JAMES YAGER

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Mitochondrial estrogen receptors--new insights into specific functions
    James D Yager
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Endocrinol Metab 18:89-91. 2007
  2. ncbi request reprint Estrogen carcinogenesis in breast cancer
    James D Yager
    Bloomberg School of Public Health, Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 354:270-82. 2006
  3. ncbi request reprint Arsenic: extension of its endocrine disruption potential to interference with estrogen receptor-mediated signaling
    Walter H Watson
    Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Toxicol Sci 98:1-4. 2007
  4. ncbi request reprint Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells
    Jin Q Chen
    Division of Toxicological Sciences, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Endocrinol Metab 286:E1011-22. 2004
  5. ncbi request reprint Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements
    Jin Q Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St Baltimore, Maryland 21205 2179, USA
    J Cell Biochem 93:358-73. 2004
  6. ncbi request reprint Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis
    Jin Qiang Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21285, USA
    Ann N Y Acad Sci 1028:258-72. 2004
  7. pmc Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells
    Yu Zang
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Toxicol Lett 184:134-8. 2009
  8. pmc Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine
    Leslie A Bransfield
    Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Chem Res Toxicol 21:1622-30. 2008
  9. ncbi request reprint Enhanced mitochondrial gene transcript, ATP, bcl-2 protein levels, and altered glutathione distribution in ethinyl estradiol-treated cultured female rat hepatocytes
    Jinqiang Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, The Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205 2179, USA
    Toxicol Sci 75:271-8. 2003
  10. pmc Manganese superoxide dismutase: effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts
    Britt L McAtee
    Division of Toxicology, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Mol Cell Biochem 335:107-18. 2010

Research Grants

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Mitochondrial estrogen receptors--new insights into specific functions
    James D Yager
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Endocrinol Metab 18:89-91. 2007
    ....
  2. ncbi request reprint Estrogen carcinogenesis in breast cancer
    James D Yager
    Bloomberg School of Public Health, Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 354:270-82. 2006
  3. ncbi request reprint Arsenic: extension of its endocrine disruption potential to interference with estrogen receptor-mediated signaling
    Walter H Watson
    Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Toxicol Sci 98:1-4. 2007
  4. ncbi request reprint Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells
    Jin Q Chen
    Division of Toxicological Sciences, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Endocrinol Metab 286:E1011-22. 2004
    ..These findings confirm the observations of others and provide additional support for this novel localization of the ERs and for a potentially important role of the ER in the regulation of mtDNA transcription...
  5. ncbi request reprint Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements
    Jin Q Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St Baltimore, Maryland 21205 2179, USA
    J Cell Biochem 93:358-73. 2004
    ..These results indicate that the mitochondrial ERs can interact with mtEREs and suggest that they may be directly involved in E2 induction of mtDNA transcription...
  6. ncbi request reprint Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis
    Jin Qiang Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21285, USA
    Ann N Y Acad Sci 1028:258-72. 2004
    ..Together, these results suggest that the ERs may act as transcription factors directly involved in the regulation by E2 of mtDNA transcription...
  7. pmc Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells
    Yu Zang
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Toxicol Lett 184:134-8. 2009
    ..The sustained ERK1/2 phosphorylation may contribute to the Cd-induced enhancement of DNA synthesis and pS2 mRNA in mixture with low-concentration E2...
  8. pmc Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine
    Leslie A Bransfield
    Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Chem Res Toxicol 21:1622-30. 2008
    ....
  9. ncbi request reprint Enhanced mitochondrial gene transcript, ATP, bcl-2 protein levels, and altered glutathione distribution in ethinyl estradiol-treated cultured female rat hepatocytes
    Jinqiang Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, The Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205 2179, USA
    Toxicol Sci 75:271-8. 2003
    ..This finding was supported by confocal microscopy. These effects caused by EE may contribute, at least in part, to the EE-mediated inhibition of hepatic apoptosis...
  10. pmc Manganese superoxide dismutase: effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts
    Britt L McAtee
    Division of Toxicology, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Mol Cell Biochem 335:107-18. 2010
    ....

Research Grants29

  1. CATECHOL-O-METHYLTRANSFERASE AND BREAST CANCER
    JAMES YAGER; Fiscal Year: 2001
    ....
  2. ETHINYL ESTRADIOL AND HEPATOCARCINOGENESIS
    JAMES YAGER; Fiscal Year: 2003
    ..abstract_text> ..
  3. Catechol-o-Methyltansferase and Breast Cancer
    JAMES YAGER; Fiscal Year: 2007
    ....
  4. TRAINING PROGRAM IN ENVIRONMENTAL HEALTH SCIENCES
    JAMES YAGER; Fiscal Year: 2007
    ..Fourth, all trainees participate in an annual scientific workshop, an event co-sponsored by the Training Program and the Johns Hopkins Center for Urban Environmental Health. ..
  5. ROLE OF GONADAL STEROIDS IN HEPATOCARCINOGENESIS
    JAMES YAGER; Fiscal Year: 1993
    ..These studies should provide new information on the mechanisms of both liver growth stimulation and tumor promotion by EE...