Elias T Zambidis

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors
    Tea Soon Park
    Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42838. 2012
  2. pmc Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development
    Elias T Zambidis
    Division of Immunology and Hematopoiesis, Sidney Kimmel comprehensive Cancer Center at John Hokins, The John Hopkins School of Medicine, Baltimore, MD, USA
    Blood 106:860-70. 2005
  3. pmc Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells
    Elias T Zambidis
    Institute of Cell Engineering, Stem Cell Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Blood 112:3601-14. 2008
  4. pmc Emergence of human angiohematopoietic cells in normal development and from cultured embryonic stem cells
    Elias T Zambidis
    Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Ann N Y Acad Sci 1106:223-32. 2007
  5. pmc Blood-forming endothelium in human ontogeny: lessons from in utero development and embryonic stem cell culture
    Elias T Zambidis
    Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Trends Cardiovasc Med 16:95-101. 2006
  6. pmc Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells
    Ann Peters
    Institute for Cell Engineering, Stem Cell Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Dev Biol 54:965-90. 2010
  7. pmc A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability
    Paul W Burridge
    Johns Hopkins Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e18293. 2011
  8. pmc Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility
    Adriana Blazeski
    Department of Biomedical Engineering, The Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    Prog Biophys Mol Biol 110:166-77. 2012
  9. pmc Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells
    Tea Soon Park
    Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, and Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21205, USA
    Cytometry A 83:114-26. 2013
  10. pmc Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature
    Tea Soon Park
    Institute for Cell Engineering, and Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD T S P, L Z, J S H, J A, E T Z Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD I B, R G, C M, G L Department of Radiation Oncology P N, F R and Department of Microbiology Immunology D M, R A F, University of Maryland School of Medicine, Baltimore, MD Department of Cardiovascular Medicine A J R, J C and Institute for Stem Cell Biology and Regenerative Medicine A J R, R R P, J C, Stanford University, Palo Alto, CA and Institute for Basic Biomedical Science at Johns Hopkins School of Medicine, Baltimore, MD C T
    Circulation 129:359-72. 2014

Research Grants

  1. Origin of HSC from Embryonic Stem Cells
    Elias Zambidis; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. pmc Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors
    Tea Soon Park
    Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42838. 2012
    ....
  2. pmc Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development
    Elias T Zambidis
    Division of Immunology and Hematopoiesis, Sidney Kimmel comprehensive Cancer Center at John Hokins, The John Hopkins School of Medicine, Baltimore, MD, USA
    Blood 106:860-70. 2005
    ....
  3. pmc Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells
    Elias T Zambidis
    Institute of Cell Engineering, Stem Cell Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Blood 112:3601-14. 2008
    ..Moreover, the initial events of human hematoendotheliogenesis can be delineated in a manner previously impossible because of inaccessibility to early human embryonic tissues...
  4. pmc Emergence of human angiohematopoietic cells in normal development and from cultured embryonic stem cells
    Elias T Zambidis
    Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Ann N Y Acad Sci 1106:223-32. 2007
    ..In this setting, we have documented the emergence of BB9(+) hemangioblast-like clonogenic angiohematopoietic progenitors that currently represent the earliest known founders of the human vascular and blood systems...
  5. pmc Blood-forming endothelium in human ontogeny: lessons from in utero development and embryonic stem cell culture
    Elias T Zambidis
    Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Trends Cardiovasc Med 16:95-101. 2006
    ..Importantly, converging results have recently been obtained with in vitro differentiated human embryonic stem cells, in which we have modeled primitive and definitive hematopoiesis via an endothelium-like developmental intermediate...
  6. pmc Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells
    Ann Peters
    Institute for Cell Engineering, Stem Cell Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Dev Biol 54:965-90. 2010
    ..We also focus on methods by which reprogrammed somatic cells could be used to derive autologous pluripotent stem cells, which in turn could provide unlimited sources of patient-specific hemangioblasts and HSC...
  7. pmc A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability
    Paul W Burridge
    Johns Hopkins Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e18293. 2011
    ..This system eliminated the variability in cardiac differentiation capacity of a variety of human pluripotent stem cells (hPSC), including hiPSC generated from CD34(+) cord blood using non-viral, non-integrating methods...
  8. pmc Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility
    Adriana Blazeski
    Department of Biomedical Engineering, The Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    Prog Biophys Mol Biol 110:166-77. 2012
    ..We further review extant hiPSC-CM disease models that recapitulate genetic myocardial disease...
  9. pmc Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells
    Tea Soon Park
    Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, and Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21205, USA
    Cytometry A 83:114-26. 2013
    ....
  10. pmc Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature
    Tea Soon Park
    Institute for Cell Engineering, and Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD T S P, L Z, J S H, J A, E T Z Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD I B, R G, C M, G L Department of Radiation Oncology P N, F R and Department of Microbiology Immunology D M, R A F, University of Maryland School of Medicine, Baltimore, MD Department of Cardiovascular Medicine A J R, J C and Institute for Stem Cell Biology and Regenerative Medicine A J R, R R P, J C, Stanford University, Palo Alto, CA and Institute for Basic Biomedical Science at Johns Hopkins School of Medicine, Baltimore, MD C T
    Circulation 129:359-72. 2014
    ....
  11. doi request reprint Highly efficient directed differentiation of human induced pluripotent stem cells into cardiomyocytes
    Paul W Burridge
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 997:149-61. 2013
    ..The contracting hEB derived using these methods contain high percentages of pure functional cardiomyocytes, highly reproducible electrophysiological profiles, and pharmacologic responsiveness to known cardioactive drugs...
  12. pmc Erythropoietic differentiation of a human embryonic stem cell line harbouring the sickle cell anaemia mutation
    Marina V Pryzhkova
    Institute for Cell Engineering, Stem Cell Program, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 755 Baltimore, MD 21205, USA
    Reprod Biomed Online 21:196-205. 2010
    ..These data introduce important methodologies and paradigms for using patient-specific human ESC to generate normal and haemoglobinopathic erythroid progenitors for biomedical research...
  13. pmc Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease
    Leelamma M Panicker
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 109:18054-9. 2012
    ..These findings are consistent with the known clinical efficacies of recombinant GC and isofagomine. We conclude that cell types derived from GD hiPSC can effectively recapitulate pathologic hallmarks of the disease...
  14. pmc Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model
    Susan A Thompson
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Mol Cell Cardiol 53:15-23. 2012
    ....
  15. pmc Mesenchymal stem cell secretome and regenerative therapy after cancer
    Ludovic Zimmerlin
    Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, United States Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States Electronic address
    Biochimie 95:2235-45. 2013
    ..This article reviews published models for studying interactions between MSC and cancer cells with a focus on the impact of MSC secretome on cancer cell activity, and discusses the implications for regenerative therapy after cancer. ..
  16. ncbi request reprint Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
    Xiufeng Zhong
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Commun 5:4047. 2014
    ..This success brings us one step closer to the anticipated use of hiPSC for disease modelling and open possibilities for future therapies. ..
  17. pmc Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells
    Jeffrey S Huo
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biochim Biophys Acta 1830:2385-94. 2013
    ..Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are now recognized as an important third class of regulators of the pluripotent state...
  18. pmc Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells
    Adriana Blazeski
    Department of Biomedical Engineering, The Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    Prog Biophys Mol Biol 110:178-95. 2012
    ..Finally, we present original electrophysiological data from optical maps of hESC-CM clusters...

Research Grants2

  1. Origin of HSC from Embryonic Stem Cells
    Elias Zambidis; Fiscal Year: 2007
    ..The success of these goals will lay the groundwork for characterizing human stem cells not available by any other means. ..