Michael J Wolfgang

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:7282-7. 2006
  2. doi request reprint Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity
    Michael J Wolfgang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS J 278:552-8. 2011
  3. ncbi request reprint Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Nutr 26:23-44. 2006
  4. pmc Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 105:1550-9. 2008
  5. pmc Hypothalamic malonyl-coenzyme A and the control of energy balance
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 512 WBSB, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Mol Endocrinol 22:2012-20. 2008
  6. ncbi request reprint Localization and effect of ectopic expression of CPT1c in CNS feeding centers
    Yun Dai
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N Wolfe St 512 WBSB, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 359:469-74. 2007
  7. pmc Regulation of hypothalamic malonyl-CoA by central glucose and leptin
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:19285-90. 2007
  8. doi request reprint Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly
    Amanda A Reamy
    Center for Metabolism and Obesity Research, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurochem 118:388-98. 2011
  9. pmc Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism
    Jieun Lee
    Department of Biological Chemistry, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    BMC Biochem 13:23. 2012
  10. pmc Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity
    Jessica M Ellis
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Center for Metabolism and Obesity Research, Baltimore, Maryland, USA
    Mol Cell Biol 33:1869-82. 2013

Collaborators

Detail Information

Publications14

  1. pmc The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:7282-7. 2006
    ..CPT1c KO mice also exhibit decreased rates of fatty acid oxidation, which may contribute to their increased susceptibility to diet-induced obesity. These findings indicate that CPT1c is necessary for the regulation of energy homeostasis...
  2. doi request reprint Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity
    Michael J Wolfgang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS J 278:552-8. 2011
    ..Thus, the brain can directly sense and respond to changes in nutrient availability and composition to affect body weight and adiposity...
  3. ncbi request reprint Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Nutr 26:23-44. 2006
    ..This review focuses on the regulatory roles of these enzymes and intermediates in the regulation of food intake and energy balance...
  4. pmc Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 105:1550-9. 2008
    ..Heterozygous mice display an intermediate phenotype. These findings provide further evidence that CPT1c plays a role in maintaining energy homeostasis, but not through altered fatty acid oxidation...
  5. pmc Hypothalamic malonyl-coenzyme A and the control of energy balance
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 512 WBSB, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Mol Endocrinol 22:2012-20. 2008
    ....
  6. ncbi request reprint Localization and effect of ectopic expression of CPT1c in CNS feeding centers
    Yun Dai
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N Wolfe St 512 WBSB, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 359:469-74. 2007
    ....
  7. pmc Regulation of hypothalamic malonyl-CoA by central glucose and leptin
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:19285-90. 2007
    ..These studies show that hypothalamic malonyl-CoA responds to the level of circulating glucose and leptin, both of which affect energy homeostasis...
  8. doi request reprint Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly
    Amanda A Reamy
    Center for Metabolism and Obesity Research, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurochem 118:388-98. 2011
    ..These data show that CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet...
  9. pmc Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism
    Jieun Lee
    Department of Biological Chemistry, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    BMC Biochem 13:23. 2012
    ..Although there are studies suggesting an enzymatic role of CPT1c, its role in neurochemistry remains elusive...
  10. pmc Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity
    Jessica M Ellis
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Center for Metabolism and Obesity Research, Baltimore, Maryland, USA
    Mol Cell Biol 33:1869-82. 2013
    ..In agreement, Acot7(N-/-) mice exhibit neurological dysfunction and neurodegeneration. These data show that ACOT7 counterregulates fatty acid metabolism in neurons and protects against neurotoxicity...
  11. ncbi request reprint The role of hypothalamic malonyl-CoA in energy homeostasis
    Michael J Wolfgang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 281:37265-9. 2006
    ..Together these findings support a role for malonyl-CoA as an intermediary in the control of energy homeostasis...
  12. pmc A genetically encoded metabolite sensor for malonyl-CoA
    Jessica M Ellis
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chem Biol 19:1333-9. 2012
    ..This simple genetically encoded biosensor can be used to study the metabolic properties of live mammalian cells and enable screens for novel metabolic regulators...
  13. pmc C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes
    Zhikui Wei
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:10301-15. 2012
    ..Collectively, these data establish CTRP12 as a novel metabolic regulator linking adipose tissue to whole body glucose homeostasis through insulin-dependent and independent mechanisms...
  14. pmc Targeted chemical-genetic regulation of protein stability in vivo
    Susana Rodriguez
    Department of Biological Chemistry, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chem Biol 19:391-8. 2012
    ..This provides a practical, specific, and reversible means of manipulating metabolic pathways in adult mice to provide biological insight...