Xiao Fang Yu

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly
    X F Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Virol 72:3412-7. 1998
  2. ncbi request reprint Maintaining low HIV type 1 env genetic diversity among injection drug users infected with a B/C recombinant and CRF01_AE HIV type 1 in southern China
    Xiao Fang Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 18:167-70. 2002
  3. pmc Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities
    Anjie Zhen
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e38771. 2012
  4. pmc Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles
    Chunjuan Tian
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Nucleic Acids Res 35:7288-302. 2007
  5. pmc Circulating coxsackievirus A16 identified as recombinant type A human enterovirus, China
    Ke Zhao
    First Hospital of Jilin University, Changchun, People s Republic of China
    Emerg Infect Dis 17:1537-40. 2011
  6. pmc Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFβ and CRL5 E3 ubiquitin ligase components
    Xiaohong Zhou
    Institute of Virology and AIDS Research, First Affiliated Hospital of Jilin University, Jilin, People s Republic of China
    PLoS ONE 7:e33495. 2012
  7. pmc Characterization of the relationship between APOBEC3B deletion and ACE Alu insertion
    Kang Wang
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, People s Republic of China
    PLoS ONE 8:e64809. 2013
  8. pmc Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation
    Haoran Guo
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
    PLoS ONE 8:e66201. 2013
  9. pmc HIV-1 Vif N-terminal motif is required for recruitment of Cul5 to suppress APOBEC3
    Sean L Evans
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA
    Retrovirology 11:4. 2014
  10. ncbi request reprint Characterization of HIV type 1 heterosexual transmission in Yunnan, China
    Xiao Fang Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins Univesity Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 19:1051-5. 2003

Collaborators

Detail Information

Publications71

  1. pmc Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly
    X F Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Virol 72:3412-7. 1998
    ..These results suggest that the p6 domain of HIV-1 Gag may play an important role in recruiting or retaining cleaved Pol proteins during virus assembly...
  2. ncbi request reprint Maintaining low HIV type 1 env genetic diversity among injection drug users infected with a B/C recombinant and CRF01_AE HIV type 1 in southern China
    Xiao Fang Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 18:167-70. 2002
    ..The rapid spreading of homogeneous HIV-1 strains in Guangxi may have important implications for HIV transmission as well as vaccine development and evaluation...
  3. pmc Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities
    Anjie Zhen
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e38771. 2012
    ..Thus, Pol-III RNA such as 7SL RNA binding is a conserved feature of potent anti-HIV human APOBEC3 cytidine deaminases...
  4. pmc Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles
    Chunjuan Tian
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Nucleic Acids Res 35:7288-302. 2007
    ..Virion packaging of both human cytidine deaminase APOBEC3G and cellular 7SL RNA are mapped to the same regions in HIV-1 NC domain...
  5. pmc Circulating coxsackievirus A16 identified as recombinant type A human enterovirus, China
    Ke Zhao
    First Hospital of Jilin University, Changchun, People s Republic of China
    Emerg Infect Dis 17:1537-40. 2011
    ..Complex recombinant forms of CA16-related viruses involving multiple human enteroviruses, subgroup A (CA4, CA16, and enterovirus 71), are prevalent among patients with hand, foot, and mouth disease...
  6. pmc Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFβ and CRL5 E3 ubiquitin ligase components
    Xiaohong Zhou
    Institute of Virology and AIDS Research, First Affiliated Hospital of Jilin University, Jilin, People s Republic of China
    PLoS ONE 7:e33495. 2012
    ....
  7. pmc Characterization of the relationship between APOBEC3B deletion and ACE Alu insertion
    Kang Wang
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, People s Republic of China
    PLoS ONE 8:e64809. 2013
    ....
  8. pmc Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation
    Haoran Guo
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
    PLoS ONE 8:e66201. 2013
    ..Since the linker region and HD domain may be involved in SAMHD1 multimerization, our results suggest that SAMHD1 multimerization may be required for Vpx-mediation degradation. ..
  9. pmc HIV-1 Vif N-terminal motif is required for recruitment of Cul5 to suppress APOBEC3
    Sean L Evans
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA
    Retrovirology 11:4. 2014
    ..Cul5 has previously been shown to bind amino acids within an HCCH domain as well as a PPLP motif at the C-terminus of Vif; however, it is unclear whether Cul5 binding requires additional regions of the Vif polypeptide...
  10. ncbi request reprint Characterization of HIV type 1 heterosexual transmission in Yunnan, China
    Xiao Fang Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins Univesity Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 19:1051-5. 2003
    ..The complex pattern of HIV-1 distribution in the high-risk populations in Yunnan may have important implications for HIV transmission as well as vaccine development and evaluation...
  11. ncbi request reprint Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China
    X F Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 22:180-8. 1999
    ..Designing and implementing effective intervention strategies targeted toward both injection drug use and high risk sexual behavior are urgently needed to further reduce HIV-1 spread in China...
  12. ncbi request reprint Infection with dual-tropic human immunodeficiency virus type 1 variants associated with rapid total T cell decline and disease progression in injection drug users
    X F Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 178:388-96. 1998
    ....
  13. ncbi request reprint Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif
    Zuoxiang Xiao
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Virology 349:290-9. 2006
    ..This is the first example of a zinc-binding substrate receptor responsible for the assembly of a Cullin-RING ligase, representing a new target for antiviral development...
  14. pmc Influence of primate lentiviral Vif and proteasome inhibitors on human immunodeficiency virus type 1 virion packaging of APOBEC3G
    Bindong Liu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Virol 78:2072-81. 2004
    ..These results suggest that Vif function is required during virus assembly to remove APOBEC3G from packaging into released virions. Once packaged, virion-associated Vif could not efficiently block the antiviral activity of APOBEC3G...
  15. pmc A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity
    Anjie Zhen
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    J Virol 84:1902-11. 2010
    ..We also found that residue 121 was critical for determining A3H sensitivity and binding to HIV-1 Vif...
  16. ncbi request reprint Coinfection with HIV and hepatitis C virus among injection drug users in southern China
    Rebecca J Garten
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin Infect Dis 41:S18-24. 2005
    ..We sought to examine coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) among injection drug users (IDUs) in Guangxi, China...
  17. pmc Association of potent human antiviral cytidine deaminases with 7SL RNA and viral RNP in HIV-1 virions
    Wenyan Zhang
    First Affiliated Hospital, Institute of Virology and AIDS Research, Jilin University, Changchun, Jilin Province, People s Republic of China 130062
    J Virol 84:12903-13. 2010
    ..7SL RNA binding is a conserved feature of human anti-HIV-1 cytidine deaminases. Thus, potent anti-HIV-1 cytidine deaminases have evolved to possess a unique RNA-binding ability for precise HIV-1 targeting and viral inhibition...
  18. ncbi request reprint Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex
    Xianghui Yu
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Science 302:1056-60. 2003
    ..The Cul5-SCF was also required for Vif function in distantly related simian immunodeficiency virus mac. These results indicate that the conserved Cul5-SCF pathway used by Vif is a potential target for antiviral development...
  19. pmc Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines
    Yunkai Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Genes Dev 18:2867-72. 2004
    ..Therefore, selective assembly with Cul5 versus Cul2 E3 may require protein interfaces besides the SOCS-box-ElonginC interaction...
  20. pmc Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligase
    Bindong Liu
    Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Virol 79:9579-87. 2005
    ..Developing inhibitors to disrupt the interaction between Vif and Cul5-E3 ligase could be therapeutically useful, allowing multiple host antiviral factors to suppress HIV-1...
  21. pmc Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation
    Kun Luo
    Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    J Virol 81:7238-48. 2007
    ..Thus, multiple steps of the HIV-1 replication cycle, most noticeably the formation of proviral DNA, are inhibited by both cytidine deamination-dependent and -independent mechanisms...
  22. doi request reprint A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest
    Wei Wei
    First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun, Jilin Province, China
    Cell Microbiol 14:1745-56. 2012
    ..Thus, our data reveal previously unrecognized functional interactions involved in the assembly of virally hijacked DCAF1-DDB1-based E3 ubiquitin ligase complex...
  23. doi request reprint T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction
    Wenyan Zhang
    First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun, Jilin Province 130021, China
    Nature 481:376-9. 2012
    ..Considering the importance of the interaction between Vif and CBF-β, disrupting this interaction represents an attractive pharmacological intervention against HIV-1...
  24. ncbi request reprint Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G
    Zuoxiang Xiao
    Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    FASEB J 21:217-22. 2007
    ..Zinc chelation had no effect on cellular Cul5-SOCS3 E3 ligase assembly, suggesting that zinc-dependent E3 ligase assembly may be unique to HIV-1 Vif, representing a new target for novel drug design...
  25. pmc Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging
    Kun Luo
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Virol 78:11841-52. 2004
    ..These results suggest that the N-terminal region of HIV-1 NC, which is critical for binding to RNA and mediating Gag-Gag oligomerization, plays an important role in APOBEC3G binding and virion packaging...
  26. pmc Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins
    Wenyan Zhang
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    PLoS ONE 3:e3963. 2008
    ..The domains in Vif and various APOBEC3 proteins required for APOBEC3 recognition and degradation have not been fully characterized...
  27. pmc Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G
    Kun Luo
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:11444-9. 2005
    ..Motifs in Vif that are absent from cellular proteins could also be targets for the development of innovative therapeutics...
  28. pmc 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G
    Tao Wang
    Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    J Virol 81:13112-24. 2007
    ..This selective interaction of A3G with certain Pol III-derived RNAs raises the question of whether A3G and its cofactors may have as-yet-unidentified cellular functions...
  29. pmc Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1
    Ke Zhao
    Institute of Virology and AIDS Research, First Hospital of Jilin University, 519 E Minzhu Avenue, Changchun, Jilin Province 130061, China
    Cell Rep 4:1108-15. 2013
    ..SAMHD1 inhibits ORF2p-mediated LINE-1 reverse transcription in isolated LINE-1 ribonucleoproteins by reducing ORF2p level. Thus, SAMHD1 may be a cellular regulator of LINE-1 activity that is conserved in mammals. ..
  30. ncbi request reprint Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging
    Tao Wang
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Mol Biol 375:1098-112. 2008
    ..Thus, in addition to its well-known function in SRPs, 7SL RNA, which is encapsidated into diverse retroviruses, also participates in the innate antiviral function of host cytidine deaminases...
  31. pmc Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3C
    Tao Wang
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Virology 377:71-9. 2008
    ..Deletion of the MA domain of HIV-1 Gag inhibited A3C but not A3G packaging into HIV-1 Gag particles. Thus, A3G and A3C have evolved to use distinct mechanisms for targeting retroviruses...
  32. ncbi request reprint Adenovirus E4orf6 assembles with Cullin5-ElonginB-ElonginC E3 ubiquitin ligase through an HIV/SIV Vif-like BC-box to regulate p53
    Kun Luo
    Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    FASEB J 21:1742-50. 2007
    ..Therefore, adenovirus E4orf6 molecules represent a novel family of viral BC-box proteins the cellular ancestor of which is as yet unknown...
  33. ncbi request reprint Characterization of a novel Cullin5 binding domain in HIV-1 Vif
    Zuoxiang Xiao
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Mol Biol 373:541-50. 2007
    ..We have identified a "viral Cul5 box" with consensus Hx2YFxCFx4Phix2APhix7-8Cx5H that is required for Cul5 selection and subsequent A3G degradation. This novel motif may represent a potential new target for anti-viral drug development...
  34. pmc Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association
    Anna Maria Niewiadomska
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Virol 81:9577-83. 2007
    ..The catalytic domain of APOBEC3 proteins may be important for proper folding and target factors such as RNA or protein interaction in addition to cytidine deamination...
  35. ncbi request reprint STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha
    Phuong Thi Nguyen Sarkis
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Immunol 177:4530-40. 2006
    ..However, STAT1 signaling was functional and required for IFN-gamma induction of A3G in these cells. Our results indicate that A3G may participate in antiviral cellular defenses through a novel IFN-mediated signaling pathway...
  36. doi request reprint Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif
    Anna Maria Niewiadomska
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Top Microbiol Immunol 339:1-25. 2009
    ..Here we review the research that led up to the identification of A3G, the mechanisms by which APOBEC3 proteins can inhibit retroelements, and the counter-mechanisms that HIV-1 Vif has developed to evade its antiviral activities...
  37. pmc Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase
    Elana S Ehrlich
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:20330-5. 2009
    ..The link between Cul5 and Hsp90 client regulation may represent an avenue for cancer drug development...
  38. pmc Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1
    Lindi Tan
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    FASEB J 23:279-87. 2009
    ....
  39. pmc Stable expression of primary human immunodeficiency virus type 1 structural gene products by use of a noncytopathic sindbis virus vector
    Wei Kong
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Virol 76:11434-9. 2002
    ..Efficient long-term expression of structural proteins of diverse HIV-1 strains by the noncytopathic Sindbis virus expression system may be a useful tool for functional study of HIV-1 gene products and vaccine research...
  40. pmc DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
    Lindi Tan
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Virol 81:10822-30. 2007
    ..These data suggest that Vpr assembles with DDB1 through interaction with DCAF1 to form an E3 ubiquitin ligase that targets cellular substrates for proteasome-mediated degradation and G2 arrest...
  41. ncbi request reprint The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug users
    Priya Duggal
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 38:584-9. 2005
    ..Because RANTES is a critical chemokine and competitively inhibits HIV-1 by binding to its receptor CCR5, treatment to enhance RANTES expression may assist in delaying the progression of AIDS by decreasing the initial viral load...
  42. ncbi request reprint Lentiviral Vif: viral hijacker of the ubiquitin-proteasome system
    Elana S Ehrlich
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Int J Hematol 83:208-12. 2006
    ..Here, we review the research that led up to the identification of A3G and the mechanism that the human immunodeficiency virus protein Vif developed to evade A3G's antiviral activities...
  43. pmc In vitro suppression of human immunodeficiency virus type 1 replication by measles virus
    Mayra García
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Virol 79:9197-205. 2005
    ....
  44. pmc Differential requirements for HIV-1 Vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta
    Juan Du
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China
    J Virol 87:1906-11. 2013
    ..The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors...
  45. ncbi request reprint Rapid transmission of hepatitis C virus among young injecting heroin users in Southern China
    Rebecca J Garten
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Epidemiol 33:182-8. 2004
    ..Hepatitis C virus (HCV) is quickly spread through injection drug use. The prevalence and incidence of HCV in Chinese heroin users has been rarely reported...
  46. pmc Factors influencing a low rate of hepatitis C viral RNA clearance in heroin users from Southern China
    Rebecca J Garten
    Department of Molecular Microbiology and Immunology, The Johns Hopkins University Bloomberg School of Public Health, Room E5148, 615 N Wolfe St, Baltimore, MD 21205, United States
    World J Gastroenterol 14:1878-84. 2008
    ..To study the virological and host factors influencing hepatitis C infection outcomes in heroin users in southern China...
  47. ncbi request reprint Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection
    R Renae Speck
    Department of Clinical Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 186:332-40. 2002
    ..These results suggest that the inhibition of HIV productive infection by P-gp and augmentation by MRP-1 occur predominantly at a preintegration step but act through different mechanisms...
  48. pmc A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G
    Gongying Chen
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    J Virol 83:8674-82. 2009
    ..These structural motifs in HIV-1 Vif represent attractive targets for the development of lead inhibitors to combat HIV infection...
  49. pmc Protection from lethal challenge in a neonatal mouse model by circulating recombinant form coxsackievirus A16 vaccine candidates
    Jingliang Li
    First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun, Jilin Province, PR China
    J Gen Virol 95:1083-93. 2014
    ..This lethal-challenge model using pathogenic CA16 viruses and the vaccine candidates that mediated protection in this model could be useful tools for the future development and evaluation of CA16 vaccines. ..
  50. pmc Circulating HFMD-associated coxsackievirus A16 is genetically and phenotypically distinct from the prototype CV-A16
    Wei Wei
    Insititute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 9:e94746. 2014
    ..Thus, we have found circulating recombinant forms of CV-A16 (CRF CV-A16) that are related to, but different from, the prototype CV-A16 G10 that have distinct biological phenotypes. ..
  51. doi request reprint Measles virus inhibits human immunodeficiency virus type 1 reverse transcription and replication by blocking cell-cycle progression of CD4+ T lymphocytes
    Mayra García
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Gen Virol 89:984-93. 2008
    ..It was concluded that MV inhibits HIV-1 productive replication in part by blocking the proliferation of CD4(+) T lymphocytes...
  52. pmc HIV-1 Diversity and Drug-Resistant Mutations in Infected Individuals in Changchun, China
    Ming Yan
    First Hospital of Jilin University, Changchun, Jilin, China
    PLoS ONE 9:e100540. 2014
    ..Although epidemiological and phylogenetic studies have been conducted in many regions, such analyses are lacking from Jilin province in northeastern China...
  53. pmc E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection
    Sumithra Jayaram
    Department of Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, W 8001, Baltimore, MD 21205, USA
    Virology 382:163-70. 2008
    ..Expression of E4 34k alone was not sufficient to dissociate the ligase IV/XRCC4 complex, which indicates a requirement for an additional, as yet unidentified, factor in E1B 55k-independent dissociation of the ligase IV/XRCC4 complex...
  54. pmc Characterization of full-length enterovirus 71 strains from severe and mild disease patients in northeastern China
    Xiaomei Wang
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
    PLoS ONE 7:e32405. 2012
    ..The existence of a unique cluster of EV71 related viruses in Northeast China has important implications for vaccine development that would address the increasing prevalence of HFMD...
  55. pmc Identification of HIV-1 Vif Regions Required for CBF-β Interaction and APOBEC3 Suppression
    Hong Wang
    Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
    PLoS ONE 9:e95738. 2014
    ..These new binding interfaces with CBF-β in HIV-1 Vif provide novel targets for the development of HIV-1 inhibitors. ..
  56. ncbi request reprint Molecular epidemiology of HIV-1 subtypes in southern China
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 38:356-62. 2005
    ....
  57. pmc Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infection
    Sandra Kao
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Virol 77:1131-40. 2003
    ..The results from our study provide novel insights into the biochemical properties of Vif and offer an explanation for the reported differences regarding Vif packaging...
  58. pmc Induction of primary virus-cross-reactive human immunodeficiency virus type 1-neutralizing antibodies in small animals by using an alphavirus-derived in vivo expression system
    Ming Dong
    Departments of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda 20814, USA
    J Virol 77:3119-30. 2003
    ..These findings support the expectation that induction of highly cross-reactive HIV-1 primary virus-neutralizing activity by vaccination may be realized...
  59. ncbi request reprint Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression
    Wei Zhang
    Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou 310009, China
    Cell Microbiol 10:112-21. 2008
    ..In addition, A3B protein may be a broad antiviral host factor. Thus, regulated A3B expression may contribute to non-cytolytic HBV clearance in vivo...
  60. pmc Selection in context: patterns of natural selection in the glycoprotein 120 region of human immunodeficiency virus 1 within infected individuals
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 167:1547-61. 2004
    ..Finally, the transition between NSI and SI forms is associated with a burst of evolutionary change due to strong positive selection at sites other than those that define the NSI/SI phenotypes...
  61. ncbi request reprint First snapshots of the HIV-1 RNA structure in infected cells and in virions
    Jean Christophe Paillart
    Unité Propre de Recherche 9002 du CNRS conventionnée à l Université Louis Pasteur, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    J Biol Chem 279:48397-403. 2004
    ..Taken together, our results provided the first analysis of the dynamic of RNA structure of the human immunodeficiency virus type 1 RNA genome during virus assembly ex vivo...
  62. ncbi request reprint Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope
    Eric G Meissner
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Virology 328:74-88. 2004
    ..These data suggest that SI viruses with unique envelope functions which can overcome barriers to transmission may hasten disease progression by perturbing T cell homeostasis...
  63. doi request reprint The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest
    JiangFang Wang
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 27:267-77. 2008
    ..Together, these data show that Vif mediates the degradation of Vpr and modulates Vpr-induced G2 arrest in HIV-1-infected T-cells...
  64. pmc Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly
    Bradford J Stanley
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA
    J Virol 82:8656-63. 2008
    ..Furthermore, our homology modeling reveals that the Vif Cullin box and zinc finger motif may be positioned adjacent to the N terminus of Cullin5 for interaction with loop regions in the first cullin repeat of Cullin5...
  65. doi request reprint Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction
    Zhiwen He
    Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Zhejiang, China
    J Mol Biol 381:1000-11. 2008
    ..Our data suggest that primate lentiviral Vif molecules recognize their autologous APOBEC3 proteins through conserved structural features that represent attractive targets for the development of novel inhibitors...
  66. ncbi request reprint Engineering the Japanese encephalitis virus RNA genome for the expression of foreign genes of various sizes: implications for packaging capacity and RNA replication efficiency
    Sang Im Yun
    Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, South Korea
    J Neurovirol 13:522-35. 2007
    ..These JEV-based virus/vector systems may provide useful tools for a variety of biological applications, including foreign gene expression, antiviral compound screening, and genetic immunization...
  67. pmc The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells
    JiangFang Wang
    Division of Rheumatology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Virology 359:243-52. 2007
    ..Our results may have implications for the actions and interactions of key HIV-1 accessory proteins in AIDS pathogenesis...
  68. pmc Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F
    Chunjuan Tian
    Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou, China
    J Virol 80:3112-5. 2006
    ..The fact that several highly conserved residues in Vif are required for the suppression of A3F but not that of A3G suggests a critical role for A3F in the restriction of HIV-1 in vivo...
  69. pmc Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines
    Geoffrey W Stone
    Department of Medicine 0679, Stein Clinical Sciences Bldg, Room 304, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0679, USA
    J Virol 80:1762-72. 2006
    ..In summary, multimeric CD40L and GITRL are new adjuvants for DNA vaccines. Plasmids for expressing multimeric TNFSF fusion proteins permit the rapid testing of TNFSF molecules in vivo...
  70. pmc Protection of rhesus monkeys against infection with minimally pathogenic simian-human immunodeficiency virus: correlations with neutralizing antibodies and cytotoxic T cells
    Gerald V Quinnan
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    J Virol 79:3358-69. 2005
    ..Induction of cross-reactive, primary HIV-1-neutralizing antibodies is feasible and, when potent, may result in complete protection against infection with a heterologous challenge virus strain...
  71. pmc Conserved and non-conserved features of HIV-1 and SIVagm Vif mediated suppression of APOBEC3 cytidine deaminases
    Wenyan Zhang
    College of Life Science, Jilin University, Changchun 130021, China
    Cell Microbiol 10:1662-75. 2008
    ..Furthermore, Vif and APOBEC3 binding is not sufficient for target protein degradation indicating an important but uncharacterized Vif function...

Research Grants37

  1. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2010
    ..Understanding why host genes could influence HIV-1 infection and disease progression may lead to new treatments for HIV/AIDS. ..
  2. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2004
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  3. VIRAL DETERMINANTS OF DISEASE PROGRESSION IN HIV+ IDUS
    Xiao Fang Yu; Fiscal Year: 1999
    ..They should also provide information that may prove critical for the development of candidate preventive and therapeutic strategies. ..
  4. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2004
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  5. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2003
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  6. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2004
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  7. Role of Cul5 E3 ubiquitin ligase in HIV Vif function
    Xiao Fang Yu; Fiscal Year: 2004
    ..This study should provide critical insight into the complex interplay between viral and host factors and may provide us with critical information regarding the design of effective intervention strategies for HIV. ..
  8. Role of Cul5 E3 ubiquitin ligasae in HIV Vif function
    Xiao Fang Yu; Fiscal Year: 2005
    ..This study should provide critical insight into the complex interplay between viral and host factors and may provide us with critical information regarding the design of effective intervention strategies for HIV. ..
  9. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2005
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  10. Role of Cul5 E3 ubiquitin ligasae in HIV Vif function
    Xiao Fang Yu; Fiscal Year: 2006
    ..This study should provide critical insight into the complex interplay between viral and host factors and may provide us with critical information regarding the design of effective intervention strategies for HIV. ..
  11. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2006
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  12. Regulation of antiviral APOBEC3G and APOBEC3F by interferons
    Xiao Fang Yu; Fiscal Year: 2007
    ..Furthermore, the work would potentially enhance knowledge of general IFN-mediated signaling pathways. ..
  13. Role of Cul5 E3 ubiquitin ligase in HIV Vif function
    Xiao Fang Yu; Fiscal Year: 2007
    ..This study should provide critical insight into the complex interplay between viral and host factors and may provide us with critical information regarding the design of effective intervention strategies for HIV. ..
  14. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2007
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  15. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2009
    ..Understanding why host genes could influence HIV-1 infection and disease progression may lead to new treatments for HIV/AIDS. ..
  16. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2003
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  17. VIRAL DETERMINANTS OF DISEASE PROGRESSION IN HIV+ IDUS
    Xiao Fang Yu; Fiscal Year: 2003
    ..They should also provide information that may prove critical for the development of candidate preventive and therapeutic strategies. ..
  18. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2002
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  19. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 1999
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  20. EVALUATION OF HIV GAG DNA VACCINE TO MAX T HELPER/CTL
    Xiao Fang Yu; Fiscal Year: 1999
    ..C) Combination studies by using DNA vectors identified from this specific aim with DNA vectors identified from specific aim 1. ..
  21. VIRAL DETERMINANTS OF DISEASE PROGRESSION IN HIV+ IDUS
    Xiao Fang Yu; Fiscal Year: 2000
    ..They should also provide information that may prove critical for the development of candidate preventive and therapeutic strategies. ..
  22. VIRAL DETERMINANTS OF DISEASE PROGRESSION IN HIV+ IDUS
    Xiao Fang Yu; Fiscal Year: 1999
    ..They should also provide information that may prove critical for the development of candidate preventive and therapeutic strategies. ..
  23. EVALUATION OF HIV GAG DNA VACCINE TO MAX T HELPER/CTL
    Xiao Fang Yu; Fiscal Year: 2000
    ..C) Combination studies by using DNA vectors identified from this specific aim with DNA vectors identified from specific aim 1. ..
  24. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 2000
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  25. VIRAL AND HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2000
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  26. VIRAL DETERMINANTS OF DISEASE PROGRESSION IN HIV+ IDUS
    Xiao Fang Yu; Fiscal Year: 2001
    ..They should also provide information that may prove critical for the development of candidate preventive and therapeutic strategies. ..
  27. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 2000
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  28. EVALUATION OF HIV GAG DNA VACCINE TO MAX T HELPER/CTL
    Xiao Fang Yu; Fiscal Year: 2001
    ..C) Combination studies by using DNA vectors identified from this specific aim with DNA vectors identified from specific aim 1. ..
  29. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 2001
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  30. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2001
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  31. VIRAL DETERMINANTS OF DISEASE PROGRESSION IN HIV+ IDUS
    Xiao Fang Yu; Fiscal Year: 2002
    ..They should also provide information that may prove critical for the development of candidate preventive and therapeutic strategies. ..
  32. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 2002
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  33. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2002
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  34. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2003
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..