Qian Li Xue

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer?
    Qian Li Xue
    Department of Medicine, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Epidemiol 176:534-43. 2012
  2. ncbi request reprint Combining complete multivariate outcomes with incomplete covariate information: a latent class approach
    Qian Li Xue
    Department of Epidemiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Biometrics 58:110-20. 2002
  3. ncbi request reprint Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study I
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 167:240-8. 2008
  4. ncbi request reprint Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:984-90. 2008
  5. pmc Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the Women's Health and Aging Study II
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 58:2076-84. 2010
  6. pmc The frailty syndrome: definition and natural history
    Qian Li Xue
    Department of Medicine, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205 1179, USA
    Clin Geriatr Med 27:1-15. 2011
  7. ncbi request reprint Frailty, hospitalization, and progression of disability in a cohort of disabled older women
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
    Am J Med 118:1225-31. 2005
  8. ncbi request reprint Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women
    Sean Leng
    Division of Geriatric Medicine and Gerentology, Johns Hopkins Asthma and Allergy Center, Room 5A 24, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 60:195-9. 2005
  9. pmc Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study
    George C Wang
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Epidemiol 171:1144-52. 2010
  10. ncbi request reprint Inflammation and frailty in older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Am Geriatr Soc 55:864-71. 2007

Detail Information

Publications57

  1. pmc Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer?
    Qian Li Xue
    Department of Medicine, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Epidemiol 176:534-43. 2012
    ..24, 95% confidence interval: 0.63, 2.47). Our findings suggest that physical activity does not have to be vigorous to be beneficial and that the gain may be the greatest among women who reported the lowest levels of activity...
  2. ncbi request reprint Combining complete multivariate outcomes with incomplete covariate information: a latent class approach
    Qian Li Xue
    Department of Epidemiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Biometrics 58:110-20. 2002
    ..Combining information in the proposed way is found to improve both accuracy and precision in summarizing multiple categorical outcomes, which effectively diminishes ambiguity and bias in making risk factor inferences...
  3. ncbi request reprint Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study I
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 167:240-8. 2008
    ..Together, these data suggest that a slightly constricted life space may be a marker and/or risk factor for the development of frailty that may prove useful as a screening tool or a target of intervention...
  4. ncbi request reprint Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:984-90. 2008
    ..This study aims to characterize natural history by which commonly used frailty criteria manifest and to assess whether the rate of progression to frailty depends on initial manifestations...
  5. pmc Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the Women's Health and Aging Study II
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 58:2076-84. 2010
    ..To assess the relationship between rate of change in muscle strength and all-cause mortality...
  6. pmc The frailty syndrome: definition and natural history
    Qian Li Xue
    Department of Medicine, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205 1179, USA
    Clin Geriatr Med 27:1-15. 2011
    ....
  7. ncbi request reprint Frailty, hospitalization, and progression of disability in a cohort of disabled older women
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
    Am J Med 118:1225-31. 2005
    ..To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability...
  8. ncbi request reprint Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women
    Sean Leng
    Division of Geriatric Medicine and Gerentology, Johns Hopkins Asthma and Allergy Center, Room 5A 24, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 60:195-9. 2005
    ..Although white blood cells (WBC), or leukocytes, are known to produce IL-6 in vitro, their in vivo relationship with circulating IL-6 levels is not well established...
  9. pmc Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study
    George C Wang
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Epidemiol 171:1144-52. 2010
    ..79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection...
  10. ncbi request reprint Inflammation and frailty in older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Am Geriatr Soc 55:864-71. 2007
    ..To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty...
  11. ncbi request reprint Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 40:982-7. 2005
    ..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults...
  12. ncbi request reprint Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    Anne R Cappola
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2019-25. 2003
    ..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
  13. pmc White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, 5505 Hopkins Bayview Circle, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 64:499-502. 2009
    ..WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated...
  14. pmc Lifestyle activities and memory: variety may be the spice of life. The women's health and aging study II
    Michelle C Carlson
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 18:286-94. 2012
    ..Our findings offer new perspectives in promoting a diverse repertoire of activities to mitigate age-related cognitive declines...
  15. pmc Healthcare task difficulty among older adults with multimorbidity
    Cynthia M Boyd
    Department of Medicine, Johns Hopkins University School of Medicine Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD NCQA PCORI, Washington, DC
    Med Care 52:S118-25. 2014
    ..Applying disease-specific guidelines to people with multimorbidity may result in complex regimens that impose treatment burden...
  16. pmc Low Serum Selenium Is Associated with Anemia Among Older Women Living in the Community: the Women's Health and Aging Studies I and II
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Biol Trace Elem Res 112:97-107. 2006
    ..47-0.84), adjusting for age, education, chronic diseases, iron status, and serum interleukin-6. We conclude that low serum selenium is independently associated with anemia among older women living in the community...
  17. pmc Hyperglycemia and incidence of frailty and lower extremity mobility limitations in older women
    Rita R Kalyani
    Divisions of Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Am Geriatr Soc 60:1701-7. 2012
    ..To determine the degree to which hyperglycemia predicts the development of frailty and lower extremity mobility limitations...
  18. pmc Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 46:679-84. 2011
    ..These findings suggest that detection of CMV viral DNA in monocytes may be an informative tool to evaluate chronic CMV infection and its potential role in monocyte/macrophage-mediated immune activation in the elderly...
  19. pmc Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation
    Jacqueline M Langdon
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Am J Hematol 89:470-9. 2014
    ..Am. J. Hematol. 89:470-479, 2014. © 2014 Wiley Periodicals, Inc. ..
  20. ncbi request reprint Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: the Women's Health and Aging Study I
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 60:888-93. 2005
    ..The objective of this study was to determine whether hospitalization predicts long-term Activities of Daily Living (ADL) dependence in previously ADL independent, although disabled, older women...
  21. ncbi request reprint Phenotype of frailty: characterization in the women's health and aging studies
    Karen Bandeen-Roche
    Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 61:262-6. 2006
    ..This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS)...
  22. ncbi request reprint Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studies
    Amanda L Ray
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr 136:172-6. 2006
    ..77, 95% CI 0.64-0.84/1 SD increase in log(e) total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death...
  23. ncbi request reprint Vitamin and carotenoid status in older women: associations with the frailty syndrome
    Elisabete Michelon
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 61:600-7. 2006
    ..We investigated the relationship of micronutrient deficiencies with the frailty syndrome in older women living in the community...
  24. ncbi request reprint What constitutes normal hemoglobin concentration in community-dwelling disabled older women?
    Paulo H M Chaves
    Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
    J Am Geriatr Soc 52:1811-6. 2004
    ....
  25. pmc Community aging in place, advancing better living for elders: a bio-behavioral-environmental intervention to improve function and health-related quality of life in disabled older adults
    Sarah L Szanton
    Department of Health Systems and Outcomes, School of Nursing, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 59:2314-20. 2011
    ..To determine effect size and acceptability of a multicomponent behavior and home repair intervention for low-income disabled older adults...
  26. pmc Hearing loss and cognitive decline in older adults
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    JAMA Intern Med 173:293-9. 2013
    ..Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline...
  27. pmc Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women's Health and Aging Study II
    Jennifer A Deal
    Department of Epidemiology, Center on Aging and Health, The Johns Hopkin Medical Institutions, 2024 E Monument St, Suite 2 700, Baltimore, MD 21205, USA
    J Am Geriatr Soc 57:1604-11. 2009
    ..To test the hypothesis that anemia (hemoglobin <12 g/dL) is associated with a faster rate of cognitive decline over 9 years in a community-dwelling sample of women aged 70 to 80 at baseline...
  28. pmc Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II
    Michelle M Mielke
    Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:619-24. 2008
    ..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains...
  29. pmc Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Aging Clin Exp Res 19:259-64. 2007
    ..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality...
  30. pmc Volunteering: a physical activity intervention for older adults--The Experience Corps program in Baltimore
    Erwin J Tan
    Division of Geriatric Medicine and Gerontology, Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
    J Urban Health 83:954-69. 2006
    ....
  31. pmc Marketing public health through older adult volunteering: Experience Corps as a social marketing intervention
    Erwin J Tan
    Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
    Am J Public Health 100:727-34. 2010
    ....
  32. pmc Exploring biologically relevant pathways in frailty
    Yen Yi Ho
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Bayview Circle, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 66:975-9. 2011
    ..As with longevity research, genetic analyses may help to provide insights into biologically relevant pathways that contribute to frailty...
  33. ncbi request reprint Physical activity participation by presence and type of functional deficits in older women: The Women's Health and Aging Studies
    Gerald J Jerome
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 61:1171-6. 2006
    ..This study sought to identify categories of functional deficits associated with activity levels and evaluated the potential for older women to increase their physical activity levels...
  34. pmc Executive decline and dysfunction precedes declines in memory: the Women's Health and Aging Study II
    Michelle C Carlson
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 64:110-7. 2009
    ..This study characterized in the Women's Health and Aging Study (WHAS) II 9-year declines and transitions to impairment across domains of cognition...
  35. pmc Blunted diurnal decline of cortisol among older adults with low socioeconomic status
    Owhofasa O Agbedia
    Department of Mental Health and Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1231:56-64. 2011
    ..These findings confirm prior evidence of a biologic pathway through which socioeconomic disadvantage is linked to biologic vulnerability, and through which the impact of volunteer service in Experience Corps may be measured...
  36. ncbi request reprint Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies I
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Exp Gerontol 44:511-6. 2009
    ..These findings provide initial insight into potential roles of neutrophils and monocytes in the pathogenesis of frailty and a basis for further investigation into their function and regulation in frail older women...
  37. doi request reprint A pharmacoepidemiologic study of community-dwelling, disabled older women: Factors associated with medication use
    Victor Crentsil
    Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Geriatr Pharmacother 8:215-24. 2010
    ..Although disabled older adults may be among the subpopulation of adults with the highest risk for adverse drug events (ADEs), reliable data on their use of medications are limited...
  38. pmc Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:243-8. 2009
    ..We hypothesized that associations with frailty would most likely manifest in the presence of deficits in multiple anabolic hormones...
  39. pmc Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study
    Sevil Yasar
    The Johns Hopkins University, Baltimore, MD, USA
    Neurology 81:896-903. 2013
    ....
  40. pmc Transitions among disability levels or death in African American and white older women
    Roland J Thorpe
    Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 64:670-4. 2009
    ..This study examined the racial differences in probabilities of transitioning across three disability levels of walking (1/2) mile in a community-dwelling population of older women...
  41. pmc Functional decline and recovery of activities of daily living in hospitalized, disabled older women: the Women's Health and Aging Study I
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, School of Medicine and Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Am Geriatr Soc 57:1757-66. 2009
    ..To determine, in disabled, older, community-dwelling women who were hospitalized, the rates and predictors of functional decline, the probability and time course of subsequent functional recovery, and predictors of functional recovery...
  42. ncbi request reprint Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women
    Dan E Arking
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205, USA
    J Am Geriatr Soc 54:823-6. 2006
    ..To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women...
  43. pmc Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults
    Tao Qu
    Johns Hopkins University School of Medicine, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Baltimore, MD, USA
    Mech Ageing Dev 130:161-6. 2009
    ..These findings suggest upregulated expression of specific stress-responsive genes in monocyte-mediated inflammatory pathway in the syndrome of frailty with potential mechanistic and interventional implications...
  44. ncbi request reprint Impaired vision and the ability to take medications
    Beverly Gwen Windham
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 53:1179-90. 2005
    ..To assess relationships between vision (contrast sensitivity, stereopsis, visual acuity) and a performance-based measure of ability to implement new medications...
  45. ncbi request reprint Validation of the Hopkins Medication Schedule to identify difficulties in taking medications
    Michelle C Carlson
    Center on Aging and Health, The Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 60:217-23. 2005
    ..The authors thus developed and validated the Hopkins Medication Schedule (HMS), a new objective test of one's ability to understand and implement a routine prescription medication...
  46. pmc Experience Corps: a dual trial to promote the health of older adults and children's academic success
    Linda P Fried
    Mailman School of Public Health, Columbia University, New York, NY, USA
    Contemp Clin Trials 36:1-13. 2013
    ..This trial evaluates (1) whether senior volunteer roles within Experience Corps™ beneficially impact children's academic achievement and classroom behavior in public elementary schools and (2) impact on the health of volunteers...
  47. pmc Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults
    Xu Yao
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Vaccine 29:5015-21. 2011
    ..These findings suggest that assessing frailty status in the elderly may identify those who are less likely to respond to TIV immunization and be at higher risk for seasonal influenza and its complications...
  48. pmc Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells
    Bryan J McCranor
    Division of Geriatric Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Blood Cells Mol Dis 52:126-33. 2014
    ..Our findings may indicate a novel pathway of action for IL-6 in the anemia of inflammation, and draw attention to the potential for new therapeutic targets that affect late erythroid development...
  49. pmc Chronic CMV infection in older women: longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8(+) T-cell frequencies with twelve year follow-up
    Huifen Li
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 54:84-9. 2014
    ..They also provide a basis for further investigation into chronic CMV infection as defined by detectable CMV DNA in the peripheral monocytes and its impact on immunity and health in the elderly. ..
  50. pmc Late stage erythroid precursor production is impaired in mice with chronic inflammation
    Olivier D Prince
    Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Haematologica 97:1648-56. 2012
    ....
  51. pmc Glutathione peroxidase enzyme activity in aging
    Sara E Espinoza
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 63:505-9. 2008
    ..Age-related decline in activity of the antioxidant enzyme glutathione peroxidase (GPx) may contribute to increased free radicals. We hypothesized that GPx activity decreases with age in a population of older women with disability...
  52. pmc Difficulty assisting with health care tasks among caregivers of multimorbid older adults
    Erin R Giovannetti
    Division of Geriatrics, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Gen Intern Med 27:37-44. 2012
    ..The difficulty they experience in providing this assistance, and related implications for their well-being, have not been well described...
  53. ncbi request reprint Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women's Health and Aging Study II
    Shari M Ling
    Clinical Research Branch, National Institute on Aging Intramural Research Program, and Center on Aging and Health, The Johns Hopkins Medical Institutions, 3001 South Hanover Street, Baltimore, MD 21225, USA
    Arthritis Rheum 55:256-63. 2006
    ..To assess the impact of lower extremity osteoarthritis (OA) on transitions to mobility difficulty, and to assess the influence of pain, excess weight, and quadriceps strength on these transitions...
  54. pmc DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Gerontol A Biol Sci Med Sci 61:957-62. 2006
    ..Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined...
  55. ncbi request reprint A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study
    Robert Stewart
    Institute of Psychiatry, London, United Kingdom
    Arch Neurol 62:55-60. 2005
    ..The course of weight loss associated with dementia is unclear, particularly prior to and around the onset of the clinical syndrome...
  56. ncbi request reprint Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study
    Robert Stewart
    King s College London Institute of Psychiatry, Section of Epidemiology, England
    Arch Neurol 64:103-7. 2007
    ..The relationship between total cholesterol levels and dementia is unclear...
  57. ncbi request reprint Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women
    Heidi N Schmaltz
    Division of Geriatric Medicine, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Am Geriatr Soc 53:747-54. 2005
    ..To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association...