Leyan Xu

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Transplantation 82:865-75. 2006
  2. doi A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization
    Vassilis E Koliatsos
    Division of Neuropathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Neuropathol Exp Neurol 70:399-416. 2011
  3. doi Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Exp Neurol 277:268-74. 2016
  4. doi Repetitive mild traumatic brain injury with impact acceleration in the mouse: Multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Exp Neurol 275:436-49. 2016
  5. doi Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    Stem Cell Res Ther 6:93. 2015
  6. doi Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Exp Neurol 273:168-76. 2015
  7. pmc Host induction by transplanted neural stem cells in the spinal cord: further evidence for an adult spinal cord neurogenic niche
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins University School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Regen Med 7:785-97. 2012
  8. pmc Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry
    Leyan Xu
    Department of Pathology, Division of Neuropathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Comp Neurol 514:297-309. 2009
  9. pmc Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions JHMI, Baltimore, MD 21205, USA
    Neurosci Lett 494:222-6. 2011
  10. pmc Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum
    Igor Nasonkin
    Department of Pathology, Division of Neuropathology, Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells 27:2414-26. 2009

Collaborators

Detail Information

Publications18

  1. ncbi Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Transplantation 82:865-75. 2006
    ..The adult spinal cord raises further challenges for NSC differentiation because of lack of intrinsic developmental potential and the negative outcomes of several prior attempts...
  2. doi A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization
    Vassilis E Koliatsos
    Division of Neuropathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Neuropathol Exp Neurol 70:399-416. 2011
    ..Prevention of some of these neurological effects by torso shielding may generate new ideas as to how to protect military and civilian populations in blast scenarios...
  3. doi Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Exp Neurol 277:268-74. 2016
    ..Finally, our findings confirm the protective role of torso shielding and stress the importance of improved or optimized body gear for warfighters or other individuals at risk for blast exposure. ..
  4. doi Repetitive mild traumatic brain injury with impact acceleration in the mouse: Multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Exp Neurol 275:436-49. 2016
    ..Our model can also be useful in exploring mechanisms of chronic neurological disease caused by repetitive mTBI in wild-type and transgenic mice. ..
  5. doi Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    Stem Cell Res Ther 6:93. 2015
    ..Here we explore the proof of concept that treatments based on transplants of human oligodendrocyte progenitor cells can replace or remodel myelin and, eventually, contribute to axonal regeneration in traumatic axonal injury...
  6. doi Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury
    Leyan Xu
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Exp Neurol 273:168-76. 2015
    ....
  7. pmc Host induction by transplanted neural stem cells in the spinal cord: further evidence for an adult spinal cord neurogenic niche
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins University School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Regen Med 7:785-97. 2012
    ....
  8. pmc Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry
    Leyan Xu
    Department of Pathology, Division of Neuropathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Comp Neurol 514:297-309. 2009
    ..Our results indicate an advanced degree of structural integration, via functional synapses, of differentiated human NSCs into the segmental motor circuitry of SOD1-G93A rats...
  9. pmc Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions JHMI, Baltimore, MD 21205, USA
    Neurosci Lett 494:222-6. 2011
    ..Disease duration in NSC-grafted animals was longer by 7 days compared to controls. Our results support the potential of NSC grafts at multiple levels of spinal cord as future cellular therapy for motor neuron disease...
  10. pmc Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum
    Igor Nasonkin
    Department of Pathology, Division of Neuropathology, Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells 27:2414-26. 2009
    ....
  11. pmc Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
    Jun Yan
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS Med 4:e39. 2007
    ..In most cases, neural stem cell (NSC) transplants have shown either poor differentiation or a preferential choice of glial lineages...
  12. pmc Nanofiber matrices promote the neuronal differentiation of human embryonic stem cell-derived neural precursors in vitro
    Vasiliki Mahairaki
    Division of Neuropathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Tissue Eng Part A 17:855-63. 2011
    ..Our findings demonstrate that fibrous substrates serve as an artificial extracellular matrix and provide a microenviroment that influences key aspects of the neuronal differentiation of ES-derived NPs...
  13. ncbi Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice
    Jun Yan
    Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Stem Cells 24:1976-85. 2006
    ....
  14. ncbi Human stem cell grafts as therapies for motor neuron disease
    Vassilis E Koliatsos
    The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    Expert Opin Biol Ther 8:137-41. 2008
    ....
  15. pmc The problem of axonal injury in the brains of veterans with histories of blast exposure
    Jiwon Ryu
    Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    Acta Neuropathol Commun 2:153. 2014
    ....
  16. pmc Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interference
    Vasiliki Mahairaki
    The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    J Neurosci Methods 179:292-9. 2009
    ..Furthermore, our findings raise the possibility for future considerations of lentiviral strategies as therapies for diseases of the nervous system involving NO neurotoxic cascades...
  17. ncbi DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex
    Brian Kirkpatrick
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Comp Neurol 497:436-50. 2006
    ..These anatomical localization data suggest that DISC1 participates in synaptic activity and microtubule function, and are consistent with the limited data on its adult function...
  18. ncbi Ultrastructural localization of reelin in the cortex in post-mortem human brain
    Rosalinda C Roberts
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Comp Neurol 482:294-308. 2005
    ..The presence of reelin in adult spines, PSD, and terminals suggests that in the adult human reelin has a role in synaptic remodeling, which is consistent with the evidence for its role in long-term potentiation in the adult brain...