Research Topics
Species | Qian Li XueSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Detail Information
Publications
Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer?Qian Li Xue
Department of Medicine, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Am J Epidemiol 176:534-43. 2012..24, 95% confidence interval: 0.63, 2.47). Our findings suggest that physical activity does not have to be vigorous to be beneficial and that the gain may be the greatest among women who reported the lowest levels of activity...
Combining complete multivariate outcomes with incomplete covariate information: a latent class approachQian Li Xue
Department of Epidemiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Biometrics 58:110-20. 2002..Combining information in the proposed way is found to improve both accuracy and precision in summarizing multiple categorical outcomes, which effectively diminishes ambiguity and bias in making risk factor inferences...- The frailty syndrome: definition and natural historyQian Li Xue
Department of Medicine, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205 1179, USA
Clin Geriatr Med 27:1-15. 2011.... - Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study IIQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 63:984-90. 2008..This study aims to characterize natural history by which commonly used frailty criteria manifest and to assess whether the rate of progression to frailty depends on initial manifestations... - Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study IQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Am J Epidemiol 167:240-8. 2008..Together, these data suggest that a slightly constricted life space may be a marker and/or risk factor for the development of frailty that may prove useful as a screening tool or a target of intervention... - Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the Women's Health and Aging Study IIQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
J Am Geriatr Soc 58:2076-84. 2010..To assess the relationship between rate of change in muscle strength and all-cause mortality... - Frailty, hospitalization, and progression of disability in a cohort of disabled older womenCynthia M Boyd
Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
Am J Med 118:1225-31. 2005..To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability... - Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort studyGeorge C Wang
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Epidemiol 171:1144-52. 2010..79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection... - Inflammation and frailty in older womenSean X Leng
Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Am Geriatr Soc 55:864-71. 2007..To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty... - Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older womenAnne R Cappola
Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 88:2019-25. 2003..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging... - White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, 5505 Hopkins Bayview Circle, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 64:499-502. 2009..WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated... - Lifestyle activities and memory: variety may be the spice of life. The women's health and aging study IIMichelle C Carlson
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Int Neuropsychol Soc 18:286-94. 2012..Our findings offer new perspectives in promoting a diverse repertoire of activities to mitigate age-related cognitive declines... 
Hyperglycemia and incidence of frailty and lower extremity mobility limitations in older womenRita R Kalyani
Divisions of Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Am Geriatr Soc 60:1701-7. 2012..To determine the degree to which hyperglycemia predicts the development of frailty and lower extremity mobility limitations...- Phenotype of frailty: characterization in the women's health and aging studiesKaren Bandeen-Roche
Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 61:262-6. 2006..This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS)... - Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 46:679-84. 2011..These findings suggest that detection of CMV viral DNA in monocytes may be an informative tool to evaluate chronic CMV infection and its potential role in monocyte/macrophage-mediated immune activation in the elderly... - Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: the Women's Health and Aging Study ICynthia M Boyd
Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 60:888-93. 2005..The objective of this study was to determine whether hospitalization predicts long-term Activities of Daily Living (ADL) dependence in previously ADL independent, although disabled, older women... - What constitutes normal hemoglobin concentration in community-dwelling disabled older women?Paulo H M Chaves
Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
J Am Geriatr Soc 52:1811-6. 2004.... - Community aging in place, advancing better living for elders: a bio-behavioral-environmental intervention to improve function and health-related quality of life in disabled older adultsSarah L Szanton
Department of Health Systems and Outcomes, School of Nursing, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 59:2314-20. 2011..To determine effect size and acceptability of a multicomponent behavior and home repair intervention for low-income disabled older adults... - Hearing loss and cognitive decline in older adultsFrank R Lin
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
JAMA Intern Med 173:293-9. 2013..Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline... - Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women's Health and Aging Study IIJennifer A Deal
Department of Epidemiology, Center on Aging and Health, The Johns Hopkin Medical Institutions, 2024 E Monument St, Suite 2 700, Baltimore, MD 21205, USA
J Am Geriatr Soc 57:1604-11. 2009..To test the hypothesis that anemia (hemoglobin <12 g/dL) is associated with a faster rate of cognitive decline over 9 years in a community-dwelling sample of women aged 70 to 80 at baseline... - Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study IRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Aging Clin Exp Res 19:259-64. 2007..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality... - Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study IIMichelle M Mielke
Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 63:619-24. 2008..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains... - Volunteering: a physical activity intervention for older adults--The Experience Corps program in BaltimoreErwin J Tan
Division of Geriatric Medicine and Gerontology, Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
J Urban Health 83:954-69. 2006.... - Exploring biologically relevant pathways in frailtyYen Yi Ho
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Bayview Circle, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 66:975-9. 2011..As with longevity research, genetic analyses may help to provide insights into biologically relevant pathways that contribute to frailty... - Marketing public health through older adult volunteering: Experience Corps as a social marketing interventionErwin J Tan
Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
Am J Public Health 100:727-34. 2010.... - Physical activity participation by presence and type of functional deficits in older women: The Women's Health and Aging StudiesGerald J Jerome
Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 61:1171-6. 2006..This study sought to identify categories of functional deficits associated with activity levels and evaluated the potential for older women to increase their physical activity levels... - Executive decline and dysfunction precedes declines in memory: the Women's Health and Aging Study IIMichelle C Carlson
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 64:110-7. 2009..This study characterized in the Women's Health and Aging Study (WHAS) II 9-year declines and transitions to impairment across domains of cognition... - Blunted diurnal decline of cortisol among older adults with low socioeconomic statusOwhofasa O Agbedia
Department of Mental Health and Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Ann N Y Acad Sci 1231:56-64. 2011..These findings confirm prior evidence of a biologic pathway through which socioeconomic disadvantage is linked to biologic vulnerability, and through which the impact of volunteer service in Experience Corps may be measured... - Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studiesAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
J Gerontol A Biol Sci Med Sci 64:243-8. 2009..We hypothesized that associations with frailty would most likely manifest in the presence of deficits in multiple anabolic hormones... - Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies ISean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Exp Gerontol 44:511-6. 2009..These findings provide initial insight into potential roles of neutrophils and monocytes in the pathogenesis of frailty and a basis for further investigation into their function and regulation in frail older women... - A pharmacoepidemiologic study of community-dwelling, disabled older women: Factors associated with medication useVictor Crentsil
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Geriatr Pharmacother 8:215-24. 2010..Although disabled older adults may be among the subpopulation of adults with the highest risk for adverse drug events (ADEs), reliable data on their use of medications are limited... - Transitions among disability levels or death in African American and white older womenRoland J Thorpe
Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 64:670-4. 2009..This study examined the racial differences in probabilities of transitioning across three disability levels of walking (1/2) mile in a community-dwelling population of older women... - Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian womenDan E Arking
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205, USA
J Am Geriatr Soc 54:823-6. 2006..To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women... - Validation of the Hopkins Medication Schedule to identify difficulties in taking medicationsMichelle C Carlson
Center on Aging and Health, The Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 60:217-23. 2005..The authors thus developed and validated the Hopkins Medication Schedule (HMS), a new objective test of one's ability to understand and implement a routine prescription medication... - Functional decline and recovery of activities of daily living in hospitalized, disabled older women: the Women's Health and Aging Study ICynthia M Boyd
Division of Geriatric Medicine and Gerontology, School of Medicine and Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21224, USA
J Am Geriatr Soc 57:1757-66. 2009..To determine, in disabled, older, community-dwelling women who were hospitalized, the rates and predictors of functional decline, the probability and time course of subsequent functional recovery, and predictors of functional recovery... - Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adultsTao Qu
Johns Hopkins University School of Medicine, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Baltimore, MD, USA
Mech Ageing Dev 130:161-6. 2009..These findings suggest upregulated expression of specific stress-responsive genes in monocyte-mediated inflammatory pathway in the syndrome of frailty with potential mechanistic and interventional implications... - Impaired vision and the ability to take medicationsBeverly Gwen Windham
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 53:1179-90. 2005..To assess relationships between vision (contrast sensitivity, stereopsis, visual acuity) and a performance-based measure of ability to implement new medications... - Glutathione peroxidase enzyme activity in agingSara E Espinoza
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 63:505-9. 2008..Age-related decline in activity of the antioxidant enzyme glutathione peroxidase (GPx) may contribute to increased free radicals. We hypothesized that GPx activity decreases with age in a population of older women with disability... - Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adultsXu Yao
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Vaccine 29:5015-21. 2011..These findings suggest that assessing frailty status in the elderly may identify those who are less likely to respond to TIV immunization and be at higher risk for seasonal influenza and its complications... - Difficulty assisting with health care tasks among caregivers of multimorbid older adultsErin R Giovannetti
Division of Geriatrics, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Gen Intern Med 27:37-44. 2012..The difficulty they experience in providing this assistance, and related implications for their well-being, have not been well described... - Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women's Health and Aging Study IIShari M Ling
Clinical Research Branch, National Institute on Aging Intramural Research Program, and Center on Aging and Health, The Johns Hopkins Medical Institutions, 3001 South Hanover Street, Baltimore, MD 21225, USA
Arthritis Rheum 55:256-63. 2006..To assess the impact of lower extremity osteoarthritis (OA) on transitions to mobility difficulty, and to assess the influence of pain, excess weight, and quadriceps strength on these transitions... - Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 40:982-7. 2005..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults... - Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studiesAmanda L Ray
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Nutr 136:172-6. 2006..77, 95% CI 0.64-0.84/1 SD increase in log(e) total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death... - Low Serum Selenium Is Associated with Anemia Among Older Women Living in the Community: the Women's Health and Aging Studies I and IIRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Biol Trace Elem Res 112:97-107. 2006..47-0.84), adjusting for age, education, chronic diseases, iron status, and serum interleukin-6. We conclude that low serum selenium is independently associated with anemia among older women living in the community... - Vitamin and carotenoid status in older women: associations with the frailty syndromeElisabete Michelon
The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 61:600-7. 2006..Future longitudinal studies are needed to examine the relationships between micronutrient concentrations and frailty in older women... - A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging StudyRobert Stewart
Institute of Psychiatry, London, United Kingdom
Arch Neurol 62:55-60. 2005..The potential impact on prognosis should be considered in the case of elderly persons at risk for dementia... - DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study IAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Gerontol A Biol Sci Med Sci 61:957-62. 2006..Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined... - Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging StudyRobert Stewart
King s College London Institute of Psychiatry, Section of Epidemiology, England
Arch Neurol 64:103-7. 2007..The relationship between total cholesterol levels and dementia is unclear... - Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older womenHeidi N Schmaltz
Division of Geriatric Medicine, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
J Am Geriatr Soc 53:747-54. 2005..To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association...