
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:1697-703. 2002
    ..AI can be detected in genomic tumor DNA released into the blood after necrosis or apoptosis. We evaluated plasma DNA concentration, allelic status in plasma DNA, and serum CA 125 level as screening tests for ovarian and other cancers...
  20. ncbi request reprint Annexin XI is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients
    Jin Song
    Department of Pathology, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Clin Cancer Res 13:6842-9. 2007
    ..In this study, a protein identified to be associated with cisplatin resistance in ovarian cancer cells was investigated in ovarian cancer tissues to address its clinical significance...
  21. ncbi request reprint Notch3 gene amplification in ovarian cancer
    Joon T Park
    Department of Gynecology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 66:6312-8. 2006
    ..These results indicate that Notch3 is required for proliferation and survival of Notch3-amplified tumors and inactivation of Notch3 can be a potential therapeutic approach for ovarian carcinomas...
  22. pmc Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis
    Ruben T Almaraz
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins Medical Institution, Baltimore, MD, USA
    Mol Cell Proteomics 11:M112.017558. 2012
    ..These results indicate that cancer cells can become more aggressively malignant by controlling the sialylation of proteins implicated in metastatic transformation via metabolic flux...
  23. pmc A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Meyer B 125, Baltimore, MD 21287, USA
    Cancer Epidemiol Biomarkers Prev 19:1193-200. 2010
    ..The study objective was to characterize the clinical utility of serum [-2]proPSA for prostate cancer detection and assess its association with aggressive disease...
  24. ncbi request reprint Identification of BCOX1, a novel gene overexpressed in breast cancer
    Jin Song
    Department of Pathology, Johns Hopkins Medical Institutions, 417 N Caroline Str, Baltimore, MD 21231, USA
    Biochim Biophys Acta 1760:62-9. 2006
    ..This study warrants further investigations to explore the molecular functions of BCOX1, and to determine its potential diagnostic and therapeutic applications for breast cancer...
  25. ncbi request reprint The application of clinical proteomics to cancer and other diseases
    William Clarke
    Clinical Chemistry Division, Johns Hopkins Medical Institutions, Baltimore 21287, USA
    Clin Chem Lab Med 41:1562-70. 2003
    ..Proteomic analyses are already widely in use for clinical studies ranging from cancer to other diseases such as cardiovascular disease, organ transplant, and pharmacodynamic studies...
  26. ncbi request reprint Ovarian cancer specific kallikrein profile in effusions
    Ie Ming Shih
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Gynecol Oncol 105:501-7. 2007
    ..However, a comprehensive and parallel analysis of different secreted kallikreins in ovarian cancer has not been performed. This study was undertaken to profile the secreted kallikreins in cancer effusion supernatants...
  27. pmc Characterization of renal allograft rejection by urinary proteomic analysis
    William Clarke
    Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 8611, USA
    Ann Surg 237:660-4; discussion 664-5. 2003
    ..To develop a diagnostic method with no morbidity or mortality for the detection of acute renal transplant rejection...
  28. pmc AISAIC: a software suite for accurate identification of significant aberrations in cancers
    Bai Zhang
    Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, School of Computer Science and Technology, Xidian University, Xi an 710126, China, Department of Oncology and Department of Gynecology Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA Department of Oncology and Department of Physiology and Biophysics, Georgetown University, Washington, DC 20057, USA and Department of Electrical Engineering and Computer Science, University of Michigan, An Arbor, MI 48109, USA
    Bioinformatics 30:431-3. 2014
    ..Availability and implementation: AISAIC is available as a Java application, with a user's guide and source code, at https://code.google.com/p/aisaic/...
  29. ncbi request reprint Identifying tumor origin using a gene expression-based classification map
    Phillip Buckhaults
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 63:4144-9. 2003
    ..This expression map analysis may provide a reliable and practical approach to determine tumor type in cases of metastatic carcinoma of clinically unknown origin...
  30. ncbi request reprint Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer
    Jinong Li
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem 48:1296-304. 2002
    ..This technology allows sensitive and high-throughput protein profiling of complex biological specimens...
  31. ncbi request reprint Bioinformatics strategies for proteomic profiling
    C Nicole White
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Clin Biochem 37:636-41. 2004
    ..In this review, we discuss such issues and the bioinformatics strategies used for proteomic profiling...
  32. doi request reprint The road from discovery to clinical diagnostics: lessons learned from the first FDA-cleared in vitro diagnostic multivariate index assay of proteomic biomarkers
    Zhen Zhang
    Center for Biomarker Discovery, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 19:2995-9. 2010
    ..This has become an urgent issue to be addressed because the continuing funding from both the public and private sources are called into question...
  33. pmc Analysis of N-glycoproteins using genomic N-glycosite prediction
    Shisheng Sun
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, United States
    J Proteome Res 12:5609-15. 2013
    ..We show that the described method has a great potential in the analysis of detectable N-glycoproteins from cells and tissues. ..
  34. doi request reprint Comparison of EGFR and KRAS mutations in primary and unpaired metastatic lung adenocarcinoma with potential chemotherapy effect
    Delicia Munfus-McCray
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Hum Pathol 44:1286-92. 2013
    ..Additional studies are needed to further investigate the mechanism and clinical significance of the findings...
  35. pmc Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias
    Dale McLerran
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Chem 54:44-52. 2008
    ..Details of this 3-stage process have been described. This report describes the development of the algorithm and results of the blinded test for stage 1...
  36. ncbi request reprint Early detection of ovarian cancer: promise and reality
    Robert C Bast
    Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology and Anatomic Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Treat Res 107:61-97. 2002
  37. ncbi request reprint A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays
    Wanzhi Huang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Protein Eng 16:853-60. 2003
    ..This peptide may be a useful starting point for the design of non-beta-lactam, broad-spectrum peptidomimetic inhibitors of beta-lactamases...
  38. ncbi request reprint The early detection research network surface-enhanced laser desorption and ionization prostate cancer detection study: A study in biomarker validation in genitourinary oncology
    William E Grizzle
    University of Alabama at Birmingham, Birmingham, AL, USA
    Urol Oncol 22:337-43. 2004
    ..The methodologies used for this evaluation will prove useful for guiding future biomarker studies in this challenging disease...
  39. doi request reprint Cipadonoid A, a novel limonoid with an unprecedented skeleton, from Cipadessa cinerasecns
    Xin Fang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China
    Org Lett 10:1905-8. 2008
    ..1 represents a new type of limonoid, characterized by a rearranged tetrahydropyranyl ring B incorporating usually exocyclic C-30. A possible biosynthetic pathway of 1 was also proposed...
  40. doi request reprint Genome-wide analysis of the AP2/ERF gene family in Populus trichocarpa
    Jing Zhuang
    Shanghai Academy of Agricultural Sciences, 2901 Beidi Road, Shanghai 201106, China
    Biochem Biophys Res Commun 371:468-74. 2008
    ..4-1.6-fold than those from A. thaliana. The rates were very similar for the putative homologs between Populus and Arabidopsis...
  41. ncbi request reprint Esophagectomy after concurrent chemoradiotherapy improves locoregional control in clinical stage II or III esophageal cancer patients
    Zhongxing Liao
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 60:1484-93. 2004
    ..To evaluate the effect of surgical resection on the outcome of patients with clinical Stage II or III cancer of the esophagus treated with concurrent chemoradiotherapy...
  42. ncbi request reprint [Quantitative determination of aqueous flare and cells in the eyes of patients with inflammation of anterior uvea]
    Pei zeng Yang
    Zhongshan Ophthalmic Center, Zhongshan University, Guangzhou 510060, China
    Zhonghua Yan Ke Za Zhi 40:510-3. 2004
    ..To quantify aqueous flare and cells in the eyes of patients with inflammation of anterior uvea by FC-2000 laser flare cell meter (LFCM), and to compare these results with those obtained with slit lamp microscopy...
  43. ncbi request reprint Cancer proteomics: in pursuit of "true" biomarker discovery
    Zhen Zhang
    Cancer Epidemiol Biomarkers Prev 14:2283-6. 2005
  44. ncbi request reprint Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein
    Zhen Zhang
    Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:45706-12. 2003
    ..Based on the results, a E73A/Y50A double mutant was constructed that exhibited a 220,000-fold change in binding specificity for the TEM-1 versus SME-1 enzymes...
  45. ncbi request reprint Defected expression of E-cadherin in non-small cell lung cancer
    Qingyan Fei
    Laboratory of Population and Quantitative Genetics, Institute of Genetics, Fudan University, Shanghai 200433, PR China
    Lung Cancer 37:147-52. 2002
    ....
  46. ncbi request reprint Cloning and characterization of ARHGAP12, a novel human rhoGAP gene
    Zhen Zhang
    School of Life Science, State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai 200433, PR China
    Int J Biochem Cell Biol 34:325-31. 2002
    ..Reverse transcription PCR and Northern blot indicates that it ubiquitously expresses in human tissues as well as tumor cell lines, suggesting its basic roles in cells...
  47. doi request reprint Bovine sertoli cells colonize and form tubules in murine hosts following transplantation and grafting procedures
    Zhen Zhang
    Center for Reproduction and Development, Monash Institute of Medical Research, Monash University, 27 31 Wright St Clayton, VIC 3168, Australia
    J Androl 29:418-30. 2008
    ..It identifies an approach that can readily be adapted to study other nonrodent species...
  48. pmc Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein
    Zhen Zhang
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 103:1422-7. 2006
    ..Our results suggest that Wtm1 acts either as an adaptor to facilitate nuclear import of betabeta' by Kap122 or as an anchor to retain betabeta' in the nucleus...
  49. ncbi request reprint Quality control for SELDI analysis
    C Nicole White
    Clin Chem Lab Med 43:125-6. 2005
  50. ncbi request reprint C-H stretching vibrations of methyl, methylene and methine groups at the vapor/alcohol (N = 1-8) interfaces
    Rong Lu
    State Key Laboratory of Molecular Reaction Dynamics, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, P R China, 100080
    J Phys Chem B 109:14118-29. 2005
    ..Therefore, the advancement on vibrational spectra assignment may find broad applications in the related fields using IR and Raman as vibrational spectroscopic tools...
  51. ncbi request reprint Studies of interaction between a new synthesized minor-groove targeting artificial nuclease and DNA
    Qiang Yin
    The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 66:904-8. 2007
    ..DNA binding behavior was determined by UV-vis and circular dichroism (CD) methods. It was indicated that compound 6 can enhance the Tm of oligomer DNA from 51.8 to 63.5 degrees C and possesses large binding constant (Kb=8.83x10(4)L/mol)...
  52. ncbi request reprint Development of a chemiluminescent ELISA for determining chloramphenicol in chicken muscle
    Suxia Zhang
    Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Agric Food Chem 54:5718-22. 2006
    ..After 3 days, CAP was not detected in chicken muscle. The developed method is therefore suitable for screening of CAP in chicken muscle samples...
  53. ncbi request reprint Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase
    Allison D Ortigosa
    Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 45:12282-94. 2006
    ..Thus, under normal growth conditions, the cell assembles stoichiometric amounts of Y(*) and modulation of Y(*) concentration is not involved in the regulation of RNR activity...
  54. ncbi request reprint Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma
    Ben Davidson
    Department of Pathology, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Oslo, Norway
    Clin Cancer Res 12:5944-50. 2006
    ..It remains unclear whether both tumors are molecularly distinct neoplasms. The current study compared global gene expression patterns in OC/PPC and DMPM...
  55. ncbi request reprint [Involved-field three-dimensional conformal radiation treatment for stage III non-small-cell lung]
    Jin Ming Yu
    Department of Radiation Oncology, Shandong Cancer Hospital, Jinan 250117, China
    Zhonghua Zhong Liu Za Zhi 28:526-9. 2006
    ..To investigate the feasibility of involved-field irradiation (IFI ) for stage III non-small cell lung cancer (NSCLC)...
  56. ncbi request reprint Time-resolved fluoroimmunoassay for ractopamine in swine tissue
    Jianzhong Shen
    Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Anal Bioanal Chem 387:1561-4. 2007
    ..1 to 20.5%. The detection limit was 0.1 microg kg(-1). The proposed TR-FIA method was applied to the determination of RAC in an actual residue study and the applicability was confirmed by liquid chromatography-tandem mass spectrometry...
  57. ncbi request reprint Prevention and early detection of ovarian cancer: mission impossible?
    Robert C Bast
    M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Recent Results Cancer Res 174:91-100. 2007
    ..In the future, serum markers should improve the sensitivity of detecting recurrent disease as well as facilitate earlier detection of ovarian cancer...
  58. ncbi request reprint The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo
    Deborah L Perlstein
    Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 44:15366-77. 2005
    ..These studies together demonstrate that beta' plays a crucial role in cluster assembly in vitro and in vivo and that the active form of the yeast R2 is betabeta'...
  59. ncbi request reprint Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy
    Xin Qin
    Biotechnology Center of The Fourth Military Medical University, and State Key Laboratory of Cancer Biology, 17 Chang le West Road, 710032 Xi an, People s Republic of China
    J Biochem 142:79-85. 2007
    ..In addition, the flow cytometry assay and immunofluorescence showed that the FITC labelled P1 could bind to VEGFR-3 positive carcinoma cells with specificity. Our study suggests that P1 may be a homing peptide for treatment of tumours...
  60. pmc Classification algorithms for phenotype prediction in genomics and proteomics
    Habtom W Ressom
    Lombardi Comprehensive Cancer Center, 3970 Reservoir Rd NW, Washington, DC 20057, USA
    Front Biosci 13:691-708. 2008
    ..The selected features are presented to a classifier for phenotype prediction...
  61. ncbi request reprint Dissecting phenotypic variation among AIS patients
    Minghua Wang
    Laboratory of Population and Quantitative Genetics, China s State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Morgan Tan International Center for Life Sciences, Fudan University, Shanghai, PR China
    Biochem Biophys Res Commun 335:335-42. 2005
    ....
  62. ncbi request reprint SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer
    Dale McLerran
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Chem 54:53-60. 2008
    ..This report is the 2nd of 2 companion articles describing a validation study of a SELDI-TOF MS approach with IMAC surface sample processing to identify prostatic adenocarcinoma...