D J Zack

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Ret 4, a positive acting rhodopsin regulatory element identified using a bovine retina in vitro transcription system
    S Chen
    Department of Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland 21287 9289, USA
    J Biol Chem 271:28549-57. 1996
  2. ncbi The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures
    R Kumar
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    J Biol Chem 271:29612-8. 1996
  3. ncbi Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina
    H Yamada
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    J Cell Physiol 185:135-42. 2000
  4. ncbi Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium
    J T Chang
    The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9289, USA
    Hum Mol Genet 8:575-83. 1999
  5. pmc Platelet-derived growth factor-A-induced retinal gliosis protects against ischemic retinopathy
    H Yamada
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 156:477-87. 2000
  6. ncbi Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization
    K Mori
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 188:253-63. 2001
  7. ncbi A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
    K Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Genet 27:89-93. 2001
  8. ncbi TIMP-1 promotes VEGF-induced neovascularization in the retina
    E Yamada
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
    Histol Histopathol 16:87-97. 2001
  9. pmc Fibroblast growth factor-2 decreases hyperoxia-induced photoreceptor cell death in mice
    H Yamada
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Am J Pathol 159:1113-20. 2001
  10. ncbi Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors
    D A Swanson
    Predoctoral Training Program in Human Genetics, Johns Hopkins University, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 39:2085-94. 1998

Collaborators

Detail Information

Publications39

  1. ncbi Ret 4, a positive acting rhodopsin regulatory element identified using a bovine retina in vitro transcription system
    S Chen
    Department of Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland 21287 9289, USA
    J Biol Chem 271:28549-57. 1996
    ..Together, our results suggest that multiple promoter elements and transcriptional factors are involved in regulating photoreceptor-specific rhodopsin transcription...
  2. ncbi The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures
    R Kumar
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    J Biol Chem 271:29612-8. 1996
    ....
  3. ncbi Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina
    H Yamada
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    J Cell Physiol 185:135-42. 2000
    ..These data suggest that increased retinal expression of FGF2 is angiogenic only when it is accompanied by cell injury that overcomes sequestration control mechanisms...
  4. ncbi Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium
    J T Chang
    The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9289, USA
    Hum Mol Genet 8:575-83. 1999
    ..1; human SFRP2 maps to 4q31.3. Based on the biology and complementary expression patterns of SFRP2 and SFRP5, we suggest that they may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina...
  5. pmc Platelet-derived growth factor-A-induced retinal gliosis protects against ischemic retinopathy
    H Yamada
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 156:477-87. 2000
    ..Therefore, PDGF-A increases retinal astrocytes, which promote the survival of endothelial cells as well as their expression of barrier characteristics...
  6. ncbi Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization
    K Mori
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 188:253-63. 2001
    ..These data suggest that sustained increased intraocular expression of PEDF by gene therapy might provide a promising approach for treatment of ocular neovascularization...
  7. ncbi A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
    K Zhang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Genet 27:89-93. 2001
    ..Our results are therefore the first to implicate the biosynthesis of fatty acids in the pathogenesis of inherited macular degeneration...
  8. ncbi TIMP-1 promotes VEGF-induced neovascularization in the retina
    E Yamada
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
    Histol Histopathol 16:87-97. 2001
    ....
  9. pmc Fibroblast growth factor-2 decreases hyperoxia-induced photoreceptor cell death in mice
    H Yamada
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Am J Pathol 159:1113-20. 2001
    ..This suggests that FGF2 protects photoreceptors from oxidative damage, which may play a role in complex genetic diseases such as age-related macular degeneration...
  10. ncbi Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors
    D A Swanson
    Predoctoral Training Program in Human Genetics, Johns Hopkins University, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 39:2085-94. 1998
    ..To characterize orthologous human and murine cDNAs isolated through separate screens designed to identify genes expressed preferentially in retina...
  11. pmc Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment
    M S Seo
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Am J Pathol 157:995-1005. 2000
    ..They also provide a new model of traction retinal detachment that can be used to investigate new treatments for patients with proliferative retinopathies...
  12. ncbi Sustained expression after nonviral ocular gene transfer using mammalian promoters
    S Kachi
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Gene Ther 13:798-804. 2006
    ..A potentially important finding using this new technique is the demonstration that relatively sustained passenger gene expression can be achieved with nonviral gene transfer using mammalian rather than viral promoters...
  13. ncbi Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function
    A Swaroop
    Department of Ophthalmology, Program in Cellular and Molecular Biology, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105 0714, USA
    Hum Mol Genet 8:299-305. 1999
    ....
  14. ncbi Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
    S Chen
    The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 19:1017-30. 1997
    ..These studies implicate Crx as a potentially important regulator of photoreceptor cell development and gene expression and also identify it as a candidate gene for CORDII and other retinal diseases...
  15. ncbi Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration
    P K Swain
    Department of Ophthalmology, W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Neuron 19:1329-36. 1997
    ..This data suggests that mutations in the CRX gene are associated with photoreceptor degeneration and that the Crx protein is necessary for the maintenance of normal cone and rod function...
  16. pmc Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization
    H Ozaki
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Am J Pathol 153:757-65. 1998
    ....
  17. ncbi Neurotrophic signaling in normal and degenerating rodent retinas
    K J Wahlin
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
    Exp Eye Res 73:693-701. 2001
    ..These data add to the mounting evidence suggesting that neurotrophic factors act indirectly through Müller cells to promote photoreceptor survival...
  18. ncbi Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium
    W Yan
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
    Genomics 72:193-202. 2001
    ..In addition, the finding that many of the enzymes involved in retinoid metabolism are mutated in retinal degenerations suggests that BCDO may also be a candidate gene for retinal degenerative disease...
  19. pmc A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX
    X Li
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1876-81. 1998
    ..These data suggest that Crx may play a crucial role in regulating pineal gene expression through interactions with PIRE...
  20. ncbi RER, an evolutionarily conserved sequence upstream of the rhodopsin gene, has enhancer activity
    Z Nie
    Department of Ophthalmology, Wilmer Institute, Baltimore, Maryland
    J Biol Chem 271:2667-75. 1996
    ..These results indicate that the 100-bp sequence can indeed function in vivo as a rhodopsin enhancer region...
  21. ncbi Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier
    H Nambu
    The Department of Ophthalmology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Maumenee 719, Baltimore, MD, USA
    Gene Ther 11:865-73. 2004
    ..Ang1 also significantly reduced VEGF-induced retinal vascular permeability. These data suggest that intraocular delivery of ang1 has potential for treatment of ocular neovascularization and macular edema...
  22. ncbi Nonviral ocular gene transfer
    S Kachi
    The Department of Ophthalmology and Neuroscience, Baltimore, MD 21287 9277, USA
    Gene Ther 12:843-51. 2005
    ..Also, with additional optimization, nonviral gene transfer may prove to be a valuable approach for the treatment of retinal and choroidal diseases...
  23. ncbi Cloning and characterization of rod opsin cDNA from the Old World monkey, Macaca fascicularis
    R W Nickells
    Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9289
    Invest Ophthalmol Vis Sci 36:72-82. 1995
    ..To extend our knowledge of the primate family of opsins, the authors cloned and characterized the opsin cDNA for the Old World monkey Macaca fascicularis and determined its position in the phylogenetic tree of the opsin gene family...
  24. ncbi What can we learn about age-related macular degeneration from other retinal diseases?
    D J Zack
    Departments of Ophthalmology, Molecular Biology and Genetics, and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mol Vis 5:30. 1999
    ..Alzheimer's disease, another late onset, heterogeneous degenerative disorder of the central nervous system, offers a valuable model for identifying the issues that confront AMD genetics...
  25. ncbi Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype
    J T Chang
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9289, USA
    J Neurosci 17:5881-90. 1997
    ..These results suggest the existence of similarities between the invertebrate and mammalian retina that were not previously appreciated and also identify mrdgB as a candidate gene for retinal diseases that map to 11q13.1...
  26. ncbi Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins
    C H Lee
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9289, USA
    J Neurosci 16:6784-94. 1996
    ..These results suggest that Rit and Rin define a novel subfamily of Ras-related proteins, perhaps using a new mechanism of membrane association, and that Rin may be involved in calcium-mediated signaling within neurons...
  27. pmc Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization
    N Okamoto
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9277, USA
    Am J Pathol 151:281-91. 1997
    ..This study demonstrates that over-expression of VEGF in the retina is sufficient to cause intraretinal and subretinal NV and provides a valuable new animal model...
  28. ncbi Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis
    D S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis 55455, USA
    J Immunol 163:1073-80. 1999
    ..The results also show that beta-gal can serve as an immunopathogenic neural autoantigen, and that T cells raised by immunization of normal mice with a foreign Ag can be immunopathogenic in certain transgenic recipients...
  29. ncbi Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats
    H A Quigley
    Glaucoma Research Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 41:3460-6. 2000
    ..To determine whether acute experimental glaucoma in rats obstructs retrograde transport of brain-derived neurotrophic factor (BDNF) to retinal ganglion cells (RGCs)...
  30. ncbi Alternative splicing and retinal degeneration
    M M Liu
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Clin Genet 84:142-9. 2013
    ..The development of novel therapeutic strategies to modulate aberrant splicing, including small molecule-based therapies, has the potential to lead to new treatments for retinal degenerative diseases. ..
  31. ncbi The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation
    K P Mitton
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA
    J Biol Chem 275:29794-9. 2000
    ....
  32. ncbi A mutation in NRL is associated with autosomal dominant retinitis pigmentosa
    D A Bessant
    Nat Genet 21:355-6. 1999
  33. ncbi Sequence and expression analysis of bovine pigment epithelium-derived factor
    L A Perez-Mediavilla
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1398:203-14. 1998
    ..Thus, the bovine PEDF cDNA isolated here codes for a functional soluble secreted PEDF glycoprotein...
  34. ncbi Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments
    M I Chiu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Genomics 21:440-3. 1994
    ..These results indicate that phylogenetically both mouse and bovine blue pigments belong to the S branch of visual pigments, rather than to the M branch...
  35. pmc Expression and permeation properties of the K(+) channel Kir7.1 in the retinal pigment epithelium
    M Shimura
    W. K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
    J Physiol 531:329-46. 2001
    ..On the basis of this molecular and electrophysiological evidence, we conclude that Kir7.1 channel subunits comprise the K+ conductance of the RPE apical membrane...
  36. pmc Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy
    S E Wilkie
    Division of Molecular Genetics, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Am J Hum Genet 69:471-80. 2001
    ..The overall effect of this would be the constitutive activation of guanylate cyclase in photoreceptors, even at the high Ca2+ concentrations of the dark-adapted state, which may explain the dominant disease phenotype...
  37. ncbi Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus
    L Gu
    Department of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 161:6999-7006. 1998
    ..Our results indicate that the QTLs on chromosomes 11 and 19 also control the development of vasculitis, demonstrating common genetic determinants of autoantibody levels and vasculitis...
  38. ncbi Novel structural features of autoantibodies in murine lupus: a possible superantigen binding site?
    D J Zack
    Department of Medicine, Veterans Affairs Medical Center, Sepulveda, California 91343
    Immunol Cell Biol 72:513-20. 1994
    ....
  39. ncbi Transplanted photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene
    P Gouras
    Department of Ophthalmology, E S Harkness Eye Institute, Columbia University, New York, New York 10032
    Invest Ophthalmol Vis Sci 32:3167-74. 1991
    ..These results showed that transplanted transgenic photoreceptor cells survived at least 1 month in the host retina and had a primitive outer segment and a well-developed synaptic terminal...