Zeng Jin Yang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Neurochem 121:168-79. 2012
  2. pmc Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Exp Neurol 221:166-74. 2010
  3. pmc Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum
    Zeng Jin Yang
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurobiol Dis 43:446-54. 2011
  4. pmc Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 33:1612-20. 2013
  5. pmc Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs
    Xinli Ni
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Anesth Analg 115:627-37. 2012
  6. pmc Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia
    Xiaoling Li
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurochem 113:1012-22. 2010
  7. pmc Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 27:1339-51. 2007
  8. pmc Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone
    Xinli Ni
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Dev Neurosci 33:299-311. 2011
  9. pmc Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia
    Zhenfeng Xu
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Physiol Regul Integr Comp Physiol 299:R215-21. 2010
  10. pmc Cerebrovascular autoregulation after rewarming from hypothermia in a neonatal swine model of asphyxic brain injury
    Abby C Larson
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Appl Physiol (1985) 115:1433-42. 2013

Collaborators

Detail Information

Publications12

  1. pmc Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Neurochem 121:168-79. 2012
    ..Thus, 20-HETE can exert direct effects on key proteins involved in neuronal excitotoxicity in vivo and contributes to neurodegeneration after global cerebral ischemia in immature brain...
  2. pmc Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Exp Neurol 221:166-74. 2010
    ..These findings indicate that PPBP protects striatal neurons in a large animal model of neonatal H-I and that the protection is associated with decreased coupling of nNOS to PSD-95...
  3. pmc Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum
    Zeng Jin Yang
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurobiol Dis 43:446-54. 2011
    ..These results indicate that ASIC1a activation contributes to neuronal death in newborn putamen after H-I through mechanisms that may involve protein kinase A-dependent phosphorylation of NMDA receptor and nitrative and oxidative stress...
  4. pmc Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 33:1612-20. 2013
    ..Its toxic signaling may be related to DARPP32-dependent phosphorylation of PKA-sensitive sites on NR1 and Na(+),K(+)-ATPase, thereby augmenting excitotoxicity-induced oxidative stress after reoxygenation...
  5. pmc Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs
    Xinli Ni
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Anesth Analg 115:627-37. 2012
    ....
  6. pmc Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia
    Xiaoling Li
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurochem 113:1012-22. 2010
    ..We conclude that PARP-2 contributes substantially to nuclear translocation of AIF and infarct size after transient focal cerebral ischemia in male mice, but that protection is disproportionate to the attenuation of overall PARP activity...
  7. pmc Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 27:1339-51. 2007
    ..Furthermore, mechanisms of D1 receptor toxicity may involve DARPP-32-dependent phosphorylation of NMDA receptor NR1 and Na(+),K(+)-ATPase...
  8. pmc Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone
    Xinli Ni
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Dev Neurosci 33:299-311. 2011
    ..Therefore, oxidative stress is an important mechanism for this injury, and antioxidant therapy is a rational, mechanism-based approach to neuroprotection in the newborn brain...
  9. pmc Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia
    Zhenfeng Xu
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Physiol Regul Integr Comp Physiol 299:R215-21. 2010
    ..Thus endonuclease G is not obligatory for executing PARP-dependent injury during ischemic stroke...
  10. pmc Cerebrovascular autoregulation after rewarming from hypothermia in a neonatal swine model of asphyxic brain injury
    Abby C Larson
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Appl Physiol (1985) 115:1433-42. 2013
    ..10). In conclusion, rewarming did not shift the LLA during hypotension or affect autoregulation during hypertension after asphyxic cardiac arrest. The NIRS-derived autoregulation indices identified the LLA accurately. ..
  11. pmc Noninvasive autoregulation monitoring in a swine model of pediatric cardiac arrest
    Jennifer K Lee
    Department of Pediatric Anesthesiology and Critical Care Medicine, Johns Hopkins University, Blalock 904, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Anesth Analg 114:825-36. 2012
    ..We also tested the hypothesis that autoregulation with hypertension would be impaired after cardiac arrest...
  12. pmc Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse
    Jian Zhang
    Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1404, Baltimore, MD 21287, USA
    Stroke 39:967-74. 2008
    ..The present objective was to develop an ischemic preconditioning (IPC) model of delayed tolerance in the mouse based on repetitive, transient middle cerebral artery occlusion (MCAO)...