Research Topics
Species | DEAN WONGSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
In vivo imaging of D2 dopamine receptors in schizophrenia: the ups and downs of neuroimaging researchDean F Wong
Department of Radiology, Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC Bldg, Room 3245, Baltimore, MD 21287-0807, USA
Arch Gen Psychiatry 59:31-4. 2002
18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation dosimetryDean F Wong
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Nucl Med 54:388-96. 2013....- An in vivo evaluation of cerebral cortical amyloid with [18F]flutemetamol using positron emission tomography compared with parietal biopsy samples in living normal pressure hydrocephalus patientsDean F Wong
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Mol Imaging Biol 15:230-7. 2013.... - Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine cravingDean F Wong
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Neuropsychopharmacology 31:2716-27. 2006..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine... - Brain imaging research: does the science serve clinical practice?Dean F Wong
The Russell H Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0807, USA
Int Rev Psychiatry 19:541-58. 2007..For example, an optimal dose of D2 antagonist antipsychotics produces occupancy of 65% to 80% of D2 receptors, while a greater dose carries a risk of extrapyramidal side effects... - Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PETDean F Wong
Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
Neuropsychopharmacology 33:1239-51. 2008..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD... - Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMARDean F Wong
Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
Neuroimage 52:1505-13. 2010..In addition, our initial data in subjects with schizophrenia seem to suggest an association of elevated binding specific brain regions and symptoms of the disease... - Predicting the success of a radiopharmaceutical for in vivo imaging of central nervous system neuroreceptor systemsDean F Wong
Johns Hopkins University, Department of Radiology, Baltimore, MD 21287, USA
Mol Imaging Biol 5:350-62. 2003..This article is intended to present a pragmatic overview of the radiopharmaceutical development process with emphasis on the CNS... 
In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)Dean F Wong
Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0807, USA
J Nucl Med 51:913-20. 2010..Here we present the results of a clinical trial with (E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45 or florbetapir [corrected] F 18)...- Is getting older all that rewarding?Dean F Wong
Department of Radiology, Section of High Resolution Brain PET Imaging, Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, JHOC Building Room 3245, 601 North Caroline Street, Baltimore MD 21287, USA
Proc Natl Acad Sci U S A 105:14751-2. 2008 - The role of imaging in proof of concept for CNS drug discovery and developmentDean F Wong
Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine, 601 North Caroline St, JHOC room 3245, Baltimore, MD 21287 0807, USA
Neuropsychopharmacology 34:187-203. 2009..In summary, this article reviews the vital biomarker approach of neuroimaging in proof of concept studies... - Sex differences in striatal dopamine release in healthy adultsCynthia A Munro
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Biol Psychiatry 59:966-74. 2006..Our findings indicate that future studies should control for sex and may have implications for the interpretation of sex differences in other illnesses involving the striatum... - Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primatesTomas R Guilarte
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Exp Neurol 202:381-90. 2006.... - Dopamine D2 and D3 receptor occupancy in normal humans treated with the antipsychotic drug aripiprazole (OPC 14597): a study using positron emission tomography and [11C]racloprideFuji Yokoi
Department of Radiology, Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Neuropsychopharmacology 27:248-59. 2002..This underlines aripiprazole's unique mechanism of action as a partial dopamine receptor agonist, which might become a novel principle in the treatment of schizophrenia... - Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PETHarvey S Singer
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Psychiatry 159:1329-36. 2002..These results suggest that the underlying pathobiology in Tourette's syndrome is a phasic dysfunction of dopamine transmission... - Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonismTomas R Guilarte
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Neurochem 107:1236-47. 2008..These findings provide compelling evidence that the effects of Mn on DA synapses in the striatum are mediated by inhibition of DA neurotransmission and are responsible for the motor deficits documented in these animals... - Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine releaseLynn M Oswald
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, MD 21205, USA
Neuroimage 36:153-66. 2007..No associations were observed between impulsivity or stress and cortisol responses to AMPH. The findings are consistent with notions that blunted DA responses represent an endophenotype for substance use disorders... - VMAT2 and dopamine neuron loss in a primate model of Parkinson's diseaseMing Kai Chen
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Neurochem 105:78-90. 2008..Genetic or environmental factors that decrease VMAT2 function may be important determinants of PD... - Design and implementation of an automated partial volume correction in PET: application to dopamine receptor quantification in the normal human striatumOlivier G Rousset
Section of High Resolution Brain PET Imaging, Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Nucl Med 49:1097-106. 2008..This study also offers the first, to our knowledge, large-scale application of PVC to dopamine D(2)/D(3) receptor imaging with (11)C-raclopride in humans... - Acute manganese administration alters dopamine transporter levels in the non-human primate striatumMing-Kai Chen
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neurotoxicology 27:229-36. 2006..These findings provide helpful insights on potential mechanisms of Mn-induced neurotoxicity and indicate that the DAT in the striatum is a target for Mn in the brain... - Derivatives of (-)-7-methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane are potential ligands for positron emission tomography imaging of extrathalamic nicotinic acetylcholine receptorsYongjun Gao
Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
J Med Chem 50:3814-24. 2007..2.1]heptane, exhibited good properties as a first practical PET radioligand for imaging of extrathalamic nAChR in baboon brain and holds promise for further investigation for human studies... - Striatal dopamine release and family history of alcoholismCynthia A Munro
Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 30:1143-51. 2006..CONCLUSIONS: Using amphetamine to provoke mesolimbic dopamine, we did not show significant differences in dopamine release, subjective responses, or stress hormone measures as a function of family history of alcoholism... - Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's diseaseYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Neuroimage 36:298-312. 2007..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies... - System matrix modelling of externally tracked motionArman Rahmim
Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, USA
Nucl Med Commun 29:574-81. 2008.... - Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)Andrew G Horti
Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
Bioorg Med Chem 18:5202-7. 2010..These data establish a proof of principle that CB2 receptors binding in the neuroinflammation and related disorders can be measured in vivo... - Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue modelYun Zhou
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neuroimage 18:975-89. 2003..We conclude that the new linear equations yield a reliable, computationally efficient, and robust LRSC algorithm to generate parametric images of ligand-receptor dynamic PET studies... - Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamineLynn M Oswald
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuropsychopharmacology 30:821-32. 2005..The results are consistent with those of preclinical studies, suggesting that individual differences in HPA axis function may influence vulnerability to alcohol and drug dependence in humans... - Alterations of central dopamine receptors before and after gastric bypass surgeryKimberley E Steele
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Obes Surg 20:369-74. 2010..We performed a preliminary study to investigate dopamine D2 receptor activity in obese subjects before and after laparoscopic Roux-en Y gastric bypass (LGBP)... - Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomographyYongjun Gao
Department of Radiology, Division of Nuclear Medicine, PET Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 0816, USA
Bioorg Med Chem 17:4367-77. 2009..Three of these novel nAChR ligands were radiolabeled with the positron-emitting isotope (11)C and evaluated in animal studies as potential PET radiotracers for imaging of cerebral nAChRs with improved brain kinetics... - Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokersJames Robert Brasic
Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Synapse 63:339-58. 2009..We conclude that 5-[(123)I]IA is a safe, well-tolerated, and effective pharmacologic agent for human subjects to estimate high-affinity alpha4/beta2 nAChRs in the living human brain... - Dose effects of triazolam on brain activity during episodic memory encoding: a PET studyMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 188:445-61. 2006..Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect... - Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stressGary S Wand
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 32:2310-20. 2007..The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans... - A consistent and efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studiesYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Neuroimage 44:661-70. 2009..In conclusion, the new plot is a consistent and computationally efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies... - Multi-graphical analysis of dynamic PETYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Neuroimage 49:2947-57. 2010..In conclusion, the bi-graphical analysis method using the RE-GP plots was a reliable, robust and computationally efficient kinetic modeling approach to improve the quantification of dynamic PET... - Accurate event-driven motion compensation in high-resolution PET incorporating scattered and random eventsArman Rahmim
Department of Radiology, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD 21205, USA
IEEE Trans Med Imaging 27:1018-33. 2008..The proposed approach has been extensively validated using phantom experiments as well as realistic simulations of a new mathematical brain phantom developed in this work, and the results for a dynamic patient study are also presented... - Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine usersUna D McCann
Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Synapse 62:91-100. 2008..This study was conducted to further investigate potential persistent psychomotor deficits secondary to METH abuse, and their relationship to brain DAT availability, as measured using quantitative PET methods with [(11)C]WIN 35428... - An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challengeYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC room 3245, Baltimore, MD 21287, USA
Neuroimage 33:550-63. 2006..Violations of this assumption may result in unreliable estimation of the amphetamine-induced percent change in the binding potential (DeltaBP%)... - 11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptorsAndrew G Horti
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0816, USA
J Nucl Med 47:1689-96. 2006..The goal of this study was to evaluate 11C-JHU75528, an analog of the selective CB1 antagonist rimonabant, in vivo as a potential CB1 radioligand for PET... - Effect of worry on regional cerebral blood flow in nonanxious subjectsRudolf Hoehn-Saric
Department of Psychiatry, Johns Hopkins School of Medicine, Room 117, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Psychiatry Res 140:259-69. 2005..Activity of the left orbito-frontal gyrus was negatively correlated with activity of the amygdalae. The results support the hypothesis that worry-induced prefrontal activity suppresses affect-related subcortical regions... - 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase)Martin G Pomper
Division of Neuroradiology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2182, USA
Mol Imaging 1:96-101. 2002..For PET, distribution volumes (DVs) were 1.38 then 0.87 pre- and postblocker (PMPA). Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery... - Improved parametric image generation using spatial-temporal analysis of dynamic PET studiesYun Zhou
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Neuroimage 15:697-707. 2002..NLRRSC provided a reliable estimate of glucose metabolite uptake rate with a comparable image quality compared to Patlak analysis. In conclusion, NLRRSC is a reliable and robust parametric imaging algorithm for dynamic PET studies... - New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3'-iodo-5'-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptorsYongjun Gao
Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
Bioorg Med Chem Lett 18:6168-70. 2008..In the baboon PET study [(11)C](-)-NMI-EPB did not reach steady-state within 90 min post-injection suggesting that the radioligand may have some limitations for quantitative imaging... - Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubisMohab Alexander
Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Synapse 56:94-9. 2005..Viewed collectively, the present data indicate that typical clinical doses of phentermine and (+/-)-ephedrine may not release central DA in humans, a hypothesis that should ultimately be tested in controlled clinical studies... - Direct 4D reconstruction of parametric images incorporating anato-functional joint entropyJing Tang
Department of Radiology, The Johns Hopkins University, Baltimore, MD 21287, USA
Phys Med Biol 55:4261-72. 2010.... - Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging propertYongjun Gao
Department of Radiology, Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287 0816, USA
J Med Chem 51:4751-64. 2008..This combination of imaging properties suggests that [(18)F]-(-)- 6c is a potentially superior replacement for 2-[(18)F]fluoro-A-85380 and 6-[(18)F]fluoro-A-85380, the only available nAChR PET radioligands for humans... - In vivo measurement of cell proliferation in canine brain tumor using C-11-labeled FMAU and PETPeter S Conti
PET Imaging Science Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
Nucl Med Biol 35:131-41. 2008.... - Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDSDima A Hammoud
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2182, USA
J Neurovirol 11:346-55. 2005..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV... - Brain glucose metabolism in Rett SyndromePatricia M Villemagne
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-0807, USA
Pediatr Neurol 27:117-22. 2002..This pattern differs from those described in Down syndrome, autism, and Alzheimer's disease... - Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECTMartin G Pomper
Department of Radiology, Johns Hopkins University, Baltimore, MD 21287-2182, USA
Acad Radiol 9:398-409. 2002..CONCLUSION: PET and SPECT may be more reliable than MR spectroscopic imaging for differentiating benign lesions from primary central nervous system lymphoma in patients with AIDS... - Intravenous nicotine reduces cerebral glucose metabolism: a preliminary studyJune M Stapleton
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Neuropsychopharmacology 28:765-72. 2003..The findings indicate that nicotine resembles other drugs of abuse in reducing brain metabolism, perhaps by a common mechanism... - Positron emission tomography--a tool for identifying the effects of alcohol dependence on the brainDean F Wong
Russel H. Morgan Department of Radiology and Radiological Science, John Hopkins University, School of Medicine, Baltimore, Maryland, USA
Alcohol Res Health 27:161-73. 2003..In addition, imaging studies may help in the development of new medications for alcoholism treatment...
Research Grants
- Training for Clinician Scientists in Imaging ResearchDEAN WONG; Fiscal Year: 2007..The long term goal is to attract resident physicians into a career employing imaging research as a major component of their future academic careers. ..
- Mechanisms of Dopamine and Serotonin in Tourette SyndromeDEAN WONG; Fiscal Year: 2007..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..
- Human Imaging Research in Neuropsychiatry and Drug AbuseDEAN WONG; Fiscal Year: 2007..It is my strong belief that this progress will be maintained, even accelerated, in my additional five years. ..
- High End Computing for PET/SPECTDEAN WONG; Fiscal Year: 2007....
- IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISMDEAN WONG; Fiscal Year: 2004..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
- Dedicated High Performance Human Brain/Preclinical PETDEAN WONG; Fiscal Year: 2004..abstract_text> ..
- MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROMEDEAN WONG; Fiscal Year: 2003..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
- IMAGING DOPAMINE/SEROTONIN MECHANISMS IN COCAINE CRAVINGDEAN WONG; Fiscal Year: 2003..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
- Mechanisms of Dopamine and Serotonin in Tourette SyndromeDEAN FOSTER WONG; Fiscal Year: 2010..At the end of this renewal, we will have completed our originally funded AIMS and examined new possibilities of 5HT and DA interrelationships and role of co morbid OCD and TS. ..