Robert Yolken

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia
    R H Yolken
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
    Clin Infect Dis 32:842-4. 2001
  2. ncbi Viruses and schizophrenia: a focus on herpes simplex virus
    Robert Yolken
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 4933, USA
    Herpes 11:83A-88A. 2004
  3. doi Are some cases of psychosis caused by microbial agents? A review of the evidence
    R H Yolken
    The Stanley Laboratory of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University Medical Center, Baltimore, MD 21287 4933, USA
    Mol Psychiatry 13:470-9. 2008
  4. ncbi C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia
    Faith Dickerson
    Stanley Research Center at Sheppard Pratt, Sheppard Pratt Health System, 6501 North Charles, St, Baltimore, MD 21204, USA
    Schizophr Res 93:261-5. 2007
  5. doi Markers of gluten sensitivity in acute mania: a longitudinal study
    Faith Dickerson
    The Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA
    Psychiatry Res 196:68-71. 2012
  6. doi Markers of gluten sensitivity and celiac disease in bipolar disorder
    Faith Dickerson
    The Stanley Research Program at Sheppard Pratt, 6501 North Charles Street, Baltimore, MD 21204, USA
    Bipolar Disord 13:52-8. 2011
  7. doi Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder
    Faith Dickerson
    Stanley Research Program, Sheppard Pratt, Baltimore, MD, USA
    Brain Behav Immun 22:1103-7. 2008
  8. doi Antibodies to the glutamate receptor in mania
    Faith Dickerson
    Sheppard Pratt The Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Bipolar Disord 14:547-53. 2012
  9. doi Artemisinin reduces the level of antibodies to gliadin in schizophrenia
    Faith Dickerson
    Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
    Schizophr Res 129:196-200. 2011
  10. doi Antibodies to retroviruses in recent onset psychosis and multi-episode schizophrenia
    Faith Dickerson
    The Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA
    Schizophr Res 138:198-205. 2012

Collaborators

Detail Information

Publications42

  1. ncbi Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia
    R H Yolken
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
    Clin Infect Dis 32:842-4. 2001
    ..We found that the individuals with first-episode schizophrenia had significantly increased levels of IgG, IgM, and IgA class antibodies to Toxoplasma proteins, as compared with the control subjects...
  2. ncbi Viruses and schizophrenia: a focus on herpes simplex virus
    Robert Yolken
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 4933, USA
    Herpes 11:83A-88A. 2004
    ..Further research to investigate the relationship between virus infection and schizophrenia is warranted...
  3. doi Are some cases of psychosis caused by microbial agents? A review of the evidence
    R H Yolken
    The Stanley Laboratory of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University Medical Center, Baltimore, MD 21287 4933, USA
    Mol Psychiatry 13:470-9. 2008
    ..The identification of infectious agents associated with the etiopathogenesis of schizophrenia might lead to new methods for the diagnosis, treatment and prevention of this disorder...
  4. ncbi C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia
    Faith Dickerson
    Stanley Research Center at Sheppard Pratt, Sheppard Pratt Health System, 6501 North Charles, St, Baltimore, MD 21204, USA
    Schizophr Res 93:261-5. 2007
    ..We investigated the association between serum levels of C-reactive protein (CRP), a marker of inflammation, and the severity of psychopathology and cognitive impairment in schizophrenia...
  5. doi Markers of gluten sensitivity in acute mania: a longitudinal study
    Faith Dickerson
    The Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA
    Psychiatry Res 196:68-71. 2012
    ..The monitoring and control of gluten sensitivity may have significant effects on the management of individuals hospitalized with acute mania...
  6. doi Markers of gluten sensitivity and celiac disease in bipolar disorder
    Faith Dickerson
    The Stanley Research Program at Sheppard Pratt, 6501 North Charles Street, Baltimore, MD 21204, USA
    Bipolar Disord 13:52-8. 2011
    ....
  7. doi Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder
    Faith Dickerson
    Stanley Research Program, Sheppard Pratt, Baltimore, MD, USA
    Brain Behav Immun 22:1103-7. 2008
    ..Infections with HSV-1 and the COMT Val158Val genotype are risk factors for cognitive deficits in non-elderly persons without a psychiatric disorder...
  8. doi Antibodies to the glutamate receptor in mania
    Faith Dickerson
    Sheppard Pratt The Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Bipolar Disord 14:547-53. 2012
    ..There is evidence that the glutamatergic system is involved in the pathophysiology of mania. Antibodies to the NR2 subunits of the N-methyl-D-aspartate (NMDA) receptor have been shown to adversely affect glutamate functioning...
  9. doi Artemisinin reduces the level of antibodies to gliadin in schizophrenia
    Faith Dickerson
    Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
    Schizophr Res 129:196-200. 2011
    ..To investigate if adjunctive artemisinin, an anti-malarial compound with in vivo activity against Toxoplasma gondii, reduces symptoms or antibodies in schizophrenia...
  10. doi Antibodies to retroviruses in recent onset psychosis and multi-episode schizophrenia
    Faith Dickerson
    The Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA
    Schizophr Res 138:198-205. 2012
    ..Immunological abnormalities involving the upregulation of endogenous retroviruses have been associated with schizophrenia in small studies...
  11. doi Additive effects of elevated C-reactive protein and exposure to Herpes Simplex Virus type 1 on cognitive impairment in individuals with schizophrenia
    Faith Dickerson
    Stanley Research Program at Sheppard Pratt, Sheppard Pratt Health System, 6501 North Charles, St, Baltimore, MD 21204, USA
    Schizophr Res 134:83-8. 2012
    ..We investigated the effect of elevated levels of C-reactive protein (CRP) and exposure to Herpes simplex virus type 1 (HSV-1) on the severity of cognitive impairment in individuals with schizophrenia...
  12. ncbi Elevated C-reactive protein and cognitive deficits in individuals with bipolar disorder
    Faith Dickerson
    Stanley Research Program at Sheppard Pratt, Sheppard Pratt, 6501 North Charles, St, Baltimore, MD 21204, USA
    J Affect Disord 150:456-9. 2013
    ..In previous studies, we found an association between elevated levels of C-reactive protein (CRP), a marker of inflammation, and reduced cognitive functioning in schizophrenia. This issue has not been examined in bipolar disorder...
  13. pmc Toxoplasma gondii in individuals with schizophrenia: association with clinical and demographic factors and with mortality
    Faith Dickerson
    The Stanley Research Center at the Sheppard Pratt Health System, 6501 North Charles Street, Baltimore, MD 21204, USA
    Schizophr Bull 33:737-40. 2007
    ..Increased rates of exposure to Toxoplasma gondii have been found in individuals with schizophrenia as compared with control groups, but the correlates of Toxoplasma exposure in schizophrenia have not been defined...
  14. ncbi The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophrenia
    Faith Dickerson
    Stanley Research Center at Sheppard Pratt, Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
    Schizophr Res 89:173-6. 2007
    ..There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia...
  15. doi Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia
    Faith Dickerson
    Stanley Research Program at Sheppard Pratt, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21204, USA
    Biol Psychiatry 68:100-4. 2010
    ..Increased immune sensitivity to gluten has been reported in schizophrenia. However, studies are inconsistent about this association...
  16. pmc Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii
    Christopher P Hencken
    Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    J Med Chem 53:3594-601. 2010
    ..Some of the new derivatives of artemisinin described here represent effective anti-Toxoplasma trioxanes as well as molecular probes for elucidating the mechanism of action of the DART class of artemisinin derivatives...
  17. ncbi The association between cognitive functioning and occupational status in persons with a recent onset of psychosis
    Faith B Dickerson
    Stanley Research Program, Sheppard Pratt Health System, Baltimore, Maryland, USA
    J Nerv Ment Dis 195:566-71. 2007
    ..Cognitive assessments may prove useful to identify recent onset patients who are most at risk for occupational impairment and who could most benefit from therapeutic interventions...
  18. pmc Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle
    John G D'Angelo
    Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
    J Antimicrob Chemother 63:146-50. 2009
    ....
  19. doi Antibodies to Toxoplasma gondii in individuals with mania
    Faith Dickerson
    Stanley Research Program, Sheppard Pratt Health System, Baltimore, MD, USA
    Bipolar Disord 16:129-36. 2014
    ..Increased rates of infection with Toxoplasma gondii have been found in individuals with schizophrenia as compared to control groups but this issue has not been studied in mania...
  20. ncbi Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder
    Faith Dickerson
    Stanley Research Center at Sheppard Pratt, Sheppard Pratt Health System, 6501 North Charles, St, Baltimore, MD 21204, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:952-5. 2007
    ..We also compared the levels of CRP in the bipolar disorder individuals with those of a non-psychiatric control group...
  21. ncbi Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder
    Sarven Sabunciyan
    Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1083-6. 2007
    ..All individuals with the rs28757218 polymorphism were heterozygous for the allele. Based on this positive case-control association finding, we conclude that variations in OTX2 might confer risk for the development of bipolar disorder...
  22. ncbi Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia
    E G Severance
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1105, Baltimore, MD21287 4933, USA
    Genes Brain Behav 7:37-45. 2008
    ..Our data demonstrate that alpha7 transcription is altered in several ways in SZ, suggesting that transcription-level mechanisms could account in part for the impaired cholinergic neurotransmission observed in this disease...
  23. ncbi Toxoplasma and schizophrenia
    R H Yolken
    Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
    Parasite Immunol 31:706-15. 2009
    ....
  24. ncbi Lack of RIC-3 congruence with beta2 subunit-containing nicotinic acetylcholine receptors in bipolar disorder
    E G Severance
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 1105, Baltimore, MD 21287 4933, USA
    Neuroscience 148:454-60. 2007
    ....
  25. pmc Deficit schizophrenia: association with serum antibodies to cytomegalovirus
    Faith Dickerson
    Stanley Research Center at Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
    Schizophr Bull 32:396-400. 2006
    ..Exposure to human herpesviruses is a possible risk factor for schizophrenia. We hypothesized that there would be deficit/nondeficit difference in the prevalence of serum antibodies to human herpesviruses...
  26. pmc Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs
    Bogdana Krivogorsky
    Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Antimicrob Agents Chemother 52:4466-9. 2008
    ..Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics...
  27. pmc In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin
    Lorraine Jones-Brando
    Stanley Division of Developmental Neurovirology, Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 4988, USA
    Antimicrob Agents Chemother 50:4206-8. 2006
    ..We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture...
  28. pmc No difference in antibody titers against xenotropic MLV related virus in prostate cancer cases and cancer-free controls
    Sarven Sabunciyan
    Stanley Division of Developmental Virology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21287, United States
    Mol Cell Probes 25:134-6. 2011
    ..No statistically significant differences were observed in immunoreactivity between cases and controls for either the XMRV-env or the XMRV-gag antigen...
  29. ncbi Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii
    Lorraine Jones-Brando
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street Blalock 1149, Baltimore, MD 21287 4933, USA
    Schizophr Res 62:237-44. 2003
    ..Several medications used to treat schizophrenia and bipolar disorder have the ability to inhibit the in vitro replication of T. gondii...
  30. ncbi Humoral immune responses to gag and env proteins from human immunodeficiency virus type 1 in hemophiliac patients
    J S Kinney
    Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland
    Am J Hematol 36:35-41. 1991
    ..In hemophiliac patients with HIV-1 infection a low titer of antibody to gag protein is not invariably associated with clinical deterioration and is not a useful serologic marker of impending progression to AIDS...
  31. ncbi Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium
    N L Johnston-Wilson
    Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD 21287 4933, USA
    Mol Psychiatry 5:142-9. 2000
    ..Two spots, carbonic anhydrase 1 and fructose biphosphate aldolase C, show increase in one or more diseases compared to controls. Proteomic analysis may identify novel pathogenic mechanisms of human neuropsychiatric diseases...
  32. ncbi Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder
    Y Sun
    Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Br J Psychiatry Suppl 41:s137-41. 2001
    ..CONCLUSION: The SAGE technique offers promise for the characterisation of complex human brain diseases...
  33. pmc Differential effects of three canonical Toxoplasma strains on gene expression in human neuroepithelial cells
    Jianchun Xiao
    Stanley Division of Developmental Neurovirology, Johns Hopkins School of Medicine, 600 N Wolfe Street, 1105 Blalock, Baltimore, MD 21287 4933, USA
    Infect Immun 79:1363-73. 2011
    ..These observed differences may explain some of the variation in the neurobiological effects of different strains of Toxoplasma on infected individuals...
  34. ncbi Emerging technologies for large-scale screening of human tissues and fluids in the study of severe psychiatric disease
    N L Johnston-Wilson
    Stanley Division of Devlopmental Neurovirology, John Hopkins School of Medicine, Baltimore, MD 21287, USA
    Int J Neuropsychopharmacol 4:83-92. 2001
    ..The characterization of these pathways may allow for the development of new methods for the diagnosis and treatment of schizophrenia, bipolar disorder, and other human psychiatric diseases...
  35. ncbi Endogenous retroviruses and schizophrenia
    R H Yolken
    Johns Hopkins University School of Medicine, Stanley Division of Developmental Neurovirology, Department of Pediatrics, 600 N Wolfe Street, Blalock 1111, Baltimore, MD, USA
    Brain Res Brain Res Rev 31:193-9. 2000
    ..The delineation of a role for retroviruses in disease pathogenesis might lead to new methods for the diagnosis and treatment of schizophrenia...
  36. pmc Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia
    H Karlsson
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:4634-9. 2001
    ..The further characterization of retroviral elements within the central nervous system of individuals with schizophrenia might lead to improved methods for the diagnosis and management of this disorder...
  37. ncbi A comprehensive genetic association and functional study of TNF in schizophrenia risk
    Brian H Shirts
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pennsylvania 15213, USA
    Schizophr Res 83:7-13. 2006
    ..We find no evidence to implicate TNF gene polymorphisms for schizophrenia risk in our sample...
  38. ncbi Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera
    John McGrath
    Department of Psychiatry, Queensland Centre for Schizophrenia Research, University of Queensland, The Park Centre for Mental Health, Wacol Q4076, Australia
    Schizophr Res 63:73-8. 2003
    ..Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia...
  39. ncbi Selected infectious agents and risk of schizophrenia among U.S. military personnel
    David W Niebuhr
    Department of Epidemiology, Division of Preventive Medicine, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20901
    Am J Psychiatry 165:99-106. 2008
    ..gondii antibodies among individuals discharged from the U.S. military with a diagnosis of schizophrenia and serum specimens available from both before and after diagnosis...
  40. ncbi Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia?
    Jung Jin Kim
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Ann Med 39:145-53. 2007
    ..Published data support genetic variants, as well as certain infectious agents, as potential risk factors for schizophrenia. Less is known about interactions between the risk factors...
  41. pmc Mumps virus-specific antibody titers from pre-vaccine era sera: comparison of the plaque reduction neutralization assay and enzyme immunoassays
    Jeremy Mauldin
    Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA
    J Clin Microbiol 43:4847-51. 2005
    ..Our results indicate that the PRN assay is a more sensitive and specific method of measuring serological responses to wild-type mumps virus...
  42. ncbi Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii
    Oliver Frank
    Medical Clinic III, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, D 68305 Mannheim, Germany
    J Infect Dis 194:1447-9. 2006
    ..gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells...