KEVIN J contact YAREMASummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Publications
Large-scale approaches for glycobiologyChristopher T Campbell
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
Genome Biol 6:236. 2005..This article reviews large-scale techniques for accelerating progress in glycobiology...- Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cellsZhiyun Wang
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA
BMC Genomics 10:356. 2009..This study begins to bridge this gulf by investigating static magnetic fields (SMF) through global mRNA profiling in human embryonic cells coupled with software analysis to identify the affected signaling pathways... 
Regioisomeric SCFA attachment to hexosamines separates metabolic flux from cytotoxicity and MUC1 suppressionUdayanath Aich
Department of Biomedical Engineering, Johns Hopkins University, Clark Hall 106A, 3400 N Charles St, Baltimore, Maryland 21218, USA
ACS Chem Biol 3:230-40. 2008....- Hexosamine template. A platform for modulating gene expression and for sugar-based drug discoveryNoha Elmouelhi
The Department of Biomedical Engineering, 106A Clark Hall, 3400 North Charles Street, The Johns Hopkins University, Baltimore, Maryland 21218, USA
J Med Chem 52:2515-30. 2009..Together, these results establish the SCFA-hexosamine template as a versatile platform for modulating biological activity and developing new therapeutics... 
Targeting glycosylation pathways and the cell cycle: sugar-dependent activity of butyrate-carbohydrate cancer prodrugsSrinivasa-Gopalan Sampathkumar
Whiting School of Engineering, Clark Hall 106A, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
Chem Biol 13:1265-75. 2006..These results demonstrate that the biological activity of butyrate can be tuned by sugars to improve its anticancer properties...- Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cellsChristopher T Campbell
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
J Med Chem 51:8135-47. 2008.... - Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biologySrinivasa-Gopalan Sampathkumar
Department of Biomedical Engineering, The Johns Hopkins University, 3400 N. Charles Street, Clark Hall 106A, Baltimore, Maryland 21218, USA
Nat Chem Biol 2:149-52. 2006.... - Establishment of N-acetylmannosamine (ManNAc) analogue-resistant cell lines as improved hosts for sialic acid engineering applicationsEun Jeong Kim
Whitaker Biomedical Engineering Institute, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
Biotechnol Prog 20:1674-82. 2004.... - Characterization of the metabolic flux and apoptotic effects of O-hydroxyl- and N-acyl-modified N-acetylmannosamine analogs in Jurkat cellsEun Jeong Kim
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
J Biol Chem 279:18342-52. 2004.... - A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric dataFrederick J Krambeck
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
Glycobiology 19:1163-75. 2009..Model predictions could lead to a better understanding of the changes associated with disease states, identification of disease-associated biomarkers, and bioengineered glycan modifications... - Metabolic glycoengineering: sialic acid and beyondJian Du
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
Glycobiology 19:1382-401. 2009..Finally, recent efforts to increase the "druggability" of sugar analogs used in metabolic glycoengineering, which have resulted in unanticipated "scaffold-dependent" activities, are summarized... - Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome themKarthik Viswanathan
Departments of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
Biochemistry 42:15215-25. 2003..The results of these studies may be used to enhance the sialylation of target glycoproteins in insect and other eukaryotic expression systems... - Metabolic expression of thiol-derivatized sialic acids on the cell surface and their quantitative estimation by flow cytometrySrinivasa-Gopalan Sampathkumar
Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall Rm 106A, Baltimore, Maryland 21218, USA
Nat Protoc 1:1840-51. 2006..These methods, with minimal optimization, are generally also applicable to other human cell lines. The labeling and flow cytometry steps of this protocol can be performed in five to eight hours... - Synthesis of non-natural ManNAc analogs for the expression of thiols on cell-surface sialic acidsSrinivasa-Gopalan Sampathkumar
Department of Biomedical Engineering, The Johns Hopkins University, 3400 N Charles Street, Clark Hall Rm 106A, Baltimore, Maryland 21218, USA
Nat Protoc 1:2377-85. 2006..Starting from the commercially available D-mannosamine hydrochloride (5), gram quantities of both 1 and 2 can be prepared over five steps in about 2-3 weeks... - Metabolic oligosaccharide engineering: perspectives, applications, and future directionsChristopher T Campbell
Department of Biomedical Engineering, The Johns Hopkins University, Clark Hall 106A, Baltimore, MD 21218, USA
Mol Biosyst 3:187-94. 2007..Finally, strategies for further engineering non-natural sugars to improve their pharmacological properties and provide complementary biological activities, such as addition of short chain fatty acids, are discussed in this article... - Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogues to sialic acidsMark B Jones
Department of Biomedical Engineering and the G.W.C. Whiting School of Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Biotechnol Bioeng 85:394-405. 2004..In addition, these results provide fundamental new insights into the metabolic processing of non-natural monosaccharides... - Hexosamine analogs: from metabolic glycoengineering to drug discoveryZhiyun Wang
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
Curr Opin Chem Biol 13:565-72. 2009..g. tributanoylated hexosamines) display unanticipated 'scaffold-dependent' activities; this finding establishes these molecules as a versatile platform for drug discovery... - A photochemical snapshot of CD22 bindingKevin J Yarema
Nat Chem Biol 1:69-70. 2005..Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules...
Research Grants
- Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling andKevin Yarema; Fiscal Year: 2009....
- Monosaccharide Analogs, Sialic Acid Metabolism and ApoptosisKevin Yarema; Fiscal Year: 2009....
- Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling andKevin J Yarema; Fiscal Year: 2010....
- Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling andKevin Yarema; Fiscal Year: 2009....
- Monosaccharide Analogs, Sialic Acid Metabolism and ApoptosisKevin Yarema; Fiscal Year: 2007....
- Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling andKevin Yarema; Fiscal Year: 2007....
- Mechanism and Anti-Cancer Activity of SCFA-Hexosamine AnalogsKEVIN J contact YAREMA; Fiscal Year: 2010..This project is designed to propel the testing of this emerging class of therapeutics from cell-based assays to rodent models, which will in turn set the stage for translation to clinical testing in humans. ..