Peter P Zandi

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Multilocus linkage analysis of the German asthma data
    P P Zandi
    Department of Mental Hygiene, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 21:S210-5. 2001
  2. pmc Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U S A
    Int Psychogeriatr 20:871-89. 2008
  3. pmc No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
    C A Szekely
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 70:2291-8. 2008
  4. pmc Sex-specific association of the Reelin gene with bipolar disorder
    F S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 153:549-53. 2010
  5. pmc Validation and assessment of variant calling pipelines for next-generation sequencing
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Genomics 8:14. 2014
  6. pmc A review of potassium channels in bipolar disorder
    Jennifer T Judy
    Department of Psychiatry, Johns Hopkins School of Medicine Baltimore, MD, USA
    Front Genet 4:105. 2013
  7. pmc Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder
    Jennifer Toolan Judy
    Department of Psychiatry, Johns Hopkins School of Medicine Baltimore, MD, USA
    Front Genet 4:87. 2013
  8. pmc Systematic review of genome-wide gene expression studies of bipolar disorder
    Fayaz Seifuddin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BMC Psychiatry 13:213. 2013
  9. pmc SVAw - a web-based application tool for automated surrogate variable analysis of gene expression studies
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Source Code Biol Med 8:8. 2013
  10. pmc Family-based SNP association study on 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008

Detail Information

Publications88

  1. ncbi request reprint Multilocus linkage analysis of the German asthma data
    P P Zandi
    Department of Mental Hygiene, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 21:S210-5. 2001
    ..Finally, the neural network analysis identified a potential locus on chromosome 17 that was not identified in the other analyses...
  2. pmc Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U S A
    Int Psychogeriatr 20:871-89. 2008
    ..Several examples are used to illustrate each biomarker utility in the AD context...
  3. pmc No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
    C A Szekely
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 70:2291-8. 2008
    ..One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is responsible for this apparent reduction in AD risk...
  4. pmc Sex-specific association of the Reelin gene with bipolar disorder
    F S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 153:549-53. 2010
    ..However, our findings should be interpreted with caution until further replication and functional assays provide convergent support...
  5. pmc Validation and assessment of variant calling pipelines for next-generation sequencing
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Genomics 8:14. 2014
    ..Here, we validate the variant calling of these tools and compare their relative accuracy to determine which data processing pipeline is optimal...
  6. pmc A review of potassium channels in bipolar disorder
    Jennifer T Judy
    Department of Psychiatry, Johns Hopkins School of Medicine Baltimore, MD, USA
    Front Genet 4:105. 2013
    ..We consider animal models and treatment implications of the involvement of potassium ion channelopathy in BP. Finally, we explore intriguing parallels between BP and epilepsy, the signature channelopathy of the central nervous system...
  7. pmc Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder
    Jennifer Toolan Judy
    Department of Psychiatry, Johns Hopkins School of Medicine Baltimore, MD, USA
    Front Genet 4:87. 2013
    ..The interactions between ANK3 and KCNQ2 merit further investigation, and if confirmed, may motivate a new line of research into a novel therapeutic target for BP...
  8. pmc Systematic review of genome-wide gene expression studies of bipolar disorder
    Fayaz Seifuddin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BMC Psychiatry 13:213. 2013
    ..These studies are heterogeneous, underpowered and use overlapping samples. We conducted a systematic review of these studies to synthesize the current findings...
  9. pmc SVAw - a web-based application tool for automated surrogate variable analysis of gene expression studies
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Source Code Biol Med 8:8. 2013
    ..Using SVA increases the biological accuracy and reproducibility of gene expression studies by identifying these sources of heterogeneity and correctly accounting for them in the analysis...
  10. pmc Family-based SNP association study on 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008
    ..These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility...
  11. ncbi request reprint Rh and ABO maternal-fetal incompatibility and risk of autism
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 141:643-7. 2006
    ..Furthermore, we did not find any evidence for the presence of a high-risk susceptibility allele at or near these two loci operating either through the mother or child...
  12. ncbi request reprint Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University, Hampton House Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Neurol 61:82-8. 2004
    ..Antioxidants may protect the aging brain against oxidative damage associated with pathological changes of Alzheimer disease (AD)...
  13. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003
    ..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes...
  14. ncbi request reprint Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates
    P P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Mol Psychiatry 12:630-9. 2007
    ..These findings further demonstrate the value of considering clinical features that may reflect the underlying heterogeneity of disease in order to facilitate gene mapping...
  15. ncbi request reprint SNP fine mapping of chromosome 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007
    ..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions...
  16. pmc The promise and reality of pharmacogenetics in psychiatry
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Hampton House, Baltimore, MD 21205, USA
    Psychiatr Clin North Am 33:181-224. 2010
    ....
  17. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  18. ncbi request reprint The promise and reality of pharmacogenetics in psychiatry
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Hampton House, Room 857, 624 North Broadway, Baltimore, MD 21205, USA
    Clin Lab Med 30:931-74. 2010
    ....
  19. ncbi request reprint Is pharmacological prevention of Alzheimer's a realistic goal?
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Hampton House 884, 624 N Broadway, Baltimore, MD 21205, USA
    Expert Opin Pharmacother 3:365-80. 2002
    ....
  20. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  21. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
    ....
  22. pmc A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicity
    Francis M Mondimore
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Affect Disord 100:171-7. 2007
    ..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness...
  23. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
    ..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms...
  24. ncbi request reprint Clinical correlates and familial aggregation of age at onset in bipolar disorder
    Ping I Lin
    Dept of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, 8th Floor, Baltimore, MD 21205, USA
    Am J Psychiatry 163:240-6. 2006
    ....
  25. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
    ..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
  26. ncbi request reprint Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
    Am J Psychiatry 160:680-6. 2003
    ....
  27. pmc Association between APOE epsilon4 allele and vascular dementia: The Cache County study
    Yi Fang Chuang
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Dement Geriatr Cogn Disord 29:248-53. 2010
    ..We examined the relationship between APOE epsilon4 allele and the risk of incident VaD in a large, population-based cohort of elderly adults with up to 10 years of follow-up between 1995 and 2005...
  28. ncbi request reprint Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study
    Ara S Khachaturian
    Khachaturian and Associates Inc, Potomac, MD, USA
    Arch Gen Psychiatry 61:518-24. 2004
    ..APOE is a strong genetic risk factor for AD...
  29. pmc Case-control association study of TGOLN2 in attempted suicide
    Pamela B Mahon
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1016-23. 2010
    ..Taken together, these analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders...
  30. ncbi request reprint Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12
    Virginia L Willour
    Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 61:725-7. 2007
    ..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide...
  31. pmc Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study
    Majid Fotuhi
    Department of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain and Spine Institute, Baltimore, MD, USA
    Alzheimers Dement 4:223-7. 2008
    ..05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time...
  32. ncbi request reprint Genome-wide scan of bipolar II disorder
    Evaristus A Nwulia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 9:580-8. 2007
    ..We have performed genome-wide non-parametric analysis on 74 bipolar pedigrees using only the BD II phenotype as affection model...
  33. ncbi request reprint Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees
    Francis M Mondimore
    Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 163:1554-60. 2006
    ..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder...
  34. ncbi request reprint Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1
    James B Potash
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008
    ..Further work is needed to confirm these results and uncover the functional variation underlying the association signal...
  35. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  36. doi request reprint Rapid switching of mood in families with familial bipolar disorder
    Evaristus A Nwulia
    Department of Psychiatry, Howard University, Washington, DC, USA
    Bipolar Disord 10:597-606. 2008
    ..This study aims to confirm these associations and investigate other potential correlates of rapid switching of mood using families from a multisite bipolar linkage study...
  37. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
    ..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35...
  38. ncbi request reprint Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 62:217-24. 2005
    ..Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users, but, to our knowledge, no prospective studies relate statin use and dementia incidence...
  39. ncbi request reprint Rapid switching of mood in families with multiple cases of bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Gen Psychiatry 60:921-8. 2003
    ..Phenomena in the bipolar spectrum, including rapid cycling, cyclothymia, and affective instability of borderline personality, may be important markers of etiologic heterogeneity. Rapid switching of mood may be central to these phenomena...
  40. doi request reprint Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  41. ncbi request reprint Antihypertensive medication use and incident Alzheimer disease: the Cache County Study
    Ara S Khachaturian
    Khachaturian and Associates Inc, Potomac, MD, USA
    Arch Neurol 63:686-92. 2006
    ..Recent reports suggest that antihypertensive (AH) medications may reduce the risk of dementing illnesses...
  42. pmc A hybrid likelihood model for sequence-based disease association studies
    Yun Ching Chen
    Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Genet 9:e1003224. 2013
    ..05, of which one MAPK signaling pathway (KEGG) reaches trend-level significance after correcting for multiple testing...
  43. pmc Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 156:370-8. 2011
    ..8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles...
  44. pmc Meta-analysis of genetic association studies on bipolar disorder
    Fayaz Seifuddin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 159:508-18. 2012
    ..The results of this meta-analysis and from other on-going genomic experiments in BP are available online at Metamoodics (http://metamoodics.igm.jhmi.edu)...
  45. pmc Association study of serotonin pathway genes in attempted suicide
    Jennifer T Judy
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012
    ..Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior...
  46. pmc Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
    Arch Womens Ment Health 12:27-34. 2009
    ..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use...
  47. pmc Data mining approaches for genome-wide association of mood disorders
    Mehdi Pirooznia
    School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Psychiatr Genet 22:55-61. 2012
    ..Data mining methods are available that may be applied to analyze the high dimensional data generated by GWAS of complex psychiatric disorders...
  48. ncbi request reprint Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Psychiatry 160:1696-8. 2003
    ..The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder...
  49. ncbi request reprint Rapid mood switching and suicidality in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 7:441-8. 2005
    ....
  50. ncbi request reprint Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Psychiatry 159:30-5. 2002
    ..This study used diagnostic data from the NIMH Bipolar Disorder Genetics Initiative to assess in a separate, larger family set the familiality of panic combined with bipolar disorder...
  51. pmc Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q
    Ping I Lin
    Department of Mental Health, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Hum Genet 77:545-55. 2005
    ..This inconsistency may be due to differences in the AAO characteristics of the samples examined. Future studies to fine map susceptibility genes for BP on chromosomes 21q22.13 and 18p11.2 should take AAO into account...
  52. pmc Association study of X chromosome SNPs in attempted suicide
    Dubravka Jancic
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Psychiatry Res 200:1044-6. 2012
    ..07×10(-4)) and GRIA3 (P=4.01×10(-4)). These findings highlight the need for larger sample sets and meta-analytic approaches...
  53. ncbi request reprint Risk of mortality with vitamin E supplements: the Cache County study
    Kathleen M Hayden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Med 120:180-4. 2007
    ..We sought to determine whether these mortality risks with vitamin E reflect adverse consequences of its use in the presence of cardiovascular disease...
  54. pmc QuickSNP: an automated web server for selection of tagSNPs
    Deepak Grover
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Nucleic Acids Res 35:W115-20. 2007
    ..The server is freely available and can be accessed at the URL http://bioinformoodics.jhmi.edu/quickSNP.pl...
  55. ncbi request reprint A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders
    Regina A Shih
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Int Rev Psychiatry 16:260-83. 2004
    ....
  56. pmc SynaptomeDB: an ontology-based knowledgebase for synaptic genes
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA
    Bioinformatics 28:897-9. 2012
    ..However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking...
  57. ncbi request reprint Hematologic risk factors of vascular disease and their relation to dementia
    Michelle M Mielke
    Center on Aging and Health and the Alzheimer Disease Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dement Geriatr Cogn Disord 21:335-52. 2006
    ..A necessary step is to examine multiple hematologic factors simultaneously, rather than in isolation, to determine how these factors are interrelated...
  58. pmc Genome-wide association study of suicide attempts in mood disorder patients
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 167:1499-507. 2010
    ..The authors therefore examined the association between common genomewide variation and lifetime suicide attempts...
  59. pmc Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene
    Sarah M Hartz
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Psychiatr Genet 21:77-84. 2011
    ....
  60. pmc Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults
    Pamela Belmonte Mahon
    The Johns Hopkins Mood Disorders Center, Baltimore, MD, USA
    Psychopharmacology (Berl) 227:231-41. 2013
    ..Variations in the genes encoding these proteins, FKBP5 and CRHR1, have been associated with several neuropsychiatric disorders...
  61. ncbi request reprint Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life
    Michelle M Mielke
    Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Alzheimer Dis Assoc Disord 20:30-6. 2006
    ..Nonetheless, serum potassium is a modifiable risk factor and further examination of the potassium-dementia relationship is warranted...
  62. pmc Searching for valid psychiatric phenotypes: discrete latent variable models
    Jeannie Marie S Leoutsakos
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Methods Psychiatr Res 19:63-73. 2010
    ..A primary challenge in psychiatric genetics is the lack of a completely validated system of classification for mental disorders. Appropriate statistical methods are needed to empirically derive more homogenous disorder subtypes...
  63. pmc Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans
    David T Dao
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21201, USA
    Biol Psychiatry 68:801-10. 2010
    ..Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis...
  64. ncbi request reprint NSAIDs for the chemoprevention of Alzheimer's disease
    Christine A Szekely
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Subcell Biochem 42:229-48. 2007
    ..The feasibility of using NSAIDs as a chemopreventive agent in AD is discussed...
  65. ncbi request reprint Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Neurology 59:880-6. 2002
    ..The authors re-examined these associations using data on incident AD...
  66. ncbi request reprint Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study
    Peter P Zandi
    Department of Mental Hygiene, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:2123-9. 2002
    ..Basic neuroscience findings suggest that hormone replacement therapy (HRT) could reduce a woman's risk of AD. Epidemiologic findings on AD and HRT are mixed...
  67. ncbi request reprint High total cholesterol levels in late life associated with a reduced risk of dementia
    M M Mielke
    Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 64:1689-95. 2005
    ..To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia...
  68. ncbi request reprint Hormone replacement therapy and reduced cognitive decline in older women: the Cache County Study
    M C Carlson
    Department of Mental Hygiene, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurology 57:2210-6. 2001
    ..To examine the association between postmenopausal hormone replacement therapy (HRT) and the trajectory of global cognitive change with age...
  69. ncbi request reprint How migraines impact cognitive function: findings from the Baltimore ECA
    A Kalaydjian
    Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, MD, USA
    Neurology 68:1417-24. 2007
    ..To examine the cross-sectional and longitudinal relationship between migraine headaches and cognitive functioning...
  70. pmc Exonic DNA sequencing of ERBB4 in bipolar disorder
    Fernando S Goes
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20242. 2011
    ..However, the modest sample size in this study cannot definitively rule out a role for rare variants in bipolar disorder and studies with larger sample sizes are needed to confirm the observed association...
  71. pmc Incorporating scientific knowledge into phenotype development: penalized latent class regression
    Jeannie Marie S Leoutsakos
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, U S A
    Stat Med 30:784-98. 2011
    ..Investigation of novel penalty functions may prove fruitful in further refining psychiatric phenotypes...
  72. ncbi request reprint Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
    Christine A Szekely
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neuroepidemiology 23:159-69. 2004
    ..The purpose of this meta-analysis is to summarize and evaluate available evidence regarding exposure to nonaspirin NSAIDs and risk of Alzheimer's disease using meta-analyses of published studies...
  73. ncbi request reprint Incidence of AD may decline in the early 90s for men, later for women: The Cache County study
    R A Miech
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Neurology 58:209-18. 2002
    ..To characterize the incidence of AD among the elderly population of Cache County, UT, noted for its longevity and high response rates; to explore sex differences; and to examine whether AD incidence plateaus or declines in extreme old age...
  74. pmc NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type
    C A Szekely
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Hampton House Room 857, 624 North Broadway, Baltimore, MD 21205, USA
    Neurology 70:17-24. 2008
    ..We therefore investigated the association between use of NSAIDs, aspirin, and the non-NSAID analgesic acetaminophen with incidence of dementia and AD...
  75. pmc Family-based association of YWHAH in psychotic bipolar disorder
    Deepak Grover
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:977-83. 2009
    ....
  76. ncbi request reprint Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis
    D Avramopoulos
    Department of Psychiatry, Johns Hopkins University, School of Medicine, North Wolfe Street, Baltimore, MD 21287, USA
    Mol Psychiatry 9:191-6. 2004
    ..Biologically, plausible candidate genes in this region include thyroglobulin, KCNQ3 coding for a voltage-gated potassium channel and the gene for brain adenyl-cyclase (ADCY8)...
  77. ncbi request reprint Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study
    J C Anthony
    Department of Mental Hygiene, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurology 54:2066-71. 2000
    ..To test the hypothesis that nonsteroidal anti-inflammatory drugs (NSAIDs) and histamine H2 receptor antagonists (H2RAs) are associated with a decreased risk of AD in late life...
  78. ncbi request reprint Prevention of Alzheimer's disease
    C A Szekely
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Int Rev Psychiatry 19:693-706. 2007
    ..Although none of these have yet to be definitively shown to prevent Alzheimer's disease, further research should help to clarify what role they may play in reducing the burden of this disease...
  79. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  80. ncbi request reprint Apolipoprotein E genotype and mortality: findings from the Cache County Study
    Kathleen M Hayden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina
    J Am Geriatr Soc 53:935-42. 2005
    ..To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD)...
  81. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  82. ncbi request reprint Effects of estrogen plus progestin on risk of dementia
    John C S Breitner
    JAMA 290:1706-7; author reply 1707-8. 2003
  83. ncbi request reprint Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study
    Maria C Norton
    Department of Family, Consumer and Human Development, Utah State University, Logan, 84322, USA
    Am J Geriatr Psychiatry 14:237-45. 2006
    ....
  84. ncbi request reprint A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging
    JoAnn T Tschanz
    Department of Psychology, Center for Epidemiologic Studies, Utah State University, Logan 84322 4440, USA
    Care Manag J 6:107-14. 2005
    ....
  85. pmc Church attendance and new episodes of major depression in a community study of older adults: the Cache County Study
    Maria C Norton
    Department of Family, Consumer and Human Development, Cache County Study on Memory Health and Aging, Utah State University, 4440 Old Main Hill, Logan, UT 84322 4440, USA
    J Gerontol B Psychol Sci Soc Sci 63:P129-37. 2008
    ..28-0.92). Results suggest that there may be a threshold of church attendance that is necessary for a person to garner long-term protection from depression. We discuss sociological factors relevant to LDS culture...
  86. ncbi request reprint Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study
    Kathleen M Hayden
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27705, USA
    Alzheimer Dis Assoc Disord 20:93-100. 2006
    ..Future studies should focus on specific causal pathways for each of these factors with regard to sex to determine if sex differences in the prevalence of vascular factors have an influence on sex differences in dementia risk...
  87. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...

Research Grants4

  1. BIOINFORMATICS TO DISCOVER GENES IN PSYCHIATRIC ILLNESS
    Peter Zandi; Fiscal Year: 2007
    ..The training and research plans of this proposal will provide the groundwork for the candidate to achieve his long-term goal of helping to elucidate the genetic contribution to complex psychiatric disorders. ..
  2. BIOINFORMATICS TO DISCOVER GENES IN PSYCHIATRIC ILLNESS
    Peter Zandi; Fiscal Year: 2008
    ..The training and research plans of this proposal will provide the groundwork for the candidate to achieve his long-term goal of helping to elucidate the genetic contribution to complex psychiatric disorders. ..
  3. Metamoodics: Meta-analyses and bioinformatics display of mood disorders genetics
    Peter P Zandi; Fiscal Year: 2010
    ..The web resource will provide a computational tool for analyzing the synthesized data to test the etiologic contribution of different molecular pathways, such as the Wnt signaling pathway. ..
  4. Metamoodics: Meta-analyses and bioinformatics display of mood disorders genetics
    Peter P Zandi; Fiscal Year: 2011
    ..The web resource will provide a computational tool for analyzing the synthesized data to test the etiologic contribution of different molecular pathways, such as the Wnt signaling pathway. ..