Research Topics
| A C WolffSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancerAntonio C Wolff
Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA
J Clin Oncol 31:195-202. 2013..Here, we report clinical outcomes of combining the mammalian target of rapamycin (mTOR) inhibitor temsirolimus with letrozole in AI-naive patients...
Systemic therapyA C Wolff
The Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Curr Opin Oncol 11:468-74. 1999..Early results of high-dose chemotherapy have been released, and the role of taxanes in early and advanced disease continues to expand. This article reviews these and other recent advances...
Research issues affecting preoperative systemic therapy for operable breast cancerAntonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St, Room 189, Baltimore, MD 21231 1000, USA
J Clin Oncol 26:806-13. 2008..PST requires an experienced and cohesive multidisciplinary team for it to fulfill its potential in both research and clinical care...
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancerAntonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
Clin Cancer Res 9:5922-8. 2003..This study evaluated the activity of the first-generation analog DENSpm in women with metastatic breast cancer...
Phase I study of docosahexaenoic acid-paclitaxel: a taxane-fatty acid conjugate with a unique pharmacology and toxicity profileAntonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21230 1000, USA
Clin Cancer Res 9:3589-97. 2003..This Phase I trial examined its toxicity and pharmacokinetics (PKs)...
Single-agent topotecan as first-line chemotherapy in women with metastatic breast cancer: final results of eastern cooperative oncology group trial E8193Antonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
Clin Breast Cancer 6:334-9. 2005..The purpose of this multicenter phase II trial was to evaluate the clinical activity of topotecan as first-line chemotherapy in patients with metastatic breast cancer and previous exposure to adjuvant doxorubicin...
Systemic therapyAntonio C Wolff
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Curr Opin Oncol 14:600-8. 2002..These and other important developments since 2001 are examined in this review...
Phase II trial of pegylated liposomal doxorubicin plus docetaxel with and without trastuzumab in metastatic breast cancer: Eastern Cooperative Oncology Group trial E3198Antonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
Breast Cancer Res Treat 121:111-20. 2010..In conclusion, concurrent administration of trastuzumab with PLD-docetaxel was not associated with higher risk of cardiac toxicity compared with PLD-docetaxel alone, but led to excessive hand-foot syndrome...
Preoperative therapy in breast cancer: lessons from the treatment of locally advanced diseaseAntonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
Oncologist 7:239-45. 2002..PST is increasingly being used in otherwise operable stage I and II patients aiming at greater rates of breast conservation and earlier efficacy assessment. This article reviews many of these issues and ongoing research questions...
Adjuvant systemic management of early stage carcinoma of the breastA C Wolff
Division of Medical Oncology, The Johns Hopkins Oncology Center, Baltimore, MD 21287, USA
Surg Oncol 8:93-101. 1999..This specific topic is discussed elsewhere in this issue by Singletary...
Systemic therapyA C Wolff
The Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
Curr Opin Oncol 12:532-40. 2000..Data continue to evolve on the role and optimal schedules of taxanes in early-stage and advanced breast cancer. These and other important recent findings are discussed in this review article...
Systemic therapyA C Wolff
The Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
Curr Opin Oncol 13:436-49. 2001..Discussions on the long-term effects of adjuvant therapy have taken center stage also. These and other important ongoing developments since 2000 are examined in this review article...
Use of SERMs for the adjuvant therapy of early-stage breast cancerA C Wolff
The Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Ann N Y Acad Sci 949:80-8. 2001..At present, SERMs are recognized as the first targeted and relatively nontoxic medical therapy for women with high-risk or steroid hormone receptor-positive breast cancer...
Primary systemic therapy in operable breast cancerA C Wolff
Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
J Clin Oncol 18:1558-69. 2000..This article examines the rationale for and preclinical and clinical data of PST in operable breast cancer and the potential role of intermediate biomarkers as predictive and/or prognostic factors for response and survival...
Pathologic complete response to preoperative sequential doxorubicin/cyclophosphamide and single-agent taxane with or without trastuzumab in stage II/III HER2-positive breast cancerSaranya Chumsri
University of Maryland Greenebaum Cancer Center, Baltimore, MD 21231, USA
Clin Breast Cancer 10:40-5. 2010..We evaluated pathologic complete response (pCR) rate and cardiac safety of preoperative doxorubicin and cyclophosphamide followed by a taxane with or without trastuzumab...
Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumoursWells A Messersmith
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, CRB 1M88, 1650 Orleans Street, Baltimore, MD 21231, USA
Eur J Cancer 43:78-86. 2007..A long half-life and accumulation of BPU and active metabolites were observed, recommending against a continuous administration. Weekly oral BPU therapy should be further tested using an interrupted schedule...
Insights on adjuvant endocrine therapy for premenopausal and postmenopausal breast cancerSusanne Briest
University of Leipzig, Department of Gynecology and Obstetrics, Leipzig, Germany
Expert Rev Anticancer Ther 7:1243-53. 2007..This review discusses basic principles regarding endocrine therapy, the need for accurate estrogen receptor testing and the role of menopause in therapy selection...
Colorectal cancer outcomes, recurrence, and complications in persons with and without diabetes mellitus: a systematic review and meta-analysisKelly B Stein
Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Dig Dis Sci 55:1839-51. 2010....
Therapeutic options in the management of metastatic breast cancerMichaela J Higgins
Breast Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland 21231 1000, USA
Oncology (Williston Park) 22:614-23; discussion 623, 627-9. 2008..Other novel agents are adding to the wide choices of standard chemotherapies already available. This review offers an approach to the selection of individualized and rational therapies for patients with metastatic breast cancer...
Feasibility trial of partial breast irradiation with concurrent dose-dense doxorubicin and cyclophosphamide in early-stage breast cancerRichard C Zellars
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins, 401 N Broadway, Suite 1440, Baltimore, MD 21231, USA
J Clin Oncol 27:2816-22. 2009..We hypothesized that anthracycline-based chemotherapy and concurrent partial breast irradiation (PBI) is safe and conducted a single-arm feasibility trial testing this hypothesis with dose-dense doxorubicin and cyclophosphamide (ddAC)...
Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activationLeisha A Emens
Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Clin Oncol 27:5911-8. 2009..We tested the hypothesis that cyclophosphamide (CY) and doxorubicin (DOX) can enhance vaccine-induced immunity in patients with breast cancer...
Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysisKimberly S Peairs
Division of General Internal Medicine, Johns Hopkins University School of Medicine, 10753 Falls Rd, Suite 325, Lutherville, MD 21093, USA
J Clin Oncol 29:40-6. 2011..The goal of this study was to perform a systematic review and meta-analysis to examine the effect of pre-existing diabetes on breast cancer-related outcomes...
Transitioning to breast cancer survivorship: perspectives of patients, cancer specialists, and primary care providersMelinda Kantsiper
Johns Hopkins University School of Medicine, 5200 Eastern Ave, MFL West, Baltimore, MD 21224 2780, USA
J Gen Intern Med 24:S459-66. 2009..Limited research exists regarding views of patients, oncology specialists, and primary care providers (PCPs) concerning breast cancer survivorship care...
Comparative pharmacokinetics of weekly and every-three-weeks docetaxelSharyn D Baker
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
Clin Cancer Res 10:1976-83. 2004..The comparative pharmacokinetics of docetaxel during weekly and once every 3 weeks (3-weekly) administration schedules were evaluated...
Local failure and prognostic factors in ductal carcinoma in situ: concentration on recent publicationsRichard Zellars
Division of Radiation Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231 2410, USA
Curr Opin Obstet Gynecol 15:9-12. 2003..The purpose of this review is to assess the value of commonly accepted potential prognostic factors in patients with ductal carcinoma in situ...
Liposomal anthracyclines and new treatment approaches for breast cancerAntonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University, Baltimore, Maryland 21231 1000, USA
Oncologist 8:25-30. 2003....
Comparing care for breast cancer survivors to non-cancer controls: a five-year longitudinal studyClaire F Snyder
Johns Hopkins School of Medicine, Baltimore, MD, USA
J Gen Intern Med 24:469-74. 2009..Deficiencies in care for cancer survivors may result from unclear roles for primary care providers (PCPs) and oncology specialists in follow-up...
The role of ovarian ablation in the adjuvant therapy of breast cancerSing Huang Tan
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB1 189, Baltimore, MD 21231, USA
Curr Oncol Rep 10:27-37. 2008....
Factors affecting pharmacokinetic variability following doxorubicin and docetaxel-based therapyM A Rudek
Division of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231-1000, USA
Eur J Cancer 40:1170-8. 2004..Overall, these findings suggest that incorporation of variables in addition to BSA should be considered in routine dosing strategies for doxorubicin and docetaxel...
Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysisBethany B Barone
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
JAMA 300:2754-64. 2008..Diabetes mellitus appears to be a risk factor for some cancers, but the effect of preexisting diabetes on all-cause mortality in newly diagnosed cancer patients is less clear...
Systematic review: gene expression profiling assays in early-stage breast cancerLuigi Marchionni
Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
Ann Intern Med 148:358-69. 2008..Three gene expression-based prognostic breast cancer tests have been licensed for use...
Prevention, screening, and surveillance care for breast cancer survivors compared with controls: changes from 1998 to 2002Claire F Snyder
Johns Hopkins University, 624 N Broadway, Rm 657, Baltimore, MD 21205, USA
J Clin Oncol 27:1054-61. 2009..To examine how care for breast cancer survivors compares with controls...
Needs assessments can identify scores on HRQOL questionnaires that represent problems for patients: an illustration with the Supportive Care Needs Survey and the QLQ-C30Claire F Snyder
Johns Hopkins School of Medicine, 624 N Broadway, Room 657, Baltimore, MD 21205, USA
Qual Life Res 19:837-45. 2010..We explored using needs assessments to identify HRQOL scores associated with patient-reported unmet needs...
Postoperative mortality in cancer patients with preexisting diabetes: systematic review and meta-analysisBethany B Barone
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA
Diabetes Care 33:931-9. 2010..Study population and design, results, and quality components were abstracted with standard protocols by one reviewer and checked for accuracy by additional reviewers...
Concordance of cancer patients' function, symptoms, and supportive care needsClaire F Snyder
Johns Hopkins School of Medicine, 624 N Broadway, Room 657, Baltimore, MD 21205, USA
Qual Life Res 18:991-8. 2009..Although patients' function, symptoms, and supportive care needs are obviously related, a better understanding of these relationships could improve patient management...
A method for determination of dimethyl benzoylphenyl urea (BPU) in human plasma by using LC/UVMichelle A Rudek
Division of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
Biomed Chromatogr 18:282-7. 2004..The lower limit of quantitation of 0.01 microg/mL allows for successful measurement of plasma concentrations in patients...
Symptoms, supportive care needs, and function in cancer patients: how are they related?Claire F Snyder
Johns Hopkins School of Medicine, Baltimore, MD, USA
Qual Life Res 17:665-77. 2008..To explore the associations among symptoms, supportive care needs, and function...
Asking the right questions: investigating needs assessments and health-related quality-of-life questionnaires for use in oncology clinical practiceClaire F Snyder
Division of General Internal Medicine, Johns Hopkins School of Medicine, 624 N Broadway, 6th Floor, Baltimore, MD 21205, USA
Support Care Cancer 15:1075-85. 2007..We investigated the item content from two health-related quality-of-life (HRQOL) questionnaires and two needs assessments for this purpose...
Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate dimethyl benzoylphenylurea (BPU) and its five metabolites in human plasma and urine for clinical pharmacology studiesMichelle A Rudek
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting-Blaustein Cancer Research Building, Room 1M86, 1650 Orleans Street, Baltimore, MD 21231-1000, USA
J Chromatogr B Analyt Technol Biomed Life Sci 828:41-54. 2005..1-20, 0.1-20, 0.5-100, 10-2000, 1-200, and 3-600 ng/mL for BPU, mmBPU, aminoBPU, G280, G308, and G322 in urine, respectively. The method has been successfully applied to study the pharmacokinetics of BPU...
Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applicationsMichael A Jacobs
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Technol Cancer Res Treat 3:543-50. 2004..A combination of MR, MRSI, and 23Na sodium MR parameters may be examined in a single MR imaging examination, potentially resulting in improved specificity for radiologic evaluation of malignancy...
In vitro and in vivo clinical pharmacology of dimethyl benzoylphenylurea, a novel oral tubulin-interactive agentMichelle A Rudek
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231-1000, USA
Clin Cancer Res 11:8503-11. 2005....
Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRIRonald Ouwerkerk
Division of MR Research, Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD 21287 0845, USA
Breast Cancer Res Treat 106:151-60. 2007....
Optimizing endocrine therapy for premenopausal and postmenopausal women with breast cancerMary Cianfrocca
Division of Hematology Oncology, Northwestern University, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA
Oncology (Williston Park) 21:63-9; discussion 69, 72, 75 passim. 2007..Issues regarding the optimal approach to endocrine therapy in both pre- and postmenopausal women are examined in this review...
A randomized phase II feasibility trial of BMS-275291 in patients with early stage breast cancerKathy D Miller
Indiana University, Indianapolis, Indiana, USA
Clin Cancer Res 10:1971-5. 2004..This pilot trial was performed to evaluate the safety, pharmacokinetics and feasibility of incorporating BMS-275291, a matrix metalloproteinase inhibitor (MMPI), into adjuvant breast cancer therapy...
Still waiting after 110 years: the optimal use of ovarian ablation as adjuvant therapy for breast cancerAntonio C Wolff
J Clin Oncol 24:4949-51. 2006
NCCN Task Force Report: Adjuvant Therapy for Breast CancerRobert W Carlson
Stanford Hospital and Clinics, Stanford University, Stanford, CA, USA
J Natl Compr Canc Netw 4:S1-26. 2006..This supplement summarizes the background data and ensuing discussion from the Adjuvant Task Force meeting...
Current status of taxanes as adjuvant therapy for early-stage breast cancerAntonio C Wolff
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland 21231-1000, USA
Int J Fertil Womens Med 50:227-9. 2005..In this commentary, we review much of the current data that support the use of taxanes in early-stage breast cancer...
Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studiesAlex Sparreboom
Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, 3075 EA Rotterdam, The Netherlands
Clin Cancer Res 9:151-9. 2003..11 liters/h)...
American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancerGary H Lyman
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
J Clin Oncol 23:7703-20. 2005..To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer...
Predicting cancer therapy-induced cardiotoxicity: the role of troponins and other markersJoseph A Sparano
Department of Oncology, Albert Einstein Cancer Center Montefiore Medical Center, Bronx, New York 10461, USA
Drug Saf 25:301-11. 2002..Clinical trials are currently evaluating the role of these markers in predicting both early and late, clinical and subclinical damage associated with anthracyclines and trastuzumab...
Myeloid toxicity in breast cancer patients receiving adjuvant chemotherapy with pegfilgrastim supportAntonio C Wolff
J Clin Oncol 24:2392-4; author reply 2394-5. 2006
HER2 testing in breast cancer: NCCN Task Force report and recommendationsRobert W Carlson
Stanford Hospital and Clinics
J Natl Compr Canc Netw 4:S1-22; quiz S23-4. 2006..8 to 2.2 or average number of HER2 gene copies/cell in the range of greater than 4 to less than 6 are considered to be borderline, and strategies to assign the HER2 status of such samples are proposed...
American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant settingJames L Khatcheressian
Virginia Commonwealth University/Massey Cancer Center, Richmond, VA, USA
J Clin Oncol 24:5091-7. 2006..CONCLUSION: Careful history taking, physical examination, and regular mammography are recommended for appropriate detection of breast cancer recurrence...
Intensive dose-dense compared with high-dose adjuvant chemotherapy for high-risk operable breast cancer: Southwest Oncology Group/Intergroup study 9623Halle C F Moore
Cleveland Clinic Foundation, Cleveland, OH, USA
J Clin Oncol 25:1677-82. 2007....
Invasive breast cancerRobert W Carlson
National Comprehensive Cancer Network
J Natl Compr Canc Netw 5:246-312. 2007
American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004Eric P Winer
Dana Farber Cancer Institute, 44 Binney St, D1210, Boston, MA 02115, USA
J Clin Oncol 23:619-29. 2005..To update the 2003 American Society of Clinical Oncology technology assessment on adjuvant use of aromatase inhibitors...
Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obeseAlex Sparreboom
Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
J Clin Oncol 25:4707-13. 2007..Here, we assessed the pharmacokinetics of eight anticancer drugs in adults and evaluated the potential utility of alternative weight descriptors in dose calculation for the obese...
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancerAntonio C Wolff
American Society of Clinical Oncology, Alexandria, VA, USA
J Clin Oncol 25:118-45. 2007..To develop a guideline to improve the accuracy of human epidermal growth factor receptor 2 (HER2) testing in invasive breast cancer and its utility as a predictive marker...
Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxaneHarold J Burstein
Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 26:1810-6. 2008..This phase II, open-label, multicenter study evaluated sunitinib monotherapy in patients with metastatic breast cancer (MBC)...
2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guidelineThomas J Smith
American Society of Clinical Oncology, Cancer Policy and Clinical Affairs, Alexandria, VA 22314, USA
J Clin Oncol 24:3187-205. 2006....
Breast cancerRobert W Carlson
Stanford Hospital and Clinics, USA
J Natl Compr Canc Netw 3:238-89. 2005
Luteinizing hormone-releasing hormone agonists in premenopausal hormone receptor-positive breast cancerSing Huang Tan
Department of Hematology Oncology, National University Hospital, Singapore
Clin Breast Cancer 7:455-64. 2007....
Adjuvant chemotherapy for postmenopausal lymph node-negative breast cancer: it ain't necessarily soAntonio C Wolff
J Natl Cancer Inst 94:1041-3. 2002
Weekly paclitaxel in the adjuvant treatment of breast cancerJoseph A Sparano
Eastern Cooperative Oncology Group, Philadelphia, USA
N Engl J Med 358:1663-71. 2008..We compared the efficacy of two different taxanes, docetaxel and paclitaxel, given either weekly or every 3 weeks, in the adjuvant treatment of breast cancer...
