Research Topics
Genomes and GenesSpecies | Peter P ZandiSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Multilocus linkage analysis of the German asthma dataP P Zandi
Department of Mental Hygiene, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Genet Epidemiol 21:S210-5. 2001..Finally, the neural network analysis identified a potential locus on chromosome 17 that was not identified in the other analyses...
Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapiesConstantine G Lyketsos
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U S A
Int Psychogeriatr 20:871-89. 2008..Several examples are used to illustrate each biomarker utility in the AD context...- No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studiesC A Szekely
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neurology 70:2291-8. 2008..One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is responsible for this apparent reduction in AD risk... - Sex-specific association of the Reelin gene with bipolar disorderF S Goes
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
Am J Med Genet B Neuropsychiatr Genet 153:549-53. 2010..However, our findings should be interpreted with caution until further replication and functional assays provide convergent support... - SVAw - a web-based application tool for automated surrogate variable analysis of gene expression studiesMehdi Pirooznia
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Source Code Biol Med 8:8. 2013..Using SVA increases the biological accuracy and reproducibility of gene expression studies by identifying these sources of heterogeneity and correctly accounting for them in the analysis... - The promise and reality of pharmacogenetics in psychiatryPeter P Zandi
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Hampton House, Baltimore, MD 21205, USA
Psychiatr Clin North Am 33:181-224. 2010.... - Association study of Wnt signaling pathway genes in bipolar disorderPeter P Zandi
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
Arch Gen Psychiatry 65:785-93. 2008..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder... - Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariatesP P Zandi
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Mol Psychiatry 12:630-9. 2007..These findings further demonstrate the value of considering clinical features that may reflect the underlying heterogeneity of disease in order to facilitate gene mapping... - SNP fine mapping of chromosome 8q24 in bipolar disorderPeter P Zandi
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions... - Rh and ABO maternal-fetal incompatibility and risk of autismPeter P Zandi
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 141:643-7. 2006..Furthermore, we did not find any evidence for the presence of a high-risk susceptibility allele at or near these two loci operating either through the mother or child... - Family-based SNP association study on 8q24 in bipolar disorderPeter P Zandi
Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008..These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility... - Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County StudyPeter P Zandi
Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University, Hampton House Room 857, 624 N Broadway, Baltimore, MD 21205, USA
Arch Neurol 61:82-8. 2004..Antioxidants may protect the aging brain against oxidative damage associated with pathological changes of Alzheimer disease (AD)... 
The promise and reality of pharmacogenetics in psychiatryPeter P Zandi
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Hampton House, Room 857, 624 North Broadway, Baltimore, MD 21205, USA
Clin Lab Med 30:931-74. 2010....- Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and XPeter P Zandi
Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes... - Is pharmacological prevention of Alzheimer's a realistic goal?Peter P Zandi
Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Hampton House 884, 624 N Broadway, Baltimore, MD 21205, USA
Expert Opin Pharmacother 3:365-80. 2002.... - Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33Fernando S Goes
Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:236-47. 2007..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features... - Family-based association study of Neuregulin 1 with psychotic bipolar disorderFernando S Goes
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009.... - A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicityFrancis M Mondimore
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Affect Disord 100:171-7. 2007..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness... - Clinical correlates and familial aggregation of age at onset in bipolar disorderPing-I Lin
Dept. of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N. Broadway, 8th Floor, Baltimore, MD 21205, USA
Am J Psychiatry 163:240-6. 2006..Thus, age at onset may conceivably be used to identify more homogeneous groups of bipolar disorder families and thereby facilitate the mapping of bipolar disorder susceptibility genes... - The bipolar disorder phenome database: a resource for genetic studiesJames B Potash
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:1229-37. 2007..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies... - Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County StudyAra S Khachaturian
Khachaturian and Associates Inc, Potomac, MD, USA
Arch Gen Psychiatry 61:518-24. 2004..APOE is a strong genetic risk factor for AD... - Association between APOE epsilon4 allele and vascular dementia: The Cache County studyYi Fang Chuang
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Dement Geriatr Cogn Disord 29:248-53. 2010..We examined the relationship between APOE epsilon4 allele and the risk of incident VaD in a large, population-based cohort of elderly adults with up to 10 years of follow-up between 1995 and 2005... - Case-control association study of TGOLN2 in attempted suicidePamela B Mahon
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 153:1016-23. 2010..Taken together, these analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders... - Genome-wide scan of bipolar II disorderEvaristus A Nwulia
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Bipolar Disord 9:580-8. 2007..We have performed genome-wide non-parametric analysis on 74 bipolar pedigrees using only the BD II phenotype as affection model... - Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County StudyMajid Fotuhi
Department of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain and Spine Institute, Baltimore, MD, USA
Alzheimers Dement 4:223-7. 2008..05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time... - Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12Virginia L Willour
Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 61:725-7. 2007..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide... - Genome-wide linkage and follow-up association study of postpartum mood symptomsPamela Belmonte Mahon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
Am J Psychiatry 166:1229-37. 2009..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms... - Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigreesMelvin G McInnis
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287-7463, USA
Biol Psychiatry 54:1265-73. 2003..Application of conditional analyses is potentially useful in larger sample collections to identify susceptibility genes of modest influence that may not be identified in a genome-wide scan aimed to identify single gene effects... - Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1James B Potash
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008..Further work is needed to confirm these results and uncover the functional variation underlying the association signal... - Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorderJames B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
Am J Psychiatry 160:680-6. 2003.... - Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21Virginia L Willour
The Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35... - Rapid switching of mood in families with multiple cases of bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Arch Gen Psychiatry 60:921-8. 2003..Phenomena in the bipolar spectrum, including rapid cycling, cyclothymia, and affective instability of borderline personality, may be important markers of etiologic heterogeneity. Rapid switching of mood may be central to these phenomena... - Family-based association of FKBP5 in bipolar disorderV L Willour
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Mol Psychiatry 14:261-8. 2009..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses... - Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigreesFrancis M Mondimore
Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
Am J Psychiatry 163:1554-60. 2006..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder... - Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County StudyPeter P Zandi
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Arch Gen Psychiatry 62:217-24. 2005..Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users, but, to our knowledge, no prospective studies relate statin use and dementia incidence... - Antihypertensive medication use and incident Alzheimer disease: the Cache County StudyAra S Khachaturian
Khachaturian and Associates Inc, Potomac, MD, USA
Arch Neurol 63:686-92. 2006..CONCLUSIONS: These data suggest that AH medications, and specifically potassium-sparing diuretics, are associated with reduced incidence of AD. Because the latter association is a new finding, it requires confirmation in further study... - Meta-analysis of genetic association studies on bipolar disorderFayaz Seifuddin
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 159:508-18. 2012..The results of this meta-analysis and from other on-going genomic experiments in BP are available online at Metamoodics (http://metamoodics.igm.jhmi.edu)... - Association study of serotonin pathway genes in attempted suicideJennifer T Judy
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012..Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior... - Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigreesJennifer L Payne
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
Arch Womens Ment Health 12:27-34. 2009..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use... - Data mining approaches for genome-wide association of mood disordersMehdi Pirooznia
School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Psychiatr Genet 22:55-61. 2012..Data mining methods are available that may be applied to analyze the high dimensional data generated by GWAS of complex psychiatric disorders... - Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorderPamela Belmonte Mahon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 156:370-8. 2011..8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles... - Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Psychiatry 159:30-5. 2002..This study used diagnostic data from the NIMH Bipolar Disorder Genetics Initiative to assess in a separate, larger family set the familiality of panic combined with bipolar disorder... - Rapid mood switching and suicidality in familial bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Bipolar Disord 7:441-8. 2005.... - Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
Am J Psychiatry 160:1696-8. 2003..The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder... - Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21qPing-I Lin
Department of Mental Health, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Am J Hum Genet 77:545-55. 2005..This inconsistency may be due to differences in the AAO characteristics of the samples examined. Future studies to fine map susceptibility genes for BP on chromosomes 21q22.13 and 18p11.2 should take AAO into account... - Risk of mortality with vitamin E supplements: the Cache County studyKathleen M Hayden
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Am J Med 120:180-4. 2007..We sought to determine whether these mortality risks with vitamin E reflect adverse consequences of its use in the presence of cardiovascular disease... - QuickSNP: an automated web server for selection of tagSNPsDeepak Grover
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Nucleic Acids Res 35:W115-20. 2007..The server is freely available and can be accessed at the URL http://bioinformoodics.jhmi.edu/quickSNP.pl... - A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disordersRegina A Shih
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Int Rev Psychiatry 16:260-83. 2004.... - SynaptomeDB: an ontology-based knowledgebase for synaptic genesMehdi Pirooznia
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA
Bioinformatics 28:897-9. 2012..SynaptomeDB integrates various and complex data sources for synaptic genes and proteins... - Hematologic risk factors of vascular disease and their relation to dementiaMichelle M Mielke
Center on Aging and Health and the Alzheimer Disease Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Dement Geriatr Cogn Disord 21:335-52. 2006..A necessary step is to examine multiple hematologic factors simultaneously, rather than in isolation, to determine how these factors are interrelated... - A hybrid likelihood model for sequence-based disease association studiesYun Ching Chen
Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS Genet 9:e1003224. 2013..05, of which one MAPK signaling pathway (KEGG) reaches trend-level significance after correcting for multiple testing... - Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late lifeMichelle M Mielke
Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Alzheimer Dis Assoc Disord 20:30-6. 2006..Nonetheless, serum potassium is a modifiable risk factor and further examination of the potassium-dementia relationship is warranted... - Searching for valid psychiatric phenotypes: discrete latent variable modelsJeannie Marie S Leoutsakos
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int J Methods Psychiatr Res 19:63-73. 2010..A primary challenge in psychiatric genetics is the lack of a completely validated system of classification for mental disorders. Appropriate statistical methods are needed to empirically derive more homogenous disorder subtypes... - Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humansDavid T Dao
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21201, USA
Biol Psychiatry 68:801-10. 2010..Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis... - NSAIDs for the chemoprevention of Alzheimer's diseaseChristine A Szekely
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Subcell Biochem 42:229-48. 2007..The feasibility of using NSAIDs as a chemopreventive agent in AD is discussed... - Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County StudyPeter P Zandi
Department of Mental Hygiene, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD, USA
JAMA 288:2123-9. 2002..55 [95% CI, 0.21-1.23]). CONCLUSIONS: Prior HRT use is associated with reduced risk of AD, but there is no apparent benefit with current HRT use unless such use has exceeded 10 years... - Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County StudyPeter P Zandi
Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Neurology 59:880-6. 2002..Recently initiated randomized trials of NSAID for primary prevention of AD are therefore unlikely to show effects with treatment until participants have been followed for several years... - Hormone replacement therapy and reduced cognitive decline in older women: the Cache County StudyM C Carlson
Department of Mental Hygiene, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Neurology 57:2210-6. 2001..To examine the association between postmenopausal hormone replacement therapy (HRT) and the trajectory of global cognitive change with age... - How migraines impact cognitive function: findings from the Baltimore ECAA Kalaydjian
Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, MD, USA
Neurology 68:1417-24. 2007..To examine the cross-sectional and longitudinal relationship between migraine headaches and cognitive functioning... - High total cholesterol levels in late life associated with a reduced risk of dementiaM M Mielke
Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neurology 64:1689-95. 2005..To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia... - Incorporating scientific knowledge into phenotype development: penalized latent class regressionJeannie Marie S Leoutsakos
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, U S A
Stat Med 30:784-98. 2011..Investigation of novel penalty functions may prove fruitful in further refining psychiatric phenotypes... - Exonic DNA sequencing of ERBB4 in bipolar disorderFernando S Goes
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 6:e20242. 2011..However, the modest sample size in this study cannot definitively rule out a role for rare variants in bipolar disorder and studies with larger sample sizes are needed to confirm the observed association... - Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic reviewChristine A Szekely
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neuroepidemiology 23:159-69. 2004..The purpose of this meta-analysis is to summarize and evaluate available evidence regarding exposure to nonaspirin NSAIDs and risk of Alzheimer's disease using meta-analyses of published studies... - Incidence of AD may decline in the early 90s for men, later for women: The Cache County studyR A Miech
Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Neurology 58:209-18. 2002..The presence of APOE-epsilon 4 alleles accelerated onset of AD, but did not appreciably alter lifetime incidence apparent over a span of 100 years... - Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adultsPamela Belmonte Mahon
The Johns Hopkins Mood Disorders Center, Baltimore, MD, USA
Psychopharmacology (Berl) 227:231-41. 2013..Variations in the genes encoding these proteins, FKBP5 and CRHR1, have been associated with several neuropsychiatric disorders... - NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID typeC A Szekely
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Hampton House Room 857, 624 North Broadway, Baltimore, MD 21205, USA
Neurology 70:17-24. 2008..We therefore investigated the association between use of NSAIDs, aspirin, and the non-NSAID analgesic acetaminophen with incidence of dementia and AD... - Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County studyJ C Anthony
Department of Mental Hygiene, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Neurology 54:2066-71. 2000..To test the hypothesis that nonsteroidal anti-inflammatory drugs (NSAIDs) and histamine H2 receptor antagonists (H2RAs) are associated with a decreased risk of AD in late life... - Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysisD Avramopoulos
Department of Psychiatry, Johns Hopkins University, School of Medicine, North Wolfe Street, Baltimore, MD 21287, USA
Mol Psychiatry 9:191-6. 2004..Biologically, plausible candidate genes in this region include thyroglobulin, KCNQ3 coding for a voltage-gated potassium channel and the gene for brain adenyl-cyclase (ADCY8)... - Family-based association of YWHAH in psychotic bipolar disorderDeepak Grover
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 150:977-83. 2009.... - Prevention of Alzheimer's diseaseC A Szekely
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Int Rev Psychiatry 19:693-706. 2007..Although none of these have yet to be definitively shown to prevent Alzheimer's disease, further research should help to clarify what role they may play in reducing the burden of this disease... - Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8qMatthew B McQueen
Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
Am J Hum Genet 77:582-95. 2005..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches... - Apolipoprotein E genotype and mortality: findings from the Cache County StudyKathleen M Hayden
Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina
J Am Geriatr Soc 53:935-42. 2005..To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD)... - Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection... - Rapid switching of mood in families with familial bipolar disorderEvaristus A Nwulia
Department of Psychiatry, Howard University, Washington, DC, USA
Bipolar Disord 10:597-606. 2008..This study aims to confirm these associations and investigate other potential correlates of rapid switching of mood using families from a multisite bipolar linkage study... - Effects of estrogen plus progestin on risk of dementiaJohn C S Breitner
JAMA 290:1706-7; author reply 1707-8. 2003 - Church attendance and new episodes of major depression in a community study of older adults: the Cache County StudyMaria C Norton
Department of Family, Consumer and Human Development, Cache County Study on Memory Health and Aging, Utah State University, 4440 Old Main Hill, Logan, UT 84322 4440, USA
J Gerontol B Psychol Sci Soc Sci 63:P129-37. 2008..28-0.92). Results suggest that there may be a threshold of church attendance that is necessary for a person to garner long-term protection from depression. We discuss sociological factors relevant to LDS culture... - Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County studyMaria C Norton
Department of Family, Consumer and Human Development, Utah State University, Logan, 84322, USA
Am J Geriatr Psychiatry 14:237-45. 2006.... - Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County studyKathleen M Hayden
Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27705, USA
Alzheimer Dis Assoc Disord 20:93-100. 2006..Future studies should focus on specific causal pathways for each of these factors with regard to sex to determine if sex differences in the prevalence of vascular factors have an influence on sex differences in dementia risk... - Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorderRicardo Segurado
Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 73:49-62. 2003..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region... - A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and AgingJoAnn T Tschanz
Department of Psychology, Center for Epidemiologic Studies, Utah State University, Logan 84322 4440, USA
Care Manag J 6:107-14. 2005....
Research Grants
- BIOINFORMATICS TO DISCOVER GENES IN PSYCHIATRIC ILLNESSPeter Zandi; Fiscal Year: 2007..The training and research plans of this proposal will provide the groundwork for the candidate to achieve his long-term goal of helping to elucidate the genetic contribution to complex psychiatric disorders. ..
- Metamoodics: Meta-analyses and bioinformatics display of mood disorders geneticsPeter P Zandi; Fiscal Year: 2010..The web resource will provide a computational tool for analyzing the synthesized data to test the etiologic contribution of different molecular pathways, such as the Wnt signaling pathway. ..
- Metamoodics: Meta-analyses and bioinformatics display of mood disorders geneticsPeter P Zandi; Fiscal Year: 2011..The web resource will provide a computational tool for analyzing the synthesized data to test the etiologic contribution of different molecular pathways, such as the Wnt signaling pathway. ..