Cheng Zhang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    Invest Ophthalmol Vis Sci 45:2753-9. 2004
  2. ncbi Activation of microglia and chemokines in light-induced retinal degeneration
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Vis 11:887-95. 2005
  3. ncbi Characterization of activated retinal microglia following optic axotomy
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    J Neurosci Res 73:840-5. 2003
  4. ncbi Heterogeneous populations of microglia/macrophages in the retina and their activation after retinal ischemia and reperfusion injury
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Rm 457, Woods Building, Baltimore, MD 21287 9238, USA
    Exp Eye Res 81:700-9. 2005
  5. ncbi Concentration-dependent bupivacaine myotoxicity in rabbit extraocular muscle
    Cheng Zhang
    The Krieger Children s Eye Center at The Wilmer Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J AAPOS 14:323-7. 2010
  6. ncbi Silent sinus syndrome causing cyclovertical diplopia masquerading as superior oblique paresis in the fellow eye
    Cheng Zhang
    The Krieger Children s Eye Center, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9028, USA
    J AAPOS 14:450-2. 2010
  7. ncbi βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina
    Debasish Sinha
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD, 21231, USA
    Transgenic Res 21:1033-42. 2012
  8. ncbi High expression of macrophage migration inhibitory factor in the murine lacrimal gland
    Choul Yong Park
    Department of Ophthalmology, Johns Hopkins University, Baltimore, MD 21117, USA
    Cornea 29:187-91. 2010
  9. ncbi Inflammatory cytokine expression on the ocular surface in the Botulium toxin B induced murine dry eye model
    Lei Zhu
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21117, USA
    Mol Vis 15:250-8. 2009
  10. ncbi Immunohistochemistry and electron microscopy of early-onset fuchs corneal dystrophy in three cases with the same L450W COL8A2 mutation
    Cheng Zhang
    Center for Corneal Genetics, Cornea and External Disease Service, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Trans Am Ophthalmol Soc 104:85-97. 2006

Collaborators

Detail Information

Publications52

  1. ncbi Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    Invest Ophthalmol Vis Sci 45:2753-9. 2004
    ..This study was conducted to evaluate the neuroprotective effect of minocycline and the role of microglia in light-induced retinal degeneration...
  2. ncbi Activation of microglia and chemokines in light-induced retinal degeneration
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Vis 11:887-95. 2005
    ..This study investigated the activation and migration of retinal microglial cells and expression of chemokines in retinas in light-induced photoreceptor degeneration in mice...
  3. ncbi Characterization of activated retinal microglia following optic axotomy
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    J Neurosci Res 73:840-5. 2003
    ..The ED1-positive cells, presumably recently blood-borne macrophage in the CNS, remained the same number in the axotomized retina...
  4. ncbi Heterogeneous populations of microglia/macrophages in the retina and their activation after retinal ischemia and reperfusion injury
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Rm 457, Woods Building, Baltimore, MD 21287 9238, USA
    Exp Eye Res 81:700-9. 2005
    ....
  5. ncbi Concentration-dependent bupivacaine myotoxicity in rabbit extraocular muscle
    Cheng Zhang
    The Krieger Children s Eye Center at The Wilmer Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J AAPOS 14:323-7. 2010
    ..However, there are no data on the concentration-dependence of bupivacaine in causing extraocular muscle toxicity...
  6. ncbi Silent sinus syndrome causing cyclovertical diplopia masquerading as superior oblique paresis in the fellow eye
    Cheng Zhang
    The Krieger Children s Eye Center, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9028, USA
    J AAPOS 14:450-2. 2010
    ..Inferior oblique myectomy in the fellow eye resulted in excellent alignment...
  7. ncbi βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina
    Debasish Sinha
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD, 21231, USA
    Transgenic Res 21:1033-42. 2012
    ....
  8. ncbi High expression of macrophage migration inhibitory factor in the murine lacrimal gland
    Choul Yong Park
    Department of Ophthalmology, Johns Hopkins University, Baltimore, MD 21117, USA
    Cornea 29:187-91. 2010
    ..To report the expression of macrophage migration inhibitory factor (MIF) in murine lacrimal glands...
  9. ncbi Inflammatory cytokine expression on the ocular surface in the Botulium toxin B induced murine dry eye model
    Lei Zhu
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21117, USA
    Mol Vis 15:250-8. 2009
    ..Inflammation plays an important role in dry eye syndrome. In this study, inflammatory cytokine expression on the ocular surface in the Botulium toxin B (BTX-B) induced mouse dry eye model was investigated...
  10. ncbi Immunohistochemistry and electron microscopy of early-onset fuchs corneal dystrophy in three cases with the same L450W COL8A2 mutation
    Cheng Zhang
    Center for Corneal Genetics, Cornea and External Disease Service, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Trans Am Ophthalmol Soc 104:85-97. 2006
    ....
  11. ncbi Axonal degeneration, regeneration and ganglion cell death in a rodent model of anterior ischemic optic neuropathy (rAION)
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Exp Eye Res 91:286-92. 2010
    ....
  12. ncbi A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye
    Cheng Zhang
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
    Eur J Cell Biol 90:440-8. 2011
    ..This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system...
  13. ncbi Toxic effect of methamphetamine on the retina of CD1 mice
    Hong Lai
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Eye Res 34:785-90. 2009
    ..To investigate whether systemic administration of methamphetamine (METH) induces retinal damage in CD1 mice...
  14. ncbi Lacrimal gland inflammatory cytokine gene expression in the botulinum toxin B-induced murine dry eye model
    Choul Yong Park
    Department of Ophthalmology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Mol Vis 13:2222-32. 2007
    ..And to determine the effect of various topical anti-inflammatory agents on the resulting cytokine levels...
  15. ncbi Optic nerve infarction and post-ischemic inflammation in the rodent model of anterior ischemic optic neuropathy (rAION)
    Cheng Zhang
    Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Brain Res 1264:67-75. 2009
    ..Manipulation of the inflammatory response may be an important variable that could potentially improve visual outcome...
  16. ncbi Expression of βA3/A1-crystallin in the developing and adult rat eye
    Geetha Parthasarathy
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 N Broadway, Smith Research Building, M035, Baltimore, MD 21287, USA
    J Mol Histol 42:59-69. 2011
    ....
  17. ncbi A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye
    Cheng Zhang
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Dev Dyn 234:36-47. 2005
    ..Interestingly, in human PFV (persistent fetal vasculature) disease, where the hyaloid vasculature abnormally persists after birth, we show that astrocytes express both VEGF and crystallins...
  18. ncbi A spontaneous mutation affects programmed cell death during development of the rat eye
    Debasish Sinha
    Department of Ophthalmology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Eye Res 80:323-35. 2005
    ..The transient layer of Chievitz persists in adult Nuc1 retina, indicative of delayed development. Hence, Nuc1 is a novel mutation that could be an eye-specific regulator of apoptosis...
  19. ncbi Cryopreservation and lentiviral-mediated genetic modification of human primary cultured corneal endothelial cells
    Leejee H Suh
    Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 9238, USA
    Invest Ophthalmol Vis Sci 48:3056-61. 2007
    ....
  20. ncbi Histopathologic and immunologic aspects of alphacor artificial corneal failure
    Marco Coassin
    Wilmer Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Am J Ophthalmol 144:699-704. 2007
    ..To describe the histopathologic and immunologic characteristics of late artificial corneal failure in a small series of patients who underwent AlphaCor implantation and to elucidate the mechanisms involved...
  21. ncbi Increased nuclear factor-kappa B p65 immunoreactivity following retinal ischemia and reperfusion injury in mice
    Yue guo Chen
    Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    J Neurosci Res 72:125-31. 2003
    ..The NF-kappaB p65 immunoreactivity was associated with retinal degeneration following retinal ischemia and reperfusion injury...
  22. ncbi Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat
    J Samuel Zigler
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Cell Sci 124:523-31. 2011
    ..A3/A1-crystallin is a novel lysosomal protein in RPE, essential for degradation of phagocytosed material...
  23. ncbi Fuchs corneal dystrophy: aberrant collagen distribution in an L450W mutant of the COL8A2 gene
    John D Gottsch
    Center for Corneal Genetics, Cornea and External Disease Service, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 46:4504-11. 2005
    ..To characterize histologically Descemet's membrane in an early-onset Fuchs corneal dystrophy (FCD) COL8A2 mutant and compare these findings with corneas from late-onset FCD and normal corneas...
  24. ncbi Ischemic preconditioning attenuates apoptotic cell death in the rat retina
    Cheng Zhang
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 43:3059-66. 2002
    ..CONCLUSIONS: IPC protects against ischemic injury, in part, by diminishing apoptosis-related gene expression and by altering protein phosphorylation...
  25. ncbi Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice
    Hui-Yang Zeng
    Peking University Eye Centre, Peking University Third Hospital, Beijing, China
    Invest Ophthalmol Vis Sci 46:2992-9. 2005
    ..TNF-alpha, produced by the activated microglia, may accentuate the photoreceptor cell death...
  26. ncbi The influence of apoptosis of mucosal epithelial cells on intestinal barrier integrity after scald in rats
    Cheng Zhang
    Department of Burns and Plastic Surgery, Lanzhou General Hospital, Gansu Province 730050, Lanzhou, PR China
    Burns 28:731-7. 2002
    ..To study the influence of apoptosis of intestinal epithelial cells occurring as a result of reperfusion after burn shock on the intestinal barrier...
  27. ncbi [Activation of NF-kappa B in the mouse retina after ischemia reperfusion]
    Yue guo Chen
    The Third Clinical School of Peking University, Peking University Eye Center, Beijing 100083, China
    Zhonghua Yan Ke Za Zhi 39:560-4. 2003
    ..To investigate the expression of NF-kappa B following retinal ischemia and reperfusion injury in mice...
  28. ncbi The role of oxygen-free radical in the apoptosis of enterocytes in scalded rats after delayed resuscitation
    Cheng Zhang
    Department of Burns and Plastic Surgery, Lanzhou General Hospital, Lanzhou 730050, Gansu Province, China
    J Trauma 56:611-7. 2004
    ..This study aimed to evaluate the relation between apoptosis of enterocytes and oxygen-free radical injury in scalded rats with delayed resuscitation as well as the role of antioxidants in the prevention of enterocyte apoptosis...
  29. ncbi Maternally administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species
    Xiang Yun Li
    Department of Toxicology, Anhui Medical University, Hefei 230032, China
    Toxicol Lett 176:169-77. 2008
    ..These results provide new evidence that maternal LPS exposure results in oxidative stress in fetuses, which may contribute to LPS-induced developmental toxicity...
  30. ncbi Peroxisome proliferator-activated receptor-gamma1 gene therapy attenuates atherosclerosis and stabilizes plaques in apolipoprotein E-deficient mice
    Qin Hu
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China
    Hum Gene Ther 19:287-299. 2008
    ..Thus, PPARgamma1 might offer a promising gene therapeutic target against atherosclerosis...
  31. ncbi A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs
    Cheng Zhang
    Department of Neurology, University of California at San Francisco, San Francisco, California, USA
    DNA Cell Biol 22:303-15. 2003
    ....
  32. ncbi Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA
    Baoshan Xu
    State Key Laboratories for AgroBiotechnology and Department of Animal Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, P R China
    Biol Pharm Bull 31:1182-91. 2008
    ..It indicated that there was a cholesterol levels link-modulation system between cholesterol synthetic pathway through CYP51 and cholesterol transport pathway through LDLR in vivo...
  33. ncbi Overexpression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis
    Bo Dong
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, P R China
    Arterioscler Thromb Vasc Biol 28:1270-6. 2008
    ..The purpose of this study was to test the hypothesis that ACE2 overexpression may enhance atherosclerotic plaque stability by antagonizing ACE activity and converting angiotensin II to angiotensin 1-7...
  34. ncbi [Translocation of intestinal endotoxin and bacteria induced by the apoptosis of enterocytes in scald rats after delayed resuscitation]
    Cheng Zhang
    General Hospital of Lanzhou Command, Lanzhou 730050, Gansu, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:150-3. 2003
    ..This may lead to a compromise of intestinal barrier. It may be one of the major causes of translocation of endotoxin and bacteria postburn...
  35. ncbi [Transfection and in vitro expression of human microdystrophin gene in rat mesenchymal stem cells]
    Shu Hui Wang
    Department of Neurology, First Affiliated Hospital1, Sun Yat Sen University, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:261-5. 2006
    ..To construct the eukaryotic expression vector of human microdystrophin gene and observe its expression in rat mesenchymal stem cells (rMSCs) in vitro...
  36. ncbi Maternally-administered lipopolysaccharide (LPS) increases tumor necrosis factor alpha in fetal liver and fetal brain: its suppression by low-dose LPS pretreatment
    Huan Ning
    Department of Toxicology, Anhui Medical University, Hefei 230032, PR China
    Toxicol Lett 176:13-9. 2008
    ..Taken together, these results indicate that perinatal exposure to low-dose LPS induces a reduced sensitivity to subsequent LPS challenge...
  37. ncbi Herpes simplex virus VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice
    Fu Xiong
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    Hum Gene Ther 18:490-501. 2007
    ....
  38. ncbi [A novel missense mutation, K124N, in the troponin T gene of Chinese populations with hypertrophic cardiomyopathy]
    Feng shuang An
    Department of Cardiology, Qilu Hospital, Shandong University, Jinan 250012, China
    Zhonghua Yi Xue Za Zhi 84:1340-3. 2004
    ..To study the cardiac troponin T (TNNT2) gene mutation in Chinese patients with hypertrophic cardiomyopathy (HCM) and to analyze the correlation between the genotype and phenotype...
  39. ncbi [The study of committed differentiation from adult rMSCs into neuron-like cells induced by Xiangdan injection in vitro]
    Hui Huang
    Neurology Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou
    Zhong Yao Cai 27:585-9. 2004
    ..CONCLUSIONS: The rMSCs could be differentiated into neuron-like cells in vitro with the induction of XDI in the free-serum media...
  40. ncbi Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors
    Cheng Zhang
    Department of Urology, Shiga University of Medical Science, Otsu, Japan
    Genes Chromosomes Cancer 43:104-12. 2005
    ....
  41. ncbi Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity
    Shuping Zhong
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, 90033, USA
    Mol Cell Biol 24:5119-29. 2004
    ..Since the cellular levels of the products of these genes, tRNAs and rRNAs, determine the translational capacity of cells, this event may be an important contributor to the transforming function of EGF...
  42. ncbi [Effects of granulocyte colony-stimulating factor on focal cerebral ischemia-reperfusion injury in rats]
    Song Lin Chen
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 25:503-7. 2005
    ..To study the therapeutic effects of granulocyte colony-stimulating factor (G-CSF) on focal cerebral ischemia-reperfusion injury in rats...
  43. ncbi Early activation of caspase-1 after retinal ischemia and reperfusion injury in mice
    Guang-ying Zheng
    Department of Ophthalmology, First Affiliated Hospital, Zhengzhou University, Henan 450052, China
    Chin Med J (Engl) 117:717-21. 2004
    ..CONCLUSION: Caspase-1 immunoreactivity preceds to the TUNEL labeling in the GCL and INL after retinal ischemia and reperfusion injury and its early activation may play an important role in the initiation of neuronal apoptosis...
  44. ncbi Mutation analysis of the small heat shock protein 27 gene in chinese patients with Charcot-Marie-Tooth disease
    Beisha Tang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, People s Republic of China
    Arch Neurol 62:1201-7. 2005
    ..Recently, mutations in small heat shock protein 27 (Hsp27) were reported to cause CMT disease type 2F and distal hereditary motor neuropathy...
  45. ncbi [The genes change of hMSC before and after the differentation into neuron-like cells]
    Xiaoli Yao
    Department of Neurology, The First Affiliated Hospital, Guangzhou
    Zhong Yao Cai 28:476-81. 2005
    ..CONCLUSION: hMSC express multipotentiality, and the neural differentiation comprises quantitative modulation of gene expression rather than simple on-off switching of neural specific genes...
  46. ncbi [Ultrastructural changes in muscular tissues of dystrophin/utrophin double-knockout mice after bone marrow-derived mesenchymal stem cell transplantation]
    Zhong Li
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 24:501-4. 2004
    ..To observe the ultrastructural changes in the muscular tissues of Duchenne muscular dystrophy mouse models with dystrophin/utrophin double-knockout (DKO) after transplantation of bone marrow-derived mesenchymal stem cells (MSCs)...
  47. ncbi Effect of aging on the expression of peroxisome proliferator-activated receptor gamma and the possible relation to insulin resistance
    Ping Ye
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Gerontology 52:69-75. 2006
    ..The morbidity of insulin resistance tends to increase with aging. However, studies on molecular mechanisms underlying insulin resistance in aging process is still in paucity...
  48. ncbi Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8)
    Shomir Ghosh
    Department of Medicinal Chemistry, Millennium Pharmaceuticals, 40 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    J Med Chem 49:2669-72. 2006
    ..These analogues exhibit good potency in binding and chemotaxis assays, show good selectivity versus the hERG channel, and have good eADME (early absorption, distribution, metabolism, and excretion) profiles...
  49. ncbi Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs
    Jing Quan Zhong
    Cardiology Department, Qilu Hospital of Shandong University, 107 Wen Hua Xi Lu, Jinan 250012, Shandong Province, China
    Eur J Heart Fail 9:23-9. 2007
    ..To study changes in connexin, metalloproteinase and tissue inhibitor of metalloproteinase levels during tachycardia-induced cardiomyopathy (TIC)...
  50. ncbi TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway
    Cheng Zhang
    Division of Cardiovascular Surgery, Texas Heart Institute at St Luke s Episcopal Hospital, and Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Arterioscler Thromb Vasc Biol 27:1760-7. 2007
    ..Tumor necrosis factor-alpha (TNF-alpha), a pivotal cytokine that regulates ECM metabolism by increasing degradation and decreasing production of arterial collagens, is associated with vulnerable plaques and aortic aneurysms...
  51. ncbi Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases
    Sandra S Johnson
    Department of Biochemistry and Molecular Biology, Keck School of Medicine and the Norris Comprehensive Cancer Center, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Mol Cell 26:367-79. 2007
    ..Together with the ability of Maf1 to reduce biosynthetic capacity, these findings support the idea that Maf1 regulates the transformation state of cells...
  52. ncbi [Cloning and sequencing of junction fragment with exon 51 deletion of Dystrophin gene]
    Su Yue Pan
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University of Medical Sciences, Guangzhou 510080, China
    Yi Chuan Xue Bao 29:105-10. 2002
    ..We here firstly reported that there is a THE-1 sequence in intron 50. THE-1 and non-homologue end joining repair mechanism may be associated with the Dystrophin gene deletion...