Research Topics
Species | Robert YolkenSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Antibodies to Toxoplasma gondii in individuals with first-episode schizophreniaR H Yolken
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
Clin Infect Dis 32:842-4. 2001..We found that the individuals with first-episode schizophrenia had significantly increased levels of IgG, IgM, and IgA class antibodies to Toxoplasma proteins, as compared with the control subjects...- Viruses and schizophrenia: a focus on herpes simplex virusRobert Yolken
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 4933, USA
Herpes 11:83A-88A. 2004..Further research to investigate the relationship between virus infection and schizophrenia is warranted... 
Are some cases of psychosis caused by microbial agents? A review of the evidenceR H Yolken
The Stanley Laboratory of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University Medical Center, Baltimore, MD 21287 4933, USA
Mol Psychiatry 13:470-9. 2008..The identification of infectious agents associated with the etiopathogenesis of schizophrenia might lead to new methods for the diagnosis, treatment and prevention of this disorder...- C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophreniaFaith Dickerson
Stanley Research Center at Sheppard Pratt, Sheppard Pratt Health System, 6501 North Charles, St, Baltimore, MD 21204, USA
Schizophr Res 93:261-5. 2007..We investigated the association between serum levels of C-reactive protein (CRP), a marker of inflammation, and the severity of psychopathology and cognitive impairment in schizophrenia... - Markers of gluten sensitivity in acute mania: a longitudinal studyFaith Dickerson
The Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA
Psychiatry Res 196:68-71. 2012..The monitoring and control of gluten sensitivity may have significant effects on the management of individuals hospitalized with acute mania... - Markers of gluten sensitivity and celiac disease in bipolar disorderFaith Dickerson
The Stanley Research Program at Sheppard Pratt, 6501 North Charles Street, Baltimore, MD 21204, USA
Bipolar Disord 13:52-8. 2011.... - Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorderFaith Dickerson
Stanley Research Program, Sheppard Pratt, Baltimore, MD, USA
Brain Behav Immun 22:1103-7. 2008..Infections with HSV-1 and the COMT Val158Val genotype are risk factors for cognitive deficits in non-elderly persons without a psychiatric disorder... - Antibodies to the glutamate receptor in maniaFaith Dickerson
Sheppard Pratt The Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
Bipolar Disord 14:547-53. 2012..There is evidence that the glutamatergic system is involved in the pathophysiology of mania. Antibodies to the NR2 subunits of the N-methyl-D-aspartate (NMDA) receptor have been shown to adversely affect glutamate functioning... - Artemisinin reduces the level of antibodies to gliadin in schizophreniaFaith Dickerson
Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
Schizophr Res 129:196-200. 2011..To investigate if adjunctive artemisinin, an anti-malarial compound with in vivo activity against Toxoplasma gondii, reduces symptoms or antibodies in schizophrenia... - Antibodies to retroviruses in recent onset psychosis and multi-episode schizophreniaFaith Dickerson
The Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA
Schizophr Res 138:198-205. 2012..Immunological abnormalities involving the upregulation of endogenous retroviruses have been associated with schizophrenia in small studies... - Additive effects of elevated C-reactive protein and exposure to Herpes Simplex Virus type 1 on cognitive impairment in individuals with schizophreniaFaith Dickerson
Stanley Research Program at Sheppard Pratt, Sheppard Pratt Health System, 6501 North Charles, St, Baltimore, MD 21204, USA
Schizophr Res 134:83-8. 2012..We investigated the effect of elevated levels of C-reactive protein (CRP) and exposure to Herpes simplex virus type 1 (HSV-1) on the severity of cognitive impairment in individuals with schizophrenia... - The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophreniaFaith Dickerson
Stanley Research Center at Sheppard Pratt, Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
Schizophr Res 89:173-6. 2007..There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia... 
Toxoplasma gondii in individuals with schizophrenia: association with clinical and demographic factors and with mortalityFaith Dickerson
The Stanley Research Center at the Sheppard Pratt Health System, 6501 North Charles Street, Baltimore, MD 21204, USA
Schizophr Bull 33:737-40. 2007..Increased rates of exposure to Toxoplasma gondii have been found in individuals with schizophrenia as compared with control groups, but the correlates of Toxoplasma exposure in schizophrenia have not been defined...- Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophreniaFaith Dickerson
Stanley Research Program at Sheppard Pratt, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21204, USA
Biol Psychiatry 68:100-4. 2010..Increased immune sensitivity to gluten has been reported in schizophrenia. However, studies are inconsistent about this association... - The association between cognitive functioning and occupational status in persons with a recent onset of psychosisFaith B Dickerson
Stanley Research Program, Sheppard Pratt Health System, Baltimore, Maryland, USA
J Nerv Ment Dis 195:566-71. 2007..Cognitive assessments may prove useful to identify recent onset patients who are most at risk for occupational impairment and who could most benefit from therapeutic interventions... - Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondiiChristopher P Hencken
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
J Med Chem 53:3594-601. 2010..Some of the new derivatives of artemisinin described here represent effective anti-Toxoplasma trioxanes as well as molecular probes for elucidating the mechanism of action of the DART class of artemisinin derivatives... - Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycleJohn G D'Angelo
Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
J Antimicrob Chemother 63:146-50. 2009.... - Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorderFaith Dickerson
Stanley Research Center at Sheppard Pratt, Sheppard Pratt Health System, 6501 North Charles, St, Baltimore, MD 21204, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:952-5. 2007..We also compared the levels of CRP in the bipolar disorder individuals with those of a non-psychiatric control group... - Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorderSarven Sabunciyan
Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 144:1083-6. 2007..All individuals with the rs28757218 polymorphism were heterozygous for the allele. Based on this positive case-control association finding, we conclude that variations in OTX2 might confer risk for the development of bipolar disorder... - Lack of RIC-3 congruence with beta2 subunit-containing nicotinic acetylcholine receptors in bipolar disorderE G Severance
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 1105, Baltimore, MD 21287 4933, USA
Neuroscience 148:454-60. 2007.... - Toxoplasma and schizophreniaR H Yolken
Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
Parasite Immunol 31:706-15. 2009.... - Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophreniaE G Severance
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1105, Baltimore, MD21287 4933, USA
Genes Brain Behav 7:37-45. 2008..Our data demonstrate that alpha7 transcription is altered in several ways in SZ, suggesting that transcription-level mechanisms could account in part for the impaired cholinergic neurotransmission observed in this disease... - Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogsBogdana Krivogorsky
Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Antimicrob Agents Chemother 52:4466-9. 2008..Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics... - Deficit schizophrenia: association with serum antibodies to cytomegalovirusFaith Dickerson
Stanley Research Center at Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
Schizophr Bull 32:396-400. 2006..Exposure to human herpesviruses is a possible risk factor for schizophrenia. We hypothesized that there would be deficit/nondeficit difference in the prevalence of serum antibodies to human herpesviruses... - In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisininLorraine Jones-Brando
Stanley Division of Developmental Neurovirology, Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 4988, USA
Antimicrob Agents Chemother 50:4206-8. 2006..We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture... - No difference in antibody titers against xenotropic MLV related virus in prostate cancer cases and cancer-free controlsSarven Sabunciyan
Stanley Division of Developmental Virology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21287, United States
Mol Cell Probes 25:134-6. 2011..No statistically significant differences were observed in immunoreactivity between cases and controls for either the XMRV-env or the XMRV-gag antigen... - Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondiiLorraine Jones-Brando
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street Blalock 1149, Baltimore, MD 21287 4933, USA
Schizophr Res 62:237-44. 2003..Several medications used to treat schizophrenia and bipolar disorder have the ability to inhibit the in vitro replication of T. gondii... - Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology ConsortiumN L Johnston-Wilson
Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD 21287 4933, USA
Mol Psychiatry 5:142-9. 2000..Two spots, carbonic anhydrase 1 and fructose biphosphate aldolase C, show increase in one or more diseases compared to controls. Proteomic analysis may identify novel pathogenic mechanisms of human neuropsychiatric diseases... - Serial analysis of gene expression in the frontal cortex of patients with bipolar disorderY Sun
Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Br J Psychiatry Suppl 41:s137-41. 2001..CONCLUSION: The SAGE technique offers promise for the characterisation of complex human brain diseases... - Humoral immune responses to gag and env proteins from human immunodeficiency virus type 1 in hemophiliac patientsJ S Kinney
Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland
Am J Hematol 36:35-41. 1991..In hemophiliac patients with HIV-1 infection a low titer of antibody to gag protein is not invariably associated with clinical deterioration and is not a useful serologic marker of impending progression to AIDS... - Differential effects of three canonical Toxoplasma strains on gene expression in human neuroepithelial cellsJianchun Xiao
Stanley Division of Developmental Neurovirology, Johns Hopkins School of Medicine, 600 N Wolfe Street, 1105 Blalock, Baltimore, MD 21287 4933, USA
Infect Immun 79:1363-73. 2011..These observed differences may explain some of the variation in the neurobiological effects of different strains of Toxoplasma on infected individuals... - Emerging technologies for large-scale screening of human tissues and fluids in the study of severe psychiatric diseaseN L Johnston-Wilson
Stanley Division of Devlopmental Neurovirology, John Hopkins School of Medicine, Baltimore, MD 21287, USA
Int J Neuropsychopharmacol 4:83-92. 2001..The characterization of these pathways may allow for the development of new methods for the diagnosis and treatment of schizophrenia, bipolar disorder, and other human psychiatric diseases... - Endogenous retroviruses and schizophreniaR H Yolken
Johns Hopkins University School of Medicine, Stanley Division of Developmental Neurovirology, Department of Pediatrics, 600 N Wolfe Street, Blalock 1111, Baltimore, MD, USA
Brain Res Brain Res Rev 31:193-9. 2000..The delineation of a role for retroviruses in disease pathogenesis might lead to new methods for the diagnosis and treatment of schizophrenia... - Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophreniaH Karlsson
Stanley Division of Developmental Neurovirology, Department of Pediatrics, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 98:4634-9. 2001..The further characterization of retroviral elements within the central nervous system of individuals with schizophrenia might lead to improved methods for the diagnosis and management of this disorder... - Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia?Jung Jin Kim
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Ann Med 39:145-53. 2007..Published data support genetic variants, as well as certain infectious agents, as potential risk factors for schizophrenia. Less is known about interactions between the risk factors... - Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked seraJohn McGrath
Department of Psychiatry, Queensland Centre for Schizophrenia Research, University of Queensland, The Park Centre for Mental Health, Wacol Q4076, Australia
Schizophr Res 63:73-8. 2003..Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia... - Selected infectious agents and risk of schizophrenia among U.S. military personnelDavid W Niebuhr
Department of Epidemiology, Division of Preventive Medicine, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20901
Am J Psychiatry 165:99-106. 2008..gondii antibodies among individuals discharged from the U.S. military with a diagnosis of schizophrenia and serum specimens available from both before and after diagnosis... - A comprehensive genetic association and functional study of TNF in schizophrenia riskBrian H Shirts
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pennsylvania 15213, USA
Schizophr Res 83:7-13. 2006..We find no evidence to implicate TNF gene polymorphisms for schizophrenia risk in our sample... - Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondiiOliver Frank
Medical Clinic III, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, D-68305 Mannheim, Germany
J Infect Dis 194:1447-9. 2006..gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells... - Mumps virus-specific antibody titers from pre-vaccine era sera: comparison of the plaque reduction neutralization assay and enzyme immunoassaysJeremy Mauldin
Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA
J Clin Microbiol 43:4847-51. 2005..Our results indicate that the PRN assay is a more sensitive and specific method of measuring serological responses to wild-type mumps virus...