Ying Zhang


Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA


  1. Zhang Y, Zhang J, Cui P, Zhang Y, Zhang W. Identification of Novel Efflux Proteins Rv0191, Rv3756c, Rv3008, and Rv1667c Involved in Pyrazinamide Resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Our studies indicate that these four efflux proteins may be responsible for PZA/POA efflux and cause PZA resistance in M. tuberculosis Future studies are needed to assess their roles in PZA resistance in clinical strains. ..
  2. Wang X, Han H, Lv Z, Lin Z, Shang Y, Xu T, et al. PhoU2 but Not PhoU1 as an Important Regulator of Biofilm Formation and Tolerance to Multiple Stresses by Participating in Various Fundamental Metabolic Processes in Staphylococcus epidermidis. J Bacteriol. 2017;199: pubmed publisher
    ..Analysis of differential gene expression revealed that phoU2 is involved in fundamental metabolic processes, such as the PPP pathway. These findings indicate that phoU2 is a crucial regulator in S. epidermidis. ..
  3. Shi W, Cui P, Niu H, Zhang S, Tønjum T, Zhu B, et al. Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of M. tuberculosis Confirms their Role in Causing Resistance to Pyrazinamide. Antimicrob Agents Chemother. 2019;: pubmed publisher
    ..Here, we introduced the RpsA Δ438A mutation along with the D123A mutation into Mycobacterium tuberculosis chromosome and demonstrated that these RspA mutations are indeed responsible for PZA resistance. ..
  4. Feng J, Shi W, Miklossy J, Tauxe G, McMeniman C, Zhang Y. Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi. Antibiotics (Basel). 2018;7: pubmed publisher
    ..Pers. fruits essential oils all had visible growth during subculture. Future studies are needed to determine if these highly active essential oils could eradicate persistent B. burgdorferi infection in vivo. ..
  5. Chen Y, Chen J, Zhang S, Shi W, Zhang W, Zhu M, et al. Novel Mutations Associated with Clofazimine Resistance in Mycobacterium abscessus. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..abscessus Our findings have implications for understanding mechanisms of resistance to clofazimine and for rapid detection of clofazimine resistance in this organism. ..
  6. Han J, Shi W, Xu X, Wang S, Zhang S, He L, et al. Conditions and mutations affecting Staphylococcus aureus L-form formation. Microbiology. 2015;161:57-66 pubmed publisher
    ..Our findings shed new insight into the molecular basis of S. aureus unstable L-form formation and may have implications for development of novel drugs targeting S. aureus L-forms for improved treatment. ..
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    Zhang Y, Wade M, Scorpio A, Zhang H, Sun Z. Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid. J Antimicrob Chemother. 2003;52:790-5 pubmed
    ..Inhibitors of membrane energetics increased the antituberculous activity of pyrazinamide. These findings shed new light on the mode of action of pyrazinamide and may help in the design of new drugs that shorten therapy. ..
  8. Shi W, Chen J, Zhang S, Zhang W, Zhang Y. Identification of Novel Mutations in LprG (rv1411c), rv0521, rv3630, rv0010c, ppsC, and cyp128 Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..tuberculosis. ..
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    Zhang Y. Advances in the treatment of tuberculosis. Clin Pharmacol Ther. 2007;82:595-600 pubmed
    ..Improved understanding of persister biology and development of persister drugs are likely to be important for developing a more effective therapy. ..

More Information


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    Zhang Y, Permar S, Sun Z. Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide. J Med Microbiol. 2002;51:42-9 pubmed
    ..8, with an MIC of 400 mg/L compared with 1,000 mg/L without reserpine. These findings should have implications for understanding the mode of action of PZA and for PZA susceptibility testing. ..
  2. Zhang S, Chen J, Cui P, Shi W, Shi X, Niu H, et al. Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid. Antimicrob Agents Chemother. 2016;60:2542-4 pubmed publisher
    ..Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB. ..
  3. Niu H, Cui P, Shi W, Zhang S, Feng J, Wang Y, et al. Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug Library. Antibiotics (Basel). 2015;4:179-87 pubmed publisher
    ..coli persisters in 3 days in vitro while the current UTI antibiotics failed to do so. Our findings may have implications for the development of a more effective treatment for UTIs. ..
  4. Niu H, Cui P, Yee R, Shi W, Zhang S, Feng J, et al. A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active against Staphylococcus aureus Persisters. Antibiotics (Basel). 2015;4:329-36 pubmed publisher
    ..Further studies are needed to evaluate tosufloxacin in animal models and to explain its unique activity against bacterial persisters. Our findings may have implications for improved treatment of persistent bacterial infections. ..
  5. Yee R, Cui P, Shi W, Feng J, Zhang Y. Genetic Screen Reveals the Role of Purine Metabolism in Staphylococcus aureus Persistence to Rifampicin. Antibiotics (Basel). 2015;4:627-42 pubmed publisher
    ..These findings provide new insights into the mechanisms of persistence in S. aureus and provide novel therapeutic targets for developing more effective treatment for persistent infections due to S. aureus. ..
  6. Zhang S, Chen J, Cui P, Shi W, Zhang W, Zhang Y. Identification of novel mutations associated with clofazimine resistance in Mycobacterium tuberculosis. J Antimicrob Chemother. 2015;70:2507-10 pubmed publisher
    ..Further studies are needed to address the role of rv1979c and rv2535c in clofazimine resistance and mechanisms of action. ..
  7. He L, Wang X, Cui P, Jin J, Chen J, Zhang W, et al. ubiA (Rv3806c) encoding DPPR synthase involved in cell wall synthesis is associated with ethambutol resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2015;95:149-54 pubmed publisher
    ..The essentiality of UbiA, its involvement in EMB resistance, and lack of human homologs make UbiA an attractive target for new drug development. ..
  8. Zhang J, Zhang B, Zhao Y, Yang X, Huang M, Cui P, et al. Snapshots of catalysis: Structure of covalently bound substrate trapped in Mycobacterium tuberculosis thiazole synthase (ThiG). Biochem Biophys Res Commun. 2018;497:214-219 pubmed publisher
    ..Our research will provide useful information for understanding the ThiG function and lay the basis for future drug design by targeting this essential protein. ..
  9. Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y. Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Antibiotics (Basel). 2015;4:397-410 pubmed publisher
    ..These studies may have implications for developing more effective treatments of Lyme disease. ..
  10. Feng J, Zhang S, Shi W, Zhang Y. Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi In Vitro. Antibiotics (Basel). 2017;6: pubmed publisher
    ..burgdorferi stationary phase cells. Future studies are needed to evaluate and optimize the sulfa drug combinations in vitro and also in animal models. ..
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    Zhang Y, Yew W. Mechanisms of drug resistance in Mycobacterium tuberculosis. Int J Tuberc Lung Dis. 2009;13:1320-30 pubmed
    ..Understanding the mechanisms of drug resistance in M. tuberculosis would enable the development of rapid molecular diagnostic tools and furnish possible insights into new drug development for the treatment of TB. ..
  12. Niu H, Yee R, Cui P, Tian L, Zhang S, Shi W, et al. Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library. Pathogens. 2017;6: pubmed publisher
    ..We ranked these new drug candidates according to their MICs against the MRSA strain USA300. Our findings may have implications for more effective treatment of MRSA infections. ..
  13. Yuan Y, You Y, Wen Y, Liu J, Li H, Zhang Y, et al. Identification of novel genetic loci GAL3ST4 and CHGB involved in susceptibility to leprosy. Sci Rep. 2017;7:16352 pubmed publisher
    ..The results showed that the female subjects with high frequent genotype in GAL3ST4 had a fivefold elevated expression. We suggest the polymorphisms in GAL3ST4 in different population are associated with increased risk of leprosy. ..