DEAN WONG

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint In vivo imaging of D2 dopamine receptors in schizophrenia: the ups and downs of neuroimaging research
    Dean F Wong
    Department of Radiology, Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC Bldg, Room 3245, Baltimore, MD 21287 0807, USA
    Arch Gen Psychiatry 59:31-4. 2002
  2. ncbi request reprint Brain imaging research: does the science serve clinical practice?
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0807, USA
    Int Rev Psychiatry 19:541-58. 2007
  3. doi request reprint PET imaging of high-affinity α4β2 nicotinic acetylcholine receptors in humans with 18F-AZAN, a radioligand with optimal brain kinetics
    Dean F Wong
    Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 54:1308-14. 2013
  4. doi request reprint Determination of dopamine D₂ receptor occupancy by lurasidone using positron emission tomography in healthy male subjects
    Dean F Wong
    Department of Radiology, Johns Hopkins Medical Institutions JHMI, 601 North Caroline Street, Room JHOC 3245, Baltimore, MD 21287 0807, USA
    Psychopharmacology (Berl) 229:245-52. 2013
  5. doi request reprint Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Caroline Street, Room 3245, Johns Hopkins Outpatient Center, Baltimore, MD 21287 0807, USA
    Neuroimage 75:282-90. 2013
  6. doi request reprint 18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry
    Dean F Wong
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 54:388-96. 2013
  7. doi request reprint An in vivo evaluation of cerebral cortical amyloid with [18F]flutemetamol using positron emission tomography compared with parietal biopsy samples in living normal pressure hydrocephalus patients
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Mol Imaging Biol 15:230-7. 2013
  8. doi request reprint The role of imaging in proof of concept for CNS drug discovery and development
    Dean F Wong
    Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine, 601 North Caroline St, JHOC room 3245, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 34:187-203. 2009
  9. pmc Is getting older all that rewarding?
    Dean F Wong
    Department of Radiology, Section of High Resolution Brain PET Imaging, Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, JHOC Building Room 3245, 601 North Caroline Street, Baltimore MD 21287, USA
    Proc Natl Acad Sci U S A 105:14751-2. 2008
  10. ncbi request reprint Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006

Detail Information

Publications54

  1. ncbi request reprint In vivo imaging of D2 dopamine receptors in schizophrenia: the ups and downs of neuroimaging research
    Dean F Wong
    Department of Radiology, Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC Bldg, Room 3245, Baltimore, MD 21287 0807, USA
    Arch Gen Psychiatry 59:31-4. 2002
  2. ncbi request reprint Brain imaging research: does the science serve clinical practice?
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0807, USA
    Int Rev Psychiatry 19:541-58. 2007
    ..For example, an optimal dose of D2 antagonist antipsychotics produces occupancy of 65% to 80% of D2 receptors, while a greater dose carries a risk of extrapyramidal side effects...
  3. doi request reprint PET imaging of high-affinity α4β2 nicotinic acetylcholine receptors in humans with 18F-AZAN, a radioligand with optimal brain kinetics
    Dean F Wong
    Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 54:1308-14. 2013
    ..2.1]heptane ((18)F-AZAN), a novel radiotracer that binds to α4β2 nicotinic acetylcholine receptors (α4β2-nAChRs) and shows high specific binding and rapid and reversible kinetics in the baboon and human brain...
  4. doi request reprint Determination of dopamine D₂ receptor occupancy by lurasidone using positron emission tomography in healthy male subjects
    Dean F Wong
    Department of Radiology, Johns Hopkins Medical Institutions JHMI, 601 North Caroline Street, Room JHOC 3245, Baltimore, MD 21287 0807, USA
    Psychopharmacology (Berl) 229:245-52. 2013
    ....
  5. doi request reprint Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Caroline Street, Room 3245, Johns Hopkins Outpatient Center, Baltimore, MD 21287 0807, USA
    Neuroimage 75:282-90. 2013
    ....
  6. doi request reprint 18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry
    Dean F Wong
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 54:388-96. 2013
    ....
  7. doi request reprint An in vivo evaluation of cerebral cortical amyloid with [18F]flutemetamol using positron emission tomography compared with parietal biopsy samples in living normal pressure hydrocephalus patients
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Mol Imaging Biol 15:230-7. 2013
    ....
  8. doi request reprint The role of imaging in proof of concept for CNS drug discovery and development
    Dean F Wong
    Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine, 601 North Caroline St, JHOC room 3245, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 34:187-203. 2009
    ..In summary, this article reviews the vital biomarker approach of neuroimaging in proof of concept studies...
  9. pmc Is getting older all that rewarding?
    Dean F Wong
    Department of Radiology, Section of High Resolution Brain PET Imaging, Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, JHOC Building Room 3245, 601 North Caroline Street, Baltimore MD 21287, USA
    Proc Natl Acad Sci U S A 105:14751-2. 2008
  10. ncbi request reprint Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006
    ..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine...
  11. doi request reprint Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR
    Dean F Wong
    Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Neuroimage 52:1505-13. 2010
    ..In addition, our initial data in subjects with schizophrenia seem to suggest an association of elevated binding specific brain regions and symptoms of the disease...
  12. pmc In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    J Nucl Med 51:913-20. 2010
    ..Here we present the results of a clinical trial with (E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45 or florbetapir [corrected] F 18)...
  13. ncbi request reprint Predicting the success of a radiopharmaceutical for in vivo imaging of central nervous system neuroreceptor systems
    Dean F Wong
    Johns Hopkins University, Department of Radiology, Baltimore, MD 21287, USA
    Mol Imaging Biol 5:350-62. 2003
    ..This article is intended to present a pragmatic overview of the radiopharmaceutical development process with emphasis on the CNS...
  14. pmc Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    Neuropsychopharmacology 33:1239-51. 2008
    ..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD...
  15. ncbi request reprint Sex differences in striatal dopamine release in healthy adults
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 59:966-74. 2006
    ..Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human studies have yet to substantiate these findings...
  16. ncbi request reprint Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Neurol 202:381-90. 2006
    ....
  17. ncbi request reprint Dopamine D2 and D3 receptor occupancy in normal humans treated with the antipsychotic drug aripiprazole (OPC 14597): a study using positron emission tomography and [11C]raclopride
    Fuji Yokoi
    Department of Radiology, Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neuropsychopharmacology 27:248-59. 2002
    ..This underlines aripiprazole's unique mechanism of action as a partial dopamine receptor agonist, which might become a novel principle in the treatment of schizophrenia...
  18. ncbi request reprint Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 159:1329-36. 2002
    ..The objective of this study was to test the hypothesis that presynaptic dopamine release from the striatum is abnormal in adults with Tourette's syndrome...
  19. pmc Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 107:1236-47. 2008
    ..These findings provide compelling evidence that the effects of Mn on DA synapses in the striatum are mediated by inhibition of DA neurotransmission and are responsible for the motor deficits documented in these animals...
  20. ncbi request reprint Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, MD 21205, USA
    Neuroimage 36:153-66. 2007
    ..No associations were observed between impulsivity or stress and cortisol responses to AMPH. The findings are consistent with notions that blunted DA responses represent an endophenotype for substance use disorders...
  21. ncbi request reprint Acute manganese administration alters dopamine transporter levels in the non-human primate striatum
    Ming Kai Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurotoxicology 27:229-36. 2006
    ..These findings provide helpful insights on potential mechanisms of Mn-induced neurotoxicity and indicate that the DAT in the striatum is a target for Mn in the brain...
  22. ncbi request reprint VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease
    Ming Kai Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 105:78-90. 2008
    ..Genetic or environmental factors that decrease VMAT2 function may be important determinants of PD...
  23. pmc Design and implementation of an automated partial volume correction in PET: application to dopamine receptor quantification in the normal human striatum
    Olivier G Rousset
    Section of High Resolution Brain PET Imaging, Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Nucl Med 49:1097-106. 2008
    ....
  24. ncbi request reprint Striatal dopamine release and family history of alcoholism
    Cynthia A Munro
    Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 30:1143-51. 2006
    ....
  25. ncbi request reprint Derivatives of (-)-7-methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane are potential ligands for positron emission tomography imaging of extrathalamic nicotinic acetylcholine receptors
    Yongjun Gao
    Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
    J Med Chem 50:3814-24. 2007
    ..2.1]heptane, exhibited good properties as a first practical PET radioligand for imaging of extrathalamic nAChR in baboon brain and holds promise for further investigation for human studies...
  26. pmc System matrix modelling of externally tracked motion
    Arman Rahmim
    Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, USA
    Nucl Med Commun 29:574-81. 2008
    ....
  27. pmc Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers
    James Robert Brasic
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Synapse 63:339-58. 2009
    ..We conclude that 5-[(123)I]IA is a safe, well-tolerated, and effective pharmacologic agent for human subjects to estimate high-affinity alpha4/beta2 nAChRs in the living human brain...
  28. doi request reprint Alterations of central dopamine receptors before and after gastric bypass surgery
    Kimberley E Steele
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Obes Surg 20:369-74. 2010
    ..We performed a preliminary study to investigate dopamine D2 receptor activity in obese subjects before and after laparoscopic Roux-en Y gastric bypass (LGBP)...
  29. pmc Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography
    Yongjun Gao
    Department of Radiology, Division of Nuclear Medicine, PET Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 0816, USA
    Bioorg Med Chem 17:4367-77. 2009
    ..Three of these novel nAChR ligands were radiolabeled with the positron-emitting isotope (11)C and evaluated in animal studies as potential PET radiotracers for imaging of cerebral nAChRs with improved brain kinetics...
  30. pmc Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)
    Andrew G Horti
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
    Bioorg Med Chem 18:5202-7. 2010
    ..These data establish a proof of principle that CB2 receptors binding in the neuroinflammation and related disorders can be measured in vivo...
  31. ncbi request reprint Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 30:821-32. 2005
    ..The results are consistent with those of preclinical studies, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans...
  32. ncbi request reprint Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 32:2310-20. 2007
    ..The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans...
  33. pmc Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 36:298-312. 2007
    ..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies...
  34. ncbi request reprint Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model
    Yun Zhou
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuroimage 18:975-89. 2003
    ..We conclude that the new linear equations yield a reliable, computationally efficient, and robust LRSC algorithm to generate parametric images of ligand-receptor dynamic PET studies...
  35. ncbi request reprint Dose effects of triazolam on brain activity during episodic memory encoding: a PET study
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 188:445-61. 2006
    ..Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect...
  36. ncbi request reprint 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase)
    Martin G Pomper
    Division of Neuroradiology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2182, USA
    Mol Imaging 1:96-101. 2002
    ..For PET, distribution volumes (DVs) were 1.38 then 0.87 pre- and postblocker (PMPA). Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery...
  37. pmc Multi-graphical analysis of dynamic PET
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 49:2947-57. 2010
    ..In conclusion, the bi-graphical analysis method using the RE-GP plots was a reliable, robust and computationally efficient kinetic modeling approach to improve the quantification of dynamic PET...
  38. ncbi request reprint Effect of worry on regional cerebral blood flow in nonanxious subjects
    Rudolf Hoehn-Saric
    Department of Psychiatry, Johns Hopkins School of Medicine, Room 117, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Psychiatry Res 140:259-69. 2005
    ..Activity of the left orbito-frontal gyrus was negatively correlated with activity of the amygdalae. The results support the hypothesis that worry-induced prefrontal activity suppresses affect-related subcortical regions...
  39. pmc A consistent and efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Neuroimage 44:661-70. 2009
    ..In conclusion, the new plot is a consistent and computationally efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies...
  40. ncbi request reprint An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC room 3245, Baltimore, MD 21287, USA
    Neuroimage 33:550-63. 2006
    ..Violations of this assumption may result in unreliable estimation of the amphetamine-induced percent change in the binding potential (DeltaBP%)...
  41. ncbi request reprint 11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptors
    Andrew G Horti
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0816, USA
    J Nucl Med 47:1689-96. 2006
    ..The goal of this study was to evaluate 11C-JHU75528, an analog of the selective CB1 antagonist rimonabant, in vivo as a potential CB1 radioligand for PET...
  42. ncbi request reprint Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Synapse 62:91-100. 2008
    ..This study was conducted to further investigate potential persistent psychomotor deficits secondary to METH abuse, and their relationship to brain DAT availability, as measured using quantitative PET methods with [(11)C]WIN 35428...
  43. pmc Accurate event-driven motion compensation in high-resolution PET incorporating scattered and random events
    Arman Rahmim
    Department of Radiology, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD 21205, USA
    IEEE Trans Med Imaging 27:1018-33. 2008
    ..The proposed approach has been extensively validated using phantom experiments as well as realistic simulations of a new mathematical brain phantom developed in this work, and the results for a dynamic patient study are also presented...
  44. doi request reprint New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3'-iodo-5'-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptors
    Yongjun Gao
    Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
    Bioorg Med Chem Lett 18:6168-70. 2008
    ..In the baboon PET study [(11)C](-)-NMI-EPB did not reach steady-state within 90 min post-injection suggesting that the radioligand may have some limitations for quantitative imaging...
  45. ncbi request reprint Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubis
    Mohab Alexander
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Synapse 56:94-9. 2005
    ..Viewed collectively, the present data indicate that typical clinical doses of phentermine and (+/-)-ephedrine may not release central DA in humans, a hypothesis that should ultimately be tested in controlled clinical studies...
  46. ncbi request reprint Improved parametric image generation using spatial-temporal analysis of dynamic PET studies
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neuroimage 15:697-707. 2002
    ..NLRRSC provided a reliable estimate of glucose metabolite uptake rate with a comparable image quality compared to Patlak analysis. In conclusion, NLRRSC is a reliable and robust parametric imaging algorithm for dynamic PET studies...
  47. doi request reprint Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging propert
    Yongjun Gao
    Department of Radiology, Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287 0816, USA
    J Med Chem 51:4751-64. 2008
    ..This combination of imaging properties suggests that [(18)F]-(-)- 6c is a potentially superior replacement for 2-[(18)F]fluoro-A-85380 and 6-[(18)F]fluoro-A-85380, the only available nAChR PET radioligands for humans...
  48. pmc Direct 4D reconstruction of parametric images incorporating anato-functional joint entropy
    Jing Tang
    Department of Radiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Phys Med Biol 55:4261-72. 2010
    ....
  49. ncbi request reprint In vivo measurement of cell proliferation in canine brain tumor using C-11-labeled FMAU and PET
    Peter S Conti
    PET Imaging Science Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Nucl Med Biol 35:131-41. 2008
    ....
  50. ncbi request reprint Intravenous nicotine reduces cerebral glucose metabolism: a preliminary study
    June M Stapleton
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Neuropsychopharmacology 28:765-72. 2003
    ..The findings indicate that nicotine resembles other drugs of abuse in reducing brain metabolism, perhaps by a common mechanism...
  51. ncbi request reprint Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS
    Dima A Hammoud
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2182, USA
    J Neurovirol 11:346-55. 2005
    ..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV...
  52. ncbi request reprint Brain glucose metabolism in Rett Syndrome
    Patricia M Villemagne
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
    Pediatr Neurol 27:117-22. 2002
    ..This pattern differs from those described in Down syndrome, autism, and Alzheimer's disease...
  53. ncbi request reprint Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECT
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 2182, USA
    Acad Radiol 9:398-409. 2002
    ..The purpose of this study was to examine the metabolic basis for magnetic resonance (MR) spectroscopic imaging findings in focal brain lesions of patients with acquired immunodeficiency syndrome (AIDS)...
  54. ncbi request reprint Positron emission tomography--a tool for identifying the effects of alcohol dependence on the brain
    Dean F Wong
    Russel H Morgan Department of Radiology and Radiological Science, John Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Alcohol Res Health 27:161-73. 2003
    ..In addition, imaging studies may help in the development of new medications for alcoholism treatment...

Research Grants18

  1. Training for Clinician Scientists in Imaging Research
    DEAN WONG; Fiscal Year: 2007
    ..The long term goal is to attract resident physicians into a career employing imaging research as a major component of their future academic careers. ..
  2. Mechanisms of Dopamine and Serotonin in Tourette Syndrome
    DEAN WONG; Fiscal Year: 2007
    ..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..
  3. Human Imaging Research in Neuropsychiatry and Drug Abuse
    DEAN WONG; Fiscal Year: 2007
    ..It is my strong belief that this progress will be maintained, even accelerated, in my additional five years. ..
  4. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ....
  5. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  6. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
  7. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2003
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  8. IMAGING DOPAMINE/SEROTONIN MECHANISMS IN COCAINE CRAVING
    DEAN WONG; Fiscal Year: 2003
    ..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
  9. Mechanisms of Dopamine and Serotonin in Tourette Syndrome
    DEAN FOSTER WONG; Fiscal Year: 2010
    ..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..