KEVIN J contact YAREMA

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385
    Zhiyun Wang
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 5:e13883. 2010
  2. pmc Large-scale approaches for glycobiology
    Christopher T Campbell
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Genome Biol 6:236. 2005
  3. pmc Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells
    Zhiyun Wang
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA
    BMC Genomics 10:356. 2009
  4. ncbi request reprint Regioisomeric SCFA attachment to hexosamines separates metabolic flux from cytotoxicity and MUC1 suppression
    Udayanath Aich
    Department of Biomedical Engineering, Johns Hopkins University, Clark Hall 106A, 3400 N Charles St, Baltimore, Maryland 21218, USA
    ACS Chem Biol 3:230-40. 2008
  5. pmc Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery
    Noha Elmouelhi
    The Department of Biomedical Engineering, 106A Clark Hall, 3400 North Charles Street, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Med Chem 52:2515-30. 2009
  6. ncbi request reprint Targeting glycosylation pathways and the cell cycle: sugar-dependent activity of butyrate-carbohydrate cancer prodrugs
    Srinivasa Gopalan Sampathkumar
    Whiting School of Engineering, Clark Hall 106A, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Chem Biol 13:1265-75. 2006
  7. ncbi request reprint Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology
    Srinivasa Gopalan Sampathkumar
    Department of Biomedical Engineering, The Johns Hopkins University, 3400 N Charles Street, Clark Hall 106A, Baltimore, Maryland 21218, USA
    Nat Chem Biol 2:149-52. 2006
  8. ncbi request reprint Establishment of N-acetylmannosamine (ManNAc) analogue-resistant cell lines as improved hosts for sialic acid engineering applications
    Eun Jeong Kim
    Whitaker Biomedical Engineering Institute, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Biotechnol Prog 20:1674-82. 2004
  9. ncbi request reprint Characterization of the metabolic flux and apoptotic effects of O-hydroxyl- and N-acyl-modified N-acetylmannosamine analogs in Jurkat cells
    Eun Jeong Kim
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 279:18342-52. 2004
  10. pmc Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells
    Christopher T Campbell
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Med Chem 51:8135-47. 2008

Collaborators

  • Srinivasa Gopalan Sampathkumar
  • Christopher T Campbell
  • Zhiyun Wang
  • Mark B Jones
  • Jian Du
  • Udayanath Aich
  • M Adam Meledeo
  • Pao Lin Che
  • Noha Elmouelhi
  • Eun Jeong Kim
  • Sean S Choi
  • Jun Kyu Rhee
  • Hargun S Khanna
  • Venkata D P Paruchuri
  • Frederick J Krambeck
  • Jean J Wang
  • Christopher A Weier
  • Michael J Betenbaugh
  • Adrienne V Li
  • Gautam Baskaran
  • Karthik Viswanathan
  • Barbara Ha
  • Sandra V Bennun
  • Anshu Sarje
  • Someet Narang
  • Sean Choi
  • Raja Srinivas
  • S Gopalan Sampathkumar
  • Katharina Maisel
  • Mary M Wen
  • Anthony Sheh
  • Prasra Gomutputra
  • Zhonghui Sun
  • Kaoru Hida
  • Steven R Head
  • Tim Gilmartin
  • Nicholas Lahar
  • Howard Teng
  • Scarlett Goon
  • Shawn Lawrence
  • Stephan Hinderlich
  • Yuan C Lee

Detail Information

Publications19

  1. pmc Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385
    Zhiyun Wang
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 5:e13883. 2010
    ..Building on this background, the current paper investigated SMF by focusing on the adenosine A(2A) receptor (A(2A)R) in the PC12 rat adrenal pheochromocytoma cell line that displays metabolic features of Parkinson's disease (PD)...
  2. pmc Large-scale approaches for glycobiology
    Christopher T Campbell
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Genome Biol 6:236. 2005
    ..This article reviews large-scale techniques for accelerating progress in glycobiology...
  3. pmc Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells
    Zhiyun Wang
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA
    BMC Genomics 10:356. 2009
    ..This study begins to bridge this gulf by investigating static magnetic fields (SMF) through global mRNA profiling in human embryonic cells coupled with software analysis to identify the affected signaling pathways...
  4. ncbi request reprint Regioisomeric SCFA attachment to hexosamines separates metabolic flux from cytotoxicity and MUC1 suppression
    Udayanath Aich
    Department of Biomedical Engineering, Johns Hopkins University, Clark Hall 106A, 3400 N Charles St, Baltimore, Maryland 21218, USA
    ACS Chem Biol 3:230-40. 2008
    ....
  5. pmc Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery
    Noha Elmouelhi
    The Department of Biomedical Engineering, 106A Clark Hall, 3400 North Charles Street, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Med Chem 52:2515-30. 2009
    ..Together, these results establish the SCFA-hexosamine template as a versatile platform for modulating biological activity and developing new therapeutics...
  6. ncbi request reprint Targeting glycosylation pathways and the cell cycle: sugar-dependent activity of butyrate-carbohydrate cancer prodrugs
    Srinivasa Gopalan Sampathkumar
    Whiting School of Engineering, Clark Hall 106A, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Chem Biol 13:1265-75. 2006
    ..These results demonstrate that the biological activity of butyrate can be tuned by sugars to improve its anticancer properties...
  7. ncbi request reprint Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology
    Srinivasa Gopalan Sampathkumar
    Department of Biomedical Engineering, The Johns Hopkins University, 3400 N Charles Street, Clark Hall 106A, Baltimore, Maryland 21218, USA
    Nat Chem Biol 2:149-52. 2006
    ....
  8. ncbi request reprint Establishment of N-acetylmannosamine (ManNAc) analogue-resistant cell lines as improved hosts for sialic acid engineering applications
    Eun Jeong Kim
    Whitaker Biomedical Engineering Institute, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Biotechnol Prog 20:1674-82. 2004
    ....
  9. ncbi request reprint Characterization of the metabolic flux and apoptotic effects of O-hydroxyl- and N-acyl-modified N-acetylmannosamine analogs in Jurkat cells
    Eun Jeong Kim
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 279:18342-52. 2004
    ....
  10. pmc Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells
    Christopher T Campbell
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Med Chem 51:8135-47. 2008
    ....
  11. pmc Metabolic glycoengineering: sialic acid and beyond
    Jian Du
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Glycobiology 19:1382-401. 2009
    ..Finally, recent efforts to increase the "druggability" of sugar analogs used in metabolic glycoengineering, which have resulted in unanticipated "scaffold-dependent" activities, are summarized...
  12. pmc A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data
    Frederick J Krambeck
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Glycobiology 19:1163-75. 2009
    ..Model predictions could lead to a better understanding of the changes associated with disease states, identification of disease-associated biomarkers, and bioengineered glycan modifications...
  13. pmc Hexosamine analogs: from metabolic glycoengineering to drug discovery
    Zhiyun Wang
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Curr Opin Chem Biol 13:565-72. 2009
    ..g. tributanoylated hexosamines) display unanticipated 'scaffold-dependent' activities; this finding establishes these molecules as a versatile platform for drug discovery...
  14. ncbi request reprint Metabolic expression of thiol-derivatized sialic acids on the cell surface and their quantitative estimation by flow cytometry
    Srinivasa Gopalan Sampathkumar
    Department of Biomedical Engineering, Johns Hopkins University, 3400 N Charles Street, Clark Hall Rm 106A, Baltimore, Maryland 21218, USA
    Nat Protoc 1:1840-51. 2006
    ..These methods, with minimal optimization, are generally also applicable to other human cell lines. The labeling and flow cytometry steps of this protocol can be performed in five to eight hours...
  15. ncbi request reprint Synthesis of non-natural ManNAc analogs for the expression of thiols on cell-surface sialic acids
    Srinivasa Gopalan Sampathkumar
    Department of Biomedical Engineering, The Johns Hopkins University, 3400 N Charles Street, Clark Hall Rm 106A, Baltimore, Maryland 21218, USA
    Nat Protoc 1:2377-85. 2006
    ..Starting from the commercially available D-mannosamine hydrochloride (5), gram quantities of both 1 and 2 can be prepared over five steps in about 2-3 weeks...
  16. ncbi request reprint Metabolic oligosaccharide engineering: perspectives, applications, and future directions
    Christopher T Campbell
    Department of Biomedical Engineering, The Johns Hopkins University, Clark Hall 106A, Baltimore, MD 21218, USA
    Mol Biosyst 3:187-94. 2007
    ..Finally, strategies for further engineering non-natural sugars to improve their pharmacological properties and provide complementary biological activities, such as addition of short chain fatty acids, are discussed in this article...
  17. ncbi request reprint Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogues to sialic acids
    Mark B Jones
    Department of Biomedical Engineering and the G W C Whiting School of Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biotechnol Bioeng 85:394-405. 2004
    ..In addition, these results provide fundamental new insights into the metabolic processing of non-natural monosaccharides...
  18. ncbi request reprint Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them
    Karthik Viswanathan
    Departments of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biochemistry 42:15215-25. 2003
    ..The results of these studies may be used to enhance the sialylation of target glycoproteins in insect and other eukaryotic expression systems...
  19. ncbi request reprint A photochemical snapshot of CD22 binding
    Kevin J Yarema
    Nat Chem Biol 1:69-70. 2005
    ..Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules...

Research Grants11

  1. Monosaccharide Analog/Sialic acid Metabolism & Apoptosis
    Kevin Yarema; Fiscal Year: 2005
    ....
  2. Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling and
    Kevin Yarema; Fiscal Year: 2009
    ....
  3. Monosaccharide Analogs, Sialic Acid Metabolism and Apoptosis
    Kevin Yarema; Fiscal Year: 2009
    ....
  4. Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling and
    Kevin J Yarema; Fiscal Year: 2010
    ....
  5. Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling and
    Kevin Yarema; Fiscal Year: 2009
    ....
  6. Monosaccharide Analogs, Sialic Acid Metabolism and Apoptosis
    Kevin Yarema; Fiscal Year: 2007
    ....
  7. Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling and
    Kevin Yarema; Fiscal Year: 2007
    ....
  8. Probing the Connections between Monosaccharide Analogs, Sialic Acid Metabolism, a
    Kevin Yarema; Fiscal Year: 2006
    ....
  9. Mechanism and Anti-Cancer Activity of SCFA-Hexosamine Analogs
    KEVIN J contact YAREMA; Fiscal Year: 2010
    ..This project is designed to propel the testing of this emerging class of therapeutics from cell-based assays to rodent models, which will in turn set the stage for translation to clinical testing in humans. ..