Srinivasan Yegnasubramanian

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
    Michael C Haffner
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Oncotarget 2:627-37. 2011
  2. pmc Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose
    Matthew P Vaughn
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 6:e25707. 2011
  3. pmc Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations
    Jonathan M Gerber
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Oncotarget 4:715-28. 2013
  4. pmc Explanatory chapter: next generation sequencing
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    Methods Enzymol 529:201-8. 2013
  5. pmc Preparation of fragment libraries for next-generation sequencing on the applied biosystems SOLiD platform
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    Methods Enzymol 529:185-200. 2013
  6. doi request reprint Aiming for the outliers: cancer precision medicine through targeting kinases with extreme expression
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Sol Golman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Discov 3:252-4. 2013
  7. pmc Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Genomics 12:313. 2011
  8. pmc DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 68:8954-67. 2008
  9. pmc Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer
    Laxmi G Pellakuru
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 181:560-9. 2012
  10. pmc CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer
    Patrick J Bastian
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 179:529-34; discussion 534-5. 2008

Detail Information

Publications52

  1. pmc Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
    Michael C Haffner
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Oncotarget 2:627-37. 2011
    ..Our findings suggest a distinct role for 5 hmC in tissue differentiation, and provide evidence for its large-scale loss in cancers...
  2. pmc Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose
    Matthew P Vaughn
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 6:e25707. 2011
    ..class GSTs are known to be critical determinants of liver responses to drugs and toxins: when treated with high doses of acetaminophen, mGstp1/2+/+ mice suffer marked liver damage, while mGstp1/2-/- mice escape liver injury...
  3. pmc Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations
    Jonathan M Gerber
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Oncotarget 4:715-28. 2013
    ..g., CCND1). These data represent an important resource for understanding the molecular changes in CML LSCs, which may be exploited to develop novel therapies for eradication these cells and achieve cure. ..
  4. pmc Explanatory chapter: next generation sequencing
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    Methods Enzymol 529:201-8. 2013
    ..These technologies have largely started to replace high-throughput Sanger sequencing for large-scale genomic projects, and have created significant enthusiasm for the advent of a new era of individualized medicine. ..
  5. pmc Preparation of fragment libraries for next-generation sequencing on the applied biosystems SOLiD platform
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    Methods Enzymol 529:185-200. 2013
    ..This protocol can be adapted to next-generation sequencing workflows to ultimately generate up to 1 billion 50 bp sequence tags from the ends of each of the DNA molecules in the library in a single next-generation sequencing run...
  6. doi request reprint Aiming for the outliers: cancer precision medicine through targeting kinases with extreme expression
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Sol Golman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Discov 3:252-4. 2013
    ....
  7. pmc Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Genomics 12:313. 2011
    ..This MBD-chip approach was used to characterize DNA methylation patterns across all non-repetitive sequences of human chromosomes 21 and 22 at high-resolution in normal and malignant prostate cells...
  8. pmc DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 68:8954-67. 2008
    ....
  9. pmc Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer
    Laxmi G Pellakuru
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 181:560-9. 2012
    ..These findings suggest that increased levels of decondensed chromatin in both normal progenitor cells and cancer cells are associated with global loss of H3K27me3, which is linked to MYC overexpression...
  10. pmc CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer
    Patrick J Bastian
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 179:529-34; discussion 534-5. 2008
    ..In this study we investigated the hypermethylation profile of several genes in the serum of men with localized and hormone refractory prostate cancer...
  11. ncbi request reprint Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 13:5361-7. 2007
    ..We evaluated the association of preoperative serum cell-free circulating DNA concentration in men with clinically localized prostate cancer who underwent radical prostatectomy with prostate-specific antigen (PSA) recurrence...
  12. pmc Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms
    Cheryl M Koh
    Departments of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Oncotarget 2:669-83. 2011
    ..Further, the results implicate EZH2-driven mechanisms by which Myc may stimulate prostate tumor initiation and disease progression...
  13. pmc Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene
    Cheryl M Koh
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Am J Pathol 178:1824-34. 2011
    ....
  14. pmc Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer
    Christopher Weier
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    J Pathol 230:174-83. 2013
    ..These analyses have provided important insights into the molecular mechanisms involved in generating prostate cancer-specific recurrent rearrangements...
  15. pmc Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 1650 Orleans Street, CRB 116, Baltimore, MD 21231, USA
    Nucleic Acids Res 34:e19. 2006
    ..This novel technology could significantly improve our ability to detect CGI hypermethylation...
  16. pmc Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    Michael C Haffner
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:668-75. 2010
    ..These findings implicate androgen-induced TOP2B-mediated DSBs in generating TMPRSS2-ERG rearrangements...
  17. ncbi request reprint Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy
    Patrick J Bastian
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 11:4037-43. 2005
    ..We evaluated circulating cell-free DNA GSTP1 CpG island hypermethylation as a prognostic biomarker in the serum of men with prostate cancer...
  18. pmc Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease
    Michael C Haffner
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Cell Cycle 12:1835-41. 2013
    ..These findings suggest a previously unappreciated link between 5hmC and H3K27me3 regulation that should be explored in future mechanistic studies. ..
  19. ncbi request reprint Hypermethylation of CpG islands in primary and metastatic human prostate cancer
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Cancer Res 64:1975-86. 2004
    ..Furthermore, CpG island hypermethylation patterns in prostate cancer metastases were very similar to the primary prostate cancers and tended to show greater differences between cases than between anatomical sites of metastasis...
  20. pmc Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets
    Bora Gurel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Adv Anat Pathol 15:319-31. 2008
    ..In addition, recent studies in which new molecular diagnostic approaches have been applied in the clinic will be discussed...
  21. pmc A DNA hypermethylation module for the stem/progenitor cell signature of cancer
    Hariharan Easwaran
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Johns Hopkins Medical Institutions, Baltimore, MD 21117, USA
    Genome Res 22:837-49. 2012
    ..Additionally, the capacity for global methylation profiling to cluster tumors by phenotype may have important implications for further refining tumor behavior patterns that may ultimately aid therapeutic interventions...
  22. pmc Accurate genome-scale percentage DNA methylation estimates from microarray data
    Martin J Aryee
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University and Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Biostatistics 12:197-210. 2011
    ..We illustrate the method on data generated to detect methylation differences between tissues and between normal and tumor colon samples...
  23. pmc DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases
    Martin J Aryee
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Sci Transl Med 5:169ra10. 2013
    ....
  24. ncbi request reprint Abnormal DNA methylation, epigenetics, and prostate cancer
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Brady Urological Institute, Baltimore, MD 21231, USA
    Front Biosci 12:4254-66. 2007
    ..If sufficiently safe strategies for chromatin modulation can be discovered and developed, epigenetic alterations may become rational targets for both prostate cancer prevention and prostate cancer treatment...
  25. pmc Procainamide is a specific inhibitor of DNA methyltransferase 1
    Byron H Lee
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 280:40749-56. 2005
    ..Because many reports have strongly linked DNMT1 with epigenetic alterations in carcinogenesis, procainamide may be a useful drug in the prevention of cancer...
  26. pmc Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors
    Georges J Netto
    Department of Pathology, Division of Genitourinary Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Mod Pathol 21:1337-44. 2008
    ..That is, IGCNU cells and seminoma cells remain unmethylated, whereas all other histological types appear to arise after de novo methylation...
  27. ncbi request reprint MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine
    Gloria L David
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Cancer Biol Ther 3:540-8. 2004
    ..In this state, MDR1 expression was markedly sensitive to treatment with the histone deacetylase inhibitor trichostatin A...
  28. ncbi request reprint Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer
    Agoston T Agoston
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231 1000, USA
    J Biol Chem 280:18302-10. 2005
    ..The regulation of DNMT1 destruction via this domain may be dysfunctional in cancer cells leading to subsequent cytosine hypermethylation in the genome...
  29. pmc Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
    Ping Zhang
    Division of Toxicology, Bloomberg School of Public Health, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Mol Cancer Ther 9:336-46. 2010
    ..Thus, targeting the Nrf2 pathway in prostate cancer cells may provide a novel strategy to enhance chemotherapy and radiotherapy responsiveness and ameliorate the growth and tumorigenicity, leading to improved clinical outcomes...
  30. pmc MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells
    Tsuyoshi Iwata
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9427. 2010
    ..We also identified a novel histopathologically identifiable intermediate step prior to invasion that should facilitate studies of molecular pathway alterations occurring during early progression of prostatic adenocarcinomas...
  31. pmc Epigenetic alterations in human prostate cancers
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Endocrinology 150:3991-4002. 2009
    ..Finally, a growing portfolio of epigenetic drugs, capable of reversing the phenotypic consequences of somatic epigenetic defects, has entered clinical trials for prostate cancer in the search for a new rational therapy for the disease...
  32. ncbi request reprint Molecular biomarker in prostate cancer: the role of CpG island hypermethylation
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Eur Urol 46:698-708. 2004
    ..CpG island hypermethylation may serve as a useful molecular biomarker for the detection and diagnosis of patients with prostate cancer...
  33. pmc Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth
    Jianqing Lin
    Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Prostate 71:333-43. 2011
    ..Because DNMT catalysis features attack of cytosine bases by an enzyme thiol group, we tested whether disulfiram (DSF), a thiol-reactive compound with known clinical safety, demonstrated DNMT inhibitory activity...
  34. pmc Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling
    Gabriel Ghiaur
    The Sidney Kimmel Comprehensive Cancer Center, and Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287
    Proc Natl Acad Sci U S A 110:16121-6. 2013
    ..Modulation of RA signaling also holds promise for clinical HSC expansion, a prerequisite for the wide-scale use of these cells in regenerative medicine and gene therapy. ..
  35. pmc Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?
    Michael C Haffner
    Authors Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Clin Cancer Res 17:3858-64. 2011
    ..Such strategies may find particular utility in cancers, like prostate cancer, which show low proliferation rates, in which other chemotherapeutic strategies that target rapidly proliferating cells have had limited success...
  36. pmc A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Discov 1:68-77. 2011
    ..54, 95% CI 0.37-0.79, P-trend<0.001), had a lower prostate cancer risk. Digoxin was highly potent in inhibiting prostate cancer cell growth in vitro and its use was associated with a 25% lower prostate cancer risk...
  37. ncbi request reprint GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer
    Masashi Nakayama
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Cell Biochem 91:540-52. 2004
    ..GSTP1 CpG island hypermethylation, a somatic epigenetic alteration, appears poised to serve as a molecular biomarker useful for prostate cancer screening, detection, and diagnosis...
  38. pmc Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma
    Brent A Orr
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e41036. 2012
    ..These findings suggest that 5hmC regulation in malignant glioma may represent an important determinant of tumor differentiation and aggressive behavior, as well as a potential therapeutic target...
  39. pmc Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines
    Karen Sandell Sfanos
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20874. 2011
    ..Importantly, our results suggest a need for regular screening of cancer cell lines for retroviral "contamination", much like routine mycoplasma testing...
  40. ncbi request reprint Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis
    Mark L Gonzalgo
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 10:7276-83. 2004
    ..We determine the utility of molecular profiling based on quantitative methylation analysis for characterization of sporadic renal cell carcinoma...
  41. pmc Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network
    Medha Darshan
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Prostate 74:61-9. 2014
    ..Our study aimed to determine the potential impact of the RALP procedure on the detection of known prostate cancer biomarkers, and the subsequent suitability of RALP-derived specimens for prostate cancer biomarker studies...
  42. pmc A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes
    Debika Biswal Shinohara
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 73:1007-15. 2013
    ..To study this potential link in an in vivo system, we developed a mouse model of long-term bacteria-induced chronic inflammation of the prostate using a human prostatectomy-derived strain of Propionibacterium acnes...
  43. doi request reprint USP2a activation of MYC in prostate cancer
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Cancer Discov 2:206-7. 2012
    ..Ubiquitin-specific protease 2a, a deubiquitinating enzyme, elevates MYC levels in prostate cancer cells via its stabilization of MDM2, undermining p53 regulation of microRNAs that target MYC mRNA...
  44. pmc A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts
    Judit Ribas
    The James Buchannan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Nucleic Acids Res 40:6821-33. 2012
    ..Collectively, these results indicate that miR-21 is a unique miRNA capable of being regulated by alternative polyadenylation and two independent gene promoters...
  45. pmc miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth
    Judit Ribas
    The James Buchanan Brady Urological Institute, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 69:7165-9. 2009
    ..Moreover, quantitative reverse transcription-PCR analysis revealed elevated miR-21 expression in CaP when compared with adjacent normal tissue. These results suggest that miR-21 may contribute to CaP pathogenesis...
  46. pmc Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    Rong Hu
    Department of Urology, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 72:3457-62. 2012
    ..Together, our findings support an adaptive shift toward AR-V-mediated signaling in a subset of CRPC tumors as the AR-LBD is rendered inactive, suggesting an important mechanism contributing to drug resistance to CRPC therapy...
  47. doi request reprint The diet as a cause of human prostate cancer
    William G Nelson
    Departments of Oncology, Pathology, and Urology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Weinberg Bldg 1100, 1650 Orleans Street, Baltimore, MD, 21231, USA
    Cancer Treat Res 159:51-68. 2014
    ..Specifically, nutritional agents might prevent PIA lesions or reduce the propensity of PIA lesions to suffer "catastrophic" epigenome corruption. ..
  48. pmc Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli
    Kirstie Canene-Adams
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e79842. 2013
    ....
  49. doi request reprint Prostate cancer: New answers prompt new questions regarding cell of origin
    Angelo M De Marzo
    The Brady Urological Research Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Rev Urol 7:650-2. 2010
    ..However, these results are not mutually exclusive: there are potential solutions, and alternative views on the initiating cell derivation of prostate tumors also exist...
  50. pmc Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene
    Jonathan K Alder
    Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Hum Mutat 34:1481-5. 2013
    ..These findings indicate that females with heterozygous DKC1 mutations may be at increased risk for developing penetrant telomere phenotypes that, at times, may be associated with clinical morbidity. ..
  51. pmc Resistance emerges to second-generation antiandrogens in prostate cancer
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
    Cancer Discov 3:971-4. 2013
    ....
  52. ncbi request reprint Beefing up prostate cancer therapy with performance-enhancing (anti-) steroids
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Cancer Cell 20:7-9. 2011
    ..report that the inhibition of androgen synthesis by abiraterone acetate prolonged the survival of men with prostate cancer previously treated by androgen suppression...