Florence T H Wu

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Physiol Genomics 38:29-41. 2009
  2. pmc A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e5108. 2009
  3. pmc VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model
    Florence T H Wu
    Dept of Biomedical Engineering, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, 613 Traylor Research Bldg, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 298:H2174-91. 2010
  4. pmc Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 467:461-97. 2009
  5. pmc A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Mol Med 14:528-52. 2010
  6. pmc Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model
    Marianne O Stefanini
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 70:9886-94. 2010
  7. pmc A compartment model of VEGF distribution in blood, healthy and diseased tissues
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    BMC Syst Biol 2:77. 2008
  8. pmc The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
    Marianne O Stefanini
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Comput Biol 5:e1000622. 2009

Detail Information

Publications8

  1. pmc Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Physiol Genomics 38:29-41. 2009
    ..sVEGFR1's interactions with cell surface receptors such as NRP1 are also expected to affect its molecular interplay with VEGF...
  2. pmc A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e5108. 2009
    ....
  3. pmc VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model
    Florence T H Wu
    Dept of Biomedical Engineering, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, 613 Traylor Research Bldg, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 298:H2174-91. 2010
    ....
  4. pmc Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 467:461-97. 2009
    ..g., vascular permeability and lymphatic drainage). The given examples will demonstrate the utility of computational models in aiding both basic science and clinical research on VEGF systems biology...
  5. pmc A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Mol Med 14:528-52. 2010
    ..Finally, we present the need for a systems biology perspective in interpreting circulating VEGF and sVEGFR1 concentrations as surrogate markers of angiogenic status in angiogenesis-dependent diseases...
  6. pmc Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model
    Marianne O Stefanini
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 70:9886-94. 2010
    ..Diffusible molecules extravasate, intravasate, are removed from the healthy tissue through the lymphatics, and are cleared from the blood...
  7. pmc A compartment model of VEGF distribution in blood, healthy and diseased tissues
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    BMC Syst Biol 2:77. 2008
    ..We analyze the sensitivity of this distribution to the secretion rate, clearance rate and vascular permeability of VEGF...
  8. pmc The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
    Marianne O Stefanini
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Comput Biol 5:e1000622. 2009
    ....