Munekazu Yamakuchi

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
  2. pmc miR-34a repression of SIRT1 regulates apoptosis
    Munekazu Yamakuchi
    Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:13421-6. 2008
  3. ncbi request reprint MiR-34, SIRT1 and p53: the feedback loop
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 8:712-5. 2009
  4. pmc Aldosterone activates endothelial exocytosis
    Youngtae Jeong
    Department of Medicine, Graduate Program in Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:3782-7. 2009
  5. pmc Epigallocatechin gallate inhibits endothelial exocytosis
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biol Chem 389:935-41. 2008
  6. pmc P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:6334-9. 2010
  7. doi request reprint MicroRNA-34a regulation of endothelial senescence
    Takashi Ito
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Biochem Biophys Res Commun 398:735-40. 2010
  8. pmc Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 440:203-15. 2008
  9. pmc Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells
    Tamia A Harris
    Cellular and Molecular Medicine Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arterioscler Thromb Vasc Biol 30:1990-7. 2010
  10. ncbi request reprint Regulation of Weibel-Palade body exocytosis
    Charles J Lowenstein
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Trends Cardiovasc Med 15:302-8. 2005

Collaborators

Detail Information

Publications20

  1. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
    ..These data suggest that microRNA can regulate adhesion molecule expression and may provide additional control of vascular inflammation...
  2. pmc miR-34a repression of SIRT1 regulates apoptosis
    Munekazu Yamakuchi
    Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:13421-6. 2008
    ..Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway...
  3. ncbi request reprint MiR-34, SIRT1 and p53: the feedback loop
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 8:712-5. 2009
    ..Based on this observation, we propose a positive feedback loop, in which p53 induces expression of miR-34a which suppresses SIRT1, increasing p53 activity...
  4. pmc Aldosterone activates endothelial exocytosis
    Youngtae Jeong
    Department of Medicine, Graduate Program in Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:3782-7. 2009
    ..Aldosterone antagonism may decrease vascular inflammation and cardiac fibrosis in part by blocking endothelial exocytosis...
  5. pmc Epigallocatechin gallate inhibits endothelial exocytosis
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biol Chem 389:935-41. 2008
    ..NOS inhibition revealed that NO mediates the anti-inflammatory effects of EGCG. Our data suggest that polyphenols can decrease vascular inflammation by increasing the synthesis of NO, which blocks endothelial exocytosis...
  6. pmc P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:6334-9. 2010
    ..Finally, in human colon cancer specimens, expression of miR-107 is inversely associated with expression of HIF-1beta. Taken together these data suggest that miR-107 can mediate p53 regulation of hypoxic signaling and tumor angiogenesis...
  7. doi request reprint MicroRNA-34a regulation of endothelial senescence
    Takashi Ito
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Biochem Biophys Res Commun 398:735-40. 2010
    ..Our data suggest that miR-34a contributes to endothelial senescence through suppression of SIRT1...
  8. pmc Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 440:203-15. 2008
    ..Further characterization of the factors that regulate exocytosis will lead to novel treatments for vascular diseases such as myocardial infarction and stroke...
  9. pmc Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells
    Tamia A Harris
    Cellular and Molecular Medicine Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arterioscler Thromb Vasc Biol 30:1990-7. 2010
    ..MicroRNA-126 (miR-126) is highly expressed in endothelial cells, and it regulates angiogenesis and vascular inflammation. Here we show that the transcription factors Ets-1 and Ets-2 regulate miR-126 expression...
  10. ncbi request reprint Regulation of Weibel-Palade body exocytosis
    Charles J Lowenstein
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Trends Cardiovasc Med 15:302-8. 2005
    ..This review examines the regulation of WPB exocytosis-the exocytic machinery, activators, and inhibitors of exocytosis-and speculates about the development of novel anti-exocytic drugs...
  11. ncbi request reprint HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 96:1185-92. 2005
    ..These findings may explain part of the pleiotropic effects of statin therapy for patients with cardiovascular disease...
  12. ncbi request reprint Ceramide triggers Weibel-Palade body exocytosis
    Rinky Bhatia
    Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 95:319-24. 2004
    ..These data suggest a novel mechanism by which ceramide induces vascular inflammation and thrombosis...
  13. pmc Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor
    Kenji Matsushita
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 115:139-50. 2003
    ..NO may regulate exocytosis in a variety of physiological processes, including vascular inflammation, neurotransmission, thrombosis, and cytotoxic T lymphocyte cell killing...
  14. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    ..Therefore, it is likely that an important function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53...
  15. pmc Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis
    Kenji Matsushita
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Blood 105:207-14. 2005
    ..Thus, VEGF plays a dual role in regulating endothelial exocytosis, triggering pathways that both promote and inhibit endothelial exocytosis. Regulation of endothelial exocytosis may explain part of the proinflammatory effects of VEGF...
  16. pmc Antibody to human leukocyte antigen triggers endothelial exocytosis
    Munekazu Yamakuchi
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:1301-6. 2007
    ..Our data show that antibody to host antigens can activate human endothelial cell exocytosis and leukocyte trafficking. By triggering vascular inflammation, antibody activation of exocytosis may play a role in transplant rejection...
  17. ncbi request reprint Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury
    John W Calvert
    Department of Medicine, Division of Cardiology and Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 101:1247-54. 2007
    ..These data suggest that drugs targeting endothelial exocytosis may be useful in the treatment of myocardial injury following ischemia/reperfusion...
  18. pmc Regulation of platelet granule exocytosis by S-nitrosylation
    Craig N Morrell
    Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:3782-7. 2005
    ..Platelets lacking endothelial NO synthase show increased rolling on venules, increased thrombosis in arterioles, and increased exocytosis in vivo. Regulation of exocytosis is thus a mechanism by which NO regulates thrombosis...
  19. pmc Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor
    Kenji Matsushita
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 170:73-9. 2005
    ..Increasing endogenous H(2)O(2) levels in mice decreases exocytosis and platelet rolling on venules in vivo. By inhibiting endothelial cell exocytosis, endogenous H(2)O(2) may protect the vasculature from inflammation and thrombosis...
  20. ncbi request reprint Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications
    Kazuyo Yamaji
    Department of Laboratory and Molecular Medicine, Faculty of Medicine, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    Thromb Haemost 89:875-84. 2003
    ..In conclusion, we propose that AEA may play a crucial role in EC injury under conditions of shock, and that the use of inhibitors of the AEA regulation system may have a therapeutic effect under these conditions...