J D Wood

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription
    J D Wood
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 150:939-48. 2000
  2. pmc Polyglutamine pathogenesis
    C A Ross
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Philos Trans R Soc Lond B Biol Sci 354:1005-11. 1999
  3. ncbi request reprint Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA
    G Schilling
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neurobiol Dis 8:405-18. 2001
  4. ncbi request reprint Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions
    C A Ross
    Johns Hopkins University, School of Medicine, Department of Psychiatry, Baltimore, Maryland 21205 2196, USA
    Prog Brain Res 117:397-419. 1998
  5. ncbi request reprint Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA
    G Schilling
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 24:275-86. 1999
  6. ncbi request reprint Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
    J D Wood
    Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 2196, USA
    Mol Cell Neurosci 11:149-60. 1998
  7. ncbi request reprint Huntingtin interacts with cystathionine beta-synthase
    J M Boutell
    Institute of Medical Genetics, University of Wales College of Medicine, Cardiff CF4 4XN, UK
    Hum Mol Genet 7:371-8. 1998
  8. ncbi request reprint P2X(7) receptors in the enteric nervous system of guinea-pig small intestine
    H Z Hu
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio 43210-1218, USA
    J Comp Neurol 440:299-310. 2001
  9. ncbi request reprint beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
  10. ncbi request reprint Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro
    S Liu
    Department of Physiology and Cell Biology, College of Medicine and Public Health, Ohio State University, Columbus, Ohio 43210
    Am J Physiol Gastrointest Liver Physiol 281:G237-46. 2001

Collaborators

Detail Information

Publications12

  1. pmc Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription
    J D Wood
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 150:939-48. 2000
    ....
  2. pmc Polyglutamine pathogenesis
    C A Ross
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Philos Trans R Soc Lond B Biol Sci 354:1005-11. 1999
    ..Taken together, these data lead towards a model whereby proteolytic processing, nuclear localization and protein aggregation all contribute to pathogenesis...
  3. ncbi request reprint Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA
    G Schilling
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neurobiol Dis 8:405-18. 2001
    ..We suggest that the distinct behavioral and neuropathological phenotypes in these mice reflect differences in the way these mutant proteins perturb neuronal function...
  4. ncbi request reprint Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions
    C A Ross
    Johns Hopkins University, School of Medicine, Department of Psychiatry, Baltimore, Maryland 21205 2196, USA
    Prog Brain Res 117:397-419. 1998
    ..As the investigation of the link between these inclusions and cell dysfunction and death continues, it is possible that new avenues for therapeutic intervention will emerge...
  5. ncbi request reprint Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA
    G Schilling
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 24:275-86. 1999
    ..We conclude that the evolution of neuropathology in DRPLA involves proteolytic processing of mutant atrophin-1 and nuclear accumulation of truncated fragments...
  6. ncbi request reprint Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
    J D Wood
    Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 2196, USA
    Mol Cell Neurosci 11:149-60. 1998
    ..These interactors are similar to recently isolated huntingtin-interacting proteins, suggesting possible commonality of function between two proteins responsible for very similar diseases...
  7. ncbi request reprint Huntingtin interacts with cystathionine beta-synthase
    J M Boutell
    Institute of Medical Genetics, University of Wales College of Medicine, Cardiff CF4 4XN, UK
    Hum Mol Genet 7:371-8. 1998
    ..It has been suggested that Huntington's disease involves the action of excitotoxic amino acids and this interaction with CBS may suggest a mechanism for such excitotoxic damage...
  8. ncbi request reprint P2X(7) receptors in the enteric nervous system of guinea-pig small intestine
    H Z Hu
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio 43210-1218, USA
    J Comp Neurol 440:299-310. 2001
    ..The mucosa, submucosal blood vessels, and the circular muscle coat also showed P2X(7) receptor immunoreactivity...
  9. ncbi request reprint beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
    ....
  10. ncbi request reprint Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro
    S Liu
    Department of Physiology and Cell Biology, College of Medicine and Public Health, Ohio State University, Columbus, Ohio 43210
    Am J Physiol Gastrointest Liver Physiol 281:G237-46. 2001
    ..The results suggest that nociceptin acts both pre- and postsynaptically by activating an ORL(1) receptor that is distinct from typical naloxone-sensitive opioid receptors...
  11. ncbi request reprint Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain
    J D Wood
    Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Hum Mol Genet 5:481-7. 1996
    ..These observed differences in the subcellular localisation of huntingtin between mouse and human brain are important in the context of mouse models for HD...
  12. ncbi request reprint The P2Y purinergic receptor expressed by enteric neurones in guinea-pig intestine
    N Gao
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, 43210, USA
    Neurogastroenterol Motil 18:316-23. 2006
    ..5. The results add to existing evidence for expression of a functional P2Y(1) purinergic receptor in neurones of the submucosal division of the ENS...